• Bulletin of the Korean Chemical Society
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• v.31 no.11
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• pp.3333-3340
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• 2010

A three dimensional pharmacophore model was generated for the molecules which are responsible for anti-inflammatory activities targeting Interleukin-2 inducible tyrosine kinase (Itk). 16 structurally diverse molecules were selected as training set to generate the hypotheses using Discovery Studio v2.1. The best hypothesis, Hypo1, comprises two hydrogen bond acceptor (HBA), one hydrophobic aromatic (HA), one ring aromatic (RA) and shows high cost difference (63.71), high correlation coefficient (0.97) as well as low RMS deviation (0.81). Hypo1 has been further validated toward a test set, decoy set and Fischer's randomization method. Furthermore, Hypo1 was used to screen NCI and Maybridge databases. Finally, 2 hit molecules were identified as potential leads against Itk, which may be useful for future drug development.

• Journal of Digital Convergence
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• v.14 no.11
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• pp.557-564
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• 2016

This paper was to explore the effect of maladaptive perfectionism and core self-evaluation on body dissatisfaction of female college student. This survey was conducted from March, 2016 to May, 2016 and 315 responses from the survey were used for the analysis. Maladaptive Perfectionism and core self-evaluation were set as independent variables, and body dissatisfaction was set as an dependent variable. The data was analyzed by descriptive statistics, t-test, ANOVA, Pearson correlation and Multiple Regression. As a result, core self-evaluation was the significant predictor to explain body dissatisfaction, but maladaptive perfectionism didn't have the effectiveness to the body dissatisfaction of female college student. In conclusion, to reduce body dissatisfaction, female university students' positive view regarding core self-evaluation should be increased.

• International journal of steel structures
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• v.18 no.5
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• pp.1541-1559
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• 2018

This paper addresses the dynamic loading characteristics of the shock tube onto sandwich steel beams as an efficient and accurate alternative to time consuming and complicated fluid structure interaction using finite element modeling. The corrugated sandwich steel beam consists of top and bottom flat substrates of steel 1018 and corrugated cores of steel 1008. The corrugated core layers are arranged with non-uniform thicknesses thus making sandwich beam graded. This sandwich beam is analogous to a steel beam with web and flanges. Substrates correspond to flanges and cores to web. The stress-strain relations of steel 1018 at high strain rates are measured using the split-Hopkinson pressure. Both carbon steels are assumed to follow bilinear strain hardening and strain rate-dependence. The present finite element modeling procedure with an improved dynamic impulse loading assumption is validated with a set of shock tube experiments, and it provides excellent correlation based on Russell error estimation with the test results. Four corrugated graded steel core arrangements are taken into account for core design parameters in order to maximize mitigation of blast load effects onto the structure. In addition, numerical study of four corrugated steel core placed in a reverse order is done using the validated finite element model. The dynamic behavior of the reversed steel core arrangement is compared with the normal core arrangement for deflections, contact force between support and specimen and plastic energy absorption.

• Nuclear Engineering and Technology
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• v.56 no.3
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• pp.922-932
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• 2024

This paper presents the design features and preliminary design analysis results of the Wielenga Innovation Static Salt Reactor (WISSR). The WISSR incorporates features that make it both flexible and inherently safe. It is based on innovative technology that controls a nuclear reactor by moving molten salt fuel into or out of the core. The reactor is a low-pressure, fast spectrum transuranic (TRU) burner reactor. Inherent shutdown is achieved by a large negative reactivity feedback of the liquid fuel and by the expansion of fuel out of the core. The core is made of concentric, thin annular fuel chambers containing molten fuel salt. A molten salt coolant passes between the concentric fuel chambers to cool the core. The core has both fixed and variable volume fuel chambers. Pressure, applied by helium gas to fuel reservoirs below the core, pushes fuel out of a reservoir and up into a set of variable volume chambers. A control system monitors the density and temperature of the fuel throughout the core. Using NaCl-(TRU,U)Cl₃ fuel and NaCl-KCl-MgCl₂ coolant, a road-transportable compact WISSR core design was developed at a power level of 1250 MWt. Preliminary neutronics and thermal-hydraulics analyses demonstrate the technical feasibility of WISSR.

• Journal of KIISE:Software and Applications
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• v.31 no.8
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• pp.1010-1026
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• 2004

The goal of product line engineering is to support the systematic development of a set of similar software systems by understanding and controlling their common and distinguishing characteristics. The product line engineering is a process that develops reusable core assets and develops a set of software-intensive systems from a common set of core assets in a prescribed way. Currently, many software development technologies are accomplished in context of product line. However, much of the product line engineering research have focused on the reuse of work products relating to the software's architecture, detail design, and code. The product lines fulfill the promise of tailor-made systems built specifically for the needs of particular customers or customer groups. In particular, commonality and variability play central roles in the all product line development processes. These must be treated already during the requirement analysis phase. Requirements in product line engineering are basis of software development just like as traditional system development engineering, and basis of deciding other core assets' property - commonalities and variabilities. However, it is difficult to elicit, analyze and manage correct requirements. Therefore, it is necessary to develop systematic methods which can develop and manage requirement as core asset, which can be stable in anticipative change and can be well adapted to unpredictable change. In this paper, we suggest a method of managing requirements as core asset in product line. Through this method, the reuse of domain requirements can be enhanced. As a result, the cost and time of software development can be reduced and the productivity can be increased.

• Bulletin of the Korean Chemical Society
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• v.31 no.1
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• pp.52-58
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• 2010

Human histamine H1 receptor (HHR1) is a G protein-coupled receptor and a primary target for antiallergic therapy. Here, the ligand-based three-dimensional pharmacophore models were built from a set of known HHR1 inverse agonists using HypoGen module of CATALYST software. All ten generated pharmacophore models consist of five essential features: hydrogen bond acceptor, ring aromatic, positive ionizable and two hydrophobic functions. Best model had a correlation coefficient of 0.854 for training set compounds and it was validated with an external test set with a high correlation value of 0.925. Using this model Maybridge database containing 60,000 compounds was screened for potential leads. A rigorous screening for drug-like compounds unveiled RH01692 and SPB00834, two novel molecules for HHR1 with good CATALYST fit and estimated activity values. The new lead molecules were docked into the active site of constructed HHR1 homology model based on recently crystallized squid rhodopsin as template. Both the hit compounds were found to have critical interactions with Glu177, Phe432 and other important amino acids. The interpretations of this study may effectively be deployed in designing of novel HHR1 inverse agonists.

• Proceedings of the Korean Nuclear Society Conference
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• 1996.05b
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• pp.271-276
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• 1996

Coolant flow distribution to the assemblies and core coolant/component temperatures should be determined in LMR core steady state thermal-hydraulic performance analysis. Sodium flow is distributed to core assemblies with the overall goal of equalizing the peak cladding midwall temperatures for the peak temperature pin of each pin bundle, thus pin cladding damage accrual and pin reliability. The flow orificing analysis for conceptual design will be performed with Excel spreadsheet program ORFCE which was set up and tested, using the calibration factors based on available analyses data. For the verification of this program, flow orificing calculation for the MDP 840MWth core was performed. The calculational results are satisfactory compared to those of CRIEPI calculation.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2001.10a
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• pp.154-157
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• 2001

In this paper, we propose a new CBT(core-based tree)multicast routing Mechanism by load balancing mechanism. CBT may result in traffice concentration and bottlenecks near the lore routers since traffice from all sources nodes the same set of links as approaches the core. So the router have to load packet to new core router for such congestion. Congestion information is given by rtt(round trip time) between designed core router and the other router.

• Korean Journal of Agricultural Science
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• v.37 no.1
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• pp.13-18
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• 2010

In order to prepare the technical fundamental in production of premium quality fruits of 'Niitaka' pears, we compared the quality parameters and storability of the fruits that had various fruit set position in a cluster. The fruits set on $4^{th}$ from basal part in fruit cluster had the largest fruit size. The weight of fruits set on the higher position than $4^{th}$ from basal part in fruit cluster showed decreasing tendency. The production rates of marketable fruits which had 500g to 899g in weight were the high in $3-5^{th}$ from basal part in cluster than those in other position. The differences of fruit height and diameter which represent balanced fruit shape also showed less difference in the fruits set on $4-5^{th}$ from basal part in cluster than the fruits set closely on basal part in cluster. The fruits set on $3-4^{th}$ from basal part in cluster showed lower rate in incidence of core breakdown and pithiness disorder during 4 months of cold storage than those on the closer position to basal part in cluster.

• The Journal of Economics, Marketing and Management
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• v.11 no.4
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• pp.31-39
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• 2023

Purpose: This study attempted to systematize a support system that can enhance teaching core competencies by establishing a scale for diagnosing teaching core competencies at University A. Research design, data and methodology : To this end, the first Delphi was conducted With six experts related to university core competency modeling research by extracting factors and designing structured questionnaires through a literature review process that collects and analyzes prior research related to domestic and foreign university teaching competency. The derived questions were diagnosed on 27 professors, and independent sample t-verification and ANOVA were conducted using SPSS 24.0 for analysis by key teaching competency factors. Result: What is the standard suitability of KMO. It was shown as 929 (KMO standard conformity value is close to 1), and Barlett's sphericity verification showed χ2=5773.295, df=1081, p<.It appeared as 001 and confirmed that it was suitable for conducting factor analysis. Conclusions: The core competencies of A University teachers were set based on the educational goals of A University, such as basic teaching competency, creative teaching competency, practical teaching competency, and communication teaching competency. This means that the concept and factors of the core competency of professors are likely to change, and in the end, continuous efforts to upgrade and apply research on core competency of professors are essential to quickly and organically respond to changes in competency required to increase the competitiveness of universities.