• Bulletin of the Korean Chemical Society
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• v.33 no.12
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• pp.4180-4184
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• 2012

The target compounds 6-11a-e were synthesized by condensing 4-amino-5-aryl-3H-1,2,4-triazole-3-thiones 5a-f with various aromatic carboxylic acids in the presence of phosphorous oxychloride. The structures of newly synthesized compounds were characterized by IR, $^1H$ NMR, $^{13}C$ NMR, elemental analysis and mass spectrometric studies. All the synthesized compounds were screened for their antibacterial activity. Almost all the tested compounds were potent against four different strains of bacteria when compared with that of reference drug ciprofloxacin. Compounds 6c, 6e, 8d, 9b, 9e, 11a and 11b showed nearly equal or lower MIC values than standard drug, against all four tested bacterial strains but rest of the compounds showed excellent antibacterial activities.

• Journal of the Korean Society of Safety
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• v.23 no.6
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• pp.150-157
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• 2008

The purpose of this study was to investigate the effect of short-tenn stretching type of muscular strength gymnastics on health-related fitness and rating of perceived pain for automotive industry workers. The subjects selected were 27, who were divided into 3 groups(A group=10, B group=9, C group=8). Group A performed a short-term stretching Type of Muscular Strength Gymnastics only one time. Group B continuously performed the exercise program two times. Group C was a control group. The exercise program was a stretching Type of Muscular Strength Gymnastics, which was performed 3 times per week for 4 weeks. Its intensity was RPE 11-15. Data analysis was conducted by using SPSS ver 14.0. The test was conducted with two-way repeated ANOVA, post-hoc Ducan and paired t-test (a<.05). This study showed the following results. Muscular strength, muscular endurance and flexibility increased in all intra and between groups. Ratio of %fat decreased for group B but the control group presented conversely. Rating of perceived pain of group A decreased at arm and hands. Rating of perceived pain of group A decreased at back and leg.

• Geotechnical Engineering
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• v.9 no.2
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• pp.41-54
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• 1993

This paper presents the two and three -dimensional stability analysis of nonhom- ogeneous, c-o soil slopes. Potential failure surface is assumed as a logspiral curve refracted in boundaries of layers. In 3-D analysis, rotational soil mass is assumed with a cylindroid central part terminated with plane ends. Seismic force is considered by sesmic intensity. The program developed in this study is compared with the program PCSTABLS. The ratio of three-dimensional minimum factor of safety to two-dimensional case is examined and factor of safety changes are showed for the ratio of cylindroid length to slope height and numbers of slice. On such bases the following conclusions may by made : (1) The program developed in this program is less conservative than the program PCSTABLS. (2) The value of F2 of this study shows the larger differences than that of PCSTABLS with increasing friction angle (3) Factors of safety computed for 3-D geometry differ considerablely from ordinary 2-D factors of safety. Since Fb/F2 exceeds unity, three -dimensional effects tend to increase the factor of safety. (4) As the ratio of three - dimensional failure width of slope height, b/H increase, the value of Fb/Ff decreases and approaches 1.0 when bye is 14. (5) In calculating the factor of safety using the developed program the number of slices is suitable with the ranges of 30-40

• Biomedical Science Letters
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• v.6 no.3
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• pp.201-208
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• 2000

The vancomycin, one of the family of glycopeptide antibiotics, inhibits the synthesis of bacterial cell wall peptidoglycan and has been widely used against gram-positive bacterial infections, especially for a treatment of methicillin resistant S. aureus infection. However, clinical isolate which was intermediately resistant to vancomycin (Mu50: MIC 8 $\mu\textrm{g}$/ml) was isolated in recent years. In this study we performed vancomycin susceptibility test with the increment method and population analysis with clinical isolates S. aureus. Also we did several kinds of tests with three selected isolates (s129: MIC 7 $\mu\textrm{g}$/ml, s134: MIC 7 $\mu\textrm{g}$/ml, s135: MIC 8 $\mu\textrm{g}$/ml) to find out possible mechanism of vancomycin resistance. As a result, the prevalence of vancomycin resistant S. aureus isolates among S. aureus strains resistant to methicillin was 23.3% (25/107). The vancomycin resistances of isolated strains of S. aureus were between those of Mu5O and Mu3 strains. By PCR analysis, none of the isolates with decreased vancomycin susceptibility contained known vancomycin resistant genes such as vanA, vanB, vanC1, vanC2, and vanH. Major bands of 81 kDa, 58 kDa, 33 kDa, 28 kDa were demonstrable in whole cell lysates by SDS-PAGE from all three isolates as well as reference strains. And especially,45 kDa protein was overproduced in Mu50 strains. Among them increased production of NAD$^{+}$-linked-$_{D}$-lactate dehydrogenase (dnLDH) were detected from one clinical strain (s135) and Mu5O strain. From these data, we suggest that the mechanism of vancomycin resistance in these isolates are distinct from that in enterococci.

• Journal of Animal Science and Technology
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• v.52 no.4
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• pp.313-318
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• 2010

The Jeju native pigs of 168 heads (116 barrows and 52 gilts) were examined to investigate the carcass characteristics related to gender, meat quality grades and yield grades. The averages of carcass characteristics for Jeju native pigs were 72.94 kg for carcass weight, 20.98 mm for backfat thickness, 38.14 for Hunter L*, 4.68 for a*, 6.04 for b*, 5.61 for pH, 3.61 for visual plate meat color, 3.36 for marbling scores, 1.83 for meat quality grades and 2.08 for yield grades, respectively. The carcass weight of gilts was significantly higher than that of barrows (p<0.05). There were no significant differences between barrows and gilts in carcass percent, backfat thickness, and meat color. The pH of barrows was significantly higher than that of gilts (p<0.05). The differences between gender groups were significantly noticed in carcass quality grades, and yield grades (p<0.05). The carcass weight, carcass percent, backfat thickness, and marbling scores for pigs with high grades(1 and 2 grades) were significantly higher than those for pigs with low grades (p<0.05). However, there was no significant difference among 4 carcass grades. The carcass weight, carcass percent, backfat thickness, pH, and meat color for carcass with high yield grades were significantly higher than those for carcass with low grades (p<0.05). The meat colors for Hunter L*, a* and b* were not significantly shown in carcass yield grades.

• Journal of computational fluids engineering
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• v.13 no.4
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• pp.72-79
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• 2008

This study is to investigate the air flow around a sirocco fan which is used in a range hood. The main object of the study is to improve the flow rate of the fan by analysis of unsteady 3-dimensional incompressible flow. Overall analysis is carried out using CFD method. For this, we used a commercial code, SC/Tetra, and used a sliding mesh method to give the same condition as an actual state. First, verification of the CFD results is done by comparing the experimental data with the numerical data for the suction flow rate. It is confirmed that two results are well consistent. Then for the improvent of flow rate, the effect of shape factors such as diameter ratio of fan, geometry of case, cut-off aperture and guide angle of case exit on the suction flow rate was considered. Especially, for a new design of housing, the principle of Archimedes spiral was used. The overall analysis was applied to a new design of housing, and the result showed an increase of flow rate by 10.7%.

• Transactions of Materials Processing
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• v.19 no.3
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• pp.160-166
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• 2010

In this paper, the process parameters of thread rolling were designed based on the numerical analysis results. Firstly, the effective analysis conditions that guarantee the reliability of the analysis results were found. To find the effective analysis conditions, the analyses were carried out for various numbers of teeth. And then, the effects of the process parameters such as tool shape and temperature on the thread rolling performance were investigated. The formability in thread rolling process was evaluated in terms of Cockcroft-Latham damage value. In order to evaluate formability, Cockcroft-Latham damage value was normalized by the critical damage value which was obtained from the analysis of uniaxial tensile test. The analyses were carried out using DEFORM-3D. The results showed that the flank angle and crest round had an effect on the thread rolling load. It was also shown that temperature had significant effects on the effective strain distribution, rolling load, and damage. With the reduced formability of stainless steel at higher temperature, it was shown that the normalized damage values increased as the process temperature.

• Transactions of Materials Processing
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• v.18 no.1
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• pp.39-44
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• 2009

This paper is concerned with forming technology of an automotive front side member part with ultra high strength steel sheet of DP980. The forming technology considered in this paper is the draw & form type, which installs the upper pad and lower pad to produce the complicated shape of ultra high strength steel sheet. In order to produce sound product, comparison between form type and draw & form type and between draw type and draw & form type are investigated by FE-analysis. FE-analysis is carried out with commercial sheet metal forming analysis S/W, DYNAFORM. It was shown from FE-analysis that the draw & form type satisfied the required specifications such as the dimensional accuracy and soundness of automotive front side member part. The effectiveness of the analytical result was verified by the experiment. From this investigation, the draw & form type is proved to be able to supply useful forming technology in forming ultra high strength steel.

• Journal of the Korean Society for Heat Treatment
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• v.22 no.5
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• pp.307-311
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• 2009

In this study, TiCrN films were deposited on STS 316 Land Si (100) wafer by inductively coupled plasma (ICP) assisted D.C. magnetron sputtering. The effect R.F. power for ICP discharge on the mechanical properties of TiCrN films was investigated. XRD, XPS and FE-SEM were used for the structure analysis. Also the Micro-Knoop hardness tester and profilometer were used for measuring hardness of coatings and film stress respectively. As increasing the R.F. power for ICP discharge, thickness of coating was decreased from 1633 nm to 1288 nm but hardness was increased about $Hk_{5g}$ 4200 at 400 W. All of the XRD patterns showed (111), (200) and (220) peaks of TiCrN films. Surface morphology was studied using the profilometer. FE-SEM was used to know morphology and cross-section of the films. Structure of the films was changed dense as increased ICP power.

• Journal of Ginseng Research
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• v.45 no.2
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• pp.254-263
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• 2021

Background: A chronic social defeat stress (CSDS) model has been proposed as relevant to stress-induced behavioral change in humans. In this study, we examined the effect of Korean Red Ginseng (KRG) on CSDS-induced mood disorders and protein expression in an animal model. Methods: To evaluate the effect of KRG on social defeat stress, test mice were exposed in the resident aggressor's home cage compartment for 14 days beginning 1 h after KRG treatment (10, 20, and 40 mg/kg, per oral (p.o.)). After the exposure, behavioral tests to measure anxiety, social interaction, and depression-like behavior were performed. To investigate the underlying mechanism, N-methyl-D-aspartate receptor expression levels in CSDS-induced mice were evaluated using Western blot analysis. Results: CSDS induced anxiety-like behaviors by decreasing central activity in the open-field test and open-arm approach in the elevated plus maze test and led to social avoidance behavior in the social interaction test. CSDS mice showed upregulated NR1, NR2A, and NR2B expression in the hippocampus. KRG 20 and 40 mg/kg ameliorated anxiety-like activities and KRG 20 mg/kg alleviated social avoidance by decreasing time in the corner zone. KRG treatment recovered CSDS-induced NR1, NR2A, and NR2B protein levels in the hippocampus. Conclusion: These results indicate that KRG has a therapeutic effect on CSDS-induced mood disorder by alleviating N-methyl-D-aspartate receptor overexpression in the hippocampus.