• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.23 no.5
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• pp.313-320
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• 2011

For a steam Rankine cycle to recover waste heat from the exhaust gas of an Internal combustion engine, a swash plate type of expander as a power conversion unit has been designed. Numerical simulation has been carried out to estimate the performance of the designed expander. With the steam pressure and temperature of 35 bar and $300^{\circ}C$ at the expander inlet, respectively, the expander was estimated to produce the shaft power output of about 2.67 kW from the exhaust gas waste heat of 25.2 kW. The expander output increased almost linearly with the amount of exhaust gas waste heat in the range of from 5~40 kW, and the expander and Rankine cycle efficiencies showed gradual decreases in the ranges of 72.2%~69.5% and 10.8%~10.4%, respectively.

• The Korean Journal of Physiology and Pharmacology
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• v.14 no.5
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• pp.299-304
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• 2010

Losartan is a selective angiotensin II (Ang II) type 1 ($AT_1$) receptor antagonist which inhibits vascular smooth muscle cells (VSMCs) contraction and proliferation. We hypothesized that losartan may prevent cell proliferation by activating AMP-activated protein kinase (AMPK) in VSMCs. VSMCs were treated with various concentrations of losartan. AMPK activation was measured by Western blot analysis and cell proliferation was measured by MTT assay and flowcytometry. Losartan dose- and time-dependently increased the phosphorylation of AMPK and its downstream target, acetyl-CoA carboxylase (ACC) in VSMCs. Losartan also significantly decreased the Ang II- or 15% FBS-induced VSMC proliferation by inhibiting the expression of cell cycle associated proteins, such as p-Rb, cyclin D, and cyclin E. Compound C, a specific inhibitor of AMPK, or AMPK siRNA blocked the losartan-induced inhibition of cell proliferation and the $G_0/G_1$ cell cycle arrest. These data suggest that losartan-induced AMPK activation might attenuate Ang II-induced VSMC proliferation through the inhibition of cell cycle progression.

• 한국태양에너지학회:학술대회논문집
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• 2011.11a
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• pp.169-176
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• 2011

The two-step water splitting thermochemical cycle is composed of the T-R (Thermal Reduction)and W-D (Water Decomposition)steps. The mechanism of this cycle is oxidation-reduction, which produces hydrogen. The reaction temperature necessary for this thermochemical cycle can be achieved by a dish-type solar thermal collector (Inha University, Korea). The purpose of this study is to validate a water splitting device in the field. The device is studied and fabricated by Kodama et al (2010, 2011). The validation results show that the foam device, when loaded with $NiFe_2O_4/m-ZrO_2$powder, was successfully achieved hydrogen production with 9 (10 with a Xe-light solar simulator, 2009, Kodama et al.) repeated cycles under field conditions. Two foam device used in this study were tested for validation before an experiment was performed. The lab scale ferrite-conversion rate was in the range of 24~76%. Two foam devices were designed to for structural stability in this study. In the results of the experiments, the hydrogen percentage of the weight of each foam device was 7.194 and $9.954{\mu}mol\;g^{-1}$ onaverage, and the conversion rates 4.49~29.97 and 2.55~58.83%, respectively.

• Korean Journal of Animal Reproduction
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• v.15 no.1
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• pp.59-66
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• 1991

This study was carried out to investigate the length of the estrous cycle and duration of estrus in Korean native goats. The effects of the type of last estrus : induced or natural, and the length of preceeding estrous cycle on the subsequent cycle and duration of estrus in goats were also examined. From 481 observations, the mean length of estrous cycles was 18.1${\pm}$0.5days. The cycle length was significantly(P<0.05) shorter following induced estrus (15.2${\pm}$0.8 d) than natural estrus(19.0${\pm}$0.6 d). Significantly higher(P<0.05) incidence of short estrous cycle was observed following induced estrus(40%) than natural estrus(27%). The frequency distribution in the estrous cycle was 30%, 3%, 56% and 11% for short(3-11 d), medium(12-16 d), normal(17-24 d) and long(${\geqq}$25 d), respectively. The most frequent type of short estrous cycle was 6 days in length. Mean duration of estrus was 34.0${\pm}$0.5 h with a range of 18 to 84 h. Duration of estrus was not significantly different the preceeding natural (33.8${\pm}$0.6 h) and induced estrus (34.4${\pm}$1.1 h), and was not significantly affected by the last cycle length. These results suggest that the short estrus cycles are more frequent following induced estrus than natural one, and the duration of estrus are affected greatly by the various intrinsic and extrinsic factors.

• Journal of Advanced Marine Engineering and Technology
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• v.33 no.8
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• pp.1123-1128
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• 2009

In this paper, the cycle performance characteristics of a cascade refrigeration system with internal heat exchanger using natural refrigerants is presented to offer the basic design data for the operating parameters of the system. This system considered in this study is consisted of a high temperature cycle using a carbon dioxide(R744) and low temperature cycle using refrigerants such as R290, R1270, R600a and Ethane. The main results were summarized as follows : The COP of the cascade refrigeration system of R600a with internal heat exchanger is the highest grade in low temperature cycle using refrigerants such as R290, R1270, R600a and Ethane. The COP of the cascade refrigeration system with internal heat exchanger only in high temperature cycle is the highest value among three type cycle, such as only low temperature cycle, only high temperature cycle and all the cycle.

• Mycobiology
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• v.51 no.5
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• pp.372-378
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• 2023

Lkh1, a LAMMER kinase homolog in the fission yeast Schizosaccharomyces pombe, acts as a negative regulator of filamentous growth and flocculation. It is also involved in the response to oxidative stress. The lkh1-deletion mutant displays slower cell growth, shorter cell size, and abnormal DNA content compared to the wild type. These phenotypes suggest that Lkh1 controls cell size and cell cycle progression. When we performed microarray analysis using the lkh1-deletion mutant, we found that only four of the up-regulated genes in the lkh1-deletion were associated with the cell cycle. Interestingly, all of these genes are regulated by the Mlu1 cell cycle box binding factor (MBF), which is a transcription complex responsible for regulating the expression of cell cycle genes during the G1/S phase. Transcription analyses of the MBF-dependent cell-cycle genes, including negative feedback regulators, confirmed the up-regulation of these genes by the deletion of lkh1. Pull-down assay confirmed the interaction between Lkh1 and Yox1, which is a negative feedback regulator of MBF. This result supports the involvement of LAMMER kinase in cell cycle regulation by modulating MBF activity. In vitro kinase assay and NetPhosK 2.0 analysis with the Yox1T40,41A mutant allele revealed that T40 and T41 residues are the phosphorylation sites mediated by Lkh1. These sites affect the G1/S cell cycle progression of fission yeast by modulating the activity of the MBF complex.

• Journal of the Korean Society for Precision Engineering
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• v.12 no.12
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• pp.165-172
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• 1995

Many algorithms to enhance a speed performance of a robot have been studied, but it's rare to consider disign aspect of a robot arm for time optimal problem. In this paper, section demensions of a robot arm and a velocity profile of an end-effector were optimally designed to minimize the cycle time. Capacity of actuators, deflections of end-effector, and a fundamental natural frequency of the robot arm were constrained in optimal design. For a given path with a trapezoidal velocity profile, torques of each joint were calculated using the inverse kinematics and dynamics. For the SCARA type robot which is mainly used for assembly tasks, the time optimal design of each robot arm id presented with the above constraints.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.30 no.12 s.255
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• pp.1573-1580
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• 2006

In this study, fatigue tests were carried out under push-pull loading condition using spheroidal graphite cast iron in order to clarify the internal fatigue fracture mechanism in an extremely low cycle fatigue regime. It is found that a successive observation of internal fatigue damage it is found that the fracture processes go through three stages, that is, the generation, growth and coalescence of microvoids originated from debonding of graphite-matrix interface. It is also found that the crack which is initiated from the void propagates by coalescence of neighboring cracks and the fatigue crack growth rate can be expressed in form of the Manson-Coffin rule type. In this paper, quantitative analyses of fatigue properties for realization of simulation about fatigue life evaluation are also presented.

• Journal of the Korean Society for Precision Engineering
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• v.27 no.12
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• pp.107-112
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• 2010

A gas turbine consists of an upstream compressor and a downstream turbine with a combustion chamber, and also the compressor and the turbine are generally coupled using a single shaft. Large scale gas turbine compressor is designed as multi-stage axial flow and the blade is fan-type which is thick and wide. Recently radial cracking happens occasionally at the compressor blade tip of large scale gas turbine. So, FEM was performed on the compressor blade and vibration modes and dynamic stresses were analyzed. According to the analysis, 9th natural frequency mode of the blade, which is 2 strip mode, is near the vane passing frequency by the vane located at the upstream of the blade.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2004.03a
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• pp.665-670
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• 2004

This paper reviews the latest studies of the expander cycle Air Turbo Ramjet engine (ATREX) conducted in JAXA. First, a system analysis including the vehicle and trajectory was conducted to optimize the engine cycle and turbo-machine configuration. We selected the precooled turbo-jet cycle for a prototype engine using the near term technologies. Second, a system ground-firing test was conducted to verify a defrosting system for the precooler. Methanol injection with its particles atomization could compensate 80 % of pressure loss caused by the frost. Thirdly, a feasibility of carbon/carbon composites for the engine components was investigated by making complex shapes such as a heat exchanger and a plug nozzle. Basic technologies on the gas leakage, the junction and bonding were also studied. The end of the paper, some basic studies such as wind tunnel tests of a new type air inlet and a plug nozzle are described.