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Safety Evaluation of Tobacco Substitute (Herbrette); Inhalation Toxicity, Mutagenicity and Immunotoxicity

  • Song, Kyung Seuk;Park, Kun Ho;Yoo, Gi Yong;Song, Sung-Ok;Kim, Hyun Woo;Kim, Jun Sung;Park, Jin Hong;Eu, Guk Joung;Hua, Jin;Cho, Hyun Sun;Hwang, Soon Kyung;Chang, Seung Hee;Tehrani, Arash Minai;Yu, KyeongNam;Chae, Chan Hee;Cho, Myung Haing
    • Toxicological Research
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    • v.20 no.4
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    • pp.365-374
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    • 2004
  • Inhalation toxicity, mutagenicity, and immunotoxicity tests were performed using a smoke generation system to investigate the safety of Herbrette, a tobacco substitute made with the leaves of Perilla frutescens. ICR mice were exposed to nicotine-free Herbrette smoke with concentrations of 0 (control), 4.08 $\pm$ 1.32 mg/$m^3$ (low dose), 7.72 $\pm$ 2.14 mg/$m^3$ (medium dose) and 12.83 $\pm$ 1.69 mg/$m^3$ (high dose) total particulate matters (TPM) for 4 weeks. When compared to the control group, the body weights, organ weights in the exposed groups did not show any significant differences. However, certain change of several serum chemical data and biochemical parameters were observed, however, the changes were within normal physiological ranges. Moreover, no changes in organ weight, and no gross/microscopic changes were observed between the exposed and control groups. Salmonella typhimurium reverse mutation, in vivo chromosomal aberration and micronucleus assays revealed that Herbrette did not induce mutagenicity. Upon evaluation of peripheral cellular immunity of mice through in vitro lymphocyte proliferation assay, no significant difference was observed in mean stimulation index between the exposed and control groups. Taken together, our results strongly suggest that Herbrette may not cause toxicity on mice under current condition.

The Influence of Surface Treatments on Shear Bond Strength between Zirconia Core and Heat Press Ceramic Interface (지르코니아 코어의 표면처리방법이 열 가압 세라믹과의 전단결합강도에 미치는 영향)

  • Park, Hang-Min;Chung, In-Sung
    • Journal of Technologic Dentistry
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    • v.31 no.2
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    • pp.23-30
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    • 2009
  • All-ceramic restorations have gained acceptance among clinicians and patients because of their superior esthetics. Most all-ceramic systems have a 2-layer structure, using a weak veneering ceramic over a strong supporting core. often, failure of all-ceramic restorations occurs when the veneering ceramic fractures, exposing the core material. The purpose of this study was to compare the shear bond strength of heat press ceramic system (Zirpress) to zirconia core with various surface treatments. 10 metal cores and 50 zirconia cores were fabricated and divided into six groups according to surface treatment such as Zirliner application, aluminium oxide blasting, and 9.5% HF etching. Sixty specimens were prepared using Zirpress, veneered 8mm height and 3mm in diameter, over the zirconia cores (n=10). The shear bond strength test was performed in a universal testing machine with a crosshead speed of 1/min. Ultimate shear bond strength data were analyzed with One-way ANOVA and the Scheffe's test (p=.05). Within the limits of this study, the following conclusions were drawn: The mean shear bond strengths (MPa) were: 12.93 for $110{\mu}m$ aluminium oxide blasting/Rexillium III/IPS e.Max Zirpress; 14.92 for $50{\mu}m$ aluminium oxide blasting ${\pm}9.5%$ HF etching/Zirconis core/IPS e.Max Zirpress; 16.37 for $110{\mu}$ aluminium oxide blasting + 9.5% HF etching/Zirconis core/IPS e.Max Zirpress; 12.89 for $200{\mu}$ aluminium oxide blasting + 9.5% HF etching/Zirconis core/IPS e.Max Zirpress; 19.30 for 9.5% HF etching/Zirconis core/IPS e.Max Zirpress; 19.55 for Zirliner/Zirconis core/IPS e.Max Zirpress. The mean shear bond strength for ZNTZH (Zirliner/Zirconis core) and ZNTEH (9.5% HF etching/Zirconis core) were significantly superior to MS110H ($110{\mu}$ aluminium oxide blasting/Rexillium III) and ZS200EH ($200{\mu}$ aluminium oxide blasting + 9.5% HF etching/Zirconis core) (p<0.05).

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8×8 HEVC Inverse Core Transform Architecture Using Multiplier Reuse (곱셈기를 재사용하는 8×8 HEVC 코어 역변환기 설계)

  • Lee, Jong-Bae;Lee, Seongsoo
    • Journal of IKEEE
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    • v.17 no.4
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    • pp.570-578
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    • 2013
  • This paper proposed an $8{\times}8$ HEVC inverse core transform architecture reusing multipliers. In HEVC core transform, processing of lower size block is identical with even part of upper size block. So an $8{\times}8$ core transform architecture can process both $8{\times}8$ and $4{\times}4$ core transforms. However, when $8{\times}8$ core transform architecture is exploited, frame processing time doubles in $4{\times}4$ core transform, since $8{\times}8$ and $4{\times}4$ core transforms concurrently process 8 and 4 pixels, respectively. In this paper, a novel inverse core transform architecture is proposed based on multiplier reuse. It runs as an $8{\times}8$ inverse core transformer or two $4{\times}4$ inverse core transformer. Its frame processing time is same in $8{\times}8$ and $4{\times}4$ core transforms, and reduces gate counts by 12%.

Angular Differences between the Lower Extremity and the Ground that Express Maximum Core Muscle Activation According to Core-strengthening Exercises

  • Son, Nam Jeong;Jun, Hyun Jeong;Yi, Kyung Ock
    • Korean Journal of Applied Biomechanics
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    • v.27 no.4
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    • pp.247-255
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    • 2017
  • Objective: The purpose of this study was to investigate the maximum core muscle activation angle according to core-strengthening exercises. Method: Twenty-six young female football players (age: $17.84{\pm}0.80years$, height: $163.08{\pm}5.25cm$, weight: $54.96{\pm}7.41kg$) registered in the Korea Football Association from D High School located in Seoul were the subjects of this research. An electromyogram (Noraxon, USA) was used for monitoring the maximum core muscle contraction activity. Results: The angle for the maximum core muscle strength per core exercise and muscle was the smallest for the upper rectus abdominis in the windshield wiper exercise. The angle of the vastus medialis was significantly the largest. The range of angles at which the maximum strength was observed for each core exercise were as follows: 1) abdominal flutter kicks ($11{\sim}40^{\circ}$), 2) leg raises ($21{\sim}34^{\circ}$), 3) scissors ($45{\sim}66^{\circ}$), 4) knee to elbow sit-ups ($42{\sim}64^{\circ}$), 5) reverse crunches ($9{\sim}40^{\circ}$), 6) butt-ups ($24{\sim}32^{\circ}$), 7) V sit-ups ($5{\sim}24^{\circ}$), 8) windshield wipers ($11{\sim}20^{\circ}$), 9) bird dog ($11{\sim}18^{\circ}$), and 10) raised leg plank ($38{\sim}50^{\circ}$). Conclusion: Four kinds of motion could be classified according to the range of angles at which the core muscles were maximally activated. The first group involves the range of motion that gives the maximum muscle strength when the lower extremity and ground angle was between $5^{\circ}$ and $24^{\circ}$, such as the V sit-ups, windshield wipers, and bird dog. The second group comprised the flutter kicks and reverse crunches at an angle between $9^{\circ}$ and $40^{\circ}$. The third group comprised the leg raise and butt-up exercises at an angle between $21^{\circ}$ and $34^{\circ}$. The fourth group included the scissors, knee to elbow sit-ups, and raised leg plank at an angle between $38^{\circ}$ and $66^{\circ}$. These results may be useful as basic data for core movement and core muscle training according to the purpose of exercise.

Analysis on the Performance and Temperature of the 3D Quad-core Processor according to Cache Organization (캐쉬 구성에 따른 3차원 쿼드코어 프로세서의 성능 및 온도 분석)

  • Son, Dong-Oh;Ahn, Jin-Woo;Choi, Hong-Jun;Kim, Jong-Myon;Kim, Cheol-Hong
    • Journal of the Korea Society of Computer and Information
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    • v.17 no.6
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    • pp.1-11
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    • 2012
  • As the process technology scales down, multi-core processors cause serious problems such as increased interconnection delay, high power consumption and thermal problems. To solve the problems in 2D multi-core processors, researchers have focused on the 3D multi-core processor architecture. Compared to the 2D multi-core processor, the 3D multi-core processor decreases interconnection delay by reducing wire length significantly, since each core on different layers is connected using vertical through-silicon via(TSV). However, the power density in the 3D multi-core processor is increased dramatically compared to that in the 2D multi-core processor, because multiple cores are stacked vertically. Unfortunately, increased power density causes thermal problems, resulting in high cooling cost, negative impact on the reliability. Therefore, temperature should be considered together with performance in designing 3D multi-core processors. In this work, we analyze the temperature of the cache in quad-core processors varying cache organization. Then, we propose the low-temperature cache organization to overcome the thermal problems. Our evaluation shows that peak temperature of the instruction cache is lower than threshold. The peak temperature of the data cache is higher than threshold when the cache is composed of many ways. According to the results, our proposed cache organization not only efficiently reduces the peak temperature but also reduces the performance degradation for 3D quad-core processors.

COMPARISON OF MECHANICAL PROPERTIES OF VARIOUS POST AND CORE MATERIALS

  • Ahn Seung-Geun;Sorensen John A.
    • The Journal of Korean Academy of Prosthodontics
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    • v.41 no.3
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    • pp.288-299
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    • 2003
  • Statement of problem: Many kinds of post and core systems are in the market, but there are no clear selection criteria for them. Purpose: The purpose of this study was to compare the flexural strength and modulus of elasticity of core materials, and measure the bending strength of post systems made of a variety of materials. Material and Methods: The flexural strength and elastic modulus of thirteen kinds core buildup materials were measured on beams of specimens of $2.0{\times}2.0{\times}24{\pm}0.1mm$. Ten specimens per group were fabricated and loaded on an lnstron testing machine at a crosshead speed of 0.25mm/min. A test span of 20 mm was used. The failure loads were recorded and flexural strength calculated with the measured dimensions. The elastic modulus was calculated from the slopes of the linear portions of the stress-stram graphs. Also nine kinds commercially available prefabricated posts made of various materials with similar nominal diameters, approximately 1.25mm, were loaded in a three-point bend test until plastic deformation or failure occurred. Ten posts per group were tested and the obtained data were anaylzed with analysis of variance and compared with the Tukey multiple comparison tests. Results: Clearfil Photo Core and Luxacore had flexural strengths approaching amalgam, but its modulus of elasticity was only about 15% of that of amalgam. The strengths of the glass ionomer and resin modified glass ionomer were very low. The heat pressed glass ceramic core had a high elastic modulus but a relatively low flexural strength approximating that of the lower strength composite resin core materials. The stainless steel, zirconia and carbon fiber post exhibited high bending strengths. The glass fiber posts displayed strengths that were approximately half of the higher strength posts. Conclusion: When moderate amounts of coronal tooth structure are to be replaced by a post and core on an anterior tooth, a prefabricated post and high strength, high elastic modulus core may be suitable. CLINICAL IMPLICATIONS In this study several newly introduced post and core systems demonstrated satisfactory physical properties. However when the higher stress situation exists with only a minimal ferrule extension remaining a cast post and core or zirconia post and pressed core are desirable.

UbiCore : An Effective XML-based RFID Middleware System (UbiCore : XML 기반 RFID 미들웨어 시스템)

  • Lee, Hun-Soon;Choi, Hyun-Hwa;Kim, Byoung-Seob;Lee, Myung-Cheol;Park, Jae-Hong;Lee, Mi-Young;Kim, Myung-Joon;Jin, Sung-Il
    • Journal of KIISE:Databases
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    • v.33 no.6
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    • pp.578-589
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    • 2006
  • Owing to the proliferation of Radio Frequency Identification (RFID) technologies which is being watched as a core technology of ubiquitous computing, applications which offer convenience to people using RFID technologies are more and more increased. To easily develop these applications, a middleware system which acts as a bridge between RFID hardware and application is essential. In this paper, we propose a novel XML-based RFID middleware system called UbiCore (Ubiquitous Core). UbiCore has following features: First, UbiCore employs its own query language called XQueryStream (XQuery for Stream Data) which is originated from XQuery. Second, UbiCore has the preprocessing phase called pre-filtering prior to query evaluation and reuses the intermediate result of previous evaluation to speed up the processing of RFID tag data stream. Third, UbiCore supports query on both continuously generated stream data and archived historical data. And last, UbiCore offers a distinct markup language called Context-driven Service Markup Language (CSML) to easily specify the linking information between context and service.

A Numerical Study of Sandwich Injection Mold Filling Process (샌드위치 사출성형의 충전 공정 해석에 대한 수치모사 연구)

  • 송효준;이승종
    • The Korean Journal of Rheology
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    • v.11 no.2
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    • pp.159-167
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    • 1999
  • Sandwich injection molding is one of the remarkable polymer processes recently developed from conventional injection molding. But it is almost impossible to do theoretical investigation that we've researched it through numerical simulation. In this paper, numerical simulation on the study of sandwich injection molding is based on Finite Element Method and FAN/Control Volume method. In addition to conventional filling parameter that can confirm skin polymer melt front, new filling parameters have been introduced to confirm core polymer melt front advancement. These filling parameters are defined in each layer which is divided to solve temperature field along the thickness direction. One can notice different filling patterns resulted from the variation of material properties such as viscosities and power-law indexes, and processing conditions such as switch-over times and wall temperatures. It gives us a better understanding of the sandwich injection molding process. And we can recognize that it's the core polymer spatial distribution after the completion of filling that is the most important key point to use this process for industrial molding process.

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