• Biomedical Science Letters
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• v.23 no.3
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• pp.272-276
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• 2017

HOX genes are transcription factors that play important roles in body patterning and cell fate specification during normal development. In previous study, we found aberrant overexpression of HOXB5 in breast cancer tissues and cell lines, and demonstrated that HOXB5 is important in regulation of cell proliferation, tamoxifen resistance, and invasiveness through the epithelial-mesenchymal transition (EMT). Although the relationship between HOXB5 and phenotypic changes in MCF7 breast cancer cells has been studied, the molecular function of HOXB5 as a transcription factor remains unclear. IL-6 has been reported to be involved in not only inflammation but also cancer progression, which is characterized by the increase of growth speed and invasiveness of tumor cells. In this study, we selected Interleukin-6 (IL-6) as HOXB5 putative downstream target gene and discovered that HOXB5 transcriptionally up-regulated the expression of IL-6 in HOXB5 overexpressing MCF7 cells. The upstream region (~1.2 kb) of IL-6 promoter turned out to contain several putative HOX consensus binding sites. Chromatin immunoprecipitation assay confirmed that HOXB5 directly binds to the promoter region of IL-6 and positively regulated the expression of IL-6. These data all together, indicate that HOXB5 promotes IL-6 transcription by actively binding to the putative binding sites located in the upstream region of IL-6, which enable to increase its promoter activity in MCF7 breast cancer cells.

• Journal of Advanced Marine Engineering and Technology
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• v.40 no.5
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• pp.418-428
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• 2016

In this study, a Vessel Shore Report Management System (VSRMS) is developed for the International Maritime Organization (IMO), Maritime Service Portfolio (MSP) Number 8, which comprises vessel shore reporting. Several documents have to be completed before the arrival/departure of a vessel at a port, as each national port has its own reporting format and data. The present vessel reporting system is inefficient, time-consuming, and involves excessive paperwork, which results in duplications and errors. To solve this problem, in this study, the vessel reporting formats and data contents of various national ports are investigated, as at present, the reporting documents required by the current IMO standard includes insufficient information which is requested by national ports. Initially, the vessel reporting information of various national ports are collected and analyzed. Subsequently, a database structure for managing vessel reporting data for ports worldwide is devised. To make the transfer of data and the exchange of information of vessel reports much more reliable, efficient, and paper-free, VSRMS, which is a software application for the simplification and facilitation of vessel report formalities, is developed. This application is developed using the latest Microsoft C#.Net Programming Language in the Microsoft Visual Studio framework 4.5. It provides a user interface and a backend MySQL server used for database management. SAP Crystal Reports 2013 is used for designing and generating vessel reports in the original report formats. The VSRMS can facilitate vessel reporting and improve data accuracy through the reduction of input data, efficient data exchange, and reduction of the cost of communication. Adoption of the VSRMS will allow the vessel shore reporting system to be automated, resulting in enhanced work efficiency for shipping companies. Based on this information system and architecture, the consensus of various international organizations, such as the IMO, the International Association of Marine Aids to Navigation and Lighthouse Authorities (IALA), the Federation of National Associations of Ship Brokers and Agents (FONASBA), and the Baltic and International Maritime Council (BIMCO), is required so that vessel reporting is standardized internationally.

• Journal of Preventive Medicine and Public Health
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• v.41 no.4
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• pp.225-231
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• 2008

Objectives: Bioterrorism (BT) preparedness and response plans are particularly important among healthcare workers who will be among the first involved in the outbreak situations. This study was conducted to evaluate the current status of education for BT preparedness and response in health care-related colleges/junior colleges and to develop learning objectives for use in their regular curricula. Methods: We surveyed all medical colleges/schools, colleges/junior colleges that train nurses, emergency medical technicians or clinical pathologists, and 10% (randomly selected) of them that train general hygienists in Korea. The survey was conducted via mail from March to July of 2007. We surveyed 35 experts to determine if there was a consensus of learning objectives among healthcare workers. Results: Only 31.3% of medical colleges/schools and 13.3% of nursing colleges/junior colleges had education programs that included BT preparedness and responses in their curricula. The most common reason given for the lack of BT educational programs was 'There is not much need for education regarding BT preparedness and response in Korea'. None of the colleges/junior colleges that train clinical pathologists, or general hygienists had an education program for BT response. After evaluating the expert opinions, we developed individual learning objectives designed specifically for educational institutions. Conclusions: There were only a few colleges/junior colleges that enforce the requirement to provide education for BT preparedness and response in curricula. It is necessary to raise the perception of BT preparedness and response to induce the schools to provide such programs.

• Journal of the Korean Society for Library and Information Science
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• v.42 no.1
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• pp.335-358
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• 2008

According to Wayne A. Wiegand in the 1998, he research to The "Amherst Method": The Origins of the Dewey Decimal Classification Scheme. Although a debate about the origins of the Dewey Decimal Classification Scheme has been going on for generations, historical consensus remains elusive. This paper contributes information to the historiography on the origins of the scheme: 1) by grounding an account of Dewey's thinking as he was crafting the DDC on an analysis of a large body of sources than previous classification historians have consulted; and 2) by expanding and deepening historical understanding of the contextual forces influencing on the classification structure. Because the DDC idea as it first occurred to M. Dewey in Amherst in 1872-73 is an important in the history of library development in the world. He outlined the first draft of his decimal scheme and submitted it to the Amherst College Library Committee on 8 May 1873. This paper analysis to "Three Genetic Paper", that is 1) The Merits of the System, 2) Library Classification System, 3) Its Special Adaption to our Library.

• Journal of the Korean Society for Library and Information Science
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• v.50 no.3
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• pp.533-563
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• 2016

The aim of this study is to develop a plan for university library evaluation with factors and their systems, and an evaluation process, based on the Korean University Library Promotion Act. This study adopts a consensus based method including open-ended interviews with various stakeholders around university libraries, a questionnaire survey, a public hearing, and numerous discussions with the stakeholders. Balanced Scorecard is adopted as a basic framework for the development of evaluation system, provides a balanced perspective on the whole aspects in the university library management, including factors and performances in the management, The proposed plan in this study is expected to help to examine whether the resources are used for reaching the goals in the libraries, and to contribute the growth of the university libraries.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.9
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• pp.4289-4294
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• 2016

Background: Studies have shown that a return to spirituality is a major coping response in cancer patients so that therapists can adopt a holistic approach by addressing spirituality in their patient care. The present study was conducted to develop a guideline in the spiritual field for healthcare providers who serve cancer patients in Iran. Materials and Methods: Relevant statements were extracted from scientific documents that through study questions were reviewed and modified by a consensus panel. Results: The statements were arranged in six areas, including spiritual needs assessment, spiritual care candidates, the main components of spiritual care, spiritual care providers, the settings of spiritual care and the resources and facilities for spiritual care. Conclusions: In addition to the development and preparation of these guidelines, health policy-makers should also seek to motivate and train health service providers to offer these services and facilitate their provision and help with widespread implementation.

• Proceedings of the KSR Conference
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• 2007.11a
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• pp.1647-1656
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• 2007

With the growing international consensus regarding sustainable development of transportation, the plan of transportation infrastructure needs to meet various requirements toward enhancing environmental conditions. Accordingly, the upcoming long-term plan of high-speed rail network has to be reflecting the sustainability of transportation systems. In this paper, we propose methodologies based on multi-attribute utility theory for determining priorities of sustainable high-speed rail investment. The proposed methodologies identify indicators for sustainable transportation systems such as economic, environmental, social, and transportation-related ones and then, explain the way how to evaluate the overall sustainability by comparing the relative importance among indicators. This will help transportation agencies to prioritize high-speed rail investment toward sustainable transportation systems.

• Health Policy and Management
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• v.14 no.3
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• pp.97-121
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• 2004

Recently, human embryonic stem cell research raises exciting public expectation on medical possibilities as well as ethical debate. Embryo management has become an integral part of the management of infertility treatment, researches on embryo and human embryonic stem cells and so on. Britain has permitted the research on stem cells derived from human embryo which made the first nation to allow the cloning of human embryo for the stem cell research. However, new technologies such as the assisted reproductive technologies and human embryonic stem cell research continue to pose an increasing source of ethical dilemmas for physician, scientists, legislators, religious authorities and the general publics to deal with. None the less, the United Kingdom has adopted the most liberal policies regarding human embryo and human embryonic stem cell research. The implication of the British embryo management system are as follows: 1) the development of reproductive technologies and new stem cell research technologies continue to pose legal and ethical debates, since those involve several parties; 2) the UK has taken the legal and institutional approaches to cope with those serious issues; 3) the UK adopted most liberal policies regarding embryonic and human embryonic stem cell researches; 4) the British HFE Act is consistent with the existing Acts related to human embryo management and researches; 5) through amending the HFE Act to accomodate the changes of technologies, the UK try to minimize the legal and ethical burden on undertaking research regarding embryo. The debates about the researches on human embryo and human embryonic stem cells is likely to continue in the Korean society. Because of the controversy and competing ethical values, as well as the evolving technologies, so far no consensus exists in our society. It suggest that it is premature to bring closure by ruling out any particular approaches. Thus our society needs to make an efforts to find a basis which could resolve the societal controversies through enriching the societal conversation about the profound ethical issues regarding embryo management.

• Research in Community and Public Health Nursing
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• v.15 no.2
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• pp.187-196
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• 2004

Purpose: The purposes of this study are: to evaluate the effectiveness of organizations engaged in MCH programs; and to suggest the executive organizational system of maternal and child health (MCH) services linked to HP services at public health centers. Method: This study analyzes data on the present conditions and evaluates the organizational effectiveness of MCH workers at public health centers nationwide. The organizational effectiveness of MCH organization is assessed by MCH workers. Finally, this study seeks to obtain consensus among experts in the field of MCH. Result: The results are as follows. Of public health centers, 61.9% have a MCH organization for their MCH programs. For the other 38.2%, MCH services are undertaken by HP organization. Executive organizational systems for MCH services at leading MCH health centers are classified into three types: Type I (provides MCH and HP services through MCH organizations); Type II (provides MCH and HP Services through HP organizations) ; and Type III (provides MCH services through MCH organizations and HP services through HP organizations). The evaluation of the organizational effectiveness of MCH organizations shows that Type II is the most effective in terms of teamwork, autonomy, service quality and resource utilization. Conclusion: This study suggests that executive organizations for MCH and HP services for women and children should be established in accordance with lifetime health programs in order for public health centers to utilize the limited MCH and HP resources efficiently.

• Journal of Korean Public Health Nursing
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• v.17 no.1
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• pp.132-143
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• 2003

The purpose of this study was to verify the effects of psychodrama group counselling, and to determine its applicability as a nursing intervention for the promotion of mental health of clients in their developmental stages. Methodological triangulation was used for research design. For quantitative study, quasi experimental study design with nonequivalent control group was used to test the effects of psychodrama group counselling. For each experimental and control group convenient samples of 15 nursing students were selected, and observed from May to Nov. 2000. For experimental group, the treatment was given for 2 hours each week, totaling 20 hours. The questionnaire consisted of 24 items of physical symptoms from CMI. 40 items of Spielberger Anxiety Scale, and 21 items of Beck Depression Scale. Reflective journal was written by the experimental group. The data were analyzed using chi-square and Mann-Whitney U test. For the qualitative study, the contents of the reflective journal were analyzed into categories and classifications. The results of the study were as follows; 1. There was a significant difference on physical health status between the experimental and the control group 2. There was a significant difference between two groups on the mean scores of mental health before and after psychodrama group counselling. 3. The qualitative analysis of reflective journal resulted in 4 categories and 13 classifications, which was reflected by the experience of the psychodrama group counselling. The four categories were self introspection, psychological support, improvement of interpersonal relationship and self development. The thirteen classifications are self-discovery, discovering others, emotional catharsis, positive thinking, formation of consensus, comforting, being free, being comfortable, understanding, maturing personal relationship, acquiring self-confidence, new challenges, and planning for the future. Based on the study findings, the psychodrama group counselling had promoted not only physical but also mental health of nursing students. The characteristics identified by the study suggested the applicability of psychodrama group counselling as an effective measure of nursing intervention for clients.