• YAKHAK HOEJI
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• v.41 no.6
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• pp.789-796
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• 1997

The purpose of this study was to determine the effect of sulfinpyrazone on fumonisin $B_1$-induced elevation of free sphingoid bases in LLC-$PK_1$ cells. Fumonis ins are a family of mycotoxins produced by the fungi Fusarium moniliforme which is common contaminant in corn. Fumonisins are also potent inhibiors of sphingosine and sphinganine N-acyltransferases (ceramide synthases), key enzymes in sphingolipid metabolism resulting in the elevation of free sphinganine. The cytosolic concentration of fumonisin B1 was known to be closely proportional to the elevation of free sphinganine in LLC-PK1 cells [Yoo, H.-S., Norred, W.P., Wang, E., Merrill, A.H., Jr., and Riley, R.T. (1992) Toxicol. Appl.Pharmacol. 114. 9-15]. Sulfinpyrazone, an anion transport inhibitor, reduced the elevated level of free sphinganine resulting from fumonisin B1 inhibition of de novo sphingolipid biosynthesis. Fumonisin B1 at a concentration of 20${\mu}$M showed approximately 120pmol/$10^6$ cells relative to 3-10pmol/$10^6$ cells in control cultures, and sulfinpyrazone at a concentration of 200${\mu}$M partially reversed the increased level of free sphinganine induced by fumonisin $B_1$ down to normal level after exposure to fumonisin $B_1$ for 8 to 24hr. However, the reduced effect of sulfinpyrazone on the fumonisin $B_1$-induced elevation of intracellular sphinganine was not shown after 24hr. Fumonisin $B_1$ exposure to LLC-PK1 cells for 36 and 48hr showed approximately 74 and 80pmol per $10^6$ cells relative to 82 and 76pmol,respectively, in fumonisin $B_1$ plus sulfinpyrazone-treated cultures. Sulfinpyrazone-induced less elevation of free sphinganine in confluent cells after exposure to fumonisin $B_1$ suggested that either sulfinpyrazone may block the availability of fumonisin $B_1$ to cells or act on the fumonisin $B_1$ interaction with ceramide synthase.

• Journal of the Korean Society of Food Science and Nutrition
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• v.33 no.5
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• pp.917-920
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• 2004

The migration potential of volatile organic solvents widely employed in the printing process of food packaging was investigated by using a closed experimental system, which contained a food sample and a paper sheet spiked with the contaminant solvents. The studied organic compounds included toluene and p,m,o-xylene which are relatively highly volatile. Typical food samples of caramel, beef jerky and butter were selected based on their chemical composition and were assigned to the migration system at 10, 25 and 4$0^{\circ}C$. The equilibrated migration level was very high with almost complete transfer in the butter with high fat, while caramel of high carbohydrate content and beef jerky of high protein showed migration degree of 37∼56% and 37∼77%, respectively. Temperature did significantly influence the migration on beef jerky with higher level at higher temperature. There was no difference in the migration level among the solvents.

• Journal of Korean Society of Water and Wastewater
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• v.19 no.5
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• pp.572-581
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• 2005

This research is conducted to develop predictable method of real scale nanofiltration treatability with small scale nanofiltration experiments. As a result of comparing calculated values with measured values, they are in a good agreement for the concentrations in filtered water and concentrated water. The results of that are not affected by change of system recovery from 20% to 95%. The proposed method is produced using constant recovery of elements, that is, no considering the pressure change. we can predict filtrated flux and contaminant concentrations with the method. The method has the following steps. (1) Calculate recovery of each element with water quality level after fixing recovery elements, (2) Predict system recovery with recovery of elements in 1, 2, 3, and 4 banks, (3) Run small scale nanofiltration experiments in predicted water quality and (4) Simulate large scale nanofiltration system for forecasting actual water quality. As the cost for nanofiltration pretest will reduced if we use the proposed method, it will be a promising method for introducing nanofiltration to supply safe drinking water.

• Proceedings of the Korean Society of Toxicology Conference
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• 2001.05a
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• pp.114-114
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• 2001

Di-n-butyl phthalate (DBP) is not only a plasticizer and solvent used in industry but also one of endocrine disruptor chemicals, a low level contaminant found in a wide variety of different media ranging from drinking water to infant formulae. To evaluate the cytotoxic function of NK cells in mice after contact with DBP, C57BL/6 female mice were orally dosed with di-n-butyl phthalate (250, 500, or 750 mg/kg body weight) for 14 consecutive days, and the control mice were administered vehicle (corn oil).(omitted)

• Journal of Sensor Science and Technology
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• v.28 no.6
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• pp.377-384
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• 2019

People currently spend more than 80% of their time indoors; therefore, the management of indoor air quality has become an important issue. The contamination of indoor air can cause sick house syndrome and various environmental diseases such as atopy and nephropathy. Formaldehyde gas, which is the main contaminant of indoor air, is lethal even with microscopic exposure; however, it is commonly used as an adhesive and waterproofing agent for indoor building materials. Therefore, there is a need for a gas sensor capable of detecting trace amounts of formaldehyde gas. In this review, we summarize recent studies on metal oxide-based semiconductor gas sensors for formaldehyde gas detection, methods to improve the gas-sensing properties of metal oxides of various dimensions, and the effects of catalysts for the detection of parts-per-billion level gases. Through this, we discuss the necessary characteristics of the metal oxidebased semiconductors for gas sensors for the development of next-generation sensors.

• Nuclear Engineering and Technology
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• v.52 no.7
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• pp.1471-1480
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• 2020

This research presents a case study on the remediation of a radioactive waste (uranium: U) utilizing a multi-objective fuzzy optimization in an electrocoagulation process for the iron-stainless steel and aluminum-stainless steel anode/cathode systems. The incorporation of the cumulative uncertainty of result, operational cost and energy consumption are essential key elements in determining the feasibility of the developed model equations in satisfying specific maximum contaminant level (MCL) required by stringent environmental regulations worldwide. Pareto-optimal solutions showed that the iron system (0 ㎍/L U: 492 USD/g-U) outperformed the aluminum system (96 ㎍/L U: 747 USD/g-U) in terms of the retained uranium concentration and energy consumption. Thus, the iron system was further carried out in a multi-objective analysis due to its feasibility in satisfying various uranium standard regulatory limits. Based on the 30 ㎍/L MCL, the decision-making process via fuzzy logic showed an overall satisfaction of 6.1% at a treatment time and current density of 101.6 min and 59.9 mA/㎠, respectively. The fuzzy optimal solution reveals the following: uranium concentration - 5 ㎍/L, cumulative uncertainty - 25 ㎍/L, energy consumption - 461.7 kWh/g-U and operational cost based on electricity cost in the United States - 60.0 USD/g-U, South Korea - 55.4 USD/g-U and Finland - 78.5 USD/g-U.

• Journal of the Korean Society of Safety
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• v.27 no.3
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• pp.89-95
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• 2012

The concentrations of Volatile Organic Compounds(VOCs) and Formaldehyde(HCHO) for interior materials of new vehicles are estimated and recognized by using the simulation program known as IAQx. The concentrations of contaminants are estimated and evaluated by the ventilation rates of new domestic vehicles and the required ventilation rates for new vehicles are estimated through the given contaminant data. This study is conducted to compare the ventilation rates for the contaminants between the discontinuously ventilated new vehicles and the continuously ventilated new vehicles using the simulation program. The equation of ventilation rate of new vehicles is acquired to be able to lower initial concentrations below the standard level under different conditions for both business and personal commuting.

• The Korean Journal of Ecology
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• v.9 no.4
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• pp.193-200
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• 1986

In order to investigate the antiotoxic effect of red ginseng extract on serum protein of mouse treated with methyl mercury playing a role as toxic contaminant in ecosystem, variations of the serum protein contents, electrophoretic patterns, and blood components were studied. Mice were divided into 3 groups: Control, group I treated only with methyl mercury, and group II treated together with methyl mercury and red ginseng extract. The total serum protein content of the control group was 5.8g/dl and those of groups I and II were slightly decreased as compared with the control. The control group showed 11 serum protein fractions and groups I and II showed 10 fractions except prealbumin. The amounts of albumin, ${\alpha}_1-$, ${\alpha}_2-$ globulin fractions were decreased and those $\beta$-, $\gamma$-globulin fractions were increased in groups I and II. The amount of each serum protein fraction in group II showed approximately the same level as the control. The hematocrit value and the number of white blood cells of groups I and II were increased, whereas the number of red blood cells showed the decrease as compared with the control.

• Journal of Soil and Groundwater Environment
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• v.18 no.6
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• pp.18-31
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• 2013

This study was performed to examine use of the pump-and-treat method for remediation of TCE, CF and CT in groundwater contaminated by DNAPL. The Woosan industrial complex is located in Wonju, about 120 km east of Seoul, Korea. Two pumping wells (KDPW7 and KDPW8) and five monitoring wells (KDMW7, KDMW8, KDMW9, KDMW10, and SKW2) were installed for the test. An asphalt laboratory is a main source of the extensive subsurface contamination at this site. To evaluate change in the concentrations of TCE, CF, and CT in groundwater in the study area, three rounds of pump-and-treat pilot tests were performed (6 July to 6 August, 22 August to 6 September, and 19 September to 2 December in 2011). The groundwater levels and the concentrations of TCE, CF, and CT exhibited negative correlations in the wet season but positive correlations in the dry season, which suggests that the TCE concentrations were mainly controlled by dilution through rainfall during the wet season and by residual TCE, CF, and CT in the unsaturated zone during the dry season. These possibilities should be considered in the full-scale remediation plan.

• Journal of Soil and Groundwater Environment
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• v.17 no.1
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• pp.8-12
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• 2012

This study is maintains the condition of high temperature (above $600^{\circ}C$) within a short time using on microwave and high temperature heating elements. And removal characteristics according to changes in soil moisture, microwave power and temperature through the decomposition of the contaminated soil by oil. The difficulty resolvability material was sort of lubricating oil having long carbocyclic (C18-C50) and TPH removal rate reached 85.2% at 6 kW and $700^{\circ}C$ and thus the contaminant was removed 1,788 mg/kg within a process time of 40 minutes. In the case of light oil, gasoline contaminated soil, the removal amount showed 567 mg/kg and the treatment rate reached 98.4% at 6 kW, $500^{\circ}C$ and 20 minute. In the case of non-resolvability reached TPH concentrations on 2,000 mg/kg of worrisome level of soil contamination in the 3 zones at 6 kW, $700^{\circ}C$ and 30 minute. At the time, showed up processing costs 8,173 won per ton.