• 제목/요약/키워드: Cross-over design

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Statistical Analysis of Bioequivalence Study in 2x3 Cross-over Design

  • Lim, Nam-Kyoo
    • Communications for Statistical Applications and Methods
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    • 제8권2호
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    • pp.443-452
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    • 2001
  • The 2x3 cross-over design is proposed for the bioequivalence of two test drug formulations with a reference drug formulation. Oh et al.(1999) and Park et al.(1998) derived 3x2 cross-over design and discussed its benefits, since the 3x3 cross-over design may not be of practical design. We discuss the statistical issues for2x3 cross-over design and show its statistical properties. Bioequivalence problem in 2x3 cross-over design is considered statistically and an illustrated example is given.

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Nonparametric Tests for 2×2 Cross-Over Design

  • Gee, Kyuhoon;Kim, Dongjae
    • Communications for Statistical Applications and Methods
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    • 제19권6호
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    • pp.781-791
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    • 2012
  • A $2{\times}2$ Cross-over design is widely used in clinical trials for comparison studies of two kinds of drugs or medical treatments. This design has many statistical methods such as Hills-Armitage's (1979) method or Koch's (1972) method. In this paper, we propose a nonparametric test for $2{\times}2$ Cross-over design based on a two-sample test suggested by Baumgartner et al. (1998). In addition, a Monte Carlo simulation study is adapted to compare the power of the proposed methods with those of previous methods.

한·중 크로스오버 쇼퍼들의 모바일 앱 충성도에 대한 탐색적 연구 (Mobile app Loyalty of Cross-over Shoppers: A Comparison of Korean and Chinese)

  • 박은주;구진;박신영
    • 한국의류산업학회지
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    • 제20권3호
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    • pp.293-303
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    • 2018
  • Since 2009, consumers could access a new shopping channel called 'mobile shopping' with the generalization of smartphones. Mobile shopping (based on wireless communication technology), emphasizes convenience differentiated from internet shopping. A recent report introduced fashion products as powerful global drivers for mobile shopping sales. Korea and China have the highest percentage of consumer mobile shopping experiences compared to other countries. This study investigates the effects of cross-over shopping orientation, perception of app attributes, and flow on app loyalty that compared Korean and Chinese consumers. We obtained 652 usable questionnaires from two local college students; subsequently, data were analyzed by using factor analysis, Cronbach's alpha, and regression analysis using SPSS 21.0 Package. The study results showed that the cross-over shopping orientation affected perception of app attributes that included Review/Information, Design, Response and Product. Product only affected Flow, which reflected a high similarity between Korean and Chinese consumers. However, Korean and Chinese consumers showed remarkable differences in the factors related to app loyalty. Therefore, the results indicate that retailers of fashion products have developed strategies to improve mobile sales and increase the app loyalty of cross-over shopping orientation consumers.

Distribution-Free Tests for Cross-Over Design Data

  • Kim, Dong-Jae
    • Communications for Statistical Applications and Methods
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    • 제6권1호
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    • pp.151-158
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    • 1999
  • Distribution-free tests are proposed for AB/BA 2*2 cross-over design data based on placements introduced by Orban and Wolfe(1992). In this paper we suggest the homogeneity test or carry-over effects and also suggest the test for direct effects and the test for period effects under the same carry-over effects. The properties such as iterative asymptotic distribution for the proposed tests are discussed.

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Cross-layer Design of Rate and Quality Adaptation Schemes for Wireless Video Streaming

  • Lee, Sun-Hun;Chung, Kwang-Sue
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • 제4권3호
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    • pp.324-340
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    • 2010
  • Video streaming service over wireless networks is a challenging task because of the changes in the wireless channel conditions that can occur due to interference, fading, and station mobility. To provide an efficient wireless video streaming service, the rate adaptation scheme should improve wireless node performance and channel utilization. Moreover, the quality adaptation scheme should be considered at the streaming application. To meet these requirements, we propose a new cross-layer design for video streaming over wireless networks. This design includes the rate and quality adaptation schemes. The rate adaptation scheme selects the optimal transmission mode and resolves the performance anomaly problem. Based on performance improvement by the proposed rate adaptation scheme, our quality adaptation scheme improves the quality of video streaming. Through performance evaluations, we prove that our cross-layer design improves the wireless channel utilization and the quality of video streaming.

응력-침투 연계 해석에 의한 필 댐의 최적 설계

  • 박춘식;이준석;김종환
    • 한국지반공학회:학술대회논문집
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    • 한국지반공학회 2010년도 춘계 학술발표회
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    • pp.862-870
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    • 2010
  • This thesis has been researched on optimized design method for the total cross section of embankment considering the fact that the size of embankment cross section is directly related with economic efficiency when dam designing. In general, embankment cross section of fill dam is either determined by cohesion and angle of internal friction, a strength parameter of embankment materials or by permeability of embankment. Therefore the size of embankment cross section depending on strength parameter of embankment materials was determined by using MIDAS-GTS program through stress-seepage coupled analysis at the time of fill dam design. As a result, determination of embankment cross section was more affected by the size of central core and permeability rather than by slope stability by shear strength and it was revealed that in case of embankment height being over 20m, stability against infiltration and slope action could be secured only when embankment slope is at least over 1:2.5. In addition, it was also revealed that in case of making the size of central core exceeding specification standard, total cross section of embankment could be reduced considerably and at the time of embankment design, adequate size and appropriateness of embankment cross section could be determined with referring the table suggested by this study.

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2×2 교차계획법에서 결측치가 있을 때의 결측치 처리 방법 비교에 관한 연구 (Comparison of Single Imputation Methods in 2×2 Cross-Over Design with Missing Observations)

  • 조보배;김동재
    • 응용통계연구
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    • 제28권3호
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    • pp.529-540
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    • 2015
  • 의과학 분야에서 교차계획법은 임상시험을 통한 두 처리의 비교 검정에 이용되고 있으며 생물학적 동등성 시험에 자주 이용되고 있다. $2{\times}2$ 교차계획법에서 2시기에 결측치가 발생했을 때 통상적으로 결측치가 발생한 개체를 삭제하고 모수적 검정을 한다. 하지만 소표본으로 진행되는 $2{\times}2$ 교차계획법에서 일부 관측치의 삭제가 통계적 분석에 크게 영향을 미칠 수 있다. 본 논문에서는 소표본으로 이루어지는 $2{\times}2$ 교차계획법에서 2시기에 결측치가 발생했을 때 단순대체법들을 적용한 후 Hills-Armitage (1979)의 모수적 검정법과 Koch (1972)와 Kim (1999)이 제안한 비모수적 검정법들의 제 1종오류와 검정력을 몬테카를로 모의실험(Monte-Carlo simulation)을 통하여 비교하였다.

On Rate-adaptive LDPC-based Cross-layer SVC over Bursty Wireless Channels

  • Cho, Yongju;Cha, Jihun;Radha, Hayder;Seo, Kwang-Deok
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • 제6권9호
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    • pp.2266-2284
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    • 2012
  • Recent studies have indicated that a significant improvement in wireless video throughput can be achieved by Cross Layer Design with Side-information (CLDS) protocols. In this paper, we derive the operational rate of a CLDS protocol operating over a realistic wireless channel. Then, a Rate-Distortion (R-D) empirical model for above-capacity Scalable Video Coding (SVC) is deduced to estimate the loss of video quality incurred under inaccurate rate estimation scenarios. Finally, we develop a novel Unequal Error Protection (UEP) scheme which leverages the characteristics of LDPC codes to reduce the distortion of video quality in case of typically-observed burst wireless errors. The efficacy of the proposed rate adaptation architecture over conventional protocols is demonstrated by realistic video simulations using actual IEEE 802.11b wireless traces.

크로스레이어 디자인에서 사이드 인포메이션을 활용한 채널 추정 및 예측 (Channel Estimation and Prediction in Cross-Layer Design Using Side-information)

  • 조용주;차지훈;김욱중
    • 방송공학회논문지
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    • 제16권5호
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    • pp.797-800
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    • 2011
  • MPEG에서 진행 중인 MPEG Media Transport(MMT) 표준화는 IP기반 방송통신융합망에서 효과적인 멀티미디어 전송을 목적으로 하고 있다. 본 고에서는 MMT 제안 기술로서, 유선망에 비해 채널의 변화가 많은 무선망에서 효과적인 멀티미디어 전송을 위해 제안된 크로스레이어 디자인(Cross Layer Design-CLD)에서의 신호세기(signal strength information) 활용 방법을 소개한다. 무선환경에서 신호세기를 활용하면 매우 효율적인 멀티미디어 전송이 가능함은 관련 연구 논문[1]-[5]을 통해 증명되었다. 하지만, 무선채널의 특성상 서로 다른 신호세기의 범위를 사용함으로써 신호세기 정보의 유용성에도 불구하고 레이트 어댑테이션 애플리케이션에서 활용하는데 제한이 있어왔다. 따라서 본 논문에서는 MMT 표준화 기술 기고로 제안된 무선채널 신호세기 정보의 범위를 표준화된 형식으로 활용하는 방법에 대하여 기술한다.

생물학적 동등성 시험을 위한 2×k 교차설계법의 통계적 고려 (Some Statistical Considerations on 2×k Crossover Designs for Bioequivalence Trial)

  • 노소영;박상규
    • 응용통계연구
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    • 제26권4호
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    • pp.675-686
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    • 2013
  • 현재 우리나라 식품의약품안전청에서는 $2{\times}2$ 교차설계법을 기초로 제제간의 생물학적 동등성 평가를 수행하도록 규정하고 있다. 하지만 고변동성 제제의 생물학적 동등성 평가에서 $2{\times}2$ 교차설계법에 의한 시험은 지나치게 많은 피험자를 필요로 할 수 있어 윤리적이고 경제적인 고려가 필요하다는 논의가 이루어지고 있다. $2{\times}2$ 교차설계법을 대체할 수 있는 대안으로 $2{\times}4$ 교차설계법은 미국 및 유럽 등에서는 생물학적 동등성 평가에 광범위하게 사용되는 설계 방법이고, $2{\times}3$ 교차설계법도 $2{\times}2$$2{\times}4$ 교차설계법의 단점을 개선할 수 있는 효율적인 대안으로 관심이 많다. 본 연구에서는 $2{\times}4$$2{\times}3$ 교차설계법의 통계적 모형과 제시된 통계적 모형에 연계된 분산분석표를 유도한다. 현행 국내 생물학적 동등성 시험 규정에 의하면 $2{\times}4$$2{\times}3$ 교차설계법의 분산분석표는 반드시 제시되어야 하지만 아직 문헌상에 존재하지 않아 관련 연구에 기여할 것으로 생각된다. 또한 $2{\times}4$$2{\times}3$ 교차설계법에 기초한 피험자 계산을 $2{\times}2$ 교차설계법과 비교 제시하여 고변동성 제제의 생물학적 동등성 시험 연구에 적절한 시험 설계 선택에 정보를 제공한다.