• 대한상부위장관⦁헬리코박터학회지
• /
• 제18권3호
• /
• pp.150-156
• /
• 2018

Precision medicine stands for 4Ps - precise, preventive, participatory, and personal; in which "precision" is important because the current modern medicine starts from "trial and error," and "one does not fit all". Current targeted therapies for cancer have changed treatment approaches and led the precision medicine; however, clinical use of liquid biopsy, using blood or other liquid specimens to characterize circulating tumor cells (CTC) or tumor genes instead of biopsies of tumor tissues, still awaits availability of more information regarding non-invasive cancer detection and characterization, prediction of treatment response, monitoring the disease course and relapse possibilities, identification of mechanisms of drug resistance, and newer pathogenesis. In this review, we will introduce the basic concept of CTC, circulating cell free DNA, and exosomes and their possible application for gastric cancer relevant with Helicobacter pylori infection.

• 한국인터넷방송통신학회논문지
• /
• 제9권5호
• /
• pp.109-114
• /
• 2009

현재 건물은 예전에 비해 더 높고 더 복잡하면서 다양한 형태로 설계되고 있다. 그러므로 잠재적인 위험 요소는 더 증가하고, 화재, 정전, 지진, 호수, 태풍 등의 재해가 발생할 수 있다. 이들 재난은 가능한 신속하게 건물 안의 사람들을 대피시켜야 한다. 본 논문에서는 건물 내부에서의 센서와 유도등 네트워크를 통합 구축하여 신속하게 재난을 감지하고 내부 지리 정보를 이용하여 정확하게 대피 유도할 수 있는 새로운 재난 대피 유도 개념을 제시한다. 본 논문에서는 이 개념을 이용하여 건물 내부에서 화재 재난을 관리하기 위해 센서와 유도등 네트워크 기반의 통합 논리 모델을 제시한다. 더불어 제안된 논리 모델을 지도 상에 가시화하고 운영 실험을 실시하여 검증한다.

• KIEAE Journal
• /
• 제9권5호
• /
• pp.97-104
• /
• 2009

In the process of urban development, the increase in the number and the complexity of urban facilities gives rise to a variety of problems, such as increase in construction and maintenance cost. In particular, taking into account the fact that an emergency situation in an urban facility can cause substantial loss of property as well as casualties, it becomes important to intelligently perceive states of facilities and properly execute countermeasures through real-time monitoring. In recent years, practitioners and researchers have made efforts to improve current passive and manpower-dependent facility management systems to be more active and intelligent, by applying diverse ubiquitous computing technologies for the u-City project. In this study, after discussing major drawbacks of the conventional facilities management, the concept and the model of a sensor-based integrated intelligent management system for urban facilities are proposed. The proposed model, by analyzing and processing real-time sensor data from urban facilities, not only supports the management of individual facilities, but also enables the detection of complex facility-related events and the process of their countermeasures. This active and intelligent management of urban facilities is expected to overcome the limitation of the conventional facilities management, and provide more suitable facility management services for the u-City development.

• Computers and Concrete
• /
• 제3권2_3호
• /
• pp.123-144
• /
• 2006

Reinforced concrete corbels are structural elements widely used in practical engineering. The complex response of these elements is described in design codes in a simplified manner. These formulations are not sufficient to show the real behavior, which, however, is an essential prerequisite for the manufacturing of numerous elements. Therefore, a deterministic and probabilistic study has been performed, which is described in this contribution. Real complex structures have been modeled by means of the finite element method supported primarily by experimental works. The main objective of this study was the detection of uncertainties effects and safety margins not captured by traditional codes. This aim could be fulfilled by statistical considerations applied to the investigated structures. The probabilistic study is based on advanced Monte Carlo simulation techniques and sophisticated nonlinear finite element formulations.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• 제10권9호
• /
• pp.4342-4366
• /
• 2016

Congestion control in Cluster Wireless Sensor Networks (CWSNs) has drawn widespread attention and research interests. The increasing number of nodes and scale of networks cause more complex congestion control and management. Active Queue Management (AQM) is one of the major congestion control approaches in CWSNs, and Random Early Detection (RED) algorithm is commonly used to achieve high utilization in AQM. However, traditional RED algorithm depends exclusively on source-side control, which is insufficient to maintain efficiency and state stability. Specifically, when congestion occurs, deficiency of feedback will hinder the instability of the system. In this paper, we adopt the Additive-Increase Multiplicative-Decrease (AIMD) adjustment scheme and propose an improved RED algorithm by using neighbor feedback and scheduling scheme. The congestion control model is presented, which is a linear system with a non-linear feedback, and modeled by Lur'e type system. In the context of delayed Lur'e dynamical network, we adopt the concept of cluster synchronization and show that the congestion controlled system is able to achieve cluster synchronization. Sufficient conditions are derived by applying Lyapunov-Krasovskii functionals. Numerical examples are investigated to validate the effectiveness of the congestion control algorithm and the stability of the network.

• Smart Structures and Systems
• /
• 제20권6호
• /
• pp.669-682
• /
• 2017

The normalised version of bispectrum, the so-called bicoherence, has often proved a reliable method of damage detection on engineering applications. Indeed, higher-order spectral analysis (HOSA) has the advantage of being able to detect non-linearity in the structural dynamic response while being insensitive to ambient vibrations. Skewness in the response may be easily spotted and related to damage conditions, as the majority of common faults and cracks shows bilinear effects. The present study tries to extend the application of HOSA to damage localisation, resorting to a neural network based classification algorithm. In order to validate the approach, a non-linear finite element model of a 4-meters-long cantilever beam has been built. This model could be seen as a first generic concept of more complex structural systems, such as aircraft wings, wind turbine blades, etc. The main aim of the study is to train a Neural Network (NN) able to classify different damage locations, when fed with bispectra. These are computed using the dynamic response of the FE nonlinear model to random noise excitation.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• 제9권11호
• /
• pp.4534-4555
• /
• 2015

We propose a robust object cataloging method using multiple locally distinct heterogeneous features for aiding image retrieval. Due to challenges such as variations in object size, orientation, illumination etc. object recognition is extraordinarily challenging problem. In these circumstances, we adapt local interest point detection method which locates prototypical local components in object imageries. In each local component, we exploit heterogeneous features such as gradient-weighted orientation histogram, sum of wavelet responses, histograms using different color spaces etc. and combine these features together to describe each component divergently. A global signature is formed by adapting the concept of bag of feature model which counts frequencies of its local components with respect to words in a dictionary. The proposed method demonstrates its excellence in classifying objects in various complex backgrounds. Our proposed local feature shows classification accuracy of 98% while SURF,SIFT, BRISK and FREAK get 81%, 88%, 84% and 87% respectively.

• 한국ITS학회 논문지
• /
• 제15권2호
• /
• pp.13-23
• /
• 2016

기존의 많은 돌발상황 자동감지 알고리즘은 복잡한 구조와 계산 과정, 수많은 매개변수, 그리고 필터링/평활화 같은 선 작업 때문에 지속적인 유지관리가 사실상 중단된 상태이고 오보율 또한 높아 많은 교통관리센터로부터 기피 대상이 되고 있는 등 돌발상황감지의 주력 수단으로서 자동 알고리즘의 지위가 위태해진 현실은 매우 우려할만하다. 본 연구에서는 상대 점유율과 속도 항을 활용하여 적체 교통량이라는 신 개념을 도입, 구조가 아주 간단하면서도 검측 원시자료의 보정이 거의 필요 없는 DiFI(Displaced Flow Index) 기반의 돌발상황 자동감지알고리즘을 개발하였다. DiFI 알고리즘의 성능평가는 2003년도 내부순환로 검지기자료를 활용하여 검증을 수행하였으며, 2011년도 경부고속도로 검지기 자료를 수집 정리하여 이식성 검사를 이행하였다. 성능평가는 검지율, 오보율, 평균검지시간, 기타 CR, CI, PI를 사용하였는데 100%의 검지율과 2.99%의 낮은 오보율, 1분을 약간 초과하는 평균검지시간을 보였다. 이는 SAO는 물론 국내 현장에 가장 많이 접목된 APID 및 DELOS 등과 비교해서도 모든 면에서 우월한 성능을 보이는 것이었다.

• 디지털콘텐츠학회 논문지
• /
• 제19권4호
• /
• pp.789-799
• /
• 2018

이 논문에서는 이러한 산업 단지 시스템에서의 비정상적인 동작이 일어날 때, 시간 계열의 데이터를 분석하기 위하여 Big 데이터를 이용한 접근을 기반으로 하는 머신 러닝을 보여줍니다. Long Short-Term Memory (LSTM) 네트워크는 향상된 RNN버전으로서 입증되었으며 많은 작업에 유용한 도움이 되었습니다. 이 LSTM 기반 모델은 시간적 패턴뿐만 아니라 더 높은 레벨의 시간적 특징을 학습 한 다음, 미래의 데이터를 예측하기 위해 예측 단계에 사용됩니다. 예측 오차는 예측 인자에 의해 예측 된 결과와 실제 예상되는 값의 차이입니다. 오차 분포 추정 모델은 가우스 분포를 사용하여 관찰 스코어의 이상을 계산합니다. 이러한 방식으로, 우리는 하나의 비정상적 데이터의 개념에서 집단적인 비정상적 데이터 개념으로 바뀌어 갑니다. 이 작업은 실패를 최소화하고 제조품질을 향상시키는 Smart Factory의 모니터링 및 관리를 지원할 수 있습니다.

• International Journal of Oral Biology
• /
• 제48권2호
• /
• pp.9-18
• /
• 2023

The rapid detection of bacteria in the oral cavity, its species identification, and bacterial count determination are important to diagnose oral diseases caused by pathogenic bacteria. The existing clinical microbial diagnosis methods are time-consuming as they involve observing patients' samples under a microscope or culturing and confirming bacteria using polymerase chain reaction (PCR) kits, making the process complex. Therefore, it is required to analyze the development status of substances and systems that can rapidly detect and analyze pathogenic microorganisms in the oral cavity. With research advancements, a close relationship between oral and systemic diseases has been identified, making it crucial to identify the changes in the oral cavity bacterial composition. Additionally, an early and accurate diagnosis is essential for better prognosis in periodontal disease. However, most periodontal disease-causing pathogens are anaerobic bacteria, which are difficult to identify using conventional bacterial culture methods. Further, the existing PCR method takes a long time to detect and involves complicated stages. Therefore, to address these challenges, the concept of point-of-care (PoC) has emerged, leading to the study and implementation of various chair-side test methods. This study aims to investigate the different PoC diagnostic methods introduced thus far for identifying pathogenic microorganisms in the oral cavity. These are classified into three categories: 1) microbiological tests, 2) microchemical tests, and 3) genetic tests. The microbiological tests are used to determine the presence or absence of representative causative bacteria of periodontal diseases, such as A. actinomycetemcomitans, P. gingivalis, P. intermedia, and T. denticola. However, the quantitative analysis remains impossible, and detecting pathogens other than the specific ones is challenging. The microchemical tests determine the activity of inflammation or disease by measuring the levels of biomarkers present in the oral cavity. Although this diagnostic method is based on increase in the specific biomarkers proportional to inflammation or disease progression in the oral cavity, its commercialization is limited due to low sensitivity and specificity. The genetic tests are based on the concept that differences in disease vulnerability and treatment response are caused by the patient's DNA predisposition. Specifically, the IL-1 gene is used in such tests. PoC diagnostic methods developed to date serve as supplementary diagnostic methods and tools for patient education, in addition to existing diagnostic methods, although they have limitations in diagnosing oral diseases alone. Research on various PoC test methods that can analyze and manage the oral cavity bacterial composition is expected to become more active, aligning with the shift from treatment-oriented to prevention-oriented approaches in healthcare.