• Journal of Veterinary Science
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• v.19 no.6
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• pp.817-826
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• 2018

The bursa of Fabricius (BF) is a central humoral immune organ unique to birds. Four bursal peptides (BP-I, BP-II, BP-III, and BP-IV) have been isolated and identified from the BF. In this study, the immunoadjuvant activities of BPs I to IV were examined in mice immunized with H9N2 avian influenza virus (AIV) vaccine. The results suggested that BP-I effectively enhanced cell-mediated immune responses, increased the secretion of Th1 (interferon gamma)- and Th2 (interleukin-4)-type cytokines, and induced an improved cytotoxic T-lymphocyte (CTL) response to the H9N2 virus. BP-II mainly elevated specific antibody production, especially neutralizing antibodies, and increased Th1- and Th2-type cytokine secretion. BP-III had no significant effect on antibody production or cell-mediated immune responses compared to those in the control group. A strong immune response at both the humoral and cellular levels was induced by BP-IV. Furthermore, a virus challenge experiment followed by H&E staining revealed that BP-I and BP-II promoted removal of the virus and conferred protection in mouse lungs. BP-IV significantly reduced viral titers and histopathological changes and contributed to protection against H9N2 AIV challenge in mouse lungs. This study further elucidated the immunoadjuvant activities of BPs I to IV, providing a novel insight into immunoadjuvants for use in vaccine design.

• International Journal of Computer Science & Network Security
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• v.21 no.6
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• pp.156-160
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• 2021

Every day brings a new challenge to the humanities. Life nowadays needs accuracy, privacy, integrity, authenticity, and security to run life systems especially the monetary system. Things now differ from previous centuries. Multiple varieties in digital banking have opened the new and most advanced innovations for human beings. The monetary system is going to developed day by day to facilitate the public. Electronic money has amazed the world and gave a challenge to central banking. For this purpose, there will be a need for strict security, information, and confidence. Blockchain technology has opened new gateways. Bitcoin has become the most famous digital currency, which has created a thunderstorm in digital marketing. Blockchain, as a new Financial Technology, has satisfied all the security issues and satisfied doing business in secure ways that encourage investors to invest and keep the world business wheel. Assessment of the sustainability of implementing Bitcoin in financial institutions will be discussed. Every new system has its pros and cons in which a clear vision of what we are about to use can be sought. Through this research paper, a demonstration of the monetary system evolution, the new ways of doing business, some evidence in a form of academic cases will be demonstrated through comparison a table, a suggested method to transfer to the new system in safe mode will be proposed, and a conclusion will be concluded.

• 한국정책학회보
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• v.21 no.1
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• pp.337-361
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• 2012

This study is conducted to provide empirical evidences which support that the problems of social isolation and loneliness of elderly can be alleviated by intervening the inter-generational relationship of the elderly by means of active ageing policy. The major empirical challenge to address this question is the possibility of selection bias caused by reversed causal relationship. To address this challenge, I constructed comparison group with 'Eligible Non-Participants' (ENP), and used instrumental variable method to estimate the empirical model. My findings indicate that inter-generational relationship, both in the aspects of economical solidarity and associational solidarity, is significantly improved as time use pattern of the elderly becomes more active. The improvement effect is intensively observed for the group of elderly who do not live with their adult children. The important policy implication of these findings is that the improvement of inter-generational relationship can be added as a new benefit of active ageing policy.

• International Journal of Computer Science & Network Security
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• v.23 no.10
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• pp.37-43
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• 2023

The hospital situation, timing, and patient restrictions have become obstacles to an optimum therapy session. The crowdedness of the hospital might lead to a tight schedule and a shorter period of therapy. This condition might strike a post-stroke patient in a dilemma where they need regular treatment to recover their nervous system. In this work, we propose an in-house and uncomplex serious game system that can be used for physical therapy. The Kinect camera is used to capture the depth image stream of a human skeleton. Afterwards, the user might use their hand gesture to control the game. Voice recognition is deployed to ease them with play. Users must complete the given challenge to obtain a more significant outcome from this therapy system. Subjects will use their upper limb and hands to capture the 3D objects with different speeds and positions. The more substantial challenge, speed, and location will be increased and random. Each delegated entity will raise the scores. Afterwards, the scores will be further evaluated to correlate with therapy progress. Users are delighted with the system and eager to use it as their daily exercise. The experimental studies show a comparison between score and difficulty that represent characteristics of user and game. Users tend to quickly adapt to easy and medium levels, while high level requires better focus and proper synchronization between hand and eye to capture the 3D objects. The statistical analysis with a confidence rate(α:0.05) of the usability test shows that the proposed gaming is accessible, even without specialized training. It is not only for therapy but also for fitness because it can be used for body exercise. The result of the experiment is very satisfying. Most users enjoy and familiarize themselves quickly. The evaluation study demonstrates user satisfaction and perception during testing. Future work of the proposed serious game might involve haptic devices to stimulate their physical sensation.

• Restorative Dentistry and Endodontics
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• v.22 no.1
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• pp.388-395
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• 1997

Maintaining the original canal path during instrumentation is a challenge in narrow curved canals. This study compared the maintenance of the original canal path of curved root canals during instrumentation with two kinds of stainless steel K-files(Brassler USA & Mani Japan), K-flexofiles(Maillefer Swiss) and Ni-Ti files(Brassler USA, Savannah, GA) using circumferential filing technique to # 40 MAF on 60 extracted human molars. Buccal and mesial canals with minimal initial curvature of 20 degrees were used. The maximal initial curvature was 41.5 degrees. Sixty curved canals divided into four groups according to file type(Group 1 : Ni-Ti file, Group 2 : K-flexofile, Group 3: K-file(Brassler), Group 4 : K-file(Mani)). Radiographs of canals were obtained before and after canal shaping. And postoperative radiographs were compared with preoperative radiographs using superimposition method. Data analysis was performed using Covariance analysis and paired-comparison test. The results observed were as follow ; 1. The angle of curvature was better maintained with Ni-Ti file than with stainless steel files. (p<0.01) 2. There was no significant difference in maintaining canal curvature between K-flexofile, Brassler$^{(R)}$ K-file and Mani$^{(R)}$ K-file, although there was some differences in mean values of postoperative canal curvature. 3. Paired-comparison t test revealed significant differences within each of the three stainless steel file types when comparing the mean differences before and after instrumentation, but no significant differences were observed within Ni-Ti file group.

• Journal of fish pathology
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• v.21 no.3
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• pp.201-208
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• 2008

We compared the pathogenicity and antigenicity of two different Edwardsiella tarda (E. tarda) strains KFE and Edk-2 isolated in Korea and Japan respectively. In the pathogenicity analysis with challenge test against loach, E. tarda KFE isolate showed stronger pathogenicity compared to that of E. tarda Edk-2 isolate. The differences were also confirmed by the comparison of OMP (outer membrane protein) in SDSPAGE which showed three major bands, 41kDa, 37kDa and 30kDa, for E. tarda KFE isolates and two major bands, 41kDa and 30kDa, for E. tarda Edk-2 isolates. On the base of these results, we tried to determine the differences of antigenicities of these two isolates in loach which is one of the important species in freshwater aquaculture in Korea. Numbers of specific antibody secreting cells (SASC), appeared to be higher in loach immunized with FKC of E. tarda Edk-2 than loach immunized with FKC of E. tarda KFE. ELISPOT-assay for the comparison of antigenicity showed relatively high percentage of cross-reaction and implied the presence of some common epitopes in the antigens of these two E. tarda isolates.

• Imaging Science in Dentistry
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• v.51 no.3
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• pp.279-290
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• 2021

Purpose: Using images in the facial image comparison process poses a challenge for forensic experts due to limitations such as the presence of facial expressions. The aims of this study were to analyze how morphometric changes in the face during a spontaneous smile influence the facial image comparison process and to evaluate the reproducibility of measurements obtained by digital stereophotogrammetry in these situations. Materials and Methods: Three examiners used digital stereophotogrammetry to obtain 3-dimensional images of the faces of 10 female participants(aged between 23 and 45 years). Photographs of the participants' faces were captured with their faces at rest (group 1) and with a spontaneous smile (group 2), resulting in a total of 60 3-dimensional images. The digital stereophotogrammetry device obtained the images with a 3.5-ms capture time, which prevented undesirable movements of the participants. Linear measurements between facial landmarks were made, in units of millimeters, and the data were subjected to multivariate and univariate statistical analyses using Pirouette^® version 4.5 (InfoMetrix Inc., Woodinville, WA, USA) and Microsoft Excel^® (Microsoft Corp., Redmond, WA, USA), respectively. Results: The measurements that most strongly influenced the separation of the groups were related to the labial/buccal region. In general, the data showed low standard deviations, which differed by less than 10% from the measured mean values, demonstrating that the digital stereophotogrammetry technique was reproducible. Conclusion: The impact of spontaneous smiles on the facial image comparison process should be considered, and digital stereophotogrammetry provided good reproducibility.

• Journal of the Architectural Institute of Korea Structure & Construction
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• v.36 no.3
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• pp.113-120
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• 2020

The purpose of this study is to compare the models of Deep Learning-based Convolution Neural Network(CNN) for concrete crack detection. The comparison models are AlexNet, GoogLeNet, VGG16, VGG19, ResNet-18, ResNet-50, ResNet-101, and SqueezeNet which won ImageNet Large Scale Visual Recognition Challenge(ILSVRC). To train, validate and test these models, we constructed 3000 training data and 12000 validation data with 256×256 pixel resolution consisting of cracked and non-cracked images, and constructed 5 test data with 4160×3120 pixel resolution consisting of concrete images with crack. In order to increase the efficiency of the training, transfer learning was performed by taking the weight from the pre-trained network supported by MATLAB. From the trained network, the validation data is classified into crack image and non-crack image, yielding True Positive (TP), True Negative (TN), False Positive (FP), False Negative (FN), and 6 performance indicators, False Negative Rate (FNR), False Positive Rate (FPR), Error Rate, Recall, Precision, Accuracy were calculated. The test image was scanned twice with a sliding window of 256×256 pixel resolution to classify the cracks, resulting in a crack map. From the comparison of the performance indicators and the crack map, it was concluded that VGG16 and VGG19 were the most suitable for detecting concrete cracks.

• Korean Journal of Veterinary Service
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• v.42 no.1
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• pp.1-7
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• 2019

Porcine reproductive and respiratory syndrome (PRRS) is economically the most important and challenging disease in swine industries worldwide and caused by PRRS virus (PRRSV). Previous studies reported that pigs with heterozygous genotypes in the guanylate-binding proteins (GBP1 and GBP5) exhibited increased resistance against PRRSV infection. The present study was conducted to produce higher numbers of the heterozygous pigs based on the PRRS resistant polymorphisms found in GBP1 (GBP1E2 and WUR) and GBP5, and evaluate the resistance of heterozygous pigs against challenge with a type 2 PRRSV (JA142) in comparison with homozygous pigs. In the challenge study, 12, 4 week-old PRRSV-negative piglets were selected based on the genotypes of the 3 polymorphisms (GBP1E2, WUR and GBP5). Among them, 8 piglets [homozygous (n=4) and heterozygous (n=4)] were challenged with JA142 and kept in the same room, and the remaining 4 piglets were kept separately as a negative control. In results, the sperms collected from the boars of GBP1E2-GG genotype produced approximately 28~41% higher numbers of heterozygous piglets as compared with those from the boars of GBP1E2-AG genotype. In the challenge study, we found that heterozygous piglets showed the significantly lower levels of viremia than homozygous piglets at 14, 21 and 28 dpc. Consistently, these heterozygous piglets also exhibited significantly higher ADWG than homozygous piglets. Therefore, in the current study, selection of boars based on SNP markers could increase the production of PRRS resistant piglets and the PRRS resistant pigs were found to be more resistant to PRRSV infection.

• Journal of Periodontal and Implant Science
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• v.40 no.1
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• pp.25-32
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• 2010

Purpose: The performance of implant surgery in the posterior maxilla often poses a challenge due to insufficient available bone. Sinus floor elevation was developed to increase the needed vertical height to overcome this problem. However, grafting materials used for the sinus lift technique eventually show resorption. The present study radiographically compared and evaluated the changes in height of the grafting materials after carrying out maxillary sinus elevation with a window opening procedure. This study also evaluated the difference between two xenogenic bone materials when being used for the sinus lifting procedure. Methods: Twenty-one patients were recruited for this study and underwent a sinus lift procedure. All sites were treated with either bovine bone (Bio-$Oss^{(R)}$) with platelet-rich plasma (PRP) or bovine bone (OCS-$B^{(R)}$)/PRP. A total of 69 implants were placed equally 6-8 months after the sinus lift. All sites were clinically and radiographically evaluated right after the implant surgery, 7-12 months, 13-24 months, and 25-48 months after their prosthetic loading. Results: Changes of implant length/bone length with time showed a statistically significant decreasing tendency (P<0.05). There was no significant change in the Bio-$Oss^{(R)}$ group (P>0.05). In contrast, the OCS-$B^{(R)}$ group showed a significant decrease with time (P<0.05). However, no significant difference was observed between the two groups (P>0.05). Conclusions: The results showed that there was significant reduction in comparison with data right after placement, after 7 to 12 months, 13 to 24 months, and over 25 months; however, reduction rates between each period have shown to be without significance. No significant difference in height change was observed between the Bio-$Oss^{(R)}$ and the OCS-$B^{(R)}$ groups.