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The Search of Pig Pheromonal Odorants for Biostimulation Control System Technologies: III. Comparative Molecular Field Analysis (CoMFA) on Binding Affinities between Ligands of 2-(Cyclohexyloxy) Tetrahydrofurane Derivatives and Porcine Odorant Binding Protein (생물학적 자극 통제 수단으로 활용하기 위한 돼지 페로몬성 냄새 물질의 탐색: III. 2-(Cyclohexyloxy) Tetrahydrofurane 유도체와 Porcine Odorant Binding Protein 사이의 결합 친화력에 관한 비교 분자장 분석)

  • Sung Nack-Do;Park Chang-Sik;Jung Hoon-Sung;Seong Min-Kyu
    • Reproductive and Developmental Biology
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    • v.30 no.1
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    • pp.13-19
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    • 2006
  • To search of new porcine pheromonal odorants for biostimulation control system technologies to improve reproductive efficiency in livestock species, the comparative molecular field analysis (CoMFA) for binding affinity constant $(p(Od)_{50})$ between porcine odorant binding protein (pOBP) and ligands of odorant 2-(cyclohexyloxy) tetrahydrofurane derivatives as substrate molecule was conducted and discussed. In the optimized CoMFA model AIV with chirality $(C_1'(R),\;C_2(S))$ in substrate molecule and atom based fit alignment (A) of odorants, the statistical results showed the best predictability of the binding affinities $(p(Od)_{50})$ based on the LOO cross-validated value $r^2_{cv}.\;(q^2=0.886)$ and non-cross-validated conventional coefficient $(r^2_{ncv}.=0.984)$. the binding affinity constants exhibited a good correlation with steric (40.8%), electrostatic (14.6%) and hydrophobic (44.6%) factors of the substrate molecules. from the analytical results of the contour maps, which may give us some valuable informations to the modification of odorants for effective binding affinity.

The Search of Pig Pheromonal Ordorants for Biostimulation Control System Technology: IV. Comparative Molecular Similarity Indices Analyses (CoMSIA) on the Binding Affinities between Ligands of 2-(Cyclohexyloxy)-tetrahydrofurane Derivatives and Porcine Ordorant Binding Protein (생물학적 자극 통제 수단으로 활용하기 위한 돼지 페로몬성 냄새 물질의 탐색: IV. 2-(Cyclohexyloxy)tetrahydrofurane 유도체와 Porcine Odorant Binding Protein 사이의 결합 친화력에 관한 비교분자 유사성 지수분석(CoMSIA))

  • Sung, Nack-Do;Park, Chang-Sik;Jang, Seok-Chan;Choi, Kyung-Seob
    • Reproductive and Developmental Biology
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    • v.30 no.3
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    • pp.169-174
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    • 2006
  • To search of a new porcine pheromonal odorants, the comparative molecular similarity indices analysis(CoMSIA) between porcine odorant binding protein(pOBP) as receptor and ligands of green odorants 2-(Cyclohexyloxy)tetrahydrofurane derivatives as substrate molecule were conducted and disscused quantitatively. In the optimized CoMSIA model(I-AI) with chirality($I:\;C_{1'}(R),\;C_2(S)$) in substrate molecules and atom based fit alignment(AE) of the odorants the statistical PLS results showed the best predictability of the binding affinities based on the LOO cross-validated value ${r^2}_{cv.}\;(q^2=0.856)$ and non cross-validated conventional coefficient(${r^2}_{ncv.}=0.964)$). The structural distinctions of the highest active molecules were able to understand from the interaction between pOBP and green odorants in the contour maps with CoMSIA model.

The Efficient Measurement Method of Buried Heritage by 3D Image Acquisition (3차원 영상취득에 의한 매장문화재의 효율적 측정기법)

  • Lee, Kye-Dong;Lee, Jae-Kee;Jung, Sung-Heuk
    • Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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    • v.25 no.2
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    • pp.157-163
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    • 2007
  • Recently, industrialization of a country is accelerated and request of society infrastructure is raised so national land development is activity view. Accordingly, the search for a wide-ranging buried heritage do acted in large construction region. Because the buried heritage get buried in land that it is necessary to the precision search and research for a record and a preservation. Until now, Surveying techniques of a historic site have made status map, profile and cross section map through leveling survey, total-station survey and sketch of specialist. So, to solve problems existing relic survey or drawing making method have using digital camera these researches rapidly and economically obtain stereo image of object and present a technique that constructs 3D image model for digital photogrammetry method. Also, these researches construct 3D image model for record and preservation of a historic site through site test and in 3D and graphical express a historic site and support works that produce other maps if we need it. offer base data of GIS (Geographic Information System) to collect and analyze overall, information of a historic site.

A Study of Developing a Musician Retrieval System Using Topic Maps (토픽맵기반의 뮤지션 검색시스템 구축)

  • Kwon, Jin-Man;Chung, Myung-Bum;Sung, Bo-Kyung;Kim, Jung-Soo;Ko, Il-Ju
    • 한국HCI학회:학술대회논문집
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    • 2008.02a
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    • pp.760-765
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    • 2008
  • The purpose of this paper is to propose a powerful alternative in designing knowledge portals using Topic Maps(TM). All information is processing for one topic, about each topics define to association and composite flow of information. and all topics about add occurrence to use in the OpenAPI. Also represent to UI of graphic for intuitional representation, and using JavaScript for Cross-Browsing. so that not using XTM of a standard Topic Maps(TM) and using JSON for a simple represent to data. The results made for intuitional process UI and extensive limits to display for new information before until now musician search system. In future positive to musician search for music.

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A Study on the Development of the Active Radar Reflector with Enhanced Structure (개선 된 구조를 갖는 능동 레이더 반사기 개발에 관한 연구)

  • 정종혁;강상욱;조영창;최병진;윤정오;홍영호
    • Proceedings of the Korea Society for Industrial Systems Conference
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    • 2000.05a
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    • pp.59-64
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    • 2000
  • Active radar reflector may be less familiar, since their uses have been limited to military applications, especially the enhancement of the effective radar cross-sections of missile test range in the drone aircraft and missiles. Perhaps the most widely-blown applications of radar transponders are Identification Friend or Foe(IFF) and its civilian counterpart, secondary surveilliance radar for Air Traffic Control(ATC), and most recently, as Search And Rescue Transponder(SART) in the Global Maritime Distress and Safety System(GMDSS). Since it happens frequently accidents on the sea, the problems of the contamination more seriously considered. The conventional navigation buoy and utilities are not sufficient to maintain the safety of the sea and thus new structured concept must be considered. Therefore, this paper propose and implement the active radar reflector with a enhanced structure. The results are shown that the performance of the system is significantly improved comparing with the conventional utilities.

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Landmark Recognition Method based on Geometric Invariant Vectors (기하학적 불변벡터기반 랜드마크 인식방법)

  • Cha Jeong-Hee
    • Journal of the Korea Society of Computer and Information
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    • v.10 no.3 s.35
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    • pp.173-182
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    • 2005
  • In this paper, we propose a landmark recognition method which is irrelevant to the camera viewpoint on the navigation for localization. Features in previous research is variable to camera viewpoint, therefore due to the wealth of information, extraction of visual landmarks for positioning is not an easy task. The proposed method in this paper, has the three following stages; first, extraction of features, second, learning and recognition, third, matching. In the feature extraction stage, we set the interest areas of the image. where we extract the corner points. And then, we extract features more accurate and resistant to noise through statistical analysis of a small eigenvalue. In learning and recognition stage, we form robust feature models by testing whether the feature model consisted of five corner points is an invariant feature irrelevant to viewpoint. In the matching stage, we reduce time complexity and find correspondence accurately by matching method using similarity evaluation function and Graham search method. In the experiments, we compare and analyse the proposed method with existing methods by using various indoor images to demonstrate the superiority of the proposed methods.

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A Study on the Development of the Active Radar Reflector with Enhanced Function (개선된 기능을 갖는 능동 레이더 반사기 개발에 관한 연구)

  • 정종혁;강상욱;조영창;최병진;윤정오;오주환
    • Journal of Korea Society of Industrial Information Systems
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    • v.5 no.3
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    • pp.38-43
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    • 2000
  • Active radar reflector may be less familiar, since their uses have been limited to military applications, especially the enhancement of the effective radar cross-sections of missile test range in the drone aircraft and missiles. Perhaps the most widely-Down applications of radar transponders are Identification Friend or Foe(IFF) and its civilian counterpart secondary surveilliance radar for Air Traffic Control(ATC), and most recently, as Search And Rescue Transponder(SART) in the Global Maritime Distress and Safety System(GMDSS). Since it happens frequently accidents on the sea, the problems of the contamination more seriously considered. The conventional navigation buoy and utilities are not sufficient to maintain the safety of the sea and thus new structured concept must be considered. Therefore, this paper propose and implement the active radar reflector with a enhanced function. The results are shown that the performance of the system is significantly improved comparing with the conventional utilities.

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Evidence-based approaches for establishing the 2015 Dietary Reference Intakes for Koreans

  • Shin, Sangah;Kim, Subeen;Joung, Hyojee
    • Nutrition Research and Practice
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    • v.12 no.6
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    • pp.459-468
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    • 2018
  • BACKGROUND/OBJECTIVES: The Dietary Reference Intakes for Koreans (KDRIs), a set of reference intake values, have served as a basis for guiding a balanced diet that promotes health and prevents disease in the general Korean population. In the process of developing DRIs, a systematic review has played an important role in helping the DRI committees make evidence-based and transparent decisions for updating the next DRIs. Thus, the 2015 KDRI steering committee applied the systematic review framework to the revision process of the KDRIs. The purpose of this article is to summarize the revision process for the 2015 KDRIs by focusing on the systematic review framework. MATERIALS/METHODS: The methods used to develop the systematic review framework for 2015 KDRIs followed the Agency for Healthcare Research and Quality and the Tufts Evidence-based Practice Center. The framework for systematic review of the 2015 KDRIs comprised of the 3 following steps: (1) development of an analytic framework and refinement of key questions and search terms; (2) literature search and data extraction; and, (3) appraisal of the literature and summarizing the results. RESULTS: A total of 203,237 studies were retrieved through the above procedure, with 2,324 of these studies included in the analysis. General information, main results, comments of reviewers, and results of quality assessment were extracted and organized by study design. The average points of quality appraisals were 3.0 (range, 0-5) points for intervention, 6.1 (0-9) points for cohort, 6.0 (3-9) points for nested case-control, 5.4 (1-8) points for case-control, 14.6 (0-22) points for cross-sectional studies, and 7.0 (0-11) points for reviews. CONCLUSIONS: Systematic review helped to establish the 2015 KDRIs as a useful tool for evidence-based approach. Collaborative efforts to improve the framework for systematic review should be continued for future KDRIs.

Scoping Review of Research on Mental Health of Nurses Working in Korean Medicine Hospitals (한방병원에 근무하는 간호사의 정신건강에 대한 연구동향: 국내연구를 중심으로)

  • Kwon, Chan-Young;Park, Jung Hyeon;Ha, Da-Jung
    • Journal of Oriental Neuropsychiatry
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    • v.32 no.1
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    • pp.55-66
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    • 2021
  • Objectives: The aim of this scoping review was to analyze research trends about mental health of nurses working in Korean medicine (KM) hospitals in Republic of Korea. Methods: Searches were conducted using four electronic databases including Oriental Medicine Advanced Searching Integrated System, Korean Studies Information Service System, Research Information Sharing Service, Korea Citation Index to collect relevant studies. The search date was March 4, 2021. All studies published up to the search date were considered. Observational studies reporting mental health outcomes of nurses working at KM Hospital were included. Results: A total of 11 cross-sectional observation studies were included. Four of them compared mental health of nurses working on KM and Western medicine (WM). Commonly reported outcomes related to mental health were job satisfaction, role conflict, and work stress. As a result of meta-analysis based on a 5-point Likert scale, the following factors were related to mental health of KM nurses: job satisfaction (2.844±0.067 points), role conflict (3.678±0.058 points), work stress (3.142±0.021 points), turnover intention (3.483±0.028 points), and burnout (3.180±0.033). Compared to WM nurses, KM nurses had significantly less work stress (p=0.000), role conflict (p=0.039), and job satisfaction (p=0.000). Conclusions: Mental health problems of nurses are known to be very common. Although improving them is an important social task, studies on mental health of KM nurses remain insufficient. Based on findings of this study, more cooperation between nurses and KM doctors should be made to improve the mental health of KM nurses, especially their job satisfaction in the future. The Korean Society of Oriental Neuropsychiatry needs to pay more attention to this topic.

Quality Prediction Model for Manufacturing Process of Free-Machining 303-series Stainless Steel Small Rolling Wire Rods (쾌삭 303계 스테인리스강 소형 압연 선재 제조 공정의 생산품질 예측 모형)

  • Seo, Seokjun;Kim, Heungseob
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.44 no.4
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    • pp.12-22
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    • 2021
  • This article suggests the machine learning model, i.e., classifier, for predicting the production quality of free-machining 303-series stainless steel(STS303) small rolling wire rods according to the operating condition of the manufacturing process. For the development of the classifier, manufacturing data for 37 operating variables were collected from the manufacturing execution system(MES) of Company S, and the 12 types of derived variables were generated based on literature review and interviews with field experts. This research was performed with data preprocessing, exploratory data analysis, feature selection, machine learning modeling, and the evaluation of alternative models. In the preprocessing stage, missing values and outliers are removed, and oversampling using SMOTE(Synthetic oversampling technique) to resolve data imbalance. Features are selected by variable importance of LASSO(Least absolute shrinkage and selection operator) regression, extreme gradient boosting(XGBoost), and random forest models. Finally, logistic regression, support vector machine(SVM), random forest, and XGBoost are developed as a classifier to predict the adequate or defective products with new operating conditions. The optimal hyper-parameters for each model are investigated by the grid search and random search methods based on k-fold cross-validation. As a result of the experiment, XGBoost showed relatively high predictive performance compared to other models with an accuracy of 0.9929, specificity of 0.9372, F1-score of 0.9963, and logarithmic loss of 0.0209. The classifier developed in this study is expected to improve productivity by enabling effective management of the manufacturing process for the STS303 small rolling wire rods.