• The Korean Journal of Physiology and Pharmacology
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• v.26 no.1
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• pp.59-65
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• 2022

Phosphorylation levels of glycogen synthase kinase 3β (GSK3β) negatively correlated with psychomotor stimulant-induced locomotor activity. Locomotor sensitization induced by psychomotor stimulants was previously shown to selectively accompany the decrease of GSK3β phosphorylation in the nucleus accumbens (NAcc) core, suggesting that intact GSK3β activity in this region is necessary for psychomotor stimulants to produce locomotor sensitization. Similarly, GSK3β in the NAcc was also implicated in mediating the conditioned effects formed by the associations of psychomotor stimulants. However, it remains undetermined whether GSK3β plays a differential role in the two sub-regions (core and shell) of the NAcc in the expression of drug-conditioned behaviors. In the present study, we found that GSK3β phosphorylation was significantly lower in the NAcc shell obtained from rats expressing amphetamine (AMPH)-induced conditioned locomotor activity. Further, we demonstrated that these effects were normalized by treatment with lithium chloride, a GSK3β inhibitor. These results suggest that the behavior produced by AMPH itself and a conditioned behavior formed by associations with AMPH are differentially mediated by the two sub-regions of the NAcc.

• Proceedings of the Korean Society of Crop Science Conference
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• 2017.06a
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• pp.151-151
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• 2017

In Asia, rice production has some difficulties with reduction of farm household population and increase of elderly population. As a result, it has resulted in inefficiency and we needs to reduce labor force and improve labor productivity. Direct-seeding in rice could reduce labor and production costs, the area of direct seeding is increasing in japonica rice production in Asia. In direct seedling cultivation competition against weeds is one of most important concern. So, low temperature germinability and mesocotyl elongation should be considered. In this study, we evaluated the mesocotyl length and low temperature germination conducted association analysis using 137 korea core collections. An average length of mesocotyl among 137 core collections was skewed range from 0mm to 43mm. we searched candidate gene around target SNP. Such related traits, genome-wide association study (GWAS) analysis was carried out using GAPIT. Also, average mesocotyl length of 394 korea landrace cultivars was measured ranging from minimum 0 mm to maximum 34mm. 30 out of 394 Korea landrace cultivar conducted re-sequencing, and haplotype analysis of candidate gene. we searched these related resources, which including germination of low temperature and mesocotyl elongation. This could be used for the development of direct-seeding cultivars. The valiated accession of core collection and landrace cultivars will be used development of direct-seedling cultivar in the future.

• The Plant Pathology Journal
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• v.21 no.1
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• pp.21-26
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• 2005

Homeotic proteins have pivotal roles during the development of both plant and animals. Many homeotic proteins exert control over cell fate in cells where their genes are not expressed, i.e., in a non-cell autonomous manner. Cell-to-cell communication, which delivers critical information for position-dependent specification of cell fate, is an essential biological process in multicellular organisms. In plants, there are two pathways for intercellular communication that have been identified: the ligand/receptor-mediated apoplastic pathway and the plasmodesmata-mediated symplasmic pathway. Regulatory proteins and RNAs traffic symplasmically via plasmodesmata and play a critical role in intercellular communication. Thus, the non-cell autonomous function of homeotic proteins can be explained by the recent discovery of cell-to-cell trafficking of proteins or RNAs. This article specifically focuses on understanding the intercellular movement of homeodomain proteins, a family of homeotic proteins.

• The Korean Journal of Physiology and Pharmacology
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• v.28 no.2
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• pp.145-152
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• 2024

Chemotherapy-induced cognitive impairment is recognized as the most typical symptom in patients with cancer that occurs during and following the chemotherapy treatment. Recently many studies focused on pharmaceutical strategies to control the chemotherapy side effects, however it is far from satisfactory. There may be a need for more effective treatment options. The aim of this study was to investigate the protective effect of exercise on cisplatin-induced neurotoxicity. Eight-week-old C57BL6 mice were separated into three group: normal control (CON, n = 8); cisplatin injection control (Cis-CON, n = 8); cisplatin with aerobic exercise (Cis-EXE, n = 8). Cisplatin was administered intraperitoneally at a dose of 3.5 mg/kg/day. The Cis-EXE group exercise by treadmill running (14-16 m/min for 45 min daily, 3 times/week) for 12 weeks. Compared to the CON group, the cisplatin injection groups showed significant decrease in body weight and food intake, indicating successful induction of cisplatin toxicity. The Cis-CON group showed significantly increased levels of pro-inflammatory cytokines including IL-6, IL-1β, and TNF-α in the hippocampus, while the Cis-EXE group was significantly decreased in the expression of IL-6, IL-1β, and TNF-α. In addition, compared to the CON group, the levels of synapse-related proteins including synapsin-1 and -2 were significantly reduced in the Cis-CON group, and there was a significant difference between the Cis-CON and Cis-EXE groups. Antioxidant and apoptosis factors were significantly improved in the Cis-EXE group compared with the Cis-CON group. This study suggest that exercise could be meaningful approach to prevent or improve cisplatin-induced cognitive impairment.

• The Korean Journal of Ceramics
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• v.3 no.2
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• pp.124-128
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• 1997

An attempt was made to understand the dissolution and reprecipitation behavior of the constituent phases such as TiC, TiN, and Ti(CN) in TiC-TiN-Ni system. During the liquid-phase sintering the TiC phase was found to dissolve preferentially in Ni binder. The solid-solution phase, Ti(CN), formed around the TiN phase, resulting in a core/rim structure. This result was reproduced when large TiC particles were used with fine TiN particles. The path for the microstructural change in TiC-TiN-Ni system was largely controlled by the difference in the interfacial energy of each phase with the liquid binder phase. The results were discussed with thermodynamic principles.

• MALSORI
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• v.68
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• pp.75-93
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• 2008

An example-based dialogue system tries to utilize many pairs which are stored in a dialogue database. The most important part of the example-based dialogue system is to find the most similar utterance to user's input utterance. Modality, which is characterized as conveying the speaker's involvement in the propositional content of a given utterance, is one of the core sentence features. For example, the sentence "I want to go to school." has a modality of hope. In this paper, we have proposed a modality classification system which can predict sentence modality in order to improve the performance of example-based dialogue systems. We also define a modality tag set for a dialogue system, and validate this tag set using a rule-based modality classification system. Experimental results show that our modality tag set and modality classification system improve the performance of an example-based dialogue system.

• IE interfaces
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• v.14 no.3
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• pp.318-325
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• 2001

In this paper, we estimate the investment cost for the IMT-2000 services in Korea. The network elements for the IMT-2000 system are drawn out and the required number of base stations(Node-B) is predicted by using the coverage of the base station. With the assumption of the 2-generation mobile communications network configuration, the number of radio network controllers(RNC's) and core network facilities is estimated. We also setup different scenarios by considering the utilization of the transmission facilities between base stations, RNC's and switching systems, and then evaluate the investment cost for each scenario.

• The Journal of Sustainable Design and Educational Environment Research
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• v.12 no.1
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• pp.1-14
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• 2013

This study focuses on the criteria for lessons that develop secondary students' creativity and character in mathematics classes. Literature used in this study is related to the future direction of education (e.g., Core competencies, Information and Communication Technology, Constructivism education) and intent of the revised mathematics curriculum. Lesson criteria for developing students' creativity and character include educational content associated with the real-world contexts, use of tools and resources, active participation and interaction, problem-solving skills, teachers' attitudes, and the classroom environment. This study suggests ways to implement mathematics lessons that build students' creativity and character.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.10 no.5
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• pp.31-37
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• 2011

For the domestic glasses industry to procure competitiveness in the world CA(Cellulose Acetate) frame of spectacles market, CNC machining system for CA frame including high-value added CA cutting technologies should be developed with new materials for the rim based on Cellulose and sheet manufacturing base. The spindle system of glasses frame equipment that is the core to the quality of CA frame is the key technologies to realize high-speed, high-precision so its importance is remarkably emerging. In the study, at the structural design of the high spindle system of the private equipment for CA glasses frame embedded a motor of 40,000rpm, the stability of design was analyzed and investigated through selecting lubrication structure and thermal characteristics of the spindle system.

• Economic and Environmental Geology
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• v.27 no.5
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• pp.423-440
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• 1994

The Samhwa iron ore deposit, which is of typical magnetite skarn type, is located in the Samhwadong area of Donghae city, Kangwon-do, Korea. Skarn minerals are mainly composed of garnet, clinopyroxene, vesuvianite, wollastonite and small amounts of epidote and quartz. The garnets are isotropic $(Ad_{92.82{\sim}98.37})$ or anisotropic andradite $(Ad_{45.30{\sim}75.85})$ and grossular $(Gr_{86.26{\sim}24.47})$, the clinopyroxenes are ferrosalite and salite, Homogenization temperature of gas rich two phase inclusions in garnet are $368{\sim}593^{\circ}C$, and salnities of polyphase inclusions in garnet have 33.9~68.4 equ. NaCl wt. %. Garnet grain often shows composional variation from its core to rim. In other words, Fe and Al contents in garnet vary inversely, which suggest that the variation depends upon $f_{o2}$ during skarn formation.