Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
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Disposition of sulfathiazole in plasma and tissue of broiler chicks following oral administration

육계에서 sulfathiazole 경구투여 후 혈장 및 조직내 잔류량

  • 서형석 (전라북도축산진흥연구소) ;
  • 임정철 (전라북도축산진흥연구소) ;
  • 허부홍 (전라북도축산진흥연구소) ;
  • 권정택 ((주)하림) ;
  • 김성문 (전라북도축산진흥연구소) ;
  • 천희웅 (전라북도축산진흥연구소) ;
  • 최인방 (전라북도축산진흥연구소) ;
  • 김진상 (전북대학교 생체안전성연구소)
  • Published : 2002.09.01
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Abstract

The purposes of this study were to characterize the disposition of sulfathiazole(ST) and to investigate the effects of sodium bicarbonate on the disposition of ST in broiler chicks(2.5～3.0kg). Animals were given ST acutely(10～80mg/kg, PO), and plasma, kidney, muscle, heart, liver and spleen samples were collected and analyzed for ST by high performance liquid chromatography. The plasma and tissue data was consistent with a one-compartment pharmacokinetic model. The drug is rapidly but incompletely(2.5～3.87%) absorbed with peak plasma and tissue levels being achieved within one hour after dosing. The plasma and tissue levels depended on drug dosage, and the descending order in concentration of ST was kidney > plasma > heart > muscle $\geq$ spleen $\geq$ liver from animals sacrificed at one hour after dosing. Moreover, significant positive correlations(r>0.9) existed between plasma and tissue levels of ST. In addition, sodium bicarbonate pretreatment decreased plasma level, indicating that an alkalinization stimulate the excretion of ST. Results of this study suggest that oral application of ST was rapidly absorbed and eliminated, and confirmed that tissue residues of ST can be estimated from plasma drug concentration in broiler chicks.

Keywords

References

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