• Maxillofacial Plastic and Reconstructive Surgery
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• v.36 no.3
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• pp.85-93
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• 2014

Purpose: Nodal metastasis is the main prognostic factor in the patients with oral squamous cell carcinoma (OSCC). We investigated the association between tumor-associated lymphatics and OSCC characteristics. Methods: Thirty-four specimens were used for the immunohistochemical staining with the antibody for vascular endothelial growth factor (VEGF)-C, VEGF-D, VEGF receptor (VEGFR)-3, phosphorylated VEGFR-3, D2-40, and matrix metallproteinases (MMPs). We observed the distribution of the lymphangiogenic factors and quantified the degree of expression. We determined lymphatic vessel density (LVD) and lymphatic vessel dilatation with D2-40 immunostaining. We assessed the association of LVD or lymphatic vessel dilatation with tumor progression or tumor differentiation. Results: OSCC cells expressed lymphangiogenic ligands. Lymphangiogenic receptor, VEGFR-3, was expressed and activated in some tumor cells as well as in tumor-associated endothelial cells. LVD was not associated with tumor size or nodal status, but lymphatic vessel dilatation was higher in tumors with nodal metastasis, and also higher in poorly differentiated tumors. In stromal area of OSCC, MMP-1 and MMP-10 were up-regulated and the basement membrane of tumor-associated endothelial cells was destroyed by these collagenases. Conclusion: In the primary tumors with nodal metastasis, especially in poorly differentiated OSCC, tumor cells invaded the dilated lymphatic vessels via ruptured sites. MMP-1 and MMP-10 are important in the lysis of the glycocalyx inside the tumor-associated lymphatic endothelial cells.

• The Proceeding of the Korean Institute of Electromagnetic Engineering and Science
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• v.24 no.2
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• pp.51-57
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• 2013

The current expanding mobile markets incessantly demands small form factor, low power consumption and high aggregate throughput for silicon-level integration such as memory to logic system. One of emerging solution for meeting this high market demand is 3D through silicon stacking (TSS) technology. Main challenges to bring 3D TSS technology to the volume production level are establishing a cost effective supply chain and building a reliable manufacturing processes. In addition, this technology inherently help increase number of IOs and shorten interconnect length. With those benefits, however, potential signal and power integrity risks are also elevated; increase in PDN inductance, channel loss on substrate, crosstalk and parasitic capacitance. This paper will report recent progress of wide IO memory to high count TSV logic device assembly development work. 28 nm node TSV test vehicles were fabricated by the foundry and assembled. Successful integration of memory wide IO chip with less than a millimeter package thickness form factor was achieved. For this successful integration, we discussed potential signal and power integrity challenges. This report demonstrated functional wide IO memory to 28 nm logic device assembly using 3D package architecture with such a thin form factor.

• Journal of Aerospace System Engineering
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• v.14 no.6
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• pp.58-67
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• 2020

In this study, finite element fatigue analysis combined with a fatigue correlation factor is proposed to predict the bending fatigue life of a gear in an electro-mechanical aircraft actuator. First, stress-life curves are obtained for the gear material via a round bar fatigue test. Subsequently, stochastic stress-life (P-S-N) curves are derived for 50% and 1% failure probabilities, separately. The curves are applied to the fatigue analysis model of a single gear tooth, and the effect of the fatigue correction factor is analyzed. The analytical P-S-N curves reflecting the fatigue correction factor matched the experimental data. This shows that the analytical fatigue life is reliable and that the analysis technique is effective.

• Journal of Sensor Science and Technology
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• v.32 no.6
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• pp.470-474
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• 2023

In this study, a diaphragm-type pressure sensor was developed using multi-layer(four-layer) graphene produced at 1 nm thickness by thermally transferring single-layer graphene produced by chemical vapor deposition (CVD) to a 6" silicon wafer. By measuring the gauge factor, we investigated whether it was possible to produce a pressure sensor of consistent quality. As a result of the measurement, the pressure sensor using multilayer graphene showed linearity and had a gauge factor of about 17.5. The gauge factor of the multilayer graphene-based pressure sensor produced through this study is lower than that of doped silicon, but is more sensitive than a general metal sensor, showing that it can be sufficiently used as a commercialized sensor.

• Culinary science and hospitality research
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• v.13 no.2
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• pp.22-34
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• 2007

We researched the previous study about the restaurant's physical environment and had made up questionnaires. The purpose of this study is to analyze the effect of physical facilities of family restaurants on customers' satisfaction. The result was as follows: First, customers visited with friends or family irrespective of days $2{\sim}3$ times a month. Second, the physical environment factors of family restaurants were interior design, interior, making atmosphere and exterior. Third, it was the interior factor(0.268), making atmosphere factor(0.353) and exterior factor(0.244) that affected customers' satisfaction in family restaurants(p<0.001). $R^2$ change was 0.659 and the regression model was suited to our study(F=56.475). To increase customers' satisfaction, the physical environment of family restaurants needs remodeling in proper time.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.12C
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• pp.1208-1215
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• 2006

In this paper, we propose an algorithm that creates three-dimensional (3D) stereoscopic video from two-dimensional (2D) video encoded by H.264 instead of using the conventional stereo-camera process. Motion information of each frame can be obtained by the given motion vectors in most of videos encoded by MPEG standards. Especially, we have accurate motion vectors for H.264 streams because of the availability of a variety of block sizes. 2D/3D video conversion algorithm proposed in this paper can create the left and right images that correspond to the original image by using cut detection method, delay factors, motion types, and image types. We usually have consistent motion type na direction in a given cut because each frame in the same cut has high correlation. We show the improved performance of the proposed algorithm through experimental results.

• Progress in Medical Physics
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• v.13 no.1
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• pp.27-31
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• 2002

Output factors for 6MeV electron were directly measured under the condition of an individual beam cutout and these factors were compared with the output factors by 1D method which is an easy means to predict the output factors of electron beam. Output factors by 1D method are defined as output factors of rectangular fields where one side is always equal to the side of the square reference field and the output of an arbitrary rectangular field X, Y is given by the product of the 1D output factors. The output of very large square fields is overestimated using 1D method for the 6MeV electron, but it results in agreement with measured data under the condition of an individual cutout within 1% error adopting a correction factor $CF=C\times$[(X-10)(Y-10)/$\mid$(X-10)(Y-10)$\mid^{1/2}]$.

• Journal of Convergence for Information Technology
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• v.11 no.11
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• pp.125-136
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• 2021

Innovation is essential for the survival of a company in the fierce competitive environment of the global era of borders along with rapid technological development and changes from the environment. It is very important to secure your own competitive advantage. In this study, the relationship between internal R&D capability and organizational support as a company internal factor and external R&D capability, external knowledge search, and absorptive capability as a company external factor on performance was examined. As a result of the analysis, it was found that internal R&D capability, organizational support, and external knowledge search had a significant effect on absorptive capability, and innovation performance had a positive effect on new product performance. However, the mediating effect of absorptive capacity has not been verified, suggesting that absorptive capacity has a low correlation between innovation performance and new product performance, or that other important factors act between absorptive capacity and performance variables. The results of this study are expected to be utilized as useful guidelines when establishing R&D strategies in companies.

• Journal of the Korean Society of Radiology
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• v.16 no.5
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• pp.505-512
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• 2022

In this study, a 3D printed assistive device was applied to X-ray examinations to diagnose human diseases. Based on the results of evaluating the device, statistical and regression analyses were conducted to evaluate its clinical utility and purchase intention, respectively. In the experiment, 90 radiologists performed X-ray examinations on patients who agreed with the use of the assistive device in oblique view X-rays of the lumbar spine, and then statistical analyses were undertaken with a traditional aid and factor analysis. The non-standardized coefficient values of the multiple regression analysis performed by setting the purchase intention of the 3D printed device as the dependent variable and the 3D printed device and traditional aid calculated by factor analysis as independent variables were 0.893 (p<0.001) and 0.269 (p<0.001), indicating statistically significant results. The results show that the 3D printed assistive device proposed in this study has higher clinical utility than traditional aids used in oblique view X-rays of the lumbar spine.

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2002.11a
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• pp.43-50
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• 2002