• Journal of the Society of Cosmetic Scientists of Korea
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• v.48 no.3
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• pp.197-212
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• 2022

This study was conducted to empirically analyze the effects and interactions among beneficial bacteria, commensal bacteria, and acne bacteria, which are factors in the skin microbiomes, on detrimental bacteria by 289 people, who are 20 to 49 years old among Koreans. As a result of multiple regression models using bio big data of skin microbiomes, when the difference in skin microbiomes according to the sex and age of the subjects was controlled, the beneficial bacteria showed a negative (-) effect on the detrimental bacteria, while the commensal and acne bacteria showed a positive (+) effect. Particularly, the negative (-) effect of beneficial bacteria on detrimental bacteria was different through interaction with acne bacteria according to the level of commensal bacteria. These results demonstrate that the activation of beneficial bacteria inhibits detrimental bacteria, and the effect of skin microbiomes on detrimental bacteria is balanced with skin microbiomes through interaction with independent influence. Therefore, it is suggested that when studying skin microbiomes products to help the proliferation of beneficial bacteria and to create a skin environment that inhibits detrimental bacteria in the personalized cosmetics manufacturing industry, it is necessary to consider the independent effects and interactions among skin microbiome factors together.

• The Journal of Engineering Geology
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• v.32 no.4
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• pp.467-482
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• 2022

The Yeonghae basin is located at the northeastern part of the Yangsan fault (YSF; a potentially active fault). The study of the architecture of the Yeonghae basin is important to understand the activity of the Yangsan fault system (YSFS) as well as the basin formation mechanism and the activity of the YSFS. For this study, Digital Elevation Model (DEM) was used to highlight the marginal faults, and structural fieldwork was performed to understand the geometry of the intra-basinal structures and the nature of the bounding faults. DEM analysis reveals that the eastern margin is bounded by the northern extension of the YSF whereas the western margin is bounded by two curvilinear sub-parallel faults; Baekseokri fault (BSF) and Gakri fault (GF). The field data indicate that the YSF is striking in the N-S direction, steeply dipping to the east, and experienced both sinistral and dextral strike-slip movements. Both the BSF and GF are characterized dominantly by an oblique right-lateral strike-slip movement. The stress indicators show that the maximum horizontal compressional stress was in NNE to NE and NNW-SSE, which is consistent with right-lateral and left-lateral movements of the YSFS, respectively. The plotted structural data show that the NE-SW is the predominant direction of the structural elements. This indicates that the basin and marginal faults are mainly controlled by the right-lateral strike-slip movements of the YSFS. Based on the structural architecture of the Yeonghae basin, the study area represents a contractional zone rather than an extensional zone in the present time. We proposed two models to explain the opening and developing mechanism of the Yeonghae basin. The first model is that the basin developed as an extensional pull-apart basin during the left-lateral movement of the YSF, which has been reactivated by tectonic inversion. In the second model, the basin was developed as an extensional zone at a dilational quadrant of an old tip zone of the northern segment of the YSF during the right-lateral movement stage. Later on, the basin has undergone a shortening stage due to the closing of the East Sea. The second model is supported by the major trend of the collected structural data, indicating predominant right-lateral movement. This study enables us to classify the Yeonghae basin as an inverted strike-slip basin. Moreover, two opposite strike-slip movement senses along the eastern marginal fault indicate multiple deformation stages along the Yangsan fault system developed along the eastern margin of the Korean peninsula.

• BMB Reports
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• v.56 no.3
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• pp.196-201
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• 2023

Renal fibrosis is the final manifestation of chronic kidney disease (CKD) regardless of etiology. Hypoxia-inducible factor-2 alpha (HIF-2α) is an important regulator of chronic hypoxia, and the late-stage renal tubular HIF-2α activation exerts protective effects against renal fibrosis. However, its specific role in progressive renal fibrosis remains unclear. Here, we investigated the effects of the long-term tubular activation of HIF-2α on renal function and fibrosis, using in vivo and in vitro models of renal fibrosis. Progressive renal fibrosis was induced in renal tubular epithelial cells (TECs) of tetracycline-controlled HIF-2α transgenic (Tg) mice and wild-type (WT) controls through a 6-week adenine diet. Tg mice were maintained on doxycycline (DOX) for the diet period to induce Tg HIF-2α expression. Primary TECs isolated from Tg mice were treated with DOX (5 ㎍/ml), transforming growth factor-β1 (TGF-β1) (10 ng/ml), and a combination of both for 24, 48, and 72 hr. Blood was collected to analyze creatinine (Cr) and blood urea nitrogen (BUN) levels. Pathological changes in the kidney tissues were observed using hematoxylin and eosin, Masson's trichrome, and Sirius Red staining. Meanwhile, the expression of fibronectin, E-cadherin and α-smooth muscle actin (α-SMA) and the phosphorylation of p38 mitogen-activated protein kinase (MAPK) was observed using western blotting. Our data showed that serum Cr and BUN levels were significantly lower in Tg mice than in WT mice following the adenine diet. Moreover, the protein levels of fibronectin and E-cadherin and the phosphorylation of p38 MAPK were markedly reduced in the kidneys of adenine-fed Tg mice. These results were accompanied by attenuated fibrosis in Tg mice following adenine administration. Consistent with these findings, HIF-2α overexpression significantly decreased the expression of fibronectin in TECs, whereas an increase in α-SMA protein levels was observed after TGF-β1 stimulation for 72 hr. Taken together, these results indicate that long-term HIF-2α activation in CKD may inhibit the progression of renal fibrosis and improve renal function, suggesting that long-term renal HIF-2α activation may be used as a novel therapeutic strategy for the treatment of CKD.

• 한국체육학회지인문사회과학편
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• v.51 no.2
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• pp.305-314
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• 2012

This study estimated the causal relationship among leisure identity salience (LIS), leisure constraints negotiation (LCN), and intentions to participate in leisure activity (IPLA). For this, we estimated structural equation models controlled by leisure constraints, and we used data collected from 296 college students residing in Seoul and Kyoung-gi providence. The following was obtained. First, for both groups with high and low levels of leisure constraints, LIS positively caused LCN, and this became more evident for the group with high level of leisure constraint. Second, for the group with low level of leisure constraints, LIS positively and directly caused IPLA, whereas this causal relationship could not observed from the group with high level of leisure constraints. Nevertheless, it indirectly and positively caused IPLA though LCN for the same group. This implies that the mediative role of LCN became more important as the level of leisure constraints became more restrictive. Further, we separately showed that the role of LIS was important in the process of LCN.

• Korean Journal of Acupuncture
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• v.40 no.3
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• pp.79-89
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• 2023

Objectives : The purpose of this study is to investigate various application methods of focused ultrasound and apply them to clinical use in Korean medicine. Methods : Search was performed using the search engines of electronic databases, including PubMed, ScienceDirect, Cumulative Index to Nursing and Allied Health Literature (CINAHL), ScienceON, Oriental Medicine Advanced Searching Integrated System (OASIS), China National Knowledge Infrastructure (CNKI), Wanfang Data, Japan Science Technology Information Aggregator, Electronic (J-STAGE) and Citation Information by NII (CiNii), from inception to July 2023 without language limitation. Inclusion criteria were clinical studies including randomized controlled trials (RCTs), and animal experimental studies related with focused ultrasound treatments for acupoints or meridian sinews. Results : Total 17 papers, 7 for RCT, 6 for in vivo animal studies, and other experimental studies, were finally selected. Indications used in studies were shoulder pain, back pain, chronic back pain, and degenerative knee arthritis. In experimental studies, studies on animal models of hypoxic ischemic brain damage and hyperlipidemia were also conducted. As for the acupoints, LR3, LI4, and ST36 were used in clinical studies and, in animal experimental studies, GV20, KI1, and ST36 were used. As for the dose, 4 studies below 3 W/cm² and 3 studies in the range of 0.625 to 5 W/cm² in clinical studies, and all studies did not exceed 5 W/cm². In animal experimental studies, 0.5 W/cm², 2 W/cm², 7.5 WW/cm², 15 W/cm², 10~20 W/cm² were used. In all three studies describing the penetration depth during irradiation, it was less than 1 cm. Conclusions : We suggest that focused ultrasound is an appropriate treatment tool for stimulating the acupoints to transfer heat energy. Future studies with rigorous and well-designed RCTs for various diseases will be required to ascertain the focused ultrasound stimulate acupoints or meridian sinews.

• Journal of the Korean Geotechnical Society
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• v.23 no.4
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• pp.33-46
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• 2007

HWAW (Harmonic Wavelet Analysis of Wave) method, which is non-destructive method using body and surface waves, has the advantages of obtaining 2D subsurface imaging because it uses a short receiver spacing to obtain the $V_s$ profile of whole depth. Even though the reliability of HWAW method has already been verified by using the numerical simulation in the various layered models, it is very difficult to evaluate the reliability of HWAW in the field because the exact $V_s$ values of the experimental site are unknown. In this study, a model testing site where the material properties and layer information could be controlled was constructed to verify the reliability of HWAW method. The detailed geometry of the testing site was strictly measured by surveying, and 140 vertical and horizontal geophones were established at the boundary of each layer to evaluate the dynamic material properties. Using the interval travel times between the upper and lower geophones, the body wave velocities of each layer were 2 dimensionally obtained as reference data, and comparative study using HWAW method was performed. By comparing 2D Vs profile obtained by HWAW method to the reference data, the reliability of HWAW method was verified.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.2A
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• pp.259-267
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• 2008

The ultimate strengths of reinforced concrete deep beams are governed by the capacity of the shear resistance mechanism composed of concrete and shear reinforcing bars, and the structural behaviors of the beams are mainly controlled by the mechanical relationships according to the shear span-to-effective depth ratio, flexural reinforcement ratio, load and support conditions, and material properties. In this study, a simple indeterminate strut-tie model reflecting all characteristics of the ultimate strengths and complicated structural behaviors is presented for the design of simply supported reinforced concrete deep beams. In addition, a load distribution ratio, defined as a magnitude of load transferred by a vertical truss mechanism, is proposed to help structural designers perform the design of simply supported reinforced concrete deep beams by using the strut-tie model approaches of current design codes. In the determination of a load distribution ratio, a concept of balanced shear reinforcement ratio requiring a simultaneous failure of inclined concrete strut and vertical steel tie is introduced to ensure the ductile shear failure of reinforced concrete deep beams, and the prime design variables including the shear span-to-effective depth ratio, flexural reinforcement ratio, and compressive strength of concrete influencing the ultimate strength and behavior are reflected upon based on various and numerous numerical analysis results. In the companion paper, the validity of presented model and load distribution ratio was examined by employing them to the evaluation of the ultimate strengths of various simply supported reinforced concrete deep beams tested to failure.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.30 no.1B
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• pp.89-100
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• 2010

The performance evaluation of a conventional Wave Resonator at the entrance of harbors against solitary wave has been performed using 3D numerical wave flume. A wave resonator has been designed for the attenuation of the transmitted wave energy by trapping the short periodic incident waves only. In this study, however, the controlled performance of the wave resonator by its various widths has been numerically investigated for solitary waves. Source distribution method based on the Green function and the 3D one-field Model for immiscible TWO-Phase flows (TWOPM-3D) using 3D numerical wave flume were used for the short-periodic waves and the solitary waves, respectively, and these models were verified through the comparisons with the previous experimental and numerical results by other researchers. It was confirmed that the wave resonator is effective enough to control the solitary waves as well as the periodic waves when it compares with the case of no resonance system. Further, it was found that there is the optimal width of a wave resonator to attenuate the target solitary waves.

• Mood & Emotion
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• v.9 no.3
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• pp.189-193
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• 2011

Objectives : Pro-inflammatory cytokines are related to the pathophysiology of both cancer and depression, and their secretion is controlled by the transcriptional activity of particular gene polymorphisms. This study aimed to investigate whether interleukin (IL)-1β -511C/T gene polymorphism is associated with depression following mastectomy for breast cancer. Methods : A total of 309 patients with breast cancer were evaluated one week after mastectomy, and 244 (79%) were followed one year later. Depression (major+minor depressive disorders) was diagnosed according to DSM-IV criteria using the Mini International Neuropsychiatric Interview, and classified into prevalent, persistent, and incident depression. Associations of IL-1β -511C/T polymorphism with the three depressive status were estimated using logistic regression models. Results : At baseline, 74 (24%) patients were classified with prevalent depression ; and at follow up, 19 (8%) and 25 (10%) patients were classified with persistent and incident depression, respectively. The IL-1β -511T/T genotype was independently associated with prevalent and persistent depression, but not with incident depression. Conclusion : IL-1β -511T/T genotype may involve in the etiology of depression occurring in women with breast cancer who receive a mastectomy.

• Information Systems Review
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• v.23 no.4
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• pp.23-43
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• 2021

Due to the recent transition to a non-face-to-face society, many organizations are quickly adapting to foster a smart work environment. The introduction of smart work does not simply end with incorporating ICT systems or solutions into business models since fundamental factors such as forms of employment and work styles need to be in line with the progression of technological advances. However, previous studies regarding smart work focus on improvements in productivity and efficiency from a technology acceptance perspective. Therefore, there is a lack of discussion on innovation resistance from employees and management control when ICT systems are introduced into the workplace. This study empirically analyzes the moderating effects of the organizational control method for employees and innovation resistance within a smart work environment. Additionally, this study aims to identify the structural characteristics that employees resist from an innovation resistance perspective when organizational innovation occurs. The empirical analysis of this study suggests that when smart work such as ICT technology is introduced into the workplace the level of innovation resistance decreases when there is a high level of relative advantage and self-efficacy, whereas the level of innovation resistance increases when there is a high level of use complexity. Moreover, this study revealed that the level of innovation resistance increases when the employees' behaviors were controlled. The results of this study intend to contribute to improving business management by suggesting factors worth considering when incorporating smart work into work places through a thorough case analysis.