• Title/Summary/Keyword: Correlation Coefficient($\gamma$)

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Clinical implementation of PerFRACTIONTM for pre-treatment patient-specific quality assurance

  • Sang-Won Kang;Boram Lee;Changhoon Song;Keun-Yong Eeom;Bum-Sup Jang;In Ah Kim;Jae-Sung Kim;Jin-Beom Chung;Seonghee Kang;Woong Cho;Dong-Suk Shin;Jin-Young Kim;Minsoo Chun
    • Journal of the Korean Physical Society
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    • v.80
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    • pp.516-525
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    • 2022
  • This study is to assess the clinical use of commercial PerFRACTIONTM for patient-specific quality assurance of volumetric-modulated arc therapy. Forty-six pretreatment verification plans for patients treated using a TrueBeam STx linear accelerator for lesions in various treatment sites such as brain, head and neck (H&N), prostate, and lung were included in this study. All pretreatment verification plans were generated using the Eclipse treatment planning system (TPS). Dose distributions obtained from electronic portal imaging device (EPID), ArcCHECKTM, and two-dimensional (2D)/three-dimensional (3D) PerFRACTIONTM were then compared with the dose distribution calculated from the Eclipse TPS. In addition, the correlation between the plan complexity (the modulation complexity score and the leaf travel modulation complexity score) and the gamma passing rates (GPRs) of each quality assurance (QA) system was evaluated by calculating Spearman's rank correlation coefficient (rs) with the corresponding p-values. The gamma passing rates of 46 patients analyzed with the 2D/3D PerFRACTIONTM using the 2%/2 mm and 3%/3 mm criteria showed almost similar trends to those analyzed with the Portal dose imaging prediction (PDIP) and ArcCHECKTM except for those analyzed with ArcCHECKTM using the 2%/2 mm criterion. Most of weak or moderate correlations between GPRs and plan complexity were observed for all QA systems. The trend of mean rs between GPRs using PDIP and 2D/3D PerFRACTIONTM for both criteria and plan complexity indices as in the GPRs analysis was significantly similar for brain, prostate, and lung cases with lower complexity compared to H&N case. Furthermore, the trend of mean rs for 2D/3D PerFRACTIONTM for H&N case with high complexity was similar to that of ArcCHECKTM and slightly lower correlation was observed than that of PDIP. This work showed that the performance of 2D/3D PerFRACTIONTM for pretreatment patient-specific QA was almost comparable to that of PDIP, although there was small difference from ArcCHECKTM for some cases. Thus, we found that the PerFRACTIONTM is a suitable QA system for pretreatment patient-specific QA in a variety of treatment sites.

A Study on the Difference Between Wife and Husband in the Level of Stress Recognition and Distress (부부간의 스트레스 인지수준 및 디스트레스 수준의 차이에 관한 연구)

  • 최동숙
    • Journal of the Korean Home Economics Association
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    • v.27 no.1
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    • pp.165-179
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    • 1989
  • The purpose of this study is to examine the difference between wife and husband in the level of stress recognition and distress subsequent to the life events, and thus 5 kinds of study questions have been established for the achievement of this purpose. Data were obtained from 371 couples who resided in Seoul through Likert-Type questionaire, and Frequency, Percentage, Mean, T-Test, One Way ANOVA, Pearson ${\gamma}$ Correlation, Multiple Regression, Cronbach ${\alpha}$ Coefficient were calculated. As the result of this studay, the experiences subsequent to life events, the level stress recognition and distress was different from wife and husband, and it was generally shown that those are higher for wife rather than husband.

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Generation of a adaptive tetrahedral refinement mesh for GaAs full band monte carlo simulation (풀밴드 GaAs monte carlo 시뮬레이션을 위한 최적사면체격자의 발생)

  • 정학기
    • Journal of the Korean Institute of Telematics and Electronics D
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    • v.34D no.7
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    • pp.37-44
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    • 1997
  • A dadaptive refinement tetrahedron mesh has been presented for using in full band GaAs monte carlo simulation. A uniform tetrahedron mesh is used without regard to energy values and energy variety in case of the past full band simulation. For the uniform tetrahedron mesh, a fine tetrahedron is demanded for keeping up accuracy of calculation in the low energy region such as .GAMMA.-valley, but calculation time is vast due to usin gthe same tetrahedron in the high energy region. The mesh of this study, thererfore, is consisted of the fine mesh in the low energy and large variable energy region and rough mesh n the high energy. The density of states (DOS) calculated with this mesh is compared with the one of the uniform mesh. The DOS of this mesh is improved th efive times or so in root mean square error and the ten times in the correlation coefficient than the one of a uniform mesh. This refinement mesh, therefore, can be used a sthe basic mesh for the full band GaAs monte carlo simulation.

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Applications of quantitative convergent beam electron diffraction measurement for structural characterization (Convergent beam electron diffraction의 정량분석을 응용한 재료의 구조분석)

  • Kim, Gyu-Hyeon;Lee, Min-Hui;Jeong, Sae-Eun;Go, Se-Hyeon
    • Proceedings of the Korean Institute of Surface Engineering Conference
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    • 2014.11a
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    • pp.176-177
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    • 2014
  • The new algorithm was proposed to quantify symmetry recorded in convergent beam electron diffraction (CBED) patterns and symmetry mapping. The proposed algorithm is based on the normalized cross-correlation coefficient (${\gamma}$) for quantifying the amount of symmetry in a CBED pattern. The quantification and mapping procedures are automatically controlled by the script implemented in Gatan Digital Micrograph$^{(c)}$. We apply the quantitative CBED measurement to a strained Si sample to test the sensitivity to defects.

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Free fatty acid-induced histone acetyltransferase activity accelerates lipid accumulation in HepG2 cells

  • Chung, Sangwon;Hwang, Jin-Taek;Park, Jae Ho;Choi, Hyo-Kyoung
    • Nutrition Research and Practice
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    • v.13 no.3
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    • pp.196-204
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    • 2019
  • BACKGROUND/OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is a common metabolic disease triggered by epigenetic alterations, including lysine acetylation at histone or non-histone proteins, affecting the stability or transcription of lipogenic genes. Although various natural dietary compounds have anti-lipogenic effects, their effects on the acetylation status and lipid metabolism in the liver have not been thoroughly investigated. MATERIALS/METHODS: Following oleic-palmitic acid (OPA)-induced lipid accumulation in HepG2 cells, the acetylation status of histone and non-histone proteins, HAT activity, and mRNA expression of representative lipogenic genes, including $PPAR{\gamma}$, SREBP-1c, ACLY, and FASN, were evaluated. Furthermore, correlations between lipid accumulation and HAT activity for 22 representative natural food extracts (NExs) were evaluated. RESULTS: Non-histone protein acetylation increased following OPA treatment and the acetylation of histones H3K9, H4K8, and H4K16 was accelerated, accompanied by an increase in HAT activity. OPA-induced increases in the mRNA expression of lipogenic genes were down-regulated by C-646, a p300/CBP-specific inhibitor. Finally, we detected a positive correlation between HAT activity and lipid accumulation (Pearson's correlation coefficient = 0.604) using 22 NExs. CONCLUSIONS: Our results suggest that NExs have novel applications as nutraceutical agents with HAT inhibitor activity for the prevention and treatment of NAFLD.

The Properties of Boron-doped Zinc Oxide Film Deposited according to Oxygen Flow Rate

  • Kim, Dong-Hae;Son, Chan-Hee;Yun, Myoung-Soo;Lee, Jin-Young;Jo, Tae-Hoon;Seo, Il-Won;Jo, I-Hyun;Roh, Jun-Hyung;Choi, Eun-Ha;Uhm, Han-Sup;Kwon, Gi-Chung
    • Proceedings of the Korean Vacuum Society Conference
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    • 2012.08a
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    • pp.358-358
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    • 2012
  • The application of BZO (Boron-doped Zinc Oxide) films use as the TCO(Transparent Conductive Oxide) material for display and solar cell industries, where the conductivity of the BZO films plays a critical role for improvement of cell performance. Thin BZO films are deposited on glass substrates by using RF sputter system. Then charging flow rates of O2 gas from zero to 10 sccm, thereby controlling the impurity concentration of BZO. BZO deposited on soda lime glass and RF power was 300 W, frequency was 13.56 MHz, and working pressure was $5.0{\times}10-6$ Torr. The Substrate and glass between distance 200 mm. We measured resistivity, conductivity, mobility by hall measurement system. Optical properties measured by photo voltaic device analysis system. We measured surface build according to oxygen flow rate from XPS (X-ray Photoelectron Spectroscopy) system. The profile of the energy distribution of the electrons emitted from BZO films by the Auger neutralization is measured and rescaled so that Auger self-convolution arises, revealing the detail structure of the valence band. It may be observed coefficient ${\gamma}$ of the secondary electron emission from BZO by using ${\gamma}$-FIB (Gamma-Focused Ion Beam) system. We observed the change in electrical conductivity by correlation of the valence band structure. Therefore one of the key issues in BZO films may be the valence band that detail structure dominates performance of solar cell devices. Demonstrating the secondary electron emission by the Auger neutralization of ions is useful for the determination of the characteristics of BZO films for solar cell and display developments.

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Development and Evaluation of a Badge-type Passive Sampler for the Measurement of Short-term Nitrogen Dioxide in Ambient Air (대기 중 이산화질소의 단기 측정을 위한 뱃지형 passive sampler의 개발 및 평가)

  • Kim Sun Kyu;Yim Bong Been;Jung Eui Suk;Kim Sun Tae
    • Journal of Korean Society for Atmospheric Environment
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    • v.22 no.1
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    • pp.117-126
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    • 2006
  • The purpose of this study is to develop a badge-type passive sampler for the measurement of short-term nitrogen dioxide and to evaluate its performance. The principle of the method is a colorimetric reaction of nitrogen dioxide with sulfanilic acid, N-1-naphthylethylendiamine, and phosphoric acid. First, it has been shown that the filter paper should be rinsed with ultrapure water and ultrasound, and then dried in a vacuumed desiccator. The concentration and volume of absorption reagent (triethanolamine) were $20\%$ and 100 ${\mu}L$, respectively. The extraction time was determined as 60 min. Second, duplicate measurements (n= 116) were carried out for evaluating the precision of the passive sampler. The relative error and the correlation coefficient between duplicates are $3.4\pm 3.0\%$ and 0.994, respectively. In addition, the $95\%$ confidence interval of intraclass correlation coefficient and the estimated value are 0.992$\sim$0.996 and 0.994, respectively. Third, a paired t-test was carried out for evaluating the accuracy of the passive sampler (n=40). In the result of the test, the $95\%$ confidence interval of the difference was -1.710 ppb <$\gamma$< 0.788 ppb. Finally, the average concentration of blanks, measurement detection limit, limit of detection, and limit of quantification are $2.4\pm 0.4$ ppb, 104 ppb, 3.8 ppb, and 7.0 ppb, respectively.

Spatial effect on the diffusion of discount stores (대형할인점 확산에 대한 공간적 영향)

  • Joo, Young-Jin;Kim, Mi-Ae
    • Journal of Distribution Research
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    • v.15 no.4
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    • pp.61-85
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    • 2010
  • Introduction: Diffusion is process by which an innovation is communicated through certain channel overtime among the members of a social system(Rogers 1983). Bass(1969) suggested the Bass model describing diffusion process. The Bass model assumes potential adopters of innovation are influenced by mass-media and word-of-mouth from communication with previous adopters. Various expansions of the Bass model have been conducted. Some of them proposed a third factor affecting diffusion. Others proposed multinational diffusion model and it stressed interactive effect on diffusion among several countries. We add a spatial factor in the Bass model as a third communication factor. Because of situation where we can not control the interaction between markets, we need to consider that diffusion within certain market can be influenced by diffusion in contiguous market. The process that certain type of retail extends is a result that particular market can be described by the retail life cycle. Diffusion of retail has pattern following three phases of spatial diffusion: adoption of innovation happens in near the diffusion center first, spreads to the vicinity of the diffusing center and then adoption of innovation is completed in peripheral areas in saturation stage. So we expect spatial effect to be important to describe diffusion of domestic discount store. We define a spatial diffusion model using multinational diffusion model and apply it to the diffusion of discount store. Modeling: In this paper, we define a spatial diffusion model and apply it to the diffusion of discount store. To define a spatial diffusion model, we expand learning model(Kumar and Krishnan 2002) and separate diffusion process in diffusion center(market A) from diffusion process in the vicinity of the diffusing center(market B). The proposed spatial diffusion model is shown in equation (1a) and (1b). Equation (1a) is the diffusion process in diffusion center and equation (1b) is one in the vicinity of the diffusing center. $$\array{{S_{i,t}=(p_i+q_i{\frac{Y_{i,t-1}}{m_i}})(m_i-Y_{i,t-1})\;i{\in}\{1,{\cdots},I\}\;(1a)}\\{S_{j,t}=(p_j+q_j{\frac{Y_{j,t-1}}{m_i}}+{\sum\limits_{i=1}^I}{\gamma}_{ij}{\frac{Y_{i,t-1}}{m_i}})(m_j-Y_{j,t-1})\;i{\in}\{1,{\cdots},I\},\;j{\in}\{I+1,{\cdots},I+J\}\;(1b)}}$$ We rise two research questions. (1) The proposed spatial diffusion model is more effective than the Bass model to describe the diffusion of discount stores. (2) The more similar retail environment of diffusing center with that of the vicinity of the contiguous market is, the larger spatial effect of diffusing center on diffusion of the vicinity of the contiguous market is. To examine above two questions, we adopt the Bass model to estimate diffusion of discount store first. Next spatial diffusion model where spatial factor is added to the Bass model is used to estimate it. Finally by comparing Bass model with spatial diffusion model, we try to find out which model describes diffusion of discount store better. In addition, we investigate the relationship between similarity of retail environment(conceptual distance) and spatial factor impact with correlation analysis. Result and Implication: We suggest spatial diffusion model to describe diffusion of discount stores. To examine the proposed spatial diffusion model, 347 domestic discount stores are used and we divide nation into 5 districts, Seoul-Gyeongin(SG), Busan-Gyeongnam(BG), Daegu-Gyeongbuk(DG), Gwan- gju-Jeonla(GJ), Daejeon-Chungcheong(DC), and the result is shown

    . In a result of the Bass model(I), the estimates of innovation coefficient(p) and imitation coefficient(q) are 0.017 and 0.323 respectively. While the estimate of market potential is 384. A result of the Bass model(II) for each district shows the estimates of innovation coefficient(p) in SG is 0.019 and the lowest among 5 areas. This is because SG is the diffusion center. The estimates of imitation coefficient(q) in BG is 0.353 and the highest. The imitation coefficient in the vicinity of the diffusing center such as BG is higher than that in the diffusing center because much information flows through various paths more as diffusion is progressing. A result of the Bass model(II) shows the estimates of innovation coefficient(p) in SG is 0.019 and the lowest among 5 areas. This is because SG is the diffusion center. The estimates of imitation coefficient(q) in BG is 0.353 and the highest. The imitation coefficient in the vicinity of the diffusing center such as BG is higher than that in the diffusing center because much information flows through various paths more as diffusion is progressing. In a result of spatial diffusion model(IV), we can notice the changes between coefficients of the bass model and those of the spatial diffusion model. Except for GJ, the estimates of innovation and imitation coefficients in Model IV are lower than those in Model II. The changes of innovation and imitation coefficients are reflected to spatial coefficient(${\gamma}$). From spatial coefficient(${\gamma}$) we can infer that when the diffusion in the vicinity of the diffusing center occurs, the diffusion is influenced by one in the diffusing center. The difference between the Bass model(II) and the spatial diffusion model(IV) is statistically significant with the ${\chi}^2$-distributed likelihood ratio statistic is 16.598(p=0.0023). Which implies that the spatial diffusion model is more effective than the Bass model to describe diffusion of discount stores. So the research question (1) is supported. In addition, we found that there are statistically significant relationship between similarity of retail environment and spatial effect by using correlation analysis. So the research question (2) is also supported.

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  • Construction of Correlation between Basic Soil Properties and Deformation Modulus of Trackbed Soils Based on Laboratory and Field Mechanical Tests (역학적 실내외 시험에 의한 철도궤도 상부노반용 흙재료의 기본물성과 변형계수 상관성 평가)

    • Park, Jae Beom;Choi, Chan Yong;Ji, Sang Hyun;Lim, Sang Jin;Lim, Yu Jin
      • Journal of the Korean Society for Railway
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      • v.19 no.2
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      • pp.204-212
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      • 2016
    • The soils used as trackbed in Korea are selected using USCS utilizing basic soil properties such as Grain Size Distribution(GSD), % passing of #200 sieve ($P_{200}$), % passing of #4 sieve ($P_4$), Coefficient of uniformity ($C_u$), and Coefficient of curvature ($C_c$). Degree of compaction of the soils adapted in the code by KR should be evaluated by maximum dry density (${\gamma}_{d-max}$) and deformation modulus $E_{v2}$. The most important influencing factor that is critical to stability and deformation of the compacted soils used as trackbed is stiffness. Thus, it is necessary to construct a correlation between the modulus and the basic soil properties of trackbed soil in order to redefine a new soil classification system adaptable only to railway construction. To construct the relationship, basic soil test data is collected as a database, including GSD, maximum dry unit weight (${\gamma}_{d-max}$), OMC, $P_{200}$, $P_4$, $C_u$, $C_c$, etc.; deformation modulus $E_{v2}$ and $E_{vd}$ are obtained independently by performing a Repeated Plated Bearing Test (RPBT) and Light Weight Deflectometer Test (LWDT) for ten different railway construction sites. A linear regression analysis is performed using SPSS to obtain the relationship between the basic soil properties and the deformation modulus $E_{v2}$ and $E_v$. Based on the constructed relationship and the various obtained mechanical test data, a new soil classification system will be proposed later as a guideline for the design and construction of trackbed foundation in Korea.

    An Analysis of Characteristic Parameters for the Design of Detention Pond in Urbanized Area (도시유역에서 저류지 설계를 위한 특성인자 분석)

    • Lee, Jae-Joon;Kim, Ho-Nyun;Kwak, Chang-Jae
      • Journal of the Korean Society of Hazard Mitigation
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      • v.6 no.4 s.23
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      • pp.37-47
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      • 2006
    • Urban development results in increased runoff volume and flowrates and shortening in time of concentration, which may cause frequent flooding downstream. Flow retardation structures to limit adverse downstream effects of urban storm runoff are used. There are various types of flow retardation measures include detention basins, retention basins, and infiltration basins. In basic planning phase, a number of planning models of detention ponds which decide storage volume by putting main variables were used to design detention ponds. The characteristics of hydrological parameters $\alpha,\;\gamma$ which are used in planning models of detention pond were analyzed. In this study, detention ponds data of Disaster Impact Assessment report at 22 sites were analyzed in order to investigate correlation between characteristic of urban drainage basin parameter and characteristics of detention pond parameter due to urbanization effects. The results showed that storage volume was influenced by peak discharge ratio $\alpha$ more than runoff coefficient ratio $\beta$ and peak discharge ratio $\alpha$ was influenced by runoff coefficient ratio $\beta$ less than regional parameter n. Storage ratio was mainly influenced by duration of design rainfall in the case of trapezoidal inflow hydrograph such as Donahue et al. method.


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