• Environmental Analysis Health and Toxicology
• /
• v.31
• /
• pp.16.1-16.9
• /
• 2016

Objectives Banha-sasim-tang (BST), which consists of seven different herbs, is one of the most popular herbal formulae for treating gastrointestinal disorders in Eastern Asia. The commonly used herbal medicine is often co-administered with other therapeutic drugs, which raises the possibility of herb-drug interactions and may modify the clinical safety profile of therapeutic drugs. Methods We investigated the potential herb-drug interactions between BST extract and midazolam (MDZ) in mice. The area under the plasma concentration-time curve (AUC) of MDZ and 1'-hydroxymidazolam (1'-OH-MDZ) was evaluated for both oral and intraperitoneal administration of MDZ, following oral administration of BST (0.5 and 1 g/kg). Results It was found that the AUC of MDZ and 1'-OH-MDZ was lower in case of oral administration of MDZ. Administration of BST extract was not associated with hepatic cytochrome P450 activity. BST extract induced a strong reduction in pH and it has been reported that oral mucosal absorption of MDZ is lower at low pH. The decreased absorption rate of MDZ might be caused by the ingredients of BST and may not be related to other factors such as increased excretion of MDZ by P-glycoprotein. Conclusions The altered pharmacokinetics of midazolam caused by co-administration with BST in vivo could be attributed to a decrease in pH and subsequent reduction of MDZ absorption rate.

• Journal of Science Education
• /
• v.35 no.2
• /
• pp.262-273
• /
• 2011

This research was aimed to develop and apply the molecular genetics teaching program based on the history of science and creative problem solving model (HS-CPS model) for gifted students. Based on the strategies of creative problem solving and scientific theory development, the HS-CPS teaching program were developed. This program was applied to 8 first and second graders of the special class for invention activity in a high school. Creative problem solving ability in science and the understanding of DNA and gene concept were tested in pre and post of 12 lessons. The results were as follows: First, creative problem solving ability in science was improved meaningfully. Second, HS-CPS teaching program was effective in the understanding of DNA and gene concepts. Third, the students responded positively to the program evaluation questionnaire.

• Journal of Engineering Education Research
• /
• v.14 no.3
• /
• pp.15-24
• /
• 2011

The purpose of this study is to develop the 'Engineering Team Mission Project Education Program and Textbook', which is improved creativity and creative problem for Juniors(middle school students) that is in the growth stage to become the leading role in future society. This can be applied the creative experience activities time of revised curriculum in 2009 being implemented to secondary education by 2011. The results of this study are as follows. The formation of Team Mission Project Education Program is the big field 2 project, lower field 8 module and 38 total lessons. This education program has secured the validity of the SME(Subject Matter Expert) expert conference. Actually, by putting the education program and textbook to the invention talent class formed by middle school students and by normally analyzing, it has been analyzed as very satisfying result. Therefore, the "Engineering Team Mission Project Education Program and Textbook" can be provided as a practical education course of new talent training and engineering talent model of the nation's knowledge property education. And it can perform as an education program using usefully in the creative experience activity education course in middle class education stage. Also, it is concluded to become the basis of engineering design education's high grade education and department of engineering's creative engineering.

• Journal of the Korean Chemical Society
• /
• v.57 no.6
• /
• pp.845-854
• /
• 2013

The purpose of this study was to develop a teaching strategy focused on science writing and to investigate its effects on enhancing students' creative thinking skills. In advance, students in the experiment were led to write by inquiry elements. And students in the experiment group were taught by science writing strategy. Students in the control group were taught by traditional lecture-based instructions. The program was implemented over a semester. The results indicated that the experimental group presented statistically meaningful improvement in creative thinking skills(p<.05). Especially, science writing was effective on fluency and flexibility development(p<.05). This study suggests that science writing can be effective for improvement of creative thinking skills.

• Journal of Elementary Mathematics Education in Korea
• /
• v.10 no.1
• /
• pp.1-19
• /
• 2006

It is generally accepted that fostering creative thinking is a core in mathematics education and accumulating research products on that topic is really needed. In this study, I hoped to investigate and verify that in mathematics education it was possible to cultivate creative thinking through various and divergent activities, For this purpose, I delat with some illustrations, in which students learned mathematics through the operational activities using teaching tools, problem solving and problem posing activities, and finally they seemed to foster creative mathematical thinking. In conclusion of this paper, I have suggested that in math education those activities should be used to cultivate students' creative thinking in kindergarten or early elementary school. Also I asserted that it is urgently need to store up research products about various materials and methods for those mathematics teaching and learning.

• Journal of the Korea Society of Computer and Information
• /
• v.27 no.6
• /
• pp.181-188
• /
• 2022

This study analyzed the effectiveness of sharing activities through software creative sharing classes. The purpose is to find a way for related activities to be carried out continuously. For this study, pre and post were test on changes in self-esteem, responsibility, and sense of community targeting 25 university students in Chungnam. The collected data were analyzed with SPSS 24. The results derived from this study are as follows. First, the self-esteem was significantly higher after the software creative sharing class than before. Second, the responsibility was significantly higher after the software creative sharing class compared to the prior. Third, the sense of community was found to be significantly higher after the software creative sharing class than before. Therefore, it was found that the software creative sharing class had a positive effect on self-esteem responsibility and sense of community. Based on these data, a method to expand continuous participation in talent sharing was suggested.

• Journal of Korean Society of Forest Science
• /
• v.106 no.2
• /
• pp.230-239
• /
• 2017

This study was performed to analyze the relationship between the participative motivation and satisfaction of adolescents participating in Green Camp which was the field centered forest experience camp as analyzing the factor of the participative motivation and its influence on the satisfaction. Also, this study identified the changes in creative personality before and after participation to Green Camp. In results, there were five motivation factors: 'Adventure and Interest', 'Forest Activity', 'Improve Physical Health', 'Rest', 'Suggestion'. When respective factors were analyzed, the mean of 'Interest and adventure' was the highest at 4.303, and then 'Forest activity' at 4.287, 'Rest' at 3.970 followed. In the case of participant satisfaction, 'the teaching materials and tools of the camp' was the highest at 4.530, and then 'contents of the camp' at 4.410, 'lecture performer of the camp' at 4.229, 'the way of progress of the camp' at 4.036, 'the place of the camp' at 3.952, 'the passage time of the camp' at 3.843 followed. It showed that 'Forest activity' factor and satisfaction had a positive relationship (p<0.05). In addition, the means of creative personality before-and after-program participation increased from 3.687 to 3.773 (t=-2.218, p=0.029). Based on the analysis of satisfaction, this study suggested improvements of Green camp. Also, it proved that the participation Green camp had influence on the creative personality. The finding of this study is meaningful in that it proposed the necessity of activation forest education focusing on experience.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.14 no.6
• /
• pp.2898-2907
• /
• 2013

The purpose of this study was to develop the creative thinking training program(CTTP) focused on a nursing case for registered nurses(RN) working at hospital, and to examine the CTTP's effects on nurses' creative thinking ability and disposition. This quasi-experimental study was conducted on the basis of pre and post-test design with a comparison group for nurses enrolled in registered nurse bachelor science degree program in a University located in Southern area of Korea. The 5 hour-CTTP, including 7 creative activity tasks related to a nursing case, was implemented on 35 RNs of the experimental group from November 21, throughout November 28, 2011. The 39 RNs were participated in this study as a control group. Pre-and post-tests were done with the questionnaire items of the Integrated Creativity Instrument for creative ability and creative disposition. There were significant differences in creative thinking ability(t=3.62, p=001) and creative disposition(t=2.91, p=.01) between the experimental and the control group. The CTTP, developed in this research would contribute to increasing creativity competency for registered nurses.

• Journal of The Korean Association of Information Education
• /
• v.21 no.3
• /
• pp.309-320
• /
• 2017

In this study, we developed the activity program for data visualization utilizing scratch and applied it to preliminary coding instructors and then verified its effect. The activity program was developed based on the procedure of ADDIE model based on the result of preliminary requirement analysis conducted for 20 teachers of computer elementary school incumbent primary school. The developed program was organized by "${\bigcirc}{\bigcirc}$Center for Creative Economy and Innovation" and a total of 21 hours set lectures and practical training for 4 weeks for 3 hours each 3 times per week in "Youth Coding Project" held at "${\bigcirc}{\bigcirc}$University" It applied to time. Application of the program In order to verify the effect on creativity, Torrance Tests of Creative Thinking Figures A and B were introduced and pre- and post tests were carried out. As a result of the verification, it was found that the educational program developed in this research is effective for improving the creativity of the preliminary coding instructors.

• Journal of Korean Elementary Science Education
• /
• v.31 no.1
• /
• pp.40-56
• /
• 2012

The purpose of this study was to understand the teaching effects after conducting ASI module in the open inquiry activities of the elementary science class. in order to understand the effects of ASI(Authentic Scientific Inquiry) module application using science research notes in open inquiry activities to students' science research ability. The results of this study were as follow. First, the after test results were covariance-analyzed to be the effects to science process skills were statistically significant in 0.5 significance level. Second, in the covariance analysis of the after test of the study group and the comparative group, the effects to scientific creative problem solving skills were statistically significant in 0.5 significance level. Third, the covariance analysis of the after test in the effects of ASI module application using science notebooks to students' scientific attitude revealed that the two groups' average difference was statistically significant in 0.5 significance level. In conclusion, application of the ASI module using science notebooks had a positive effect on improvements of students' science process skills, science creative problem solving ability and scientific attitude. Therefore, the ASI module using science notebooks is hopefully to be provided as an effective instructive strategy in the open inquiry activities courses in school in the future.