The Korean journal of helicobacter and upper gastrointestinal research (대한상부위장관⦁헬리코박터학회지)

Korean College of Helicobacter and upper Gastrointestinal Reseaarch (대한상부위장관ㆍ헬리코박터학회)
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Liquid Biopsy: Current Status and Future Perspective in Gastric Cancer and Helicobacter Infection

액체 생검(Liquid Biopsy): 위암 및 헬리코박터 감염증에서 적응과 전망

  • Kang, Eun A (CHA Bio Complex, CHA Cancer Prevention Research Center) ;
  • Han, Young Min (CHA Bio Complex, CHA Cancer Prevention Research Center) ;
  • Park, Jong Min (CHA Bio Complex, CHA Cancer Prevention Research Center) ;
  • Yoo, In Kyung (Digestive Disease Center, CHA Bundang Medical Center, CHA University School of Medicine) ;
  • Hong, Sung Pyo (Digestive Disease Center, CHA Bundang Medical Center, CHA University School of Medicine) ;
  • Hahm, Ki Baik (CHA Bio Complex, CHA Cancer Prevention Research Center)
  • 강은아 (CHA Bio Complex 차 암예방 연구센터) ;
  • 한영민 (CHA Bio Complex 차 암예방 연구센터) ;
  • 박종민 (CHA Bio Complex 차 암예방 연구센터) ;
  • 유인경 (차 의과학대학교 분당차병원 소화기센터) ;
  • 홍성표 (차 의과학대학교 분당차병원 소화기센터) ;
  • 함기백 (CHA Bio Complex 차 암예방 연구센터)
  • Received : 2018.04.04
  • Accepted : 2018.06.05
  • Published : 2018.09.30
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Abstract

Precision medicine stands for 4Ps - precise, preventive, participatory, and personal; in which "precision" is important because the current modern medicine starts from "trial and error," and "one does not fit all". Current targeted therapies for cancer have changed treatment approaches and led the precision medicine; however, clinical use of liquid biopsy, using blood or other liquid specimens to characterize circulating tumor cells (CTC) or tumor genes instead of biopsies of tumor tissues, still awaits availability of more information regarding non-invasive cancer detection and characterization, prediction of treatment response, monitoring the disease course and relapse possibilities, identification of mechanisms of drug resistance, and newer pathogenesis. In this review, we will introduce the basic concept of CTC, circulating cell free DNA, and exosomes and their possible application for gastric cancer relevant with Helicobacter pylori infection.

Keywords

Acknowledgement

Supported by : Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET)

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