• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.29 no.2
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• pp.195-207
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• 2019

Objectives: This study was performed to confirm whether plasma lead can be used as a chronic biomarker for the biological monitoring of exposure to lead. Methods: Lead concentrations in 66 plasma samples from retired lead workers (G.M. 60.25 years, Median 61.00 years) and 42 plasma samples from the general population (G.M. 53.76 years, Median 56.50 years) were measured using ICP/Mass. Tibia, whole blood, hemoglobin, hematocrit, and blood zinc protophorphyrin (ZPP) concentrations and urinary ${\delta}$-aminolevulinic acid (${\delta}-ALA$) were measured for correlation analysis with plasma lead. Results: The geometric mean concentration of lead in plasma was $0.23{\mu}g/L$ for the retired lead workers and $0.10{\mu}g/L$ for the general population sample. A simple correlation analysis of biomarkers showed that plasma lead concentration among the retired lead workers was highly correlated with lead concentration in the tibia and with blood lead concentration, and the plasma lead concentration among the general population correlated with ZPP concentration in the blood. The lead concentration in the tibia and the lead concentration in the whole blood increased with length of working period. As the period in the lead workplace increased, the ratio of lead in plasma to lead concentration in whole blood decreased. Conclusion: This study confirmed the possibility of a chronic biomarker of lead concentration in blood plasma as a biomarker. In the future, comparative studies with specific indicators will lead to more fruitful results.

• Journal of Korean Society on Water Environment
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• v.21 no.4
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• pp.360-367
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• 2005

We have performed to analyze the trophic state resulting of Lake Yongdam as a result of water quality and nutrient concentration. Lake Yongdam is artifitial multi-purpose Dam resulting from the floods of 2001. The water quality of Lake Yongdam may affect the status of the Geum river basin including the Daecheong reservoir. It is necessary to understand the trophic state to assess water quality until stability after flooding. Water quality was surveyed using depth and hydraulic condition analysis. Further density flow was estimated for stratification and trophic state of Lake Yongdam by chlorophyll ${\alpha}$ concentration (2001~2004). And Environmental factors on chlorophyll ${\alpha}$ concentration were analyzed statistically. Trophic state was evaluated as the oligotrophic state at the main stream of the reservoir and eutrophic state at the upper stream in 2001, but evaluated as eutrophic state in 2002 and 2003 by TSI of Aizaki. From the results of multiple regression analysis using stepwise method, chlorophyll ${\alpha}$ concentration was shown to be very significant when nutrient concentration is high upon initial filling of the Dam. Chlorophyll ${\alpha}$ concentration varied according to sample site, season and year. Concentration were high in the upper stream of Lake Yongdam 4, algae bloom in these watershed were affected by location and high nutrient levels in the summer season which have in turn increased phytoplankton bloom into the reservoir.

• Journal of Environmental Science International
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• v.25 no.2
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• pp.217-229
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• 2016

The government has conducted a plan of total maximum daily loads(TMDL), which divides with unit watershed, for management of stable water quality target by setting the permitted total amount of the pollutant. In this study, BOD concentration trends over the last 10 years from 2005 to 2014 were analyzed in the Geumho river. Improvement effect of water quality throughout the implementation period of TMDL was evaluated using the seasonal Mann-Kendall test and a LOWESS(locally weighted scatter plot smoother) smooth. As a study result of the seasonal Mann-Kendall test and the LOWESS smooth, BOD concentration in the Geumho river appeared to have been reduced or held at a constant. As a result of quantitatively analysis for BOD concentration with exploratory data analysis(EDA), the mean and the median of BOD concentration appeared in the order of GH8 > GH7 > GH6 > GH5 > GH4 > GH3 > GH2 > GH1. The monthly average concentration of BOD appeared in the order of Apr > Mar > Feb >May > Jun > Jul > Jan > Aug > Sep > Dec > Nov > Oct. As a result of the outlier, its value was the most frequent in February, which is estimated 1.5 times more than July, and was smallest frequent in July. The outlier in terms of water quality management is necessary in order to establish a management plan for the contaminants in watershed.

• Journal of Pharmacopuncture
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• v.25 no.4
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• pp.390-395
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• 2022

Objectives: Sweet bee venom (sBV) is purified from Apis mellifera, containing a high level of melittin-its main component. It has been used as a therapeutic agent for pain relief and anti-inflammation, as well as for treating neuronal abnormalities. Recently, there have been studies on the therapeutic application of sBV for anticancer treatment. In the present study, we investigated the pharmacological effect of sBV treatment in A549 human lung cancer cells. Methods: We used microscopic analysis to observe the morphological changes in A549 cells after sBV treatment. The MTT assay was used to examine the cytotoxic effect after dose-dependent sBV treatment. Molecular changes in sBV were evaluated by the expression of apoptosis marker proteins using western blot analysis. Results: Microscopic analysis suggested that the growth inhibitory effect occurred in a dose-dependent manner; however, cell lysis occurred at a concentration over 20 ㎍/mL of sBV. The MTT assay indicated that sBV treatment exhibited a growth inhibitory effect at a concentration over 5 ㎍/mL. On fluorescence activated cell sorting analysis, G0 dead cells were observed after G1 arrest at treatment concentrations up to 10 ㎍/mL. However, rapid cell rupture was observed at a concentration of 20 ㎍/mL. Western blot analysis demonstrated that sBV treatment modulated the expression of multiple cell death-related proteins, including cleaved-PARP, cleaved-caspase 9, p53, Bcl2, and Bax. Conclusion: sBV induced cell death in A549 human lung cancer cells at a pharmacological concentration, albeit causing hemolytic cell death at a high concentration.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.11 no.1
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• pp.88-94
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• 2012

An axle drive shaft with double joint shaft, cross kit and yoke has an important role by transferring power and changing steering angle between axle and wheel in power train system. It has been used widely in the heavy machinery requiring a high reliability in the power train system. At fatigue failures of the axle drive shaft with the long span, a relatively high stress concentration at a snap ring groove on the drive shaft brings to significant fatigue damages under repeated loading condition. As Peterson's suggestions on this study, a relief groove in the vicinity of the snap ring groove is applied by decreasing the stress concentration and improving the fatigue life of axle drive shaft. By using FEM analysis, the decreasing effect of the stress concentration and extended fatigue life are due to the change of design parameters related with size and location of the relief groove. The relief groove with the design parameters such as d/b=2.0 and r/h=1.2 enables to decrease the stress concentration of 22.3% and increase the fatigue life more than 3 times by comparing with no relief groove application.

• The Journal of the Korea institute of electronic communication sciences
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• v.9 no.5
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• pp.589-594
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• 2014

It has been known that the particular brain waves are induced when a human concentrates. In our study, we aimed to analysis the brain waves related to human concentration using visual stimulus to induce the concentration. The visual stimulus tasks were presented to subjects for concentration. We measured EEG signals with several channels and analyzed the signals into several frequency bands. In the measured EEG signals, we analyzed to focus on theta waves, SMR waves and mid-beta waves. Therefore we presented the results to investigate characteristics of the EEG signals related to the human concentration.

• Journal of Korean Society of Water and Wastewater
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• v.33 no.5
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• pp.389-394
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• 2019

In order to determine the location of average concentration and distribution status of dissolved oxygen in the rectangular aeration tank of the sewage treatment plant was analyzed and the difference of dissolved oxygen concentration was remarkable at each location. Compared with the computational fluid dynamics analysis, it was found that the results were consistent with the measurement results by showing the difference of dissolved oxygen concentration between the locations. Based on the measured data, the representative location of dissolved oxygen in aeration tank was selected by using statistical analysis method and the representative location was expressed in three-dimensional coordinates(LWH : 25%, 50%, 33%) from flow direction and left wall. Also the difference between the dissolved oxygen concentration at the actual measurement location and the average concentration value of the entire aeration tank was founded, and the equations for calibrating the automatic measurement data considering the actual measurement location were calculated.

• Wind and Structures
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• v.27 no.6
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• pp.417-430
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• 2018

The concentration fields in the proximities of a local gas emission source are experimentally analyzed in several combinations of wind incidences and source emissions. These conditions are determined by the plume buoyancy, emission velocity and incident flow wind speed. Concentration measurements are performed by an aspirating probe in a boundary layer wind tunnel. The analysis included the mean concentration values and the intensity of concentration fluctuations in a neutral atmospheric boundary layer flow. Different configurations are tested: an isolated stack in a homogeneous terrain and a stack with a bluff body in close proximity, located windward and leeward from the emission source. The experimental mean concentration values are contrasted with Gaussian profiles and the dilution factor is analyzed with respect to the empirical curves of the minimum dilution. Finally, a study on the plume intermittency is performed in a cross-sectional plane near the emission source. It is possible to highlight the following observations: a) plume vertical asymmetry in the case of an isolated emission source, b) significant differences in the dispersion process related to the relative location of the emission source and bluff body effects, and c) different probabilistic behavior of the concentration fluctuation data in a cross-sectional measurement plane inside the plume.

• Journal of Environmental Science International
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• v.8 no.4
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• pp.465-471
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• 1999

The concentration of air pollution in a large city such as Pusan has been increased every years due to the increase on fuel consumption at factories and by vehicles as well as the gravitation of the population. In this study, we have analyzed $NO_2$ concentration data and various data of meteorological factors during 1994-1997 to investigate the characteristics of $NO_2$ concentration and how the high $NO_2$ concentration is generated under the meterological condition. According to the study, $NO_2$ peak concentration at most sites occured about 1h later after the rush hour. In the characteristics of emissions in sites, sinpyeong-dong was highly contributed to point source while the other sites were highly contributed to line source. The high $NO_2$ concentration had high generation probability when temperature contained typical seasonal characteristics and wind speed was low. Using the relationship between meteorological factors and the daily average $NO_2$ concentration, correlation analysis was practiced. the seasonal variation of the daily average $NO_2$ concentration was correlated with air temperature, solar radiation and wind speed, but the correlation coefficient between meteorological factors and the daily average $NO_2$ concentration was not so much high. Thus we have known that the daily average $NO_2$ concentration is partially explained by meteorological factors.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 2004.09a
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• pp.235-240
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• 2004

This study is to study accumulation of the heavy metals by riparian vegetation throughout analysis of the heavy metal concentration in riparian vegetation, water, and sediment near mine drainage. According to analyzing concentration of the heavy metals in riparian vegetation, water, and sediment, the heavy metal was indicated at the leaf significantly. Compared with the concentration of sediment soil, the maximum concentration of the As, Cd, CN, Pb, Zn was higher 2.6, 2.6, 2.5, non-detect, and 1.5 times in leaf, Also those concentration have 9.6, 16.6, 2.5, 1.6, and 2.5 times in root. As the results, the author can know the sediment has a very relative to vegetation in mine drainage, because the increasing of concentration of heavy metal in sediment gives the more accumulative concentration of heavy metal in vegetation. Compared with the concentration of contaminated site and non-contaminated site. As, Cd, CN, Pb, Zn the maximum concentration in sediment soil was higher 5.7, 258.1, 10.9, 370.0, and 298.3 times respectively. In case of vegetation, the maximum concentration of the As, Cd, CN, Pb, Zn was higher 5.6, 62.3, 5.0, non-detect, and 30.6 times in leaf. Also those concentration have 8.5, 63.3, 2.6, 60.7, and 62.1 times in root. In this study, the author can surmise that there indicated a lot of adsorption with the heavy metal concentration in contaminated mine drainage.