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3차원 다공성 콜라겐지지체의 제조 및 특성 분석 (Fabrication and Characterization of 3-D Porous Collagen Scaffold)

  • 김진태;임수민;김병수;이득용;최재하
    • 대한의용생체공학회:의공학회지
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    • 제35권6호
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    • pp.192-196
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    • 2014
  • Collagen scaffolds were synthesized by cross linking into a solution mixture of 1-ethyl-3-[3-dimethylaminopropyl] carbodiimide hydrochlorid(EDC) in ethanol, followed by pressing, cleaning and lyophilization process after the type I atelo-collagen solutions in D.I water(pH3). The experimental conditions are collagen concentration of 1.0 wt%, 3.0 wt%, 5.0 wt% and differential concentration of cross-linker. Then, parametric studies were performed by varying the parameters to investigate the morphology, the porosity, the swelling ratio and the thickness and genotoxicity of the scaffolds. The scaffolds thickness pattern was regular to concentration of the degree of cross-linker and collagen. It was observed that the swelling ratio, the degree of crosslink, and the pore size(thickness of scaffold) can be controlled by adjusting the collagen, crosslinker. Among the parameters investigated, the smallest thickness can be achieved by collagen, crosslinker concentrate condition. The collagen scaffold is induced no genotoxicity. The lowest swelling ratio, as an indication of the highest degree of crosslink, can be obtained by adding crosslink agent.

훌륭한 의사를 기르는 인적환경 - 사례에서 구조까지 - (Human Environment for being a Great doctor - from case to construction -)

  • 류숙희
    • 의학교육논단
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    • 제9권2호
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    • pp.57-66
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    • 2007
  • Purpose How can be a great doctor with excellence and ethics? In this study, I wanted to find out the characteristics of human environment to make a great doctor. Methods: First, I researched factors and construct of the human environment. So I conceived a model for analyzing human environment with two construction model : Howard Gardner's System Model and Bron-fenbrenner's ecological systems model. Second, I analyzed the life of the Oliver R. Evison M.D. and Ki Ryu Jang M.D. Oliver R. Evison was the pioneer of medicine of Korea and establisher of the Severance Hospital and medical college. Dr KiRyu Jang, who was called 'Schweitzer of Korea', was a good doctor of the poor and weak patients in Korea. Third, I tried to find out a new human environment model to make a great doctor. Results One model for analyzing human environment was made of relationship based on emotion. relationship teaching knowledge and skill, and relationship communicating on value. In the light of analyzing of two great doctors. Oliver R. Evison M.D. and KiRyu Jang M.D, I found out special interrelationship, Hardie, Allen, Severance for Evison, Kyosin Kim, Kyucheol Choi etc. for Ki Ryu Jang These special people were religious actors or social thinkers. Conclusions: To be a great doctor to excel and innovate medical field, medical students should have the chance to meet with people based on religious, ethical and social action, discuss on value across social fields, and can construct the idea to make and realize higher value of medical action. In sum, another important human environment for medical students would be a person who could be communicate with true value.

A Study on a One-step Pairwise GM-estimator in Linear Models

  • Song, Moon-Sup;Kim, Jin-Ho
    • Journal of the Korean Statistical Society
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    • 제26권1호
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    • pp.1-22
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    • 1997
  • In the linear regression model $y_{i}$ = .alpha. $x_{i}$ $^{T}$ .beta. + .epsilon.$_{i}$ , i = 1,2,...,n, the weighted pairwise absolute deviation (WPAD) estimator was defined by minimizing the dispersion function D (.beta.) = .sum..sum.$_{{i $w_{{ij}}$$\mid$ $r_{j}$ (.beta.) $r_{i}$ (.beta.)$\mid$, where $r_{i}$ (.beta.)'s are residuals and $w_{{ij}}$'s are weights. This estimator can achive bounded total influence with positive breakdown by choice of weights $w_{{ij}}$. In this paper, we consider a more general type of dispersion function than that of D(.beta.) and propose a pairwise GM-estimator based on the dispersion function. Under some regularity conditions, the proposed estimator has a bounded influence function, a high breakdown point, and asymptotically a normal distribution. Results of a small-sample Monte Carlo study are also presented. presented.

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Japanese Organic Standards and the Private Effort to Build Domestic Structure to Strengthen Organic and Environment-friendly Agriculture

  • Tokue, Michiaki
    • 한국유기농업학회:학술대회논문집
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    • 한국유기농업학회 2001년도 심포지엄
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    • pp.219-227
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    • 2001
  • First, I'd like to express my great respect to the highly developed environment-friendly and organic agriculture in South Korea, especially in this region of Yangpyong. I've heard that rural farmers and city people cooperated together to develop the environment-friendly agriculture in Yangpyong. I believe Japanese farmers and people can learn a lot from the experience of your people. We'd like to exchange our knowledge and experience to develop environment-friendly and organic agriculture in both countries, for we share a lot in common. In this paper, I'd like to introduce how the Japanese have been developing organic and environment-friendly agriculture, and how we are working with the official organic standard and building the social structure to encourage the overall development of organic and environment-friendly agriculture.

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ANNULUS CRITERIA FOR OSCILLATION OF SECOND ORDER DAMPED ELLIPTIC EQUATIONS

  • Xu, Zhiting
    • 대한수학회지
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    • 제47권6호
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    • pp.1183-1196
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    • 2010
  • Some annulus oscillation criteria are established for the second order damped elliptic differential equation $$\sum\limits_{i,j=1}^N D_i[a_{ij}(x)D_jy]+\sum\limits_{i=1}^Nb_i(x)D_iy+C(x,y)=0$$ under quite general assumption that they are based on the information only on a sequence of annuluses of $\Omega(r_0)$ rather than on the whole exterior domain $\Omega(r_0)$. Our results are extensions of those due to Kong for ordinary differential equations. In particular, the results obtained here can be applied to the extreme case such as ${\int}_{\Omega(r0)}c(x)dx=-\infty$.

INCENTIVE/DISINCENTIVE PROJECT SUCCESS FACTORS DURING MACARTHUR MAZE I-580 BRIDGE SPAN REPLACEMENT

  • Jae-Ho Pyeon;Marc Zomoradi
    • 국제학술발표논문집
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    • The 5th International Conference on Construction Engineering and Project Management
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    • pp.328-331
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    • 2013
  • Incentive/Disincentive (I/D) contracting experiences in many states have been evaluated in terms of time and cost performance and substantial project time savings were found in many project cases. However, there is little understanding on individual project success factors for I/D projects during construction. This paper explores the significance of I/D clause in the success of the MacArthur Maze reconstruction project and summarizes a list of group causes that explains and elaborates on the detailed factors. The methods used for carrying out this study started with a search of online media and news reports and contract documents were also obtained from Caltrans. After review of the preliminary information, Interviews were performed with the Caltrans Resident Engineer and the contractor's project manager who were in charge of the MacArthur Maze reconstruction. In conclusion, the evaluation of their responses hinted at six significant cause groups responsible for the project's success. These groups can be listed as: 1) Motivation, 2) Policy, 3) Teamwork, 4) Communication, 5) Expectation, and 6) Resource Management.

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Effects of Phloretin, Cytochalasin B, and D-Fructose on 2-deoxy-D-Glucose Transport of the Glucose Transport System Present in Spodoptera frugiperda Clone 21-AE Cells

  • Lee Chong-Kee
    • 대한의생명과학회지
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    • 제12권1호
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    • pp.17-22
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    • 2006
  • The baculovirus expression system is a powerful method for producing large amounts of the human erythrocyte-type glucose transport protein, heterologously. Characterization of the expressed protein is expected to show its ability to transport sugars directly. To achieve this, it is a prerequisite to know the properties of the endogenous sugar transport system in Spodoptera frugiperda Clone 21 (Sf21) cells, which are commonly employed as a host permissive cell line to support the baculovirus replication. The Sf21 cells can grow well on TC-100 medium that contains 0.1% D-glucose as the major carbon source, strongly suggesting the presence of endogenous glucose transport system. However, unlike the human glucose transport protein that has a broad substrate and inhibitor specificity, very little is known about the nature of the endogenous sugar transport system in Sf21 cells. In order to characterize further the inhibitor recognition properties of the Sf21 cell transporter, the ability of phloretin, cytochalasin B and D-fructose to inhibit 2-deoxy-D-glucose (2dGlc) transport was examined by measuring inhibition constants $(K_i)$. The $K_i's$ for reversible inhibitors were determined from plots of uptake versus inhibitor concentration. The 2dGlc transport in the Sf21 cells was very potently inhibited by phloretin, the aglucone of phlorizin with a $K_i$ similar to the value of about $2{\mu}M$ reported for inhibition of glucose transport in human erythrocytes. However, the Sf21 cell transport system was found to differ from the human transport protein in being much less sensitive to inhibition by cytochalasin B (apparent $K_i$ approximately $10\;{\mu}M$). In contrast, It is reported that the inhibitor binds the human erythrocyte counterpart with a $K_d$ of approximately $0.12\;{\mu}M$. Interestingly, the Sf21 glucose transport system also appeared to have high affinity for D-fructose with a $K_i$ of approximately 5mM, contrasting the reported $K_m$ of the human erythrocyte transport protein for the ketose of 1.5M.

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아두이노와 Processing을 사용한 그래픽 성능 검증 (Using Arduino and Processing Graphics performance validation)

  • 최철길;이성진;이경무;최병윤
    • 한국정보통신학회:학술대회논문집
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    • 한국정보통신학회 2013년도 춘계학술대회
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    • pp.975-977
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    • 2013
  • 아두이노는 오픈 소스 기반 전자 프로토타이핑 플랫폼으로서, 예술가, 디자이너, 취미 활동가 등 인터랙티브 객체 또는 환경 구축에 관심이 있는 모든 이들을 위해 제작되었다. 아두이노의 강점은 하드웨어에 대한 깊은 지식이 없어도 손쉽게 하드웨어 어플리케이션을 제작할 수 있다. 아두이노의 구성은 AVR 마이크로컨트롤러 ATmega 168을 사용하며 아두이노를 동작시키기 위한 소프트웨어로는 아두이노 프로그램, MATLAB, Processing을 주로 사용하고 있다. 아두이노는 오픈 소스 기반이며 하드웨어를 직접 제작할 수 있거나 실드를 이용하여 추가적으로 아두이노를 결합할 수도 있다. Processing은 오픈 소스로 공개되어 있으며 2D, 3D, PDF 출력을 사용할 수 있으며 그래픽 처리 부분은 P3D와 OpenGL을 사용한다. 또한 독립 응용프로그램을 실행해서 확인할 수 있다. 아두이노의 결합을 통해 사운드, 비디오, 컴퓨터 비전 등 수 많은 라이브러리 지원을 확장할 수 있으며 안드로이드폰과 아이폰 프로그래밍이 가능한 프로그램이다. 본 논문에서는 소프트웨어 부분은 Processing을 사용하였고 하드웨어 부분은 아두이노 MegaADK 보드를 사용하였으며 이 소프트웨어와 하드웨어를 이용하여 간단한 2차원 게임을 제작한 후 전체적인 아두이노와 Processing의 그래픽 처리 성능을 확인하고 검증하였다.

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월경통 환자의 체열분포에 대한 연구 (소음인, 태음인을 대상으로) (Study on the Thermography of Dysmenorreic women)

  • 김미진;이인선;김종원
    • 대한한방체열의학회지
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    • 제2권1호
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    • pp.11-16
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    • 2003
  • Purpose D.I.T.I. can be used to diagnose the dysmenorrhea and prove the Oriental Medical Theory and the Sasang Constitutional Medicine concerning Dysmenorrhea. According to the Sasang Constitutional Medicine, we chose 39 dysmenorrhea patients (Soeumin 26 Patients, Taeumin 13 Patients) and expremented D.I.T.I. to find difference of chilliness and fever in the upper part of body and the lower part of body. Methods We expremented 39 dysmenorrhea patients chosena expremental group from Apr 1. 2002 to May 30, 2002. We diagnosed the constitution by Q.S.C.C. and selected six acu-points CV-17, CV-12, CV-4, G-21, B-15 and B-23. To appraise difference of temperature according to constitution we compared skin temperature of front to back. Result Mean Absolute Value of ${\Delta}T$ in body (front and back) shows significant difference. Totally the temperature of front is higher than the temperature of back. the temperature of Soeumin is higher than the temperature of Taeumin in whole. Conciusion Especially the upper abdomen area(CV-17) shows high temperature in 39 dysmenorrhea patients, the lower abdomen area (CV-4) of Soeumin shows lower temperature relatively.

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KSLV-I 외부 음향 하중 예측 및 비행 시험 결과와의 비교 (Prediction of Lift-off Acoustic Loads of KSLV-I and Its Comparison with Flight Measurements)

  • 박순홍;서상현;장영순
    • 항공우주기술
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    • 제10권1호
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    • pp.13-19
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    • 2011
  • 수정된 NASA SP-8072 분포 음원 방법 (Method 2)를 이용하여 KSLV-I의 발사 음향 하중을 예측하고, 이 결과를 비행 시험시의 측정 결과와 비교하였다. 2차 비행 시험시에 케이블 마스트의 4개소에서 발사 음향 하중을 측정하였고, 인터스테이지의 텔레메트리 데이터도 입수하여 비교하였다. 예측된 음향 하중 스펙트럼은 측정 스펙트럼과 유사한 피크 주파수 및 형태를 가지며 약 7dB의 안전 여유를 가지고 예측됨을 알 수 있었다.