• 제목/요약/키워드: D.I.Y.

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Genetic Variants of Serum Proteins and Enzymes in Holstein-Friesian Cattle (홀스타인종 유우의 혈청단백질 및 효소의 유전적 변이체)

  • Sang, Byung Chan;Ryoo, Seung Heui;Seo, Kil Woong;Lee, Chang Soo
    • Korean Journal of Agricultural Science
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    • 제22권2호
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    • pp.163-169
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    • 1995
  • This study was carried out to examine the genetic constitution of serum proteins and enzymes in Holstein Friesian cattle population. The genetic variants of post-transferrin-2(pTf-2), transferrin(Tf), post-albumin(pAlb), ceruloplasmin(Cp) and amylase-I(Am-I) were analyzed by using PAGE(polyacrylamide gel electrophoresis) and STAGE(starch gel electrophoresis). In serum proteins, the pTf-2 locus were observed to be controlled by codominant alleles designated F and S, and the distribution of genotypes were 76.34, 14.50 and 9.10% for pTf-2 FF, FS and SS types, respectively. The gene frequencies of the pTf-2 F and S allele were 0.836 and 0.164. The Tf locus were found to be controlled by four alleles, Tf A, D1, D2 and E at a single locus, and the distribution of genotypes were 6.11, 32.06, 19.08, 1.53, 10.69, 18.32, 9.92 and 2.29% for Tf AA, AD1, AD2, AE, D1D1, D1D2, D2D2 and D2E type, respectively. The gene frequencies of the Tf A, D1, D2 and E wee 0.321, 0.359, 0.298 and 0.019. The pAlb locus were identified to be genetically controlled by two alleles, pAlb F and S allele, and the distribution of genotypes were 32.06, 29.77 and 38.17% for pAlb FF, FS and SS types, respectively. The gene frequencies of the pAlb F and S allele were 0.461 and 0.531. The Alb locus were observed to be controlled by Alb A and B allele, and the gene frequencies of these were 0.996 and 0.004. In serum enzymes, the Cp locus were found to be controlled by F and S allele, and the distribution of genotypes were 46.57, 27.48 and 25.95% for Cp FF, FS and SS types, respectively. The gene frequencies of F and S allele were 0.603 and 0.394. The Am-I locus were observed to be controlled by Am-I B and C allele, and the distribution of genotypes were 39.69, 21.73 and 38.93% for Am-I BB, BC and CC types, the gene frequencies of Am-I B and C were 0.503 and 0.497, respectively.

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The Difference of the $2^{nd}$ to $4^{th}$ Digit Length Ratio between Type I and Type II Alcoholism (알코올 의존 제I형 및 II형 환자에서 검지-약지 길이 비의 차이)

  • Han, Chang-Woo;Lee, Yu-Sang;Hahm, Woong;Won, Sung-Doo
    • Korean Journal of Biological Psychiatry
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    • 제18권4호
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    • pp.260-266
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    • 2011
  • Objectives The second to fourth digit ratio (2D : 4D) is known to reflect testosterone level during intrauterine period. Testosterone is essential for masculinization of brain. Cloninger's type II alcoholism is characterized by early age at onset and largely limited to males. Compared with type I alcoholism, type II alcoholism is thought to be masculine. There is a possibility that the digit ratio of type II alcoholism is low compared with type I. We examined digit length ratio in Cloninger's type I and II alcoholism to understand the effects of intrauterine testosterone on the development of alcoholism. Methods The participants were 87 alcohol dependent patients. We divided two subtypes of patients by Irwin's symptom list, based on Cloninger's concept. We captured the images of both palms by the scanner and measured the lengths of digits by the graphic program. Then we analyzed the digit ratios by independent-sample t-test. Results The mean 2D : 4D of type I was 0.942 (right), 0.952 (left). The mean 2D : 4D of type II was 0.927 (right), 0.940 (left). In both hands, 2D : 4D of type II was significantly lower than type I. Conclusions Type II alcoholism showed masculine type of digit length ratio compared with type I. It suggests the exposure of testosterone during intrauterine period might play an important role in determining the course and feature of alcoholism.

A Study on Nuclear Information Management System Utilizing Microcomputer (마이크로 컴퓨터를 이용한 원자력 분야 정보 관리 시스템 개발)

  • 김규선;김태승
    • Journal of the Korean Society for information Management
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    • 제6권1호
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    • pp.15-36
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    • 1989
  • The r a p i d i n c r e a s e o f microcomputer technology has r e s u l t e d i n t h e broad a p p l i c a t i o n t o various f i e l d s . The purpose of t h l s paper 1s to design a computerized r e t r i e v a l system f o r nuclear information m a t e r i a l s using a microcomputer.

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Performance Analysis of Multi-Carrier CDMA Trellis Coded 16 QAM System with Near/Far Effect in Frequency Selective Multipath Fading Channel (주파수 선택성 다중경로 페이딩 채널에서 Near/Far 영향을 받는 Multi-Carrier CDMA Trellis Coded 16 QAM 시스템의 성능해석)

  • 노재성;강희조;김춘길;김언곤;조성준
    • The Journal of Korean Institute of Communications and Information Sciences
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    • 제25권3A호
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    • pp.352-361
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    • 2000
  • The performance of a multi-carrier CDMA system is analyzed considering frequency selective multipath fading and Near/Far effects. The number of multicarrier, multiuser, and arms of RAKE receiver, and the decay ratio of frequency selective multipath fading are used as a parameter for the performance analysis. More over, the distribution and the strength of multiuser interference are also considered. To evaluate the Near/Far effects in a multi-carrier CDMA system, three distribution models are assumed. In the first model, interference to carrier Ratio, I/C, ranges from -4 dB to 4dB, and at each 2 dB interval, 20 % of multiuser is assumed to be uniformly distributed. In the second one, I/C ranges from -2 dB to 2 dB, and 33.3% of multiuser is assumed to be equally dispersed at each 2dB interval. The third model is 0 dB of I/C, that is, with perfect power control, multiuser are assumed to be evenly located. In this paper, multi-carrier CDMA system adoption RAKE receiver is proposed to mitigate the frequency selective multipath fading. From the results, the third model(i.e. perfect power control) shows the best performance, and the narrower range of I/C causes the less effects to the desired signal, which reads to the better performance.

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SPECTRAL LOCALIZING SYSTEMS THAT ARE t-SPLITTING MULTIPLICATIVE SETS OF IDEALS

  • Chang, Gyu-Whan
    • Journal of the Korean Mathematical Society
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    • 제44권4호
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    • pp.863-872
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    • 2007
  • Let D be an integral domain with quotient field K, A a nonempty set of height-one maximal t-ideals of D, F$({\Lambda})={I{\subseteq}D|I$ is an ideal of D such that $I{\subseteq}P$ for all $P{\in}A}$, and $D_F({\Lambda})={x{\in}K|xA{\subseteq}D$ for some $A{\in}F({\Lambda})}$. In this paper, we prove that if each $P{\in}A$ is the radical of a finite type v-ideal (resp., a principal ideal), then $D_{F({\Lambda})}$ is a weakly Krull domain (resp., generalized weakly factorial domain) if and only if the intersection $D_{F({\Lambda})}={\cap}_{P{\in}A}D_P$ has finite character, if and only if $F({\Lambda})$ is a t-splitting set of ideals, if and only if $F({\Lambda})$ is v-finite.

A VANISHING THEOREM FOR REDUCIBLE SPACE CURVES AND THE CONSTRUCTION OF SMOOTH SPACE CURVES IN THE RANGE C

  • Ballico, Edoardo
    • Communications of the Korean Mathematical Society
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    • 제34권1호
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    • pp.105-111
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    • 2019
  • Let $Y{\subset}{\mathbb{P}}^3$ be a degree d reduced curve with only planar singularities. We prove that $h^i({\mathcal{I}}_Y(t))=0$, i = 1, 2, for all $t{\geq}d-2$. We use this result and linkage to construct some triples (d, g, s), $d>s^2$, with very large g for which there is a smooth and connected curve of degree d and genus g, $h^0({\mathcal{I}}_C(s))=1$ and describe the Hartshorne-Rao module of C.

Inhibition of the Formation of Adducts Between Metabolites of Benzo(a)pyrene and DNA by Panaxydol in vivo and in vitro (Benzo(a)pyrene 대사물질들의 DNA에 대한 Adduct 형성 억제에 미치는 Parlalrydol의 효과)

  • 박진규;김신일
    • Journal of Ginseng Research
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    • 제13권1호
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    • pp.42-48
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    • 1989
  • The binding of bay region diol-epoxides of polycyclic aromatic hydrocarbons (PAHs) to target tissue DNA is thought to be essential for the initiation of cancer by these compounds. In this study we investigated the effect of polyacetylenes such as panaxynol and panaxydol on the formation of benzo(a)pyreno (BP)-metabolite-DNA adduct in the liver of ICR mice. Treatment of mice by i.p. administration of polyacetylenes produced a marked reduction in BP metabolite binding to DNA in vitro. Following i.v. administration of (3H)BP(300, ${\mu}$Ci/21 nmoles/0.1 nt DMSO) to mice, radioactivity was detected in the DNA of the liver in vivo. The result of tentative identification of the 4 peaks between the two standard markers for high pressure liquid chromatography showed that the peaks. I, II, III, and IV were BP-phenol oxide-DNA adduct (or BP-diol-epoxide-dCyt. adduct), (-) BP$.$diolepoxide I:dGuO adduct, (+) BP-diol-epoxide I: dGuo adduct, and BP-diol-epoxide II:dGuO adduct, respectively. The minor adduct, (-) BP-diol epoxide I: dGuo was reduced to 6971 of the amount of the control, while the major adduct, (+) BP-diolepoxide I: dGuO(peak II) which was produced from (-) BP-7, 8-diol was reduced to 78% of that of the control. The amount of the minor adduct, BP-diol-epoxide II:dGuo adduct(peak IV) which formed from (+) BP-7, 8-diol was 58% of the control. These results show that the panaxydol is more related to inhibition of the formation of the minor ad- ducts than of the major adducts, which were generally produced from ($\pm$) BP-7, 8-dihydro-dials.

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The Substates with Mutants That Negatively Charged Aspartate in Position 172 Was Replaced with Positive Charge in Murine Inward Rectifier Potassium Channel (Murine Kir2.1)

  • So, I.;Ashmole, I.;Stanfield, P.R.
    • The Korean Journal of Physiology and Pharmacology
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    • 제7권5호
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    • pp.267-273
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    • 2003
  • We have investigated the effect on inducing substate(s) of positively charged residues replaced in position 172 of the second transmembrane domain in murine inward rectifier potassium channels, formed by stable or transient transfection of Kir2.1 gene in MEL or CHO cells. Single channel recordings were obtained from either cell-attached patches or inside-out patches excised into solution containing 10 mM EDTA to rule out the effect of $Mg^{2+}$ on the channel gating. The substate(s) could be recorded with all mutants D172H, D172K and D172R. The unitary current-voltage (I-V) relation was not linear with D172H at $pH_i$ 6.3, whereas the unitary I-V relation was linear at $pH_i$ 8.0. The relative occupancy at $S_{LC}$ was increased from 0.018 at $pH_i$ 8.0 to 0.45 at $pH_i$ 5.5. In H-N dimer, that was increased from 0.016 at $pH_i$ 8.0 to 0.23 at $pH_i$ 5.5. The larger the size of the side chain or $pK_a$ with mutants (D172H, D172K and D172R), the more frequent the transitions between the fully open state and substate within an opening. The conductance of the substate also depended upon the pKa or the size of the side chain. The relative occupancy at substate $S_{LC}$ with monomer D172K (0.50) was less than that in K-H dimer (0.83). However, the relative occupancy at substate with D172R (0.79) was similar to that with R-N dimer (0.82). In the contrary to ROMK1, positive charge as well as negative charge in position 172 can induce the substate rather than block the pore in murine Kir2.1. The single channel properties of the mutant, that is, unitary I-V relation, the voltage dependence of the mean open time and relative occupancy of the substates and the increased latency to the first opening, explain the intrinsic gating observed in whole cell recordings.