• The Korean Journal of Physiology and Pharmacology
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• v.23 no.6
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• pp.529-537
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• 2019

Lung cancer is the most common cause of cancer deaths worldwide and several molecular signatures have been developed to predict survival in lung cancer. Increasing evidence suggests that proliferation and migration to promote tumor growth are associated with dysregulated ion channel expression. In this study, by analyzing high-throughput gene expression data, we identify the differentially expressed $K^+$ channel genes in lung cancer. In total, we prioritize ten dysregulated $K^+$ channel genes (5 up-regulated and 5 down-regulated genes, which were designated as K-10) in lung tumor tissue compared with normal tissue. A risk scoring system combined with the K-10 signature accurately predicts clinical outcome in lung cancer, which is independent of standard clinical and pathological prognostic factors including patient age, lymph node involvement, tumor size, and tumor grade. We further indicate that the K-10 potentially predicts clinical outcome in breast and colon cancers. Molecular signature discovered through $K^+$ gene expression profiling may serve as a novel biomarker to assess the risk in lung cancer.

• Journal of Communications and Networks
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• v.17 no.1
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• pp.12-20
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• 2015

Convolutional codes which are terminated by direct truncation (DT) and zero tail termination provide unequal error protection. When DT terminated convolutional codes are used to encode short messages, they have interesting error protection properties. Such codes match the significance of the output bits of common quantizers and therefore lead to a low mean square error (MSE) when they are used to encode quantizer outputs which are transmitted via a noisy digital communication system. A code construction method that allows adapting the code to the channel is introduced, which is based on time-varying convolutional codes. We can show by simulations that DT terminated convolutional codes lead to a lower MSE than standard block codes for all channel conditions. Furthermore, we develop an MSE approximation which is based on an upper bound on the error probability per information bit. By means of this MSE approximation, we compare the convolutional codes to linear unequal error protection code construction methods from the literature for code dimensions which are relevant in analog to digital conversion systems. In numerous situations, the DT terminated convolutional codes have the lowest MSE among all codes.

• Journal of Institute of Control, Robotics and Systems
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• v.6 no.8
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• pp.659-665
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• 2000

In this paper a platoon merging control system is considered as a remotely located system with state represented by a stochastic process. in the system it is common to encounter situations where a single decision maker controls a large number of subsystems and observation and control signals are sent over a communication channel with finite capacity and significant transmission delays. Unlike a classical estimation problem where the observation is a continuous process corrupted by additive noise there is a constraint that the observation must be coded and transmitted over a digital communication channel with fintie capacity. A recursive coder-estimator sequence is a state estimation scheme based on observations transmitted with finite communication capacity constraint. in this paper we introduce a stochastic model for the lead vehicle in a platoon of vehicles in a lane considering the angle between the road surface and a horizontal plane as a stochastic process. In order to merge two platoons the lead vehicle of the following platoon is controlled by a remote control station. Using the observation transmitted over communication channel the remote control station designs the feedback controller. The simulation results show that the intervehicle spacings and the deviations from the desired intervehicle spacing are well regulated.

• Clinical and Experimental Pediatrics
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• v.58 no.8
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• pp.309-312
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• 2015

Permanent neonatal diabetes mellitus refers to diabetes that occurs before the age of 6 months and persists through life. It is a rare disorder affecting one in 0.2-0.5 million live births. Mutations in the gene KCNJ11, encoding the subunit Kir6.2, and ABCC8, encoding SUR1 of the ATP-sensitive potassium ($K_{ATP}$) channel, are the most common causes of permanent neonatal diabetes mellitus. Sulfonylureas close the $K_{ATP}$ channel and increase insulin secretion. KCNJ11 and ABCC8 mutations have important therapeutic implications because sulfonylurea therapy can be effective in treating patients with mutations in the potassium channel subunits. The mutation type, the presence of neurological features, and the duration of diabetes are known to be the major factors affecting the treatment outcome after switching to sulfonylurea therapy. More than 30 mutations in the KCNJ11 gene have been identified. Here, we present our experience with a patient carrying a novel p.H186D heterozygous mutation in the KCNJ11 gene who was successfully treated with oral sulfonylurea.

• JSTS:Journal of Semiconductor Technology and Science
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• v.12 no.1
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• pp.66-74
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• 2012

In this paper, the impact of segregation layer density ($N_{DSL}$) and length ($L_{DSL}$) on scalability and analog/RF performance of dopant-segregated Schottky barrier (DSSB) SOI MOSFET has been investigated in sub-30 nm regime. It has been found that, although by increasing the $N_{DSL}$ the increased off-state leakage, short-channel effects and the parasitic capacitances limits the scalability, the reduced Schottky barrier width at source-to-channel interface improves the analog/RF figures of merit of this device. Moreover, although by reducing the $L_{DSL}$ the increased voltage drop across the underlap length reduces the drive current, the increased effective channel length improves the scalability of this device. Further, the gain-bandwidth product in a common-source amplifier based on optimized DSSB SOI MOSFET has improved by ~40% over an amplifier based on raised source/drain ultrathin-body SOI MOSFET. Thus, optimizing $N_{DSL}$ and $L_{DSL}$ of DSSB SOI MOSFET makes it a suitable candidate for future nanoscale analog/RF circuits.

• Journal of The Korean Society of Clinical Toxicology
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• v.18 no.1
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• pp.1-10
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• 2020

Pharmaceutical agents are the most common causes of poisoning in Korea. Calcium channel blockers (CCBs) are commonly used in Korea for the management of hypertension and other cardiovascular diseases, but are associated with a risk of mortality due to overdose. Due to the frequent fatalities associated with CCB overdose, it is essential that the emergency physician is capable of identifying CCB intoxication, and has the knowledge to manage CCB overdose. This article reviews the existing clinical guidelines, retrospective studies, and systematic reviews on the emergency management of CCB overdose. The following are the varied treatments of CCB overdose currently administered. 1) For asymptomatic patients: observation with enough time and decontamination, if indicated. 2) For symptomatic patients: infusion of calcium salt, high dose insulin therapy, and vasopressor (norepinephrine) or atropine for bradycardia. 3) For patients refractory to the first line therapy or with refractory shock or impending arrest: lipid emulsion therapy and extracorporeal membrane oxygenation. 4) As adjunct therapy: phosphodiesterase inhibitors, glucagon, methylene blue, pacemaker for AV block. Small CCB ingestion is known to be fatal for pediatric patients. Hence, close observation for sufficient time is required.

• The Journal of Korean Medicine
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• v.16 no.2 s.30
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• pp.149-176
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• 1995

The results were as follow: 1. In classification of the virulence of medicines, it is the virulent animal that have a deadly poison and the rest is the animal of weak nor non-toxic. 2. In classification of the channel distribution, the most is the medicine that belongs to liver channel, the next are the stomach, lung, kidney and spleen channel. 3. In classification of four characters, the most parts are cool, common and warm medicine and there is a few that is hot and cooling. 4. In classification of five tastes, the most numerous tastes are sweet and salty and the next are acrid, bitter and sour tastes. 5. In classification of the medical action, there are few medicine of invigorating vital energy, tonic therapy and astringent and a great part of the medicine are regulating vital energy and blood, removing blood stasis and mass, clearing away heat-evil and eliminating sputum, calming the river to inhibit the wind-evil and pain control. 6. In classification of the application of cancer, the most numerous disease is the liver cancer and the next are stomach cancer, esophageal cancer, lung cancer, leukemia, uterine cancer,mastitis, brain tumor.

• East Asian Journal of Business Economics (EAJBE)
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• v.6 no.1
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• pp.47-63
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• 2018

Purpose - The objective of this research is to investigate how selected Korean General Trading Companies, (KGTCs), manage their international distribution channels to sustain the growth of the international marketplace. Specifically, the following questions were answered: What is the profile of the respondents in the position from the company, the experience in channel of distribution operations, the number of distribution channels existing in the international marketplace. Research design, data, methodology -The thirty-nine respondents representing 55 percent have less than 10 years of experience in channel of distribution operations while 34 respondents, equivalent to 45 percent have 10 or more years of experience. All of the respondent KGTCs are using the channel of distribution in their export operations in Asia. Respondent KGTCs' 2015 export sales in Asia were between US$ 100 to 200 million. Results - There are no significant differences in the perceptions of the two groups of respondents with regard to the perceived practices of KGTC in the management of international distribution channels. Exporting companies use common sense when managing conflicts and emphasize the importance of a clear contract which states what obligations and requirements there are of each party in order to prevent conflict. Conclusions - The higher level of details in the contract, the lesser would conflicts arise. The more intense communication, the higher level of information exchange. The higher level of details in the contract, the lesser would conflicts arise.

• ETRI Journal
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• v.39 no.5
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• pp.718-728
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• 2017

Empirical modeling of wireless fading channels using common schemes such as autoregression and the finite state Markov chain (FSMC) is investigated. The conceptual background of both channel structures and the establishment of their mutual dependence in a confined manner are presented. The novel contribution lies in the proposal of a new approach for deriving the state transition probabilities borrowed from economic disciplines, which has not been studied so far with respect to the modeling of FSMC wireless fading channels. The proposed approach is based on equal portioning of the received signal-to-noise ratio, realized by using an alternative probability construction that was initially highlighted by Tauchen. The associated statistical procedure shows that a first-order FSMC with a limited number of channel states can satisfactorily approximate fading. The computational overheads of the proposed technique are analyzed and proven to be less demanding compared to the conventional FSMC approach based on the level crossing rate. Simulations confirm the analytical results and promising performance of the new channel model based on the Tauchen approach without extra complexity costs.

• ETRI Journal
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• v.42 no.5
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• pp.773-780
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• 2020

A 40 nm complementary metal oxide semiconductor carrier-aggregated drive amplifier with high linearity is presented for sub-GHz Internet of Things applications. The proposed drive amplifier consists of two high linear amplifiers, which are composed of five differential cascode cells. Carrier aggregation can be achieved by switching on both the driver amplifiers simultaneously and combining the two independent signals in the current mode. The common gate bias of the cascode cells is selected to maximize the output 1 dB compression point (P1dB) to support high-linear wideband applications, and is used for the local supply voltage of digital circuitry for gain control. The proposed circuit achieved an output P1dB of 10.7 dBm with over 22.8 dBm of output 3rd-order intercept point up to 0.9 GHz and demonstrated a 55 dBc adjacent channel leakage ratio (ACLR) for the 802.11af with -5 dBm channel power. To the best of our knowledge, this is the first demonstration of the wideband carrier-aggregated drive amplifier that achieves the highest ACLR performance.