• Experimental and Molecular Medicine
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• v.50 no.11
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• pp.7.1-7.12
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• 2018

Recent findings from The Cancer Genome Atlas project have provided a comprehensive map of genomic alterations that occur in hepatocellular carcinoma (HCC), including unexpected mutations in apolipoprotein B (APOB). We aimed to determine the clinical significance of this non-oncogenetic mutation in HCC. An Apob gene signature was derived from genes that differed between control mice and mice treated with siRNA specific for Apob (1.5-fold difference; P < 0.005). Human gene expression data were collected from four independent HCC cohorts (n = 941). A prediction model was constructed using Bayesian compound covariate prediction, and the robustness of the APOB gene signature was validated in HCC cohorts. The correlation of the APOB signature with previously validated gene signatures was performed, and network analysis was conducted using ingenuity pathway analysis. APOB inactivation was associated with poor prognosis when the APOB gene signature was applied in all human HCC cohorts. Poor prognosis with APOB inactivation was consistently observed through cross-validation with previously reported gene signatures (NCIP A, HS, high-recurrence SNUR, and high RS subtypes). Knowledge-based gene network analysis using genes that differed between low-APOB and high-APOB groups in all four cohorts revealed that low-APOB activity was associated with upregulation of oncogenic and metastatic regulators, such as HGF, MTIF, ERBB2, FOXM1, and CD44, and inhibition of tumor suppressors, such as TP53 and PTEN. In conclusion, APOB inactivation is associated with poor outcome in patients with HCC, and APOB may play a role in regulating multiple genes involved in HCC development.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2009.05a
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• pp.396-399
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• 2009

Stereo vision system is useful method for inferring 3D depth information from two or more images. So it has been the focus of attention in this field for a long time. Stereo matching is the process of finding correspondence points in two or more images. A central problem in a stereo matching is that it is difficult to satisfy both the computation time problem and accuracy at the same time. To resolve this problem, we proposed a new stereo matching technique using weighted cost aggregation. To begin with, we extract the weight in given stereo images based on features. We compute the costs of the pixels in a given window using correlation of weighted color, brightness and distance information. Then, we match pixels in a given window between the reference and target images of a stereo pair. To demonstrate the effectiveness of the algorithm, we provide experimental data from several synthetic and real scenes. The experimental results show the improved accuracy of the proposed method.

• Nuclear Engineering and Technology
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• v.41 no.9
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• pp.1143-1156
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• 2009

The SPACE code that is based on a multi-dimensional two-fluid, three-field model is under development for licensing purposes of pressurized water reactors in Korea. Among the participating research and industrial organizations, KAERI is in charge of developing the physical models and correlation packages for the constitutive equations. This paper introduces a developed wall-to-fluid heat transfer package for the SPACE code. The wall-to-fluid heat transfer package consists of twelve heat transfer subregions. For each sub-region, the models in the existing safety analysis codes and the leading models in literature have been peer reviewed in order to determine the best models which can easily be applicable to the SPACE code. Hence a wall-to-fluid heat transfer region selection map has been developed according to the non-condensable gas quality, void fraction, degree of subcooling, and wall temperature. Furthermore, a partitioning methodology which can take into account the split heat flux to the continuous liquid, entrained droplet, and vapor fields is proposed to comply fully with the three-field formulation of the SPACE code. The developed wall-to-fluid heat transfer package has been pre-tested by varying the independent parameters within the application range of the selected correlations. The smoothness between two adjacent heat transfer regimes has also been investigated. More detailed verification work on the developed wall-to-fluid heat transfer package will be carried out when the coupling of a hydraulic solver with the constitutive equations is brought to completion.

• Journal of Korean Society on Water Environment
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• v.37 no.5
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• pp.369-380
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• 2021

In this work, we analyzed the effects of drought on the water temperature (WT) of Nakdong river basin major river sections using Standardized Precipitation Index (SPI) and WT data. The analysis was carried out on a seasonal basis. After calculating the optimal time scale of the SPI through the correlation between the SPI and WT data, we used the copula theory to model the joint probability distribution between the WT and SPI on the optimal time scale. During spring and fall, the possibility of environmental drought caused by high WT increased in most of the river sections. Notably, in summer, the possibility of environmental drought caused by high WT increased in all river sections. On the other hand, in winter, the possibility of environmental drought caused by low WT increased in most river sections. From the risk map, which quantified the sensitivity of WT to the risk of environmental drought, the river sections Nakbon C, Namgang E, and Nakbon K showed increased stress in the water ecosystem due to high WT when drought occurred in summer. When drought occurred in winter, an increased water ecosystem stress caused by falling WT was observed in the river sections Gilan A, Yongjeon A, Nakbon F, Hwanggang B, Nakbon I, Nakbon J, Nakbon K, Nakbon L, and Nakbon M. The methodology developed in this study will be used in the future to quantify the effects of drought on water quality as well as WT.

• Fashion & Textile Research Journal
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• v.21 no.4
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• pp.468-479
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• 2019

This study used a three-dimensional-analysis method to quantitatively analyze the change of clothing appearance according to a gusset added to bodice and sleeve patterns for men in their twenties. Comparing six different patterns, the study found that patterns P1 and P2 with little gusset did not have a large difference in the strain map, and pattern P6 had no gusset in the motion of raising the arm $28^{\circ}$ to the side (M1). When the arm was raised $45^{\circ}$ to the side (M2), the P1 pattern had the smallest deformation, and only the P5 pattern had a large deformation from the neck to the armhole area. In contrast, except for in the P3 pattern, large wrinkles formed in the front and back when the arm was raised above $158^{\circ}$ (M3) from the side of the waist to the armpit. In addition, P3 had the smallest change in the hem of the bodice and sleeves. However, the appearance of P2, P3, and P5 was excellent when the arm was moved forward (M4), and the P2 and P5 patterns were the smallest at the bodice and sleeve hem. The P6 pattern showed the least fitness in terms of function. In the case of raising the arm, there was a strong correlation between gusset size and motion function, but when the motion of the arm changed, the motion function did not improved just by changing the ease size.

• Investigative Magnetic Resonance Imaging
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• v.23 no.1
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• pp.55-64
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• 2019

Purpose: One of the suggested potential mechanisms of tinnitus is an alteration in perception in the neural auditory pathway. The aim of this study was to investigate the difference in laterality in functional connectivity between tinnitus patients and healthy controls using resting state functional MRI (rs-fMRI). Materials and Methods: Thirty-eight chronic tinnitus subjects and 45 age-matched healthy controls were enrolled in this study. Connectivity was investigated using independent component analysis, and the laterality index map was calculated based on auditory (AN) and dorsal attention (DAN), default mode (DMN), sensorimotor, salience (SalN), and visual networks (VNs). The laterality index (LI) of tinnitus subjects was compared with that of normal controls using region-of-interest (ROI) and voxel-based methods and a two-sample unpaired t-test. Pearson correlation was conducted to assess the associations between the LI in each network and clinical variables. Results: The AN and VN showed significant differences in LI between the two groups in ROI analysis (P < 0.05), and the tinnitus group had clusters with significantly decreased laterality of AN, SalN, and VN in voxel-based comparisons. The AN was positively correlated with tinnitus distress (tinnitus handicap inventory), and the SalN was negatively correlated with symptom duration (P < 0.05). Conclusion: The results of this study suggest that various functional networks related to psychological distress can be modified by tinnitus, and that this interrelation can present differently on the right and left sides, according to the dominance of the network.

• Journal of The Korean Society of Agricultural Engineers
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• v.61 no.5
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• pp.69-77
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• 2019

The objective of this study was to calibrate and validate the HSPF (Hydrological Simulation Program-Fortran) model for estimating the runoff of the Hapcheon dam watershed. Spatial data, such as watershed, stream, land use, and a digital elevation map, were used as input data for the HSPF model. Observed runoff data from 2000 to 2016 in study watershed were used for calibration and validation. Hydrologic parameters for runoff calibration were selected based on the user's manual and references, and trial and error method was used for parameter calibration. The $R^2$, RMSE (root-mean-square error), RMAE (relative mean absolute error), and NSE (Nash-Sutcliffe efficiency coefficient) were used to evaluate the model's performance. Calibration and validation results showed that annual mean runoff was within ${\pm}4%$ error. The model performance criteria for calibration and validation showed that $R^2$ was in the rang of 0.78 to 0.83, RMSE was 2.55 to 2.76 mm/day, RMAE was 0.46 to 0.48 mm/day, and NSE was 0.81 to 0.82 for daily runoff. The amount of inflow to Hapcheon Dam was calculated from the calibrated HSPF model and the result was compared with observed inflow, which was -0.9% error. As a result of analyzing the relation between inflow and storage capacity, it was found that as the inflow increases, the storage increases, and when the inflow decreases, the storage also decreases. As a result of correlation between inflow and storage, $R^2$ of the measured inflow and storage was 0.67, and the simulated inflow and storage was 0.61.

• Journal of the Society of Disaster Information
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• v.16 no.4
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• pp.682-690
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• 2020

Purpose: This study builds a database by collecting and refining disaster occurrence data and real-time weather and atmospheric data. In conjunction with the public data provided by the API, we propose a service model for the Big Data-based Urban Safety Index. Method: The plan is to provide a way to collect various information related to disaster occurrence by utilizing public data and SNS, and to identify and cope with disaster situations in areas of interest by real-time dashboards. Result: Compared with the prediction model by extracting the characteristics of the local safety index and weather and air relationship by area, the regional safety index in the area of traffic accidents confirmed that there is a significant correlation with weather and atmospheric data. Conclusion: It proposed a system that generates a prediction model for safety index based on machine learning algorithm and displays safety index by sector on a map in areas of interest to users.

• Journal of the Korean Society for Library and Information Science
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• v.55 no.2
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• pp.147-178
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• 2021

In this study, co-word analysis was conducted to investigate the intellectual structure of the domestic open access area. Through KCI and RISS, 124 research articles related to open access in Korea were selected for analysis, and a total of 1,157 keywords were extracted from the title and abstract. Network analysis was performed on the selected keywords. As a result, 3 domains and 20 clusters were extracted, and intellectual relations among keywords from open access area were visualized through PFnet. The centrality analysis of weighted networks was used to identify the core keywords in this area. Finally, 5 clusters from cluster analysis were displayed on a multidimensional scaling map, and the intellectual structure was proposed based on the correlation between keywords. The results of this study can visually identify and can be used as basic data for predicting the future direction of open access research in Korea.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.15 no.1
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• pp.1-19
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• 2021

The graph-based tag recommendation algorithm FolkRank can effectively utilize the relationships between three entities, namely users, items and tags, and achieve better tag recommendation performance. However, FolkRank does not consider the internal relationships of user-user, item-item and tag-tag. This leads to the failure of FolkRank to effectively map the tagging behavior which contains user neighbors and item neighbors to a tripartite graph. For item-item relationships, we can dig out items that are very similar to the target item, even though the target item may not have a strong connection to these similar items in the user-item-tag graph of FolkRank. Hence this paper proposes an improved FolkRank algorithm named FolkRank++, which fully considers the user-user and item-item internal relationships in tag recommendation by adding the correlation information between users or items. Based on the traditional FolkRank algorithm, an initial weight is also given to target user and target item's neighbors to supply the user-user and item-item relationships. The above work is mainly completed from two aspects: (1) Finding items similar to target item according to the attribute information, and obtaining similar users of the target user according to the history behavior of the user tagging items. (2) Calculating the weighted degree of items and users to evaluate their importance, then assigning initial weights to similar items and users. Experimental results show that this method has better recommendation performance.