• Title/Summary/Keyword: D2Q9

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Distinct Involvement of 9p21-24 and 13q14.1-14.3 Chromosomal Regions in Raw Betel-Nut Induced Esophageal Cancers in the State of Meghalaya, India

  • Rai, Avdhesh K.;Freddy, Allen J.;Banerjee, Atanu;Kurkalang, Sillarine;Rangad, Gordon M.;Islam, Mohammad;Nongrum, Henry B.;Dkhar, Hughbert;Chatterjee, Anupam
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.6
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    • pp.2629-2633
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    • 2012
  • Background: Raw betel nut (RBN) chewing is an important contributing factor for esophageal squamous cell carcinoma (ESCC), although associated genomic changes remain unclear. One difficulty in assessing the effects of exclusively RBN induced genetic alterations has been that earlier studies were performed with samples of patients commonly using tobacco and alcohol, in addition to betel-quid. Both CDKN2A (at 9p21) and Rb1 gene (at 13q14.2) are regarded as tumor suppressors involved in the development of ESCC. Therefore, the present study aimed to verify the RBN's ability to induce ESCC and assess the involvement of CDKN2A and Rb1 genes. Methods: A panel of dinucelotide polymorphic markers were chosen for loss of heterozygosity studies in 93 samples of which 34 were collected from patients with only RBN-chewing habit. Promoter hypermethylation was also investigated. Results: Loss in microsatellite markers D9S1748 and D9S1749, located close to exon $1{\beta}$ of CDKN2A/ARF gene at 9p21, was noted in 40% ESCC samples with the habit of RBN-chewing alone. Involvement of a novel site in the 9p23 region was also observed. Promoter hypermethylation of CDKN2A gene in the samples with the habit of only RBN-chewing alone was significantly higher (p=0.01) than Rb1 gene, also from the samples having the habit of use both RBN and tobacco (p=0.047). Conclusions: The data indicate that the disruption of 9p21 where CDKN2A gene resides, is the most frequent critical genetic event in RBN-associated carcinogenesis. The involvement of 9p23 as well as 13q14.2 could be required in later stages in RBN-mediated carcinogenesis.

A Study on the Creep Fracture Life of Al 7075 alloy( I ) (Al 7075 합금의 크리이프 파단수명에 관한 연구( I ))

  • 강대민
    • Journal of the Korean Society of Safety
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    • v.8 no.4
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    • pp.27-40
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    • 1993
  • High temperature tensile tests, steady state creep tests, Internal stress tests and creep rupture tests using A17075 alloy( $T_{6}$ ) were performed over the temperature range of 9$0^{\circ}C$~50$0^{\circ}C$ (0.4 $T_{m}$ ~0.85 $T_{m}$ ) and stress range of 0.64~17.2(kgf/$\textrm{mm}^2$). The main results obtained in this paper were as follows. (1) The activation energies for yielding at the temperature of 0.4 $T_{m}$ ~0.75 $T_{m}$ were calculated to be 25.7~36.5kcal/mol, which were nearly equal to the activation energies for creep. (2) At around the temperature of 9$0^{\circ}C$~12$0^{\circ}C$ and under the stress level of 10~17.2(kgf/$\textrm{mm}^2$), and at around the temperature of 200~41$0^{\circ}C$ and under the stress level of 1.53~9.55(kgf/$\textrm{mm}^2$) and again at around the temperature of 470~50$0^{\circ}C$ and under the stress level of 0.62~l.02(kgf/$\textrm{mm}^2$), the applied stress dependence of steady state creep rate $n_{measu}$ measured were, respectively, 3.15, 6.62 and 1.1, which were in good agreement the calculated stress dependence $n_{ealeu}$ obtained by the difference of the applied stress dependence of the Internal stress and the ratio of the internal stress to the applied stress. (3) At the temperature range of 0.4~0.43 $T_{m}$ , and at the temperature range of 0.52~0.75 $T_{m}$ and again at the temperature range of 0.82~0.85 $T_{m}$ , the activation energies $Q_{measu}$ obtained by steady state creep rate, respective, 26. 16, 34.9, 36.2 and 36.1kcal/mol, which were in good agreement with those obtained with the activation energies under constant effective stress and the temperature dependence of Internal stress. (4) At the temperature range of the 0.52~0.73 $T_{m}$ and under the stress level of 1.53~9.55(kgf/$\textrm{mm}^2$), the stress dependence of rupture life(n’) measured was 6.3~6.6, which was in good agreement with the stress dependence of steady state creep rate(n). And at the same condition the activation energy for rupture( $Q_{f}$ ) measured was 32.0~36.9kca1/mol, which was also in good agreement with the activation energy obtained by steady state creep rate ( $Q_{c}$ ). (5) The rupture life( $t_{f}$ ) might be represented by athermal process attributed to the difference of the applied stress dependence of the internal stress and the ratio of the internal stress to the applied stress, and the thermal activated process attributied to the temperature dependence of the internal stress as $t_{f}$ = A'$\sigma$$_{a}$ {n(1-d $\sigma$$_{i}$ /d $\sigma$$_{a}$ )/(1-$\sigma$$_{i}$ / $\sigma$$_{a}$ )}.exp[{ $Q_{c}$ $^{*}$-( $n_{o}$ R $T^2$/ $E_{(T)}$) (d $E_{(T)}$/dT) - ( $n_{0}$ R $T^2$/ $\sigma$$_{a}$ - $\sigma$$_{i}$ ) (d $\sigma$$_{i}$ /dT)}/RT]. (6) The relationship betwween Larson-Miller rupture parameter and logarithmic stress was linearly decreased, so creep rupture life of Al 7075 alloy seemed to be predicted exactly with Larson-Miller parameter.meter.

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Mapping of Quantitative Trait Loci Associated with Viviparous Germination in Rice

  • Lee, Seung-Yeob;Ahn, Jeong-Ho;Cha, Young-Soon;Yun, Doh-Won;Lee, Myung-Cheol;Eun, Moo-Young
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.51 no.6
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    • pp.565-570
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    • 2006
  • The viviparous germination (VG) with lodging caused the yield reduction and quality deterioration in rice. We carried out the evaluation of VG tolerance (on the 40th day after heading) and mapping QTLs associated with VG tolerance using the recombinant inbred lines (M/G RILs) from a cross between Milyang 23 (japonica/indica) and Gihobyeo (japonica). The VG rates of Milyang 23 and Gihobyeo were 0.0 and 7.0%, respectively. The averaged VG rate of 162 M/G RILs was 7.7%, and their range was from 0.0 to 50.9%. Of the 162 RILs, 144 lines were tolerant less than 10%, and 18 lines were susceptible more than 10%. Using the M/G RIL Map, three QTLs associated with the viviparous trait were detected on chromosome 2 (qVG 2-1 and qVG 2-2) and 8 (qVG 8). qVG 2-1 was linked to RM 32D and RZ 166, and had LOD score of 2.97. qVG 2-2 was tightly linked to E13M59.119-Pl and E13M59.M003-P2, and showed higher LOD score of 3.41. qVG 8 was linked to RM33 and TCT116, and had LOD score of 2.67. The total phenotypic variance explained by the three QTLs was about 24.4% of the total variance in the population. The detection of new QTLs associated with VG tolerance will provide important informations for the seed dormancy, low temperature germination, or comparative genetics.

The Electrical Properties of Bi2O3 Doped BaTi4O9 Ceramic Thick Film Monopole Antenna (Bi2O3가 첨가된 BaTi4O9 세라믹 후막 모노폴 안테나의 전기적 특성)

  • Jung Chun-Suk;Ahn Sang-Chul;Ahn Sung-Hun;Heo Dae-Young;Park Eun-Chul;Lee Jae-Shin
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.15 no.9
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    • pp.826-834
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    • 2004
  • In this paper, we fabricated thick film monopole antennas using Bi$_2$O$_3$-doped BaTi$_4$$O_{9}$ ceramics for small size and broadband intenna. In the result, the high permittivity was fixed and the quality factor was also significantly decreased by the formation of secondary phase of Bi$_4$Ti$_3$O$_{12}$ repleced by addtion Bi. The antenna property influenced by the quality value more than the permittivity. The bandwidth of antenna was increased to 33 %. On the other hand, the gain was reduced to -4.3 dBi. Also radiation patterns were showed low dBi value by increasing of dielectric loss. Specially, Measured x-y plane radiation patterns was distorted as the dispersion of wavelength and high permittivity difference. But the result is showed execellent bandwidth because of low quality value in all formation range.nge.

Wideband Chirp Signal Generation for W-Band SAR (W-대역 영상레이다를 위한 광대역 Chirp 신호 발생장치)

  • Lee, Myung-Whan;Jung, Jin Mi;Lee, Jun Sub;Singh, Ashisg Kumar;Kim, Yong Hoon
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.29 no.2
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    • pp.138-141
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    • 2018
  • In this paper, we describe the designed digital waveform of a linear frequency-modulated (FM) chirp signal using field-programmable gate arrays (FPGAs) for image radar, and this signal is modulated with an I-Q modulator, and multiplied by 24 frequency multipliers to obtain a 94-GHz W-band wideband chirp generator. The developed chirp generator is an FM signal with a 94-GHz carrier frequency and a 960-MHz bandwidth, and the flatness is less than 1.0 dB at intermediate frequency (IF) (3.9 GHz), 2.0 dB in the W-band, and it has a 0.3-W output power in the W-band.

Design of 900MHz Low Noise Amplifier (900MHz대 저전력 저잡음 증폭기 설계)

  • 김영호;정항근
    • Proceedings of the IEEK Conference
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    • 1998.10a
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    • pp.671-674
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    • 1998
  • 본 논문에서는 최근 급격히 수요가 증대하고 있는 휴대용 단말기의 수신기 선단에 사용되는 저잡음 증폭기(LNA)를 0.6㎛ CMOS공정 파라미터를 사용하여 설계하였다. 설계된 LNA는 전원 전압 ±1.2v, 900㎒대에서 동작하는 전류 재사용방식의 적층 CMOS구조로서 시뮬레이션 결과 전력소모가 9.45㎽, 전력이득은 23.7dB, 선형지수 OIP3는 7.6dBm을 나타내어 저전력 저잡음 특성을 얻었다. 사용된 인덕터의 Q는 3.5이다.

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Decomposition of leaf litter of some evergreen broadleaf trees in Korea

  • Lee, Kyung Eui;Cha, Sangsub;Lee, Sang Hoon;Shim, Jae Kuk
    • Journal of Ecology and Environment
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    • v.38 no.4
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    • pp.517-528
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    • 2015
  • Litter decomposition is an important process in terrestrial ecosystem. However, studies on decomposition are rare, especially in evergreen broadleaf trees. We collected the leaf litter of five evergreen broadleaf trees (Daphniphyllum macropodum, Dendropanax morbifera, Castanopsis cuspidata var. thunbergii, Machilus thunbergii and Quercus acuta), and carried out a decomposition experiment using the litterbag method in Ju-do, Wando-gun, Korea for 731 days from December 25, 2011 to December 25, 2013. Among the five experimental tree species, C. cuspidata var. thunbergii distribution was limited in Jeju Island, and D. macropodum was distributed at the highest latitude at Mt. Baekyang (N 35°40′). About 2% of the initial litter mass of D. macropodum and D. morbifera remained, while 20.9% remained for C. cuspidata var. thunbergii, 30.4% for M. thunbergii, and 31.6% for Q. acuta. D. macropodum litter decayed four times faster (k = 2.02 yr-1) than the litter of Q. acuta (k = 0.58 yr-1). The decomposition of litter was positively influenced by thermal climate such as accumulated mean daily air temperature (year day index) and precipitation, as well as by physical characteristics such as thickness (R2=0.939, P = 0.007) and specific leaf area (SLA) (R2 = 0.964, P = 0.003). The characteristics of chemical composition such as lignin (R2 = 0.939, P = 0.007) and water-soluble materials (R2 = 0.898, P = 0.014) showed significant correlations with litter decomposition. However, the nutrients in litter showed complicated species-specific trends. The litter of D. macropodum and D. morbifera had fast decomposition despite their low nitrogen concentration and high C/N ratio. This means that the litter decomposition was more strongly affected by physical characteristics than chemical composition and nutrient content. On the other hand, the litter of Q. acuta which had the slowest decay rate had a high amount of N and low C/N ratio. Thus, the decomposition of Q. acuta litter was more affected by the P content of the litter than the N content, although all litter had similar physical characteristics.

Quantization Level Selection of Intra-Frame for MPEG-4 Video Encoder (MPEG-4 부호화기에서의 인트라 프레임 양자화 레벨 선정)

  • Kim Jeong Woo;Cho Seong Hwan
    • Journal of Korea Multimedia Society
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    • v.8 no.1
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    • pp.9-18
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    • 2005
  • This paper presents the method of calculating the quantization level of the intra-frame in MPEG-4 video encoder. The intra-frame is an essential part in that the quality of the whole GOP is affected by the quality of this frame since the intra-frame, which works as a reference frame within GOP, continuously propagates through other frames. This work proposes how to use bits assigned for gaining the quantization level of the intra-frame, complexity of input images, and GOP structures. The result shows that while existing approaches have the decline in efficiency by using fixed values or show different qualifies depending on the characteristics of the images, the current approach shows the steady results in various images. Comparing with Q2 algorithm obtained in MPEG-4 VM, the approach suggested in this paper gains the benefit of maximum 3.49dB with some variations depending on the characteristics of the images.

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Efficiency of Livestock Farming Wastewater Treatment by Trickling Filters (撒水濾床法에 依한 畜産廢水의 處理效果에 관한 연구)

  • Ahu, Soo Mi
    • Journal of Environmental Health Sciences
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    • v.11 no.2
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    • pp.17-27
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    • 1985
  • The objectives of this study is to examine efficiency of swinery wastewater treatment by trickling filters' pilot plant. The results of this study are as follows: 1. The characteristics of sample. The BOD$_5$ was from 2,450 to 2,880mg/l, COD(KMnO$_4$ acid method) was from 910 to 1,064mg/l, and SS was from 920 to 990mg/l. The pH of influent was from 7.3 to 7.6, and the temperature of water was from 17.0$\circ$C to 22.5$\circ$C. 2. For experiment by recirculation, the BODs removal efficiency is 65.2% at recirculation ratio (r)=0, and 70.7% at r=1. The ramoval efficiency of this study is higher than NRC formula of U.S.A.. The recirculation is not significant effect on removal efficiency. 3. For experiment by hydraulic load, the BOD$_5$ removal rate decreased from 73.1% at $3.1m^3/m^2\cdot d$ to 65.3% at $9.2m^3/m^2\cdot d$. The design formula of this study which shows the removal rate of soluble BOD is $Le/Li =10^{-0.24} D/Q^{0.24}$ (Q: hydraulic load, D: depth of filter). 4. For experiment by organic load, the BOD$_5$ removal rate is increased from 70.2% at $0.77kg/m^3\cdot d$ to 75.4% at $4.28kg/m^3\cdot d$. We can obtain the straight line y=0.749 x (y: removed BOD, x :applied BOD) by the least squares method. 5. We can know that trickling filters is strong with the hydraulic load and the organic matter shock load. Here, we can judge that trickling filters is a good method for the treatment of swinery wastewater which containing high concentrated organic matter.

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A Study of Subjectivity in the Perception Gender Roles of Women (여대생의 성역할에 관한 주관성 연구)

  • Kwon, Hye-Jin;Chung, Yun-Kang;Kim, Kyung-Hi;Choi, Mi-Hye;Yeoum, Soon-Gyo
    • Women's Health Nursing
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    • v.9 no.1
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    • pp.80-91
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    • 2003
  • Purpose : This study is to define the structural patterns of gender roles of women as perceived by co-eds. Method : Q-methodology was used on 174 statements collected through interviews with women aged between 20 an d 50. 38 Q-samples were selected from 330 Q-population. The Q-samples were administered to 29 co-eds. Result : Analysis of Q-type obtained by QUANAL program revealed three types of subjectivity in the perception of gender roles. Type 1, role is characterized by the tendency to play down the female gender role and think that women's body is an essential factor in forming the female gender role. Type 2, rejects motherhood image obedience and chastity dictated by male chauvinism. Type 3, shows a tendency to believeth at female gender cannot be separated from maternity and that women's basic role is housekeeping. The three types were common in believing in self-development and equal rights through economical in dependence.

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