• 제목/요약/키워드: Complex Structure Model

검색결과 1,069건 처리시간 0.024초

CRYSTAL STRUCTURE OF tRNA ($m^1$ G37) METHYLTRANSFERASE

  • Ahn, Hyung-Jun;Lee, Byung-Ill;Yoon, Hye-Jin;Yang, Jin-Kuk;Suh, Se-Won
    • 한국결정학회:학술대회논문집
    • /
    • 한국결정학회 2003년도 춘계학술연구발표회
    • /
    • pp.17-17
    • /
    • 2003
  • tRNA (m¹ G37) methyltransferase (TrmD) catalyze s the trans for of a methyl group from S-adenosyl-L-methionine (AdoMet) to G/sup 37/ within a subset of bacterial tRNA species, which have a residue G at 36th position. The modified guanosine is adjacent to and 3' of the anticodon and is essential for the maintenance of the correct reading frame during translation. We have determined the first crystal structure of TrmD from Haemophilus influenzae, as a binary complex with either AdoMet or S-adenosyl-L-homocysteine (AdoHcy), as a ternary complex with AdoHcy/phosphate, and as an apo form. The structure indicates that TrmD functions as a dimer (Figure 1). It also suggests the binding mode of G/sup 36/G/sup 37/ in the active site of TrmD and catalytic mechanism. The N-terminal domain has a trefoil knot, in which AdoMet or AdoHcy is bound in a novel, bent conformation. The C-terminal domain shows a structural similarity to DNA binding domain of trp or tot repressor. We propose a plausible model for the TrmD₂-tRNA₂ complex, which provides insights into recognition of the general tRNA structure by TrmD (Figure 2).

  • PDF

3D 설계 프로세스 정립을 통한 복잡한 시스템 설계에서의 공용부품 사용 극대화 (Maximizing Use of Common Parts in Complex System Design through Organizing 3D Design Process)

  • 최영운;박강
    • 한국CDE학회논문집
    • /
    • 제12권3호
    • /
    • pp.209-219
    • /
    • 2007
  • Designing a complex system such as an LCD developing system becomes inefficient when many designers are involved and create their own parts even though they can be used repeatedly in other sections. Thus, this paper proposes a new design process that can maximize the number of common parts in complex system design by organizing the 3D design process. The proposed design process consists of 5 stages: analysis of design intention, definition of initial product structure, definition of skeleton model, sharing design intention with all assembles, control of correlation between components. The proposed design process can maximize common parts in design process, which results in shorter lead time, less production cost, and greater economic benefits.

Cytochrome c Peroxidase: A Model Heme Protein

  • Erman, James E.;Vitello, Lidia B.
    • BMB Reports
    • /
    • 제31권4호
    • /
    • pp.307-327
    • /
    • 1998
  • Cytochrome c peroxidase (CcP) is a yeast mitochondrial enzyme which catalyzes the reduction of hydrogen peroxide to water using two equivalents of ferrocytochrome c. The CcP/cytochrome c system has many features which make it a very useful model for detailed investigation of heme protein structure/function relationships including activation of hydrogen peroxide, protein-protein interactions, and long-range electron transfer. Both CcP and cytochrome c are single heme, single subunit proteins of modest size. High-resolution crystallographic structures of both proteins, of one-to-one complexes of the two proteins, and a number of active-site mutants are available. Site-directed mutagenesis studies indicate that the distal histidine in CcP is primarily responsible for rapid utilization of hydrogen peroxide implying significantly different properties of the distal histidine in the peroxidases compared to the globins. CcP and cytochrome c bind to form a dynamic one-to-one complex. The binding is largely electrostatic in nature with a small, unfavorable enthalpy of binding and a large positive entropy change upon complex formation. The cytochrome c-binding site on CcP has been mapped in solution by measuring the binding affinities between cytochrome c and a number of CcP surface mutations. The binding site for cytochrome c in solution is consistent with the crystallographic structure of the one-to-one complex. Evidence for the involvement of a second, low-affinity cytochrome c-binding site on CcP in long-range electron transfer between the two proteins is reviewed.

  • PDF

Experimental studies on possible vortex shedding in a suspension bridge - Part I - Structural dynamic characteristics and analysis model

  • Law, S.S.;Yang, Q.S.;Fang, Y.L.
    • Wind and Structures
    • /
    • 제10권6호
    • /
    • pp.543-554
    • /
    • 2007
  • The suspension bridge is situated in an area of complex topography with both open sea and overland turbulence characteristics, and it is subject to frequent typhoon occurrences. This paper investigates experimentally the possible vortex shedding events of the structure under high wind and typhoon conditions. A single-degree-of-freedom model for the vibration of a unit bridge deck section is adopted to determine the amplitude of vibration and to estimate the parameters related to the lifting force in a vortex shedding event. The results of the studies are presented in a companion paper (Law, et al. 2007). In this paper, statistical analysis on the measured responses of the bridge deck shows that the vibration response at the first torsional mode of the structure has a significant increase at and beyond the critical wind speed for vortex shedding as noted in the wind tunnel tests on a section model of the structure.

A MATHEMATICAL MODEL FOR HISTORY-BASED ACCESS CONTROL

  • Kim, Hee-Young
    • Journal of the Korean Society for Industrial and Applied Mathematics
    • /
    • 제8권1호
    • /
    • pp.11-30
    • /
    • 2004
  • Access Control is one of essential branches to provide system's security. Depending on what standards we apply, in general, there are Role-based access control, History-based access control. The first is based on subject's role, The later is based on subject's history. In fact, RBAC has been implemented, we are using it by purchasing some orders through the internet. But, HBAC is so complex that there will occur some errors on the system. This is more and more when HBAC is used with other access controls. So HBAC's formalization and model which are general enough to encompass a range of policies in using more than one access control model within a given system are important. To simplify these, we design the mathematical model called non-access structure. This Non-access structure contains to historical access list. If it is given subjects and objects, we look into subject grouping and object relation, and then we design Non-access structure. Then we can determine the permission based on history without conflict.

  • PDF

실시간 다중고장진단 제어기법에 관한 연구 (A Study on Real time Multiple Fault Diagnosis Control Methods)

  • 배용환;배태용;이석희
    • 한국정밀공학회:학술대회논문집
    • /
    • 한국정밀공학회 1995년도 춘계학술대회 논문집
    • /
    • pp.457-462
    • /
    • 1995
  • This paper describes diagnosis strategy of the Flexible Multiple Fault Diagnosis Module for forecasting faults in system and deciding current machine state form sensor information. Most studydeal with diagnosis control stategy about single fault in a system, this studies deal with multiple fault diagnosis. This strategy is consist of diagnosis control module such as backward tracking expert system shell, various neural network, numerical model to predict machine state and communication module for information exchange and cooperate between each model. This models are used to describe structure, function and behavior of subsystem, complex component and total system. Hierarchical structure is very efficient to represent structural, functional and behavioral knowledge. FT(Fault Tree). ST(Symptom Tree), FCD(Fault Consequence Diagrapy), SGM(State Graph Model) and FFM(Functional Flow Model) are used to represent hierachical structure. In this study, IA(Intelligent Agent) concept is introduced to match FT component and event symbol in diagnosed system and to transfer message between each event process. Proposed diagnosis control module is made of IPC(Inter Process Communication) method under UNIX operating system.

  • PDF

조적채움벽 골조의 내진성능평가를 위한 등가 스트럿 모델의 비교연구 (A Comparison Study of Equivalent Strut Models for Seismic Performance Evaluation of Masonry-Infilled Frame)

  • 유은종;김민재;정대계
    • 한국지진공학회논문집
    • /
    • 제18권2호
    • /
    • pp.79-87
    • /
    • 2014
  • Masonry-infilled walls have been used in reinforced concrete(RC) frame structures as interior and exterior partition walls. Since these walls are considered as nonstructural elements, they were only considered as additional mass. However, infill walls tend to interact with the structure's overall strength, rigidity, and energy dissipation. Infill walls have been analyzed by finite element method or transposed as equivalent strut model. The equivalent strut model is a typical method to evaluate masonry-infilled structure to avoid the burden of complex finite element model. This study compares different strut models to identify their properties and applicability with regard to the characteristics of the structure and various material models.

주파수영역방법에 의한 비선형 모델변수의 실험적 규명 (Experimental identification of nonlinear model parameter by frequency domain method)

  • 김원진
    • 대한기계학회논문집A
    • /
    • 제22권2호
    • /
    • pp.458-466
    • /
    • 1998
  • In this work, a frequency domain method is tested numerically and experimentally to improve nonlinear model parameters using the frequency response function at the nonlinear element connected point of structure. This method extends the force-state mapping technique, which fits the nonlinear element forces with time domain response data, into frequency domain manipulations. The force-state mapping method in the time domain has limitations when applying to complex real structures because it needd a time domain lumped parameter model. On the other hand, the frequency domain method is relatively easily applicable to a complex real structure having nonlinear elements since it uses the frequency response function of each substurcture. Since this mehtod is performed in frequency domain, the number of equations required to identify the unknown parameters can be easily increased as many as it needed, just by not only varying excitation amplitude bot also selecting excitation frequency domain method has some advantages over the classical force-state mapping technique in the number of data points needed in curve fit and the sensitivity to response noise.

조립용 로봇의 가변구조 적응제어 (Variable Structure Adaptive Control of Assembling Robot)

  • 한성현
    • 한국공작기계학회:학술대회논문집
    • /
    • 한국공작기계학회 1997년도 춘계학술대회 논문집
    • /
    • pp.131-136
    • /
    • 1997
  • This paper represent the variable structure adaptive mode control technique which is new approach to implement the robust control of industrial robot manipulator with external disturbances and parameter uncertainties. Sliding mode control is a well-known technique for robust control of uncertain nonlinear systems. The robustness of sliding model controllers can be shown in contiuous time, but digital implementation may not preserve robustness properties because the sampling process limits the existence of a true sliding mode. the sampling process often forces the trajectory to oscillate in the neighborhood of the sliding surface. Adaptive control technique is particularly well-suited to robot manipulators where dynamic model is highly complex and may contain unknown parameters. Adaptive control algorithm is designed by using the principle of the model reference adaptive control method based upon the hyperstability theory. The proposed control scheme has a simple sturcture is computationally fast and does not require knowledge of the complex dynamic model or the parameter values of the manipulator or the payload. Simulation results show that the proposed method not only improves the performance of the system but also reduces the chattering problem of sliding mode control, Consequently, it is expected that the new adaptive sliding mode control algorithm will be suited for various practical applications of industrial robot control system.

  • PDF

Feasibility study of improved particle swarm optimization in kriging metamodel based structural model updating

  • Qin, Shiqiang;Hu, Jia;Zhou, Yun-Lai;Zhang, Yazhou;Kang, Juntao
    • Structural Engineering and Mechanics
    • /
    • 제70권5호
    • /
    • pp.513-524
    • /
    • 2019
  • This study proposed an improved particle swarm optimization (IPSO) method ensemble with kriging model for model updating. By introducing genetic algorithm (GA) and grouping strategy together with elite selection into standard particle optimization (PSO), the IPSO is obtained. Kriging metamodel serves for predicting the structural responses to avoid complex computation via finite element model. The combination of IPSO and kriging model shall provide more accurate searching results and obtain global optimal solution for model updating compared with the PSO, Simulate Annealing PSO (SimuAPSO), BreedPSO and PSOGA. A plane truss structure and ASCE Benchmark frame structure are adopted to verify the proposed approach. The results indicated that the hybrid of kriging model and IPSO could serve for model updating effectively and efficiently. The updating results further illustrated that IPSO can provide superior convergent solutions compared with PSO, SimuAPSO, BreedPSO and PSOGA.