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Stiffening evaluation of flat elements towards stiffened elements under axial compression

  • Manikandan, P.;Arun, N.
    • Advances in Computational Design
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    • v.3 no.1
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    • pp.71-86
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    • 2018
  • Thin-walled cross-sections can be optimized to enhance their resistance and progress their behaviour, leading to more competent and inexpensive structural system. The aim of this study is to afford a methodology that would facilitate progress of optimized cold formed steel (CFS) column section with maximum ultimate strength for practical applications. The proposed sections are designed to comply with the geometrical standards of pre-qualified column standards for CFS structures as well as with the number of industrialized and practical constraints. The stiffening evaluation process of CFS lipped channel columns, a five different cross section are considered. The experimental strength and behaviour of the proposed sections are verified by using the finite element analysis (FEA). A series comprehensive parametric study is carried out covering a wide range of section slenderness and overall slenderness ratio of the CFS column with and without intermediate web stiffeners. The ultimate strength of the sections is determined based on the Direct Strength Specification and other design equation available from the literature for CFS structures. A modified design method is proposed for the DSM specification. The results indicate that the CFS column with complex edge and intermediate web stiffeners provides an ultimate strength which is up to 78% higher than standard optimized shapes with the same amount of cross sectional area.

Seismic response analysis of mega-scale buckling-restrained bracing systems in tall buildings

  • Gholipour, Mohammadreza;Mazloom, Moosa
    • Advances in Computational Design
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    • v.3 no.1
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    • pp.17-34
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    • 2018
  • Tall buildings are categorized as important structures because of the large number of occupants and high construction costs. The choice of competent lateral load resisting systems in tall buildings is of crucial importance. Bracing systems have long been an economic and effective method for resisting lateral loads in steel structures. However, there are some potential adverse aspects to bracing systems such as the limitations they inflict on architectural plans, uplift forces and poor performances in compression. in order to eliminate the mentioned problems and for cost optimization, in this paper, six 20-story steel buildings and frames with different types of bracing, i.e., conventional, mega-scale and buckling-restrained bracing (BRB) were analyzed. Linear and modal push-over analyses were carried out. The results pointed out that Mega-Scale Bracing (MSB) system has significant superiority over the conventional bracing type. The MSB system is 25% more economic. Some other advantages of MSB include: up to 63% less drift ratio, up to 38% better performance in lateral displacement, up to 100% stiffer stories, and about 50% smaller uplift forces. Moreover, MSB equipped with BRB attests even a better seismic behavior in the aforementioned parameters.

A Study of the Present Conditions and Consideration of Manufacture-Innovative Instruction Methods in Korea (국내 제조혁신 교육방법의 현황과 고찰)

  • Kim, Eun-Bi;Jeon, Tae-Woong;Han, Chang-Hee
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.35 no.2
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    • pp.147-154
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    • 2012
  • In the manufacturing industry, fostering talented workers has become a core activity as well as an important resource leading to manufacturing enterprises' innovative activities, which has come to the fore as one of the biggest success factors for innovative activities indeed. In other countries, there are many researches actively conducted on talent-fostering programs related to manufacture innovation. In Korea, however, manufacturers or several different education agencies don't actively carry out manufacture innovation instructions and have failed to faster special competent workers since their instructions focus on theories most of the time. Therefore, this study was conducted to understand the present conditions of manufacture-innovative instructions in Korea by classifying them in a method of educational technology and to investigate various teaching methods through oversea cases and cases from non-manufacture fields so that it might make a proposal for a better manufacture-innovative instruction method.

A Case of Disseminated Cutaneous Cryptococcosis Accompanied by Pulmonary Tuberculosis (폐 결핵과 동반된 파종성 피부 크립토콕쿠스증 1예)

  • Choi, Hae Jin;Lee, Sang Hwa;Lee, Tae Hoon;Yoo, Kwang Ha;Lee, Kye Young;Kim, Sun Jong
    • Tuberculosis and Respiratory Diseases
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    • v.65 no.6
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    • pp.527-531
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    • 2008
  • Although disseminated cryptococcosis occurs most commonly in immunocompromised patients, particularly those with a human immunodeficiency virus (HIV) infection, it can occur in immune competent persons. There are no case reports of disseminated cutaneous crytpcoccosis associated with pulmonary tuberculosis in Korea. A 71-year-old female presented with fever and multiple cutaneous nodules. She was finally diagnosed with disseminated cutaneous cryptococcosis accompanied by pulmonary tuberculosis, and was treated successfully with anti-tuberculous medication and fluconazole. She had no apparent predisposing conditions for systemic cryptococcosis. We report this case with a review of the relevant literature.

Undergraduate Nursing Students' Perceived Knowledge and Attitudes Toward Genetics and Nursing Competencies for Genetics (간호대학생이 인지하는 유전학에 대한 지식과 태도 및 유전간호 역량)

  • Choi, Hyunkyung
    • Journal of Korean Biological Nursing Science
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    • v.16 no.2
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    • pp.69-79
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    • 2014
  • Purpose: The purpose of this descriptive, cross-sectional study was to examine Korean undergraduate nursing students' perceived knowledge and attitudes toward genetics. Nursing competencies for genetics among nursing students were also assessed. Methods: Two hundred eighty-six Korean junior and senior undergraduate nursing students who went through their clinical practicum completed a packet of self-report questionnaires exploring opinions about the integration of genetics into the nursing curriculum, as well as their perceived knowledge, attitudes, and nursing competencies toward genetics. Collected data were analyzed using descriptive statistics, t-test, one-way ANOVA. Results: Overall, Korean undergraduate nursing students reported limited genetic knowledge, but most of them were comfortable with drawing pedigree. In general, nursing students were competent in providing genetic nursing. Their genetic nursing competencies were significantly different depending on the level of general understanding of genetics. There was no significant difference between juniors and seniors regarding knowledge, attitudes, and competencies toward genetics. More than 60% of nursing students reported the need for genetic nursing, and the majority considered lectures to be the most effective method to learn genetic knowledge. Conclusion: It is imperative to integrate genetics into nursing curriculum in order to improve nursing students' genetic nursing competencies as well as genetic knowledge.

Economic Feasibility Analysis for P2G Using PEM Water Electrolysis (PEM 수전해를 이용한 P2G에 대한 경제적 타당성 분석)

  • JEONG, SEONJU;CHOI, NAK HEON;MOON, CHANGHWAN;MOON, SANGBONG;LIM, HANKWON
    • Journal of Hydrogen and New Energy
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    • v.28 no.3
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    • pp.231-237
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    • 2017
  • With worldwide efforts to increase the portion of renewable energy for $CO_2$ reductions, a lot of attention has been paid to P2G (power-to-gas) in Europe and Japan to efficiently utilize the surplus electricity. In this paper, economic feasibility analysis has been carried out for P2G using PEM water electrolysis by reflecting current economic status in Korea. In addition, efficiency and electricity price required to be competent in Korean market were provided. Based on cash flow diagrams, unit production costs for $H_2$ and $CH_4$ were estimated and profitability of P2G using PEM water electrolysis was analyzed.

Gene Therapy for Mice Sarcoma with Oncolytic Herpes Simplex Virus-1 Lacking the Apoptosis-inhibiting Gene, icp34.5

  • Lan, Ping;Dong, Changyuan;Qi, Yipeng;Xiao, Gengfu;Xue, Feng
    • BMB Reports
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    • v.36 no.4
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    • pp.379-386
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    • 2003
  • A mutant herpes simplex virus 1, mtHSV, was constructed by inserting the E. coli beta-galactosidase gene into the loci of icp34.5, the apoptosis-inhibiting gene of HSV. The mtHSV replicated in and lysed U251 (human glioma cells), EJ (human bladder cells), and S-180 (mice sarcoma cells), but not Wish (human amnion cells) cells. With its intact tk (thymidine kinase) gene, mtHSV exhibited susceptibility to acyclovir (ACV), which provided an approach to control viral replication. An in vivo test with mtHSV was conducted in immune-competent mice bearing sarcoma S-180 tumors, which were treated with a single intratumoral injection of mtHSV or PBS. Tumor dimensions then were measured at serial time points, and the tumor volumes were calculated. Sarcoma growth was significantly inhibited with prolonged time and reduced tumor volume. There was microscopic evidence of necrosis of tumors in treated mice, whereas no damage was found in other organs. Immunohistochemical staining revealed that virus replication was exclusively confined to the treated tumor cells. HSV-1 DNA was detected in tumors, but not in the other organs by a polymerase chain reaction analysis. From these experiments, we concluded that mtHSV should be a safe and promising oncolytic agent for cancer treatment.

Production of Monoclonal Antibodies Against Nervous Necrosis Virus (NNV, RGNNV genotype) (신경괴사증바이러스(nervous necrosis virus, RGNNV genotype)에 대한 단클론 항체 생산)

  • Kim, Wi-Sik;Kim, Si-Woo;Oh, Myung-Joo
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.51 no.3
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    • pp.328-331
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    • 2018
  • We developed and subsequently characterized mouse monoclonal antibodies (MAbs) against nervous necrosis virus (NNV, RGNNV genotype). We established six hybridoma clones secreting MAbs against NNV antigen: 2B1, 2B11, 2C12, 13C1-1, 13C1-2 and 14D11. All six MAbs belonged to the IgG2a isotype with a kappa light chain and their reactivity recognized against the 41 kDa coat protein of NNV by Western blot analysis. The affinity constants of the six MAbs were measured by enzyme-linked immunosorbent assay (ELISA). All six MAbs reacted with two NNV isolates (SgNag05 and Gemunodo06), while no reactivity was observed with five know fish viruses, namely marine birnavirus, infectious pancreatic necrosis virus, viral hemorrhagic septicemia virus, hirame rhabdovirus, and infectious hematopoietic necrosis virus. Moreover, high ELISA optical density (OD) values (0.87-1.42) were observed in the brain tissues of NNV-infected sevenband grouper, while low OD values (less than 0.12) were recorded in the brain tissues of uninfected fish. These results suggest that these six MAbs are highly competent and useful for the detection of NNV with the RGNNV genotype.

Determinants of Information Technology Audit Quality: Evidence from Vietnam

  • NGUYEN, Anh Huu;HA, Hanh Hong;NGUYEN, Soa La
    • The Journal of Asian Finance, Economics and Business
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    • v.7 no.4
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    • pp.41-50
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    • 2020
  • The paper aims to investigate auditors, auditing firms and other external factors that affect quality of information technology audit in Vietnam. We conducted 2 types of data collections including direct and on survey. For direct survey, we sent directly to auditors at the training classes organized by State Securities Exchanges Commission. An online survey was established and Google doc link was provided to the Big4 and non-Big4 auditors. We received 138 survey responses in that 90 auditors came from Big4 and 48 auditors from non-Big4 firms. The data are analyzed using a factor analysis and compare means approaches to illustrate the potential IT audit quality factors and identify differences between two groups of auditors. The results show that independence and accounting knowledge and audit skills are the most important factors. And since external auditors perform many assurance services, the independence is critical. The result also shows that the auditors need to have enough competent and professional skills when conducting an audit, especially within an IT environment that requires high quality. The findings suggest a similar pattern of two groups in the context of Vietnam and some factors of auditors and auditing firms appear to have a statistically significant impact on quality of IT audit.

Factors Affecting Foreign Direct Investment: Evidence on Tay Ninh Province

  • TRAN, Thinh Quoc;DANG, Tuan Anh;TRAN, Ngoc Anh Thu
    • The Journal of Asian Finance, Economics and Business
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    • v.7 no.9
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    • pp.263-269
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    • 2020
  • The purpose of this paper is to examine the impact of consumer price index, infrastructure, human resources, trade openness, and private credit on the attraction of foreign direct investment (FDI) in Tay Ninh province as well as to emphasize the important role of FDI in economic growth of developing areas. The research data was collected from Tay Ninh Statistical Office with 80 samples of a 20-year period from 2000 to 2019. Also, OLS regression method using Eviews software was employed to analyze the data obtained. The findings revealed that human resources, infrastructure and private credit have a positive and significant impact on FDI attraction in Tay Ninh province, while consumer price index was proven to affect FDI attraction negatively. Accordingly, competent authorities of Tay Ninh province should focus on stabilizing prices as well as implementing policies for developing local human resources and attracting high-quality personnel from foreign countries. Tay Ninh province also needs to pay more attention to information technology investment for synchronous development of infrastructure. Moreover, the State Bank of Tay Ninh branch needs to consider more credit sources to provide support packages for businesses, creating a strong basis for establishments to attract FDI for the province's economic development.