• Clinical and Experimental Vaccine Research
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• v.11 no.2
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• pp.173-183
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• 2022

The coronavirus disease 2019 pandemic has not ended, and several variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus continue to emerge. The emergence of new variants is worrying because higher transmission leads to spikes in infections, vaccine efforts, and other therapeutic developments. Existing literature reports that with new variants affecting vaccine efficacy, hospitalization and risk of a recurrent infection increase. In this review article, we describe the latest variants of SARS-CoV-2, and the impact of each new variant on the efficacy of the developed vaccines reported in the literature and findings. The report concludes that the emergence of a variant that completely evades the immune response and reduces neutralizing antibodies.

• IMMUNE NETWORK
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• v.20 no.5
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• pp.41.1-41.11
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• 2020

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is a positive-sense single-stranded RNA (+ssRNA) that causes coronavirus disease 2019 (COVID-19). The viral genome encodes twelve genes for viral replication and infection. The third open reading frame is the spike (S) gene that encodes for the spike glycoprotein interacting with specific cell surface receptor - angiotensin converting enzyme 2 (ACE2) - on the host cell membrane. Most recent studies identified a single point mutation in S gene. A single point mutation in S gene leading to an amino acid substitution at codon 614 from an aspartic acid 614 into glycine (D614G) resulted in greater infectivity compared to the wild type SARS-CoV2. We were interested in investigating the mutation region of S gene of SARS-CoV2 from Korean COVID-19 patients. New mutation sites were found in the critical receptor binding domain (RBD) of S gene, which is adjacent to the aforementioned D614G mutation residue. This specific sequence data demonstrated the active progression of SARS-CoV2 by mutations in the RBD of S gene. The sequence information of new mutations is critical to the development of recombinant SARS-CoV2 spike antigens, which may be required to improve and advance the strategy against a wide range of possible SARS-CoV2 mutations.

• Journal of Yeungnam Medical Science
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• v.38 no.4
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• pp.344-349
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• 2021

Background: Cancer patients have been disproportionally affected by the coronavirus disease 2019 (COVID-19) pandemic, with high rates of severe outcomes and mortality. Fever is the most common symptom in COVID-19 patients. During the COVID-19 pandemic, physicians may have difficulty in determining the cause of fever (COVID-19, another infection, or cancer fever) in cancer patients. Furthermore, there are no specific guidelines for managing cancer patients with fever during the COVID-19 pandemic. Thus, this study evaluated the clinical characteristics and outcomes of cancer patients with fever during the COVID-19 pandemic. Methods: This study retrospectively reviewed the medical records of 328 cancer patients with COVID-19 symptoms (fever) admitted to five hospitals in Daegu, Korea from January to October 2020. We obtained data on demographics, clinical manifestations, laboratory test results, chest computed tomography images, cancer history, cancer treatment, and outcomes of all enrolled patients from electronic medical records. Results: The most common COVID-19-like symptoms were fever (n=256, 78%). Among 256 patients with fever, only three (1.2%) were diagnosed with COVID-19. Most patients (253, 98.8%) with fever were not diagnosed with COVID-19. The most common solid malignancies were lung cancer (65, 19.8%) and hepatobiliary cancer (61, 18.6%). Twenty patients with fever experienced a delay in receiving cancer treatment. Eighteen patients discontinued active cancer treatment because of fever. Major events during the treatment delay period included death (2.7%), cancer progression (1.5%), and major organ dysfunction (2.7%). Conclusion: Considering that only 0.9% of patients tested for COVID-19 were positive, screening for COVID-19 in cancer patients with fever should be based on the physician's clinical decision, and patients might not be routinely tested.

• The Journal of the Korea Contents Association
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• v.22 no.9
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• pp.602-613
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• 2022

This study was performed to identify the factors affecting 'the organizational culture for infection control', 'the resource support', 'the knowledge about COVID-19', and 'the resilience' among hospital nurses on the performance of COVID-19 infection control. A total of 150 nurses, registered in Korea, participated in the current study. The data were collected through self-report questionnaires. From 27th July to 10th August, 2022, 147 questionnairesout of 150 were collected. In multiple regression analysis, 'the resource support', 'the knowledge about COVID-19' and 'the resilience' were analyzed as significant factors in performing of the infection control for COVID-19 (β = 0.68, p < .001, β = 0.12, p = .023 and β = 0.20, p = .005 respectively). For improving the nurses' performance of infection control against Coronavirus Disease 2019(COVID-19) during the pandemic, it is necessary to develop and evaluate the programs through the organizational support and strategies to improve individual knowledge.

• Journal of Advanced Technology Convergence
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• v.2 no.3
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• pp.25-32
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• 2023

This study was conducted to find out the relationship between knowledge and attitudes about COVID-19 and infection control performance among college students in paramedicine. The subjects of the study were 154 university students attending a 3-4 year paramedicine located in Gwangju Metropolitan City, Jeollabuk-do Province, and the collected data were frequency, percentage, sum, average and It was analyzed by standard deviation, t-test, ANOVA(Scheffe), Pearson's Correlation Coefficient, and Multiple Linear Regression. The order of attitude and knowledge about COVID-19 affected the infection control performance of college students in the paramedicine. Therefore, it is necessary to develop and apply regular or non-regular curriculum and multidisciplinary curriculum that can improve knowledge and attitudes about COVID-19 in order to improve the infection control performance of paramedic students.

• Korean journal of aerospace and environmental medicine
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• v.30 no.3
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• pp.95-99
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• 2020

Coronavirus disease 2019 (COVID-19) reduces airline passengers, which leads to a sharp decline in airline sales. They are concerned about the dismissal or unpaid leave of the flight pilot and crew, and the management of the passengers is also under great stress. Stress management methods for COVID-19 can be divided into general stress management such as 'Let's change me', 'Let's find the source of life', and 'Let's ask for help', and mental health management in a disaster situation.

• Korean Journal of Occupational Health Nursing
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• v.29 no.3
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• pp.202-207
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• 2020

Purpose: COVID-19 infections have been erupting in places of worship, long-term care facilities, and call centers in Korea since January 2020. This study aims to diagnose and present an infection control system solution for long-term care facilities where at-risk elderly individuals are actively engaged in communal life. Methods: We conducted comparative analyses of infection control systems between long-term care facilities and medical institutions respective of relevant laws and this study's evaluation system. Results: To prepare for future infectious diseases, it is necessary to establish a long-term care facility infection control system and strengthen the standards thereof, to strengthen long-term care facility evaluation standards and to newly establish medical charges for infection control. Conclusion: Systematic procedure fortification and financial support provisions are necessary for infection control at long-term care facilities.

• Asian Journal of Innovation and Policy
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• v.9 no.2
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• pp.164-186
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• 2020

It is generally known that a Science and Technology Park - as a representative example of an Innovation Cluster - produces network synergy among industry, university, research institutes, and other innovation actors in a specific area, so that it has a competitive edge over other regions in technological innovation. However, as the novel Coronavirus (COVID-19) pandemic unfolds, it has become necessary to reduce face-to-face contacts and this could lead to lesser network synergy being produced in an Innovation Cluster. With this background, this research was designed and conducted to evaluate how COVID-19 has changed the activities in Innovation Clusters and explore future development scenarios. In order to find out the changes occurring in an Innovation Cluster, a survey was conducted among the people in Science and Technology Parks. The survey result shows that people are experiencing difficulties in technological innovation and support activities, and face-to-face contacts have been reduced in the Innovation Cluster. A scenario planning sought to explore the future development of the Innovation Cluster. It suggests that the transformation into a Digital Innovation Cluster, which is less affected by physical distance, but can still maintain the effectiveness of the networks, can be the key strategy for the future Innovation Cluster.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.10
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• pp.19-28
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• 2021

The present study aims to evolve the value cycle of e-business through value co-creation during the Coronavirus pandemic. The population of the study is experts consisting of university professors in the fields of marketing management, e-commerce, and managers of organizations and companies in Iran. Using the snowball sampling method, 50 of them were selected as the sample. This study employs the factor analysis method and structural equation modeling (SEM) approach for identification of the factors. The findings of this study reveal that 10 factors affect the evolution of the value chain into the value cycle, including customer relationship management, e-literacy, value co-creation, e-readiness, and integrated value creation, the logic of service dominance, shared value creation, virtual culture, e-trust, and network economics. Despite the difficulties that COVID-19 has created for businesses worldwide, the evolution of the e-business value cycle through value co-creation in the Coronavirus pandemic can be considered as a positive aspect of the pandemic. In fact, with more pandemics and more customers turning to e-businesses due to the co-creation of customer value, e-businesses can cover their weaknesses and improve their strengths by engaging customers and receiving their feedback, thus transforming their value chain into the value cycle.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.2
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• pp.737-745
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• 2021

This study aims to determine whether there are differences in the average abnormal return, trading volume activity, and trading frequency activity in pharmaceutical stocks before and after the announcement of the first case of the coronavirus (COVID-19) in Indonesia. The sample was selected using a purposive sampling method and collected as many as nine pharmaceutical companies listed on the Indonesia Stock Exchange during 2019-2020. The data used in this study were secondary data in the form of daily data on stock closing prices, Composite Stock Price Index (IHSG), stock volume trading, number of shares outstanding, and stock trading frequency. This study was an event study with an observation period of 14 days, namely seven days before and seven days after the announcement of the coronavirus's first positive case in Indonesia. Hypothesis testing employed the paired sample t-test method. Based on the results, it was found that there was no difference in the average abnormal return of pharmaceutical stocks before and after the announcement of the first case of COVID-19. However, there was a difference in the average trading volume activity and the average trading frequency activity in pharmaceutical stocks before and after the announcement of the first case of COVID-19.