• The Korean Journal of Physiology and Pharmacology
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• v.8 no.1
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• pp.65-67
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• 2004

Dehydroevodiamine (DHED) is one of the bioactive components of the Chinese herbal medicine Wu-chu-yu-tang that has been shown to produce various pharmacological effects. In the present study, we investigated the pharmacokinetics of DHED after intravenous administration of two doses (2.5 and 5 mg/kg) in anesthetized rats. The plasma concentration of DHED was measured by reverse-phase high-performance liquid chromatography with UV detection. The mean area under the curve of the time-concentration profile was $21.9\;and\;53.9\;{\mu}g{\cdot}min/ml$ after the 2.5- and 5-mg/kg doses, respectively, and the volume of distribution was 1584.9 and 1580.6 ml following 2.5- and 5-mg/kg doses, respectively. Plasma concentration profiles versus time were compatible with a two-compartment model and first-order kinetics. The terminal elimination half-life was $91.8{\pm}16.6\;min$ and $78.7{\pm}11.9\;min$ in the dose of 2.5 and 5 mg/kg, respectively. This is the first report to study the pharmacokinetics of DHED in animals.

• Korean Journal of Veterinary Service
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• v.25 no.3
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• pp.299-308
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• 2002

The purposes of this study were to characterize the disposition of sulfathiazole(ST) and to investigate the effects of sodium bicarbonate on the disposition of ST in broiler chicks(2.5～3.0kg). Animals were given ST acutely(10～80mg/kg, PO), and plasma, kidney, muscle, heart, liver and spleen samples were collected and analyzed for ST by high performance liquid chromatography. The plasma and tissue data was consistent with a one-compartment pharmacokinetic model. The drug is rapidly but incompletely(2.5～3.87%) absorbed with peak plasma and tissue levels being achieved within one hour after dosing. The plasma and tissue levels depended on drug dosage, and the descending order in concentration of ST was kidney > plasma > heart > muscle $\geq$ spleen $\geq$ liver from animals sacrificed at one hour after dosing. Moreover, significant positive correlations(r>0.9) existed between plasma and tissue levels of ST. In addition, sodium bicarbonate pretreatment decreased plasma level, indicating that an alkalinization stimulate the excretion of ST. Results of this study suggest that oral application of ST was rapidly absorbed and eliminated, and confirmed that tissue residues of ST can be estimated from plasma drug concentration in broiler chicks.

• Proceedings of the Korea Institute of Fire Science and Engineering Conference
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• 2010.10a
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• pp.241-245
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• 2010

화재방호에 성능기반 개념을 도입함에 따라 화재모델링의 활용도는 점점 높아지고 있다. 본 연구의 목적은 FDS를 이용하여 원자력발전소 펌프실의 윤활유 화재 시 케이블의 손상여부를 평가하고, 확인분석을 통해 화재모델링의 적합성을 파악하는 데 있다. 화재는 펌프 주변의 누출된 윤활유에서 발생하며 화원의 면적은 $2.75m^2$이고 단위면적당 열방출율은 $1,794kW/m^2$로 가정하였다. 계산결과, 고온기체층의 온도는 $400^{\circ}C$를 상회하고 있으나 케이블 트레이의 온도는 $50^{\circ}C$ 아래로 예측되고 있어 본 화재시나리오에서 케이블의 건전성은 유지되고 있으며 밀폐된 격실에서의 대형화재는 환기지배형 화재가 된다는 것을 보여주고 있다. 또한 확인분석 결과, 화재 시나리오의 주요 변수인 열방출율, 격실크기 그리고 강제 환기 변수가 확인계산 범위 내에 있어 본 계산결과는 NUREG-1824의 확인요건을 만족하고 있다. 따라서 펌프실 윤활유 화재에 대한 모델링의 적합성을 확인하였다.

• Nuclear Engineering and Technology
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• v.35 no.2
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• pp.108-120
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• 2003

In assessing the long term post closure radiological safety assessment of a potential HLW repository in Korea, three categories of uncertainties exist. The first one is the scenario uncertainty where series of different natural events are translated into written statements. The second one is the modeling uncertatinty where different mathematical models are applied for an identical scenario. The last one is the data uncertainty which can be expressed in terms of probabilistic density functions. In this analysis, three different scenarios are seleceted; a small well scenario, a radiolysis scenario, and a naturally discharged scenario. The MASCOT-K and the AMBER, probabilistic safety assessment codes based on connection of sub-modules and a compartment theory respectively, are applied to assess annual individual doses for a generic biosphere. Results illustrate that for a given scenario, predictions from two different codes fairly match well each other But the discrepancies for the different scenarios are significant. However, total doses are still well below the guideline of 2 mRem/yr. Detailed analyses with model and data uncertainties are underway to further assure the safety of a Korean reference dispsoal concept.

• Archives of Pharmacal Research
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• v.29 no.7
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• pp.598-604
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• 2006

In many conventional drug delivery systems in vogue, failure to deliver efficient drug delivery at the target site/organs; is evident as a result, less efficacious pharmacological response is elicited. Microspheres can be derived a remedial measure which can improve site-specific drug delivery to a considerable extent. As an application, Lung-targeting Ofloxacin-loaded gelatin microspheres (GLOME) were prepared by water in oil emulsion method. The Central Composite Design (CCD) was used to optimize the process of preparation, the appearance and size distribution were examined by scanning electron microscopy, the aspects such as in vitro release characteristics, stability, drug loading, loading efficiency, pharmacokinetics and tissue distribution in albino mice were studied. The experimental results showed that the microspheres in the range of $0.32-22\;{\mu}m$. The drug loading and loading efficiency were 61.05 and 91.55% respectively. The in vitro release profile of the microspheres matched the korsmeyer’s peppas release pattern, and release at 1h was 42%, while for the original drug, ofloxacin under the same conditions 90.02% released in the first half an hour. After i.v. administration (15 min), the drug concentration of microspheres group in lung in albino mice was $1048\;{\mu}g/g$, while that of controlled group was $6.77\;{\mu}g/g$. GLOME found to release the drug to a maximum extent in the target tissue, lungs.

• The Korean Journal of Pharmacology
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• v.25 no.1
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• pp.101-107
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• 1989

To evaluate disposition characteristics of procainamide and its active metabolite, N-acetylprocainamide (NAPA), cross-over study for procainamide and NAPA was performed in 5 male adult dogs. After single administration of 10 mg/kg procainamide over 15 minutes, the range of measured plasma NAPA concentrations during experimental period were 0.03 to 0.124 ug/ml and early 'dip' phenomenon was distinct on NAPA concentration to time curve in all 5 dogs. Volume of distribution (Vss) and central compartment volume (Vc) of procainamide were $1.20{\pm}0.27\;L/kg$ of body weight and $0.36{\pm}0.08\;L/kg$, respectively. Vss and Vc of NAPA were $1.21{\pm}0.21\;L/kg$ and $0.26{\pm}0.07\;L/kg$, respectively. Intercompartmental clearance (Clint) of procainamide was 3.44 L/kg/hr and that of NAPA was 1.62 L/kg/hr. Total body clearance (Cl) of procainamide and NAPA were $0.47{\pm}0.08$ and $0.35{\pm}0.08\;L/kg/hr$. The half-life $(t_{1/2{\beta}})$ of procainamide and NAPA were 2.85 hrs and 2.77 hrs, respectively. Metabolic clearance (Clm)of procainamide by N-acetylation was $18.24{\pm}6.22\;ml/kg/hr$, which corresponded to 3.9% of total procainamide clearance.

• Journal of Radiation Protection and Research
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• v.33 no.4
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• pp.135-141
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• 2008

This paper describes a dynamic compartment model to predict the time-dependent $^{14}C$ activity in a plant as a result of a direct exposure to an amount of $^{14}CO_2$ for a short period of time, and experimental results for the model validation. In the model, the plant consists of two compartments of the body and ears, and five carbon fluxes between the compartments, which are the function of parameters relating to the growth and photosynthesis of a plant, are considered. Model predictions were made for an investigation into the effects of the exposure time, the elapsed exposure time, and the model parameters on the $^{14}C$ radioactivity of a plant. The present model converged to a region where the specific activity model is applicable when the elapsed time of the exposure was extended up to the harvest time of a plant. The $^{14}C$ activity of a plant was predicted to be the greatest when the exposure had happened in the period between the flowering and ears-maturity on account of the most vigorous photosynthesis rate for the period. Comparison of model predictions with the observed 14C radioactivity of rice plants showed that the present model could predict the $^{14}C$ radioactivity of the rice plants reasonably well.

• Journal of Environmental Science International
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• v.24 no.10
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• pp.1273-1283
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• 2015

In present study, the temporal characteristics of nine selected volatile organic compounds (VOCs), including four alcohol, 2 aldehyde, and 3 ketone compounds, in high-stories urban apartments over a 2-y period were investigated. The indoor VOC concentrations had generally a decreasing trend over the 2-y follow-up period. For examples, the 2E1H indoor concentration decreased from $10.8{\mu}g/m^3$ for the first two months to $5.1{\mu}g/m^3$ for the last two months. In addition, the DCA and ACT indoor concentrations decreased from 5.0 and $14{\mu}g/m^3$ for the first two months to 2.2 and $6.4{\mu}g/m^3$, respectively, for the last two months. The indoor-to outdoor concentration ratios over the 2-y period were much greater than 1, indicating that indoor VOC concentrations were higher than the outdoor VOC concentrations. Similar to those of the individual VOCs, the indoor-to-outdoor concentration ratios of all three VOC groups were higher than 1 over the 2-y follow-up period, suggesting higher indoor concentrations of the three VOC groups than outdoor concentrations. In consistence with the results of VOC indoor concentrations, the VOC emission rates decreased gradually as time passed, due to the decreased VOC emission strengths of indoor sources. Finally, there was an initial sharp decrease in the indoor VOC concentrations followed by a slower decrease, indicating a multi-exponential decay model for the target VOCs, which was demonstrated by comparison of the residuals and the adjusted coefficient of determination associated with the one and two-exponential fits of each data set.

• Transactions of the Korean Society of Automotive Engineers
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• v.18 no.5
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• pp.115-123
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• 2010

Cool-down performance after soaking is important because it affects passenger's thermal comfort. The cooling capacity of HVAC system determines initial cool down performance in most cases, the performance is also affected by location, and shape of panel vent, indoor seat arrangement. Therefore, optimal indoor designs are required in developing a new car. In this paper, initial cool down performance is predicted by CFD(computational fluid dynamics) analysis. Experimental time-averaging temperature data are used as inlet boundary condition. For more reliable analysis, real vehicle model and human FE model are used in grid generation procedure. Thermal and aerodynamic characteristics on re-circulation cool vent mode are investigated using CFX 12.0. Thermal comfort represented by PMV(predicted mean vote) is evaluated using acquired numerical data. Temperature and velocity fields show that flow in passenger's compartment after soaking is considerably unstable at the view point of thermodynamics. Volume-averaged temperature is decreased exponentially during overall cool down process. However, temperature monitored at different 16 spots in CFX-Solver shows local variation in head, chest, knee, foot. The cooling speed at the head and chest nearby panel vent are relatively faster than at the knee and foot. Horizontal temperature contour shows asymmetric distribution because of the location of exhaust vent. By evaluating the passenger's thermal comfort, slowest cooling region is found at the driver's seat.

• Environmental Analysis Health and Toxicology
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• v.28
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• pp.13.1-13.5
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• 2013

Objectives: Potential environmental risks caused by chemicals that could be released from a recycled plastic product were assessed using a screening risk assessment procedure for chemicals in recycled products. Methods: Plastic slope protection blocks manufactured from recycled plastics were chosen as model recycled products. Ecological risks caused by four model chemicals - di-(2-ethylhexyl) phthalate (DEHP), diisononyl phthalate (DINP), cadmium (Cd), and lead (Pb)-were assessed. Two exposure models were built for soil below the block and a hypothetic stream receiving runoff water. Based on the predicted no-effect concentrations for the selected chemicals and exposure scenarios, the allowable leaching rates from and the allowable contents in the recycled plastic blocks were also derived. Results: Environmental risks posed by slope protection blocks were much higher in the soil compartment than in the hypothetic stream. The allowable concentrations in leachate were $1.0{\times}10^{-4}$, $1.2{\times}10^{-5}$, $9.5{\times}10^{-3}$, and $5.3{\times}10^{-3}mg/L$ for DEHP, DINP, Cd, and Pb, respectively. The allowable contents in the recycled products were $5.2{\times}10^{-3}$, $6.0{\times}10^{-4}$, $5.0{\times}10^{-1}$, and $2.7{\times}10^{-1}mg/kg$ for DEHP, DINP, Cd, and Pb, respectively. Conclusions: A systematic ecological risk assessment approach for slope protection blocks would be useful for regulatory decisions for setting the allowable emission rates of chemical contaminants, although the method needs refinement.