• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.11
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• pp.157-165
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• 2018

Companies conduct R&D for continuous development and enhancement of corporate value, and obtain patents as an intangible asset resulting from this process. This study screened 103 medical device firms whose R&D information, patent information, and management performance information were all published to determine how R&D activities and patents affect corporate operational performance. The number of patents, R&D costs, company type and Inno-Biz of the company were set as independent variables, and the companies' sales, intangible assets, operating profit ratios, net profit margins, corporate ratings and profit-related financial ratios were used as dependent variables. The results confirmed that R&D expenditure had negative (-) effects on most indicators, including sales volume, operating profit ratio, and net profit ratio, while it had positive (+) [ED highlight - these are unnecessary if negative and positive are also written out.] effects only on intangible assets. Additionally, domestic patents were found to have negative (-) effects on sales, cash flow ratings, and dropped capital return, and positive (+) effects on net profit growth. Moreover, the business performance variables affected by the company characteristics were sales volume and cash flow ratings. The medical device industry is dominated by small and medium-sized businesses Although research and development activities and patents have been shown to have a negative impact on corporate management in the short term, they are expected to have a positive long-term impact when reflecting the characteristics of the medical device industry that must undergo clinical trials and authorization procedures after R&D.

• Journal of Korea Water Resources Association
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• v.54 no.11
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• pp.955-968
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• 2021

A water resource plan is routinely based on a natural flow and can be estimated using observed streamflow data or a long-term continuous rainfall-runoff model. However, the watershed with the natural flow is very limited to the upstream area of the dam. In particular, for the ungauged watershed, a rainfall-runoff model is established for the gauged watershed, and the model is then applied to the ungauged watershed by transferring the associated parameters. In this study, the GR4J rainfall-runoff model is mainly used to regionalize the parameters that are estimated from the 14 dam watershed via an optimization process. In terms of optimizing the parameters, the Bayesian approach was applied to consider the uncertainty of parameters quantitatively, and a number of parameter samples obtained from the posterior distribution were used for the regionalization. Here, the relationship between the estimated parameters and the topographical factors was first identified, and the dependencies between them are effectively modeled by a Copula function approach to obtain the regionalized parameters. The predicted streamflow with the use of regionalized parameters showed a good agreement with that of the observed with a correlation of about 0.8. It was found that the proposed regionalized framework is able to effectively simulate streamflow for the ungauged watersheds by the use of the regionalized parameters, along with the associated uncertainty, informed by the basin characteristics.

• Journal of the Korean Association of Geographic Information Studies
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• v.24 no.1
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• pp.40-53
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• 2021

Research vessels(R/Vs) used for ocean research move to the planned research area and perform ocean observations suitable for the research purpose. The five research vessels of the Korea Institute of Ocean Science & Technology(KIOST) are equipped with global positioning system(GPS), water depth, weather, sea surface layer temperature and salinity measurement equipment that can be observed at all times during cruise. An information platform is required to systematically manage and utilize the data produced through such continuous observation equipment. Therefore, the data flow was defined through a series of business analysis ranging from the research vessel operation plan to observation during the operation of the research vessel, data collection, data processing, data storage, display and service. After creating a functional design for each stage of the business process, KIOST Underway Meteorological & Oceanographic Information System(KUMOS), a Web-Geographic information system (Web-GIS) based information platform, was built. Since the data produced during the cruise of the R/Vs have characteristics of temporal and spatial variability, a quality management system was developed that considered these variabilities. For the systematic management and service of data, the KUMOS integrated Database(DB) was established, and functions such as R/V tracking, data display, search and provision were implemented. The dataset provided by KUMOS consists of cruise report, raw data, Quality Control(QC) flagged data, filtered data, cruise track line data, and data report for each cruise of the R/V. The business processing procedure and system of KUMOS for each function developed through this study are expected to serve as a benchmark for domestic ocean-related institutions and universities that have research vessels capable of continuous observations during cruise.

• IMMUNE NETWORK
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• v.1 no.2
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• pp.104-108
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• 2001

Aging is a senescence and defined as a normal physiologic and structural alterations in almost all organ systems with age. As Leonard Hayflick, one of the first gerontologists to propose a theory of biologic aging, indicated that a theory of aging or longevity satisfies the changes of above conditions to be universal, progressive, intrinsic and deleterious. Although a number of theories have been proposed, it is now clear that cell aging (cell senescence) is multifactorial. No single mechanism can account for the many varied manifestations of biological aging. Many theories have been proposed in attempt to understand and explain the process of aging. Aging is effected in individual by genetic factors, diet, social conditions, and the occurrence of age-related diseases as diabetes, hypertension, and arthritis. It involves an endogenous molecular program of cellular senescence as well as continuous exposure throughout life to adverse exogenous influences, leading to progressive infringement on the cell's survivability so called wear and tear. So we could say the basic mechanism of aging depends on the irreversible and universal processes at cellular and molecular level. The immediate cause of these changes is probably an interference in the function of cell's macromolecules-DNA, RNA, and cell proteins-and in the flow of information between these macromolecules. The crucial questions, unanswered at present, concerns what causes these changes in truth. Common theories of aging are able to classify as followings for the easy comprehension. 1. Biological, 1) molecular theories - a. error theory, b. programmed aging theory, c. somatic mutation theory, d. transcription theory, e. run-out-of program theory, 2) cellular theories - a. wear and tear theory, b. cross-link theory, c. clinker theory, d. free radical theory, e. waste product theory, 3) system level theory-a. immunologic/autoimmune theory, 4) others - a. telomere theory, b. rate of living theory, c. stress theory, etc. Prevention of aging is theoretically depending on the cause or theory of aging. However no single theory is available and no definite method of delaying the aging process is possible by this moment. The most popular action is anti-oxidant therapy using vitamin E and C, melatonin and DHEA, etc. Another proposal for the reverse of life-span is TCP-17 and IL-16 administration from the mouse bone marrow B cell line study for the immunoglobulin VDJ rearrangement with RAG-1 and RAG-2. Recently conclusional suggestion for the extending of maximum life-span thought to be the calory restriction.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.7
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• pp.29-37
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• 2020

In the past, meta-heuristic optimization algorithms were developed to solve the problems caused by complex nonlinearities occurring in natural phenomena, and various studies have been conducted to examine the applicability of the developed algorithms. The self-adaptive vision correction algorithm (SAVCA) showed excellent performance in mathematics problems, but it did not apply to complex engineering problems. Therefore, it is necessary to review the application process of the SAVCA. The SAVCA, which was recently developed and showed excellent performance, was applied to the advanced Muskingum flood routing model (ANLMM-L) to examine the application and application process. First, initial solutions were generated by the SAVCA, and the fitness was then calculated by ANLMM-L. The new value selected by a local and global search was put into the SAVCA. A new solution was generated, and ANLMM-L was applied again to calculate the fitness. The final calculation was conducted by comparing and improving the results of the new solution and existing solutions. The sum of squares (SSQ) was used to calculate the error between the observed and calculated runoff, and the applied results were compared with the current models. SAVCA, which showed excellent performance in the Muskingum flood routing model, is expected to show excellent performance in a range of engineering problems.

• Korean Chemical Engineering Research
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• v.50 no.1
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• pp.149-154
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• 2012

The adsorption and desorption behavior of biofilter-medium was investigated on the performance of an adsorption column. Continuous flow-isothermal adsorption experiments were performed to treat waste air containing such a VOC as ethanol under the same condition of > 90% relative humidity as the condition of the feed to a biofilter process. In case of feeding waste air containing ethanol of 1,000 ppmv (or 2,050 mg ethanol/$m^3$) to the adsorption system at the rate of 2 L/min, the onsets of its breakthrough and reaching the state of dynamic equilibrium at the exit had been delayed 10 and 3 times, respectively, later than those at the 1st stage sampling port. Moreover, in case of 2,000 ppmv (or 4,100 mg ethanol/$m^3$), they had been delayed 9 and 3 times, respectively. Thus, regardless of feeding concentration, the ratios of delaying period were observed to be quite consistent each other at the exit of the adsorption column. With regard to the period of desorption, the ratios of delaying period were consistent each other to be 1.5 for both cases. In addition, the effect of microbial activity and sterilization-process was studied on adsorption equilibrium. The ethanol concentration in the vapor phase of vials packed with sterilized granular activated carbon (GAC) was quite consistent to that with unsterilized GAC. However, the ethanol concentrations in the vapor phase of vials packed with unsterilized compost and the unsterilized mixture of GAC and compost were higher than those with sterilized compost and the sterilized mixture of GAC and compost, respectively.

• Clean Technology
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• v.18 no.2
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• pp.191-199
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• 2012

In order to reduce or remove off-flavor and volatile organic compounds (VOCs) from Laminaria japonica effectively, continuous treatment process by supercritical carbon dioxide (SC-$CO_2$) was applied. After freeze-drying, Laminaria japonica powdered with $710{\mu}m$ was used. Experiments were carried out at temperature range from 35 to $55^{\circ}C$, and pressure range from 10 to 25 MPa for evaluation of SC-$CO_2$ treatment effect. Flow rate of carbon dioxide used in this reseach was constantly fixed at 26.81 g/min. Before and after treatment of SC-$CO_2$, off-flavor and VOCs from Laminaria japonica were analyzed by gas chromatography-mass spectrometry detector (GC-MSD). Total 47 VOCs emitted from Laminaria japonica were identified before treatment of SC-$CO_2$, major components of seaweed smell (ordor) in Laminaria japonica were identified as alcohols, aldehydes, ester and acids, ketone, halogenated compounds and hydrocarbon. Off-flavor and VOCs in all experimental conditions was reduced or removed after SC-$CO_2$ treatment. Among the experimental conditions, the highest removal yield was at 25 MPa and $55^{\circ}C$.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.36 no.3
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• pp.75-87
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• 2018

The purpose of this study is to investigate conservation and management methods of the Joseon Royal Tombs under the Eastern District Management Office. Through the literature survey, we understood the process of change of Joseon royal tombs, and through field surveys and interviews, we understood the status of the interior and the surrounding area. In this process, topography, land use and flow of human traffic, architecture and stone objects, water system, historical forests, and facilities were set as the main evaluation indicators. Urbanization has damaged the original terrains of Royal Tombs as national roads, buildings and facilities have constructed in the inner and outer area of Joseon Royal Tombs. Construction of underground passage, land purchase, relocation and demolition of the buildings are required for the conservation of the Royal Tombs area, and then it is necessary to recover the original terrain. In the case of land use and pathways, there are many disconnection of the original ritual circulation, they should be maintained to remind the sacred atmosphere of the royal tomb. And It is necessary to collect accurate information on the lost buildings and stoneworks through literature survey and excavation investigation, and that investigations should be lead to the exposure or restoration of the ruins. Historical forests require periodic and ongoing monitoring and management, and it is necessary to establish new entrance area and appropriate facilities following the long-Term conservation and management plan. These plans should be classified into short, medium and long-Term projects according to urgency and securing financial resources with a long perspective to implement continuous and systematic projects.

• Economic and Environmental Geology
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• v.40 no.4
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• pp.403-418
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• 2007

The objective of this research was to characterize the fate and transport of Cr(VI) contaminated groundwater in the Daejeon industrial area. Five subsidiary monitoring wells were newly installed and two existing wells were utilized for the investigation and the reduction process of Cr(VI) contaminated groundwater of the Daejeon(Mun-pyeong) national groundwater monitoring station. The Cr(VI) concentrations at the shallow aquifer well of the station were in the range of 3.2-4.5 mg/L indicating continuous contamination. However, Cr was not detected at the deep bedrock well and the other monitoring wells except MPH-1 and 3. The Cr(VI) concentrations of MPH-1 and MPH-3 were below the drinking water guideline value (0.05 mg/L). Therefore, the plume of the Cr(VI) contaminated groundwater was predicted to be confined within the narrow boundary around the station. The soluble/exchangeable Cr(VI) concentrations were below the detection limit in all core and slime samples taken from the five newly installed wells. Although the exact source of contamination was not directly detected in the study area, the spatial Cr(VI) distribution in groundwater and characteristics of the core samples indicated that the source and the dispersion range were confined within the 100 m area from the monitoring station. The contamination might be induced from the unlined landfill of industrial wastes which was observed during the installation of an subsidiary monitoring well. For the evaluation of the natural attenuation of Cr(VI), available reduction capacities of Cr(VI) with an initial concentration of 5 mg/L were measured in soil and aquifer materials. Dark-gray clay layer samples have high capacities of Cr(VI) reduction ranging from 58 to 64%, which is obviously related to organic carbon contents of the samples. The analysis of reduction capacities implied that the soil and aquifer materials controlled the dispersion of Cr(VI) contamination in this area. However, some possibilities of dispersion by the preferential flow cannot be excluded due to the limited numbers of monitoring wells. We suggest the removal of Cr(VI) contaminated groundwater by periodical pumping, and the continuous groundwater quality monitoring for evaluation of the Cr(VI) dispersion should be followed in the study area.

• Microbiology and Biotechnology Letters
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• v.37 no.4
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• pp.377-382
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• 2009

Viral safety is an important prerequisite for clinical preparations of all biopharmaceuticals derived from plasma, cell lines, or tissues of human or animal origin. To ensure the safety, implementation of multiple viral clearance (inactivation and/or removal) steps has been highly recommended for manufacturing of biopharmaceuticals. Of the possible viral clearance strategies, Ultraviolet-C (UVC) irradiation has been known as an effective viral inactivating method. However it has been dismissed by biopharmaceutical industry as a result of the potential for protein damage and the difficulty in delivering uniform doses. Recently a continuous flow UVC reactor (UVivatec) was developed to provide highly efficient mixing and maximize virus exposure to the UV light. In order to investigate the effectiveness of UVivatec to inactivate viruses without causing significant protein damage, the feasibility of the UVC irradiation process was studied with a commercial therapeutic protein. Recovery yield in the optimized condition of $3,000\;J/m^2$ irradiation was more than 98%. The efficacy and robustness of the UVC reactor was evaluated with regard to the inactivation of human immunodeficiency virus (HIV), hepatitis A virus (HAV), bovine herpes virus (BHV), bovine viral diarrhea virus (BVDV), porcine parvovirus (PPV), bovine parvovirus (BPV), minute virus of mice (MVM), reovirus type 3 (REO), and bovine parainfluenza virus type 3 (BPIV). Non enveloped viruses (HAV, PPV, BPV, MVM, and REO) were completely inactivated to undetectable levels by $3,000\;J/m^2$ irradiation. Enveloped viruses such as HIV, BVDV, and BPIV were completely inactivated to undetectable levels. However BHV was incompletely inactivated with slight residual infectivity remaining even after $3,000\;J/m^2$ irradiation. The log reduction factors achieved by UVC irradiation were ${\geq}3.89$ for HIV, ${\geq}5.27$ for HAV, 5.29 for BHV, ${\geq}5.96$ for BVDV, ${\geq}4.37$ for PPV, ${\geq}3.55$ for BPV, ${\geq}3.51$ for MVM, ${\geq}4.20$ for REO, and ${\geq}4.15$ for BPIV. These results indicate that UVC irradiation using UVivatec was very effective and robust in inactivating all the viruses tested.