• Journal of the Korean Magnetic Resonance Society
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• v.24 no.4
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• pp.117-122
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• 2020

Transcription factors are proteins that bind specific sites or elements in regulatory regions of DNA, known as promoters or enhancers, where they control the transcription or expression of target genes. MEIS1 protein is a DNA-binding domain present in human transcription factors and plays important roles in various biological functions. The hydrogen exchange rate constants of the imino protons were determined for the wild-type containing the consensus DNA-binding site for the MEIS1 and those of the mutant DNA duplexes using NMR spectroscopy. The G2A-, A3G- and C4T-mutant DNA duplexes lead to clear changes in thermal stabilities of these four consensus base pairs. These unique dynamic features of the four base pairs in the consensus 5'-TGAC-3' sequence might play crucial roles in the effective DNA binding of the MEIS1 protein.

• IMMUNE NETWORK
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• v.1 no.2
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• pp.109-115
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• 2001

Background: The role of the interferon consensus sequence binding protein (ICSBP), a member of interferon regulatory factor family, in protecting against a vesicular stomatitis virus (VSV) infection has not been firmly elucidated. Thus, it was investigated utilizing the human promyelocytic leukemia HL-60 cells which do not express ICSBP. Methods: HL-60 cells were stably transfected with plasmid containing cDNA for either ICSBP or DNA binding domain (DBD) and tested for their VSV-susceptibilities. The susceptibility of each transfectant group to a VSV infection was determined by a plaque assay at 1 h, 24 h, and 48 h post-infection in the presence (500 IU/ml) or absence of interferon ${\alpha}$ ($IFN{\alpha}$). Results: In the absence of $IFN{\alpha}$, the three groups showed similar sensitivities to a VSV infection. However, when pre-treated with IFN, the viral titers in both the ICSBP and control clones steadily decreased over 48 h of incubation, indicating the existence of $IFN{\alpha}$-mediated protection against VSV infection. The $IFN{\alpha}$-treated ICSBP clones appeared to be more resistant to infection compared with the control clones, although the difference was not great. On the contrary, the viral titers in the $IFN{\alpha}$-treated DBD clones increased at 24 h then decreased by 48 h. Conclusion: The expression of truncated ICSBP (DBD) does not appear to underlie the impaired protection against a VSV infection in the DBD clones, since even the control clones lacking ICSBP were protected from a VSV infection. This suggests that ICSBP does not play a critical role in the $IFN{\alpha}$- mediated anti-VSV response of HL-60 cells, although it appears to confer some resistance to a VSV infection.

• Journal of the Korean Chemical Society
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• v.43 no.1
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• pp.110-118
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• 1999

In this study, the instructional influences of the conceptual change model based on the cognitive conflict and the conceptual change model emphasizing the social consensus were investigated. The subjects were 109 7th-graders in a boys' middle school in Seoul, and were taught about the changes of states, density, and dissolution for 8 class periods. The hypotheses provided in the instructions were constructed from the results of a pilot test. Prior to the instructions, three tests regarding the perceptions of discussion, the attitudes toward science instructions, and the perceptions of participation were administered. Two types of the conceptual change instructions and the traditional instruction were used in the treatment groups and the control group, respectively. After the instructions, the students' achievement, the conceptions, the perceptions of discussion, the attitudes toward science instructions, and the perceptions of participation were investigated. ANCOVA results revealed that the scores of the treatment groups were significantly higher than those of the control group in the achievement test. Although the score of the treatment group using the conceptual change model emphasizing social consensus were higher than those of other groups in the conceptions test, the differences were not statistically significant. The perceptions of discussion were significantly more positive in the treatment group using the conceptual change model emphasizing social consensus than in the control group. However, there were no significant differences in the scores of the attitudes toward science class and the perceptions of participation among the three groups. Educational implications are discussed.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.20 no.2
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• pp.45-53
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• 2020

Blockchain can control transactions in a decentralized way and is already being considered for manufacturing, finance, banking, logistics, and medical industries due to its advantages such as transparency, security, and flexibility. And it is predicted to have a great economic effect. However, Blockchain has a Trilemma that is difficult to simultaneously improve scalability, decentralization and security characteristics. Among them, the biggest limitation of blockchain is scalability, which is very difficult to cope with the constantly increasing number of transactions and nodes. To make the blockchain scalable, higher performance should be achieved by modifying existing consensus methods or by improving the characteristics and network efficiency that affect many ways of scaling. Therefore, in this paper, we propose a cluster-based scalable PBFT consensus algorithm called CBS-PBFT which reduces the message complexity O(n²) of PBFT to O(n), which is a representative consensus algorithm of blockchain, and the validity is verified through simulation experiments.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2018.05a
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• pp.330-331
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• 2018

It's prohibited to take sand from southeastern EEZ(Exclusive Economic Zone) from January 2017 in korea. So, the supply of sea sand has been decreased and costs of sea sand are rising as a result in the southeast region. This paper deal with appropriateness of the taking sea sand, circumstance and fisheries damages by extraction of EEZ sand and proposed control measures for ensuring quality of sea sand and consider fishermen support plan for ensuring a stable supply of sand in southeast region of korea.

• Analyses & Alternatives
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• v.4 no.2
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• pp.5-38
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• 2020

This paper investigates how public opinion has affected the United States Senate's votes on arms control treaties. Applying multilevel modeling with post-stratification to national polls, this paper produces estimates of state-level opinion on both the New Strategic Arms Reduction Treaty of 2010 and the Comprehensive Test Ban Treaty of 1999. Using these estimate, this paper examines the relationship between public opinion and the Senate's votes on the treaties. This paper finds that the influence of public opinion was mostly significant but indirect. These findings indicate that some version of the delegate model of representation is more applicable to foreign policy making in Congress.

• Journal of Institute of Control, Robotics and Systems
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• v.19 no.5
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• pp.398-409
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• 2013

This paper provides an overview of distance-based formation control. Firstly, in this paper, we introduce preliminary background materials that are used in defining the distance-based formation control. Then, based on the preliminary background, we briefly review main results developed thus far in this field. Lastly, we provide some issues that need to be studied further in future works.

• Journal of Power Electronics
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• v.17 no.6
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• pp.1650-1657
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• 2017

In this study, the distributed secondary voltage control of islanded microgrids with multi-agent consensus algorithm is investigated. As an alternative to a time-triggered approach, an event-triggered scheme is proposed to reduce the communication load among inverter-based distributed generators (DGs). The proposed aperiodic control scheme reduced unnecessary utilization of limited network bandwidth without degrading control performance. By properly establishing a distributed triggering condition in DG local controller, each inverter is only required to send voltage information when its own event occurs. The compensation of voltage amplitude deviation can be realized, and redundant data exchange related to fixed high sampling rate can be avoided. Therefore, an efficient use of communication infrastructure can be realized, particularly when the system is operating in steady state. The effectiveness of the proposed scheme is verified by simulations on a microgrid test system.

• Journal of Internet Computing and Services
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• v.5 no.1
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• pp.51-57
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• 2004

Mobile Internet allows users to request critical information and receive swift responses at any places, but mobile users could suffer from unreliable and ill-timed services due to the characteristics of wireless media, One way that reduces possibility of the unsatisfactory services is data replication. Data Replica1ion, however, inevitably induces the overhead of maintaining replica consistency which requires more expensive synchronization mechanism. We propose a new replicated data management scheme in distributed mobile environment, In order to alleviate negative impact of synchronization message overhead in fault-prone mobile Internet environment, we devise a new replication control scheme called proxy quorum consensus (PQC), PQC minimizes the message overhead by coordinating quorum access activities by means of proxy mediated voting (PMV) which exploits reliable proxy hosts instead of unreliable mobile hosts in voting process, We also propose a simulation model to show the performance of PQC. Based on the results of the performance evaluation, we conclude that PQC scheme outperforms the traditional schemes.

• Journal of Korea Society of Industrial Information Systems
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• v.21 no.6
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• pp.81-93
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• 2016

An actual analysis was made regarding how different the effect of the online WOM information characteristics on the expansion of the WOM information characteristics was depending on the level of the receiver's expertise in consideration of the sender's expertise, the vividness and Consensus of WOM information which can affect the acceptance of WOM information in this study. To begin with, the analysis results showed that the online WOM information characteristics had the positive effect on the information acceptance intention in proportion to the sender's expertise and the vividness and Consensus of WOM information. Secondly, the information acceptance intention was found to have a positive effect on the re-WOM intention. Finally, the level of receiver's expertise was found to control the effect of the online WOM information characteristics on the information acceptance intention.