• Title/Summary/Keyword: Cross Regulation

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The Study on Time Series Analysis of Groundwater Data and Groundwater Recharge in Jeju Island (제주도 수리자료에 대한 시계열 분석 및 지하수 함양률 추정 연구)

  • Choi, Hyun-Mi;Lee, Jin-Yong;Ha, Kyoo-Chul;Kim, Gee-Pyo
    • The Journal of Engineering Geology
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    • v.21 no.4
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    • pp.337-348
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    • 2011
  • We examined temporal variations in and relationships among groundwater level, groundwater temperature, and electric conductivity, and estimated groundwater recharge at Jeju Island. The time lag and regulation time of groundwater level data revealed that monitoring well in Ansung (JM-AS) has the highest auto-correlation. The cross-correlations for electric conductivity-water level, precipitation-water level, and air temperature-water temperature revealed that monitoring well in Seogwi-2 (JR-SG2) (electric conductivity-water level), monitoring well in Hamo (JD-HM) (precipitation-water level), and monitoring well in Wonjongjang-2 (JT-WJJ2) (air temperature-water temperature) had the highest cross-correlations. The average groundwater recharge ratio was 39.61%, and the average groundwater recharge amount was 1,153,490,407 $m^3/yr$, which is consistent with the results of previous studies.

Phosphate Deficiency Stress Response Mediated by Pho Regulon in Bacillus subtilis (Bacillus subtilis의 Pho Regulon을 통한 인산 결핍 스트레스 반응)

  • Park, Jae-Yong
    • Korean Journal of Microbiology
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    • v.46 no.2
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    • pp.113-121
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    • 2010
  • Bacillus subtilis PhoP-PhoR two-component system (TCS) senses phosphate deficiency conditions, and then controls expression of the Pho regulon to prolong survival. The sensor histidine kinase, PhoR, is autophosphorylated and transfers the phosphate to the response regulator, PhoP. Phosphorylated PhoP (PhoP~P) binds to repeated 6-bp consensus PhoP binding sequences of Pho regulon promoters and activates or represses gene expression. Pho signal transduction systems are part of interconnected signal transduction network involving at least three TCSs (PhoP-PhoR, ResD-ResE TCS, SpoOA phosphorelay), a global carbon metabolism regulator (CcpA), and transition state regulators (AbrB, ScoC). In addition, PhoP-PhoR TCS is cross related with YycF-YycG TCS by cross-regulation. While indescribable progress has been made in understanding phosphate deficiency stress response through refined expression of the Pho regulon in the recent past years, many important questions still remain. Solving these questions may provide important information for application study using B. subtilis.

CaPUB1, a Hot Pepper U-box E3 Ubiquitin Ligase, Confers Enhanced Cold Stress Tolerance and Decreased Drought Stress Tolerance in Transgenic Rice (Oryza sativa L.)

  • Min, Hye Jo;Jung, Ye Jin;Kang, Bin Goo;Kim, Woo Taek
    • Molecules and Cells
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    • v.39 no.3
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    • pp.250-257
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    • 2016
  • Abiotic stresses such as drought and low temperature critically restrict plant growth, reproduction, and productivity. Higher plants have developed various defense strategies against these unfavorable conditions. CaPUB1 (Capsicum annuum Putative U-box protein 1) is a hot pepper U-box E3 Ub ligase. Transgenic Arabidopsis plants that constitutively expressed CaPUB1 exhibited drought-sensitive phenotypes, suggesting that it functions as a negative regulator of the drought stress response. In this study, CaPUB1 was over-expressed in rice (Oryza sativa L.), and the phenotypic properties of transgenic rice plants were examined in terms of their drought and cold stress tolerance. Ubi:CaPUB1 T3 transgenic rice plants displayed phenotypes hypersensitive to dehydration, suggesting that its role in the negative regulation of drought stress response is conserved in dicot Arabidopsis and monocot rice plants. In contrast, Ubi:CaPUB1 progeny exhibited phenotypes markedly tolerant to prolonged low temperature ($4^{\circ}C$) treatment, compared to those of wild-type plants, as determined by survival rates, electrolyte leakage, and total chlorophyll content. Cold stress-induced marker genes, including DREB1A, DREB1B, DREB1C, and Cytochrome P450, were more up-regulated by cold treatment in Ubi:CaPUB1 plants than in wild-type plants. These results suggest that CaPUB1 serves as both a negative regulator of the drought stress response and a positive regulator of the cold stress response in transgenic rice plants. This raises the possibility that CaPUB1 participates in the cross-talk between drought and low-temperature signaling pathways.

A Case Study on the Cross-Well Travel-Time Tomography Regulated by the Error in the Measurement of the First Arrival Time (초동 주시 측정 오차로 제어된 공대공 주시 토모그래피 사례연구)

  • Lee, Doo-Sung
    • Geophysics and Geophysical Exploration
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    • v.12 no.3
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    • pp.233-238
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    • 2009
  • An inversion method regulated by the error in the measurement of the first arrival time was developed, and we conducted a feasibility study by applying the method to a real cross-well seismic data. The inversion is a two-step regulation process; 1) derive the measurement error bound based on the resolution of the velocity image want to derive, and exclude the records whose picking error is larger than the error bound, 2) set the travel time residual to zero if the residual is less than the measurement error. This process prevents the trivial residuals are accumulated and contribute to the velocity-model update. Comparison of two velocity images, one by using all records and another by using the regulate inversion method, shows that the later velocity image exhibits less numerical artefacts, and it also indicates that, according to the Fermat's principle, the latter image is a more feasible velocity model.

A Cross-Cultural Comparison of Academic Attitudes for Gifted Elementary and Middle School Students (청소년기 영재들의 학업 태도에 대한 국제 비교)

  • Moon, Jeong-Hwa;Van Eman, Linnea;Montgomery, Diane
    • Journal of Gifted/Talented Education
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    • v.20 no.3
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    • pp.867-883
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    • 2010
  • Recognizing the importance of motivation, goal orientation, and attitudes toward schools is an important component for educators to consider as they establish positive learning communities for gifted learners. The purpose of this study was to describe attitudes toward school and self relationship to schoolwork for students who are enrolled in the 5th, 6th, and 7th grade, identified as gifted, accelerated in at least one subject (mathematics), and living in Korea or the United States. Comparisons were conducted for country of origin and gender for all subscales on the School Attitude Assessment Survey-Revised (McCoach & Siegle, 2004). Of the 507 participants (278 Korean and 229 American), girls scored higher on the motivation/self-regulation scale than boys and American students scored higher than Korean students on attitudes toward school, academic self perceptions, goal orientation, and motivation. There were no differences by country or gender on attitudes toward teachers.

Association between Self-efficacy, Stress, Violence Experiences, Economic state, Relationship Conflict, Health Behaviors and Depression in Graduate Student (대학원생의 자기효능감, 스트레스, 폭력 경험, 경제적 환경, 관계갈등, 건강행위가 우울에 미치는 영향)

  • Kim, Da Hye;Ham, Ok Kyung;Suh, Min Hee;Park, Sihyun
    • Journal of Korean Public Health Nursing
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    • v.35 no.1
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    • pp.89-103
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    • 2021
  • Purpose: This study examined the factors associated with depression among Korean graduate students. Specifically, personal (self-efficacy, stress), environmental (violence experience, economic state, and relationship conflict), and behavioral (health behavior) factors were analyzed. Methods: This study used a cross-sectional study design. One hundred and fifty participants currently enrolled in graduate programs were recruited. Google Drive was used for online data collection. Descriptive statistics, correlational analyses, and hierarchical regression analysis were conducted. Results: First, 52% of the participants were male, with an average age of 28.05(±3.19). Master's students comprised the largest proportion (63.3%). Approximately about 38.7% were engineering majors. Second, approximately 27.3% had depressive symptoms; and 7.3% had major depression. Third, there was a significant correlation between personal, environmental (financial burdens), and behavioral factors. Fourth, hierarchical regression analysis revealed a lower depression level to be associated with a higher self-efficacy level and health behavior. In contrast, a higher depression level was related to violence experience. Conclusion: The government should press on establishing rules on the prevention and regulation of violence in universities, and impose strong disciplinary measures to root out the problem. In addition, universities must pay attention to the mental health of graduate students and establish systems to manage them.

A Study on the Forms and Character of Huhdai Mergen in Mongolian Mythology through the archery (활쏘기를 통해 본 몽골 신화상의 후흐데이 메르겐의 형상과 성격)

  • Lee, An-na
    • Cross-Cultural Studies
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    • v.35
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    • pp.185-214
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    • 2014
  • This paper presents an investigation into the forms of master archer Huhdai Mergen from Mongolian mythology and his character through archery. In Mongolian mythology, master archer Huhdai Mergen is usually connected to the regulation of the sun, the moon, and the stars in Heaven and the creation of stars. Such a series of acts are conducted through archery, which used to be performed as an incantatory ritual to resolve a disaster in life, dispel an evil spirit, and pray for affluence as well as for hunting. In Mongolian mythology, Huhdai Mergen is a master archer and hunter that rises to Heaven while hunting a deer and becomes Sirius with the deer becoming Orion. The Mongolian have believed that the two constellations protect them since ancient times. While Orion is related to the deer totem, Huhdai Mergen or Sirius is related to the wolf totem faith. Huhdai Mergen takes too much pride in his archery skills and ends up causing damage to himself, which can be understood as a pattern of controlling the power of personified Huhdai Mergen through excessive natural force. He also has something to do with Polaris, which is regarded as the stake to bind his horse to by the Mongolian. They also believe that their ancestral gods reside in the horse stake or column. The stake is the residence of Huhdai Mergen protecting the Mongolian people, which reflects his aspect as an ancestral god. He is also depicted as the god of thunder and lightning born in a cow. The stones he throws and the arrows he shoots in Heaven are the embodiments of thunder and lightning. The Mongolian have understood lightning of dispelling an evil spirit and striking wicked things as the arrow of Huhdai Mergen. The god of thunder and lightning has the attributes of a fertility god such as eliminating bad devils and bringing affluence. Huhdai Mergen is also manifested as the creator to create the earth and the savior to save mankind. Such forms all derive from his archery skills.

Analysis of changes in cross section and flow rate due to vegetation establishment in Naeseong stream (내성천 하도 내 식생활착에 의한 단면 및 유량변화 분석)

  • Lee, Tae Hee;Kim, Su Hong
    • Journal of Korea Water Resources Association
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    • v.54 no.3
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    • pp.203-215
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    • 2021
  • In the present study, hydrologic data and topographical data from 2010 to 2019 were collected from three gauging stations placed in the watershed of Naeseong stream to determine changes and rates of changes in rainfall, water level & mean velocity, and water level & discharge, together with changes in rates of erosion and deposition at cross-sections of the river. Besides, effects of regulated and non-regulated rivers according to the presence of artificial regulation of flow rate of the river via artificial structure located at Seo stream (Yeongju si (Wolhogyo) station), the tributary free from construction of dams, were compared and analyzed. Results of analyses conducted in the present study revealed vegetational establishment and landforming due to increasing area of vegetational sandbar evolved in the flood plain (intermediate- or high- water level) by the drought sustained from 2013 to 2015. Continuous erosion of river bed was appeared because of narrowed flow area with low water level and increased velocity and tractive force on river bed.

Induction of apoptosis by water extract Glycyrrhizae radix in human bladder T24 cancer cells (인체 방광암 T24 세포에서 Glycyrrhizae radix 열수추출물에 의한 apoptosis 유도)

  • Eom, Jung Hye;Hwang, Buyng Su;Jeong, Yong Tae;Kim, Min-Jin;Shin, Su Young;Kim, Chul Hwan;Lee, Seung Young;Choi, Kyung Min;Cho, Pyo Yun;Jeong, Jin-Woo;Oh, Young Taek
    • Proceedings of the Plant Resources Society of Korea Conference
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    • 2019.04a
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    • pp.111-111
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    • 2019
  • Glycyrrhizae radix is one of the most frequently prescribed ingredients in Oriental medicine, and G. radix extract has been shown to exert anti-cancer effects. However, the cellular and molecular mechanisms of apoptosis by G. radix are poorly defined. In the present study, it was examined the biochemical mechanisms of apoptosis by water extract of G. radix (WEGR) in human bladder T24 cancer cells. It was found that WEGR could inhibit the cell growth of T24 cells in a dose-dependent manner, which was associated with the induction of apoptotic cell death, as evidenced by the formation of apoptotic bodies, DNA fragmentation and increased populations of annexin-V positive cells. The induction of apoptotic cell death by WEGR was connected with an up-regulation of pro-apoptotic Bax protein expression and down-regulation of anti-apoptotic Bcl-2 and Bcl-xL proteins, and inhibition of apoptosis family proteins (XIAP, cIAP-1 and cIAP-2). In addition, apoptosis-inducing concentrations of WEGR induced the activation of caspase-9, an initiator caspase of the mitochondrial-mediated intrinsic pathway, and caspase-3, accompanied by proteolytic degradation of poly (ADP-ribose)-polymerase. WEGR also induced apoptosis via a death receptor-mediated extrinsic pathway by caspase-8 activation, resulting in the down-regulation of total Bid and suggesting the existence of cross-talk between the extrinsic and intrinsic pathways. Taken together, the present results suggest that WEGR may be a potential chemotherapeutic agent for the control of human bladder cancer cells.

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Cloning and Characterization of Liver cDNAs That Are Differentially Expressed between Chicken Hybrids and Their Parents

  • Sun, Dong-Xiao;Wang, Dong;Yu, Ying;Zhang, Yuan
    • Asian-Australasian Journal of Animal Sciences
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    • v.18 no.12
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    • pp.1684-1690
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    • 2005
  • Using mRNA differential display technique, we investigated differential gene expression in hybrids relative to their parents in a diallel cross involving four chicken breeds in order to provide an insight into the molecular basis of heterosis in chicken. The results indicated that there was extensive differential gene expression between chicken F1 hybrids and their parents which was classified into four kinds of patterns as following: (1) bands only detected in hybrid F1; (2) bands only absent in hybrid F1; (3) bands only detected in parent P1 or P2; (4) bands absent in parent P1 or P2. Forty-two differentially expressed cDNAs were cloned and sequenced, and their expression patterns were confirmed by Reverse-Northern dot blot. Sequence analysis and database searches revealed that genes showed differential expression between hybrid and parents were regulatory and functional genes involved in metabolism, mRNA splicing, transcriptional regulation, cell cycles and protein modification. These results indicated that hybridization between two parents can cause changes in expression of a variety of genes. In conclusion, that the altered pattern of gene expression in hybrids may be responsible for heterosis in chickens.