• Title/Summary/Keyword: Cross-over design

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Statistical Analysis of Bioequivalence Study in 2x3 Cross-over Design

  • Lim, Nam-Kyoo
    • Communications for Statistical Applications and Methods
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    • v.8 no.2
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    • pp.443-452
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    • 2001
  • The 2x3 cross-over design is proposed for the bioequivalence of two test drug formulations with a reference drug formulation. Oh et al.(1999) and Park et al.(1998) derived 3x2 cross-over design and discussed its benefits, since the 3x3 cross-over design may not be of practical design. We discuss the statistical issues for2x3 cross-over design and show its statistical properties. Bioequivalence problem in 2x3 cross-over design is considered statistically and an illustrated example is given.

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Nonparametric Tests for 2×2 Cross-Over Design

  • Gee, Kyuhoon;Kim, Dongjae
    • Communications for Statistical Applications and Methods
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    • v.19 no.6
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    • pp.781-791
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    • 2012
  • A $2{\times}2$ Cross-over design is widely used in clinical trials for comparison studies of two kinds of drugs or medical treatments. This design has many statistical methods such as Hills-Armitage's (1979) method or Koch's (1972) method. In this paper, we propose a nonparametric test for $2{\times}2$ Cross-over design based on a two-sample test suggested by Baumgartner et al. (1998). In addition, a Monte Carlo simulation study is adapted to compare the power of the proposed methods with those of previous methods.

Mobile app Loyalty of Cross-over Shoppers: A Comparison of Korean and Chinese (한·중 크로스오버 쇼퍼들의 모바일 앱 충성도에 대한 탐색적 연구)

  • Park, Eunjoo;Jin, Gu;Park, Shinyoung
    • Fashion & Textile Research Journal
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    • v.20 no.3
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    • pp.293-303
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    • 2018
  • Since 2009, consumers could access a new shopping channel called 'mobile shopping' with the generalization of smartphones. Mobile shopping (based on wireless communication technology), emphasizes convenience differentiated from internet shopping. A recent report introduced fashion products as powerful global drivers for mobile shopping sales. Korea and China have the highest percentage of consumer mobile shopping experiences compared to other countries. This study investigates the effects of cross-over shopping orientation, perception of app attributes, and flow on app loyalty that compared Korean and Chinese consumers. We obtained 652 usable questionnaires from two local college students; subsequently, data were analyzed by using factor analysis, Cronbach's alpha, and regression analysis using SPSS 21.0 Package. The study results showed that the cross-over shopping orientation affected perception of app attributes that included Review/Information, Design, Response and Product. Product only affected Flow, which reflected a high similarity between Korean and Chinese consumers. However, Korean and Chinese consumers showed remarkable differences in the factors related to app loyalty. Therefore, the results indicate that retailers of fashion products have developed strategies to improve mobile sales and increase the app loyalty of cross-over shopping orientation consumers.

Distribution-Free Tests for Cross-Over Design Data

  • Kim, Dong-Jae
    • Communications for Statistical Applications and Methods
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    • v.6 no.1
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    • pp.151-158
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    • 1999
  • Distribution-free tests are proposed for AB/BA 2*2 cross-over design data based on placements introduced by Orban and Wolfe(1992). In this paper we suggest the homogeneity test or carry-over effects and also suggest the test for direct effects and the test for period effects under the same carry-over effects. The properties such as iterative asymptotic distribution for the proposed tests are discussed.

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Cross-layer Design of Rate and Quality Adaptation Schemes for Wireless Video Streaming

  • Lee, Sun-Hun;Chung, Kwang-Sue
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.4 no.3
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    • pp.324-340
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    • 2010
  • Video streaming service over wireless networks is a challenging task because of the changes in the wireless channel conditions that can occur due to interference, fading, and station mobility. To provide an efficient wireless video streaming service, the rate adaptation scheme should improve wireless node performance and channel utilization. Moreover, the quality adaptation scheme should be considered at the streaming application. To meet these requirements, we propose a new cross-layer design for video streaming over wireless networks. This design includes the rate and quality adaptation schemes. The rate adaptation scheme selects the optimal transmission mode and resolves the performance anomaly problem. Based on performance improvement by the proposed rate adaptation scheme, our quality adaptation scheme improves the quality of video streaming. Through performance evaluations, we prove that our cross-layer design improves the wireless channel utilization and the quality of video streaming.

응력-침투 연계 해석에 의한 필 댐의 최적 설계

  • Park, Chun-Sik;Lee, Jun-Suk;Kim, Jong-Hwan
    • Proceedings of the Korean Geotechical Society Conference
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    • 2010.03a
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    • pp.862-870
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    • 2010
  • This thesis has been researched on optimized design method for the total cross section of embankment considering the fact that the size of embankment cross section is directly related with economic efficiency when dam designing. In general, embankment cross section of fill dam is either determined by cohesion and angle of internal friction, a strength parameter of embankment materials or by permeability of embankment. Therefore the size of embankment cross section depending on strength parameter of embankment materials was determined by using MIDAS-GTS program through stress-seepage coupled analysis at the time of fill dam design. As a result, determination of embankment cross section was more affected by the size of central core and permeability rather than by slope stability by shear strength and it was revealed that in case of embankment height being over 20m, stability against infiltration and slope action could be secured only when embankment slope is at least over 1:2.5. In addition, it was also revealed that in case of making the size of central core exceeding specification standard, total cross section of embankment could be reduced considerably and at the time of embankment design, adequate size and appropriateness of embankment cross section could be determined with referring the table suggested by this study.

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Comparison of Single Imputation Methods in 2×2 Cross-Over Design with Missing Observations (2×2 교차계획법에서 결측치가 있을 때의 결측치 처리 방법 비교에 관한 연구)

  • Jo, Bobae;Kim, Dongjae
    • The Korean Journal of Applied Statistics
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    • v.28 no.3
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    • pp.529-540
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    • 2015
  • A cross-over design is frequently used in clinical trials (especially in bioequivalence tests with a parametric method) for the comparison of two treatments. Missing values frequently take place in cross-over designs in the second period. Usually, subjects that have missing values are removed and analyzed. However, it can be unsuitable in clinical trials with a small sample size. In this paper, we compare single imputation methods in a $2{\times}2$ cross-over design when missing values exist in the second period. Additionally, parametric and nonparametric methods are compared after applying single imputation methods. A Monte-Carlo simulation study compares type I error and the power of methods.

On Rate-adaptive LDPC-based Cross-layer SVC over Bursty Wireless Channels

  • Cho, Yongju;Cha, Jihun;Radha, Hayder;Seo, Kwang-Deok
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.6 no.9
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    • pp.2266-2284
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    • 2012
  • Recent studies have indicated that a significant improvement in wireless video throughput can be achieved by Cross Layer Design with Side-information (CLDS) protocols. In this paper, we derive the operational rate of a CLDS protocol operating over a realistic wireless channel. Then, a Rate-Distortion (R-D) empirical model for above-capacity Scalable Video Coding (SVC) is deduced to estimate the loss of video quality incurred under inaccurate rate estimation scenarios. Finally, we develop a novel Unequal Error Protection (UEP) scheme which leverages the characteristics of LDPC codes to reduce the distortion of video quality in case of typically-observed burst wireless errors. The efficacy of the proposed rate adaptation architecture over conventional protocols is demonstrated by realistic video simulations using actual IEEE 802.11b wireless traces.

Channel Estimation and Prediction in Cross-Layer Design Using Side-information (크로스레이어 디자인에서 사이드 인포메이션을 활용한 채널 추정 및 예측)

  • Cho, Yong-Ju;Cha, Ji-Hun;Kim, Wook-Joong
    • Journal of Broadcast Engineering
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    • v.16 no.5
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    • pp.797-800
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    • 2011
  • The objective of MPEG Media Transport (MMT), which is on going standard, is to develop efficient delivery of media over packet based networks in an adaptive, progressive, download/streaming fashion over various IP based networks, including terrestrial, satellite and cable broadcast networks. In this paper we introduce utilization of signal strength information based on Cross Layer Design(CLD) to efficient multimedia delivery over wireless network in which in practice the wireless conditions can vary significantly. Many recent studies have shown that a significant improvement in wireless video throughput can be achieved by utilizing signal strength information on CLD [1][2]. Despite of its usefulness, however, it was difficult to employ signal strength information in rate adaptation applications due to different representation of signal strength information for each underlying wireless network. To that end, we proposed syntax and semantics of signal strength information in such a way that the information can be interpreted in the unified way. The proposed signal strength information was proposed for the MMT standardization.

Some Statistical Considerations on 2×k Crossover Designs for Bioequivalence Trial (생물학적 동등성 시험을 위한 2×k 교차설계법의 통계적 고려)

  • Noh, So-Young;Park, Sang-Gue
    • The Korean Journal of Applied Statistics
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    • v.26 no.4
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    • pp.675-686
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    • 2013
  • The Korea Food and Drug Administration(KFDA) recommends the use of a $2{\times}2$ crossover design to assess the bioequivalence of generic drugs. However, a standard $2{\times}2$ crossover design for bioequivalence trials is often considered problematic due to ethical and economic issues as highly variable drugs are usually required by large numbers of subjects when designing the trial. To overcome this problem a $2{\times}4$ crossover design has been a recommended option as per US regulations; in addition, a $2{\times}3$ crossover design has also recently drawn special attention as an efficient alternative. The current KFDA regulation requires an ANOVA table for every bioequivalence study; however, ANOVA tables of $2{\times}4$ and $2{\times}3$ crossover designs have never been published in the literature. This study shows the derivation of tables of analysis of variance for a $2{\times}4$ cross-over design and a $2{\times}3$ cross-over design. We also suggest a sample size formulas for $2{\times}2$, $2{\times}4$ and $2{\times}3$ crossover designs to provide information on the selection of efficient designs for highly variable drugs.