• Sleep Medicine and Psychophysiology
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• v.1 no.2
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• pp.125-144
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• 1994

Recently excessive daytime sleepiness was found to have relations with various social, occupational, and health problems. This condition is common symptom of several sleep disorders, among which sleep apnea syndrome is most contributive. It is essential to assess daytime sleepiness exactly for the diagnosis of such sleep disorders. Multiple sleep latency test which is a valid and objective measurement technique of sleepiness is time and cost consuming, and so there is increasing need of scales measuring general level of daytime sleepiness which are quick and simple to perform for clinical and research purpose. And also, there have been a lot of sleep researches viewing sleep as a chronobiological process, especially in the study of circadian type of shift workers. In these studies they used various techniques of multiple demensions to assess sleepiness or circadian rhythm which concerns various psychological variables. Of these measurement techniques circadian type questionnaires might have some problems in their psychometric properties. So some of these morningness-eveningness questionnaires have been revised and more valid scales are being suggested by different authors. The author briefly reviewed various measurement techniques of sleepiness and circadian rhythm and introduced recently developed scales which are more valid allegedly, and finally discussed psychometric properties of these morningness-eveningness questionnaires.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.14
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• pp.5977-5981
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• 2015

Background: Worldwide, breast cancer is the most common cancer diagnosed among women and a leading cause of cancer deaths. The age of onset in Iran has become reduced by a decade for unknown reasons. Herceptin, a humanized monoclonal antibody, is a target therapy for breast cancer cells with over expression of HER2-neu receptors, but it is an expensive drug with only 20% beneficial rate of survival. This study introduces a novel approach to enhance the efficacy of this drug through immunoconjugation of the antibody to botulinum toxin. Decreasing the cost and adverse effects of the antibody were secondary goals of this study. Materials and Methods: Botulinum toxin was conjugated with Herceptin using heterobifunctional cross linkers, succinimidyl acetylthiopropionate (SATP) and sulfo-succinimidyl-4-(N-maleimidomethyl) cyclohexane-1-carboxylate (SMCC) according to the supplier's guidelines and tested on two breast cancer cell lines: SK-BR-3 and BT-474. Toxin and Herceptin were also used separately as controls. The cytotoxicity assay was also performed using the new bioconjugate on cultured cells with Alamar blue and a fluorescence plate reader. Results: Herceptin-Toxin bioconjugation significantly improved Herceptin efficacy on both breast cancer cell lines when compared to the control group. Conclusions: Toxin-Herceptin bioconjugation can be a potential candidate with increased efficiency for treating breast cancer patients with over expression of the HER2 receptor.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.13
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• pp.5211-5217
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• 2015

Background: We earlier used PCR-dHPLC for mutation analysis of BRCA1 and BRCA2. In this article we report application of targeted resequencing of 30 genes involved in hereditary cancers. Materials and Methods: A total of 91 patient samples were analysed using a panel of 30 genes in the Illumina HiScan SQ system. CLCBio was used for mapping reads to the reference sequences as well as for quality-based variant detection. All the deleterious mutations were then reconfirmed using Sanger sequencing. Kaplan Meier analysis was conducted to assess the effect of deleterious mutations on disease free and overall survival. Results: Seventy four of the 91 samples had been run earlier using the PCR-dHPLC and no deleterious mutations had been detected while 17 samples were tested for the first time. A total of 24 deleterious mutations were detected, 11 in BRCA1, 4 in BRCA2, 5 in p53, one each in RAD50, RAD52, ATM and TP53BP1. Some 19 deleterious mutations were seen in patients who had been tested earlier with PCR-dHPLC [19/74] and 5/17 in the samples tested for the first time, Together with our earlier detected 21 deleterious mutations in BRCA1 and BRCA2, we now had 45 mutations in 44 patients. BRCA1c.68_69delAG;p.Glu23ValfsX16 mutation was the most common, seen in 10/44 patients. Kaplan Meier survival analysis did not show any difference in disease free and overall survival in the patients with and without deleterious mutations. Conclusions: The NGS platform is more sensitive and cost effective in detecting mutations in genes involved in hereditary breast and/or ovarian cancers.

• Journal of Advanced Marine Engineering and Technology
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• v.39 no.1
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• pp.8-12
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• 2015

Non-esterified bio-diesel fuel saves cost by no esterified process and its performance was more similar to diesel oil than esterified bio-diesel fuel when the fuel blended 95% diesel oil and 5% it was used on diesel engine with electronic control system. A performance optimization is necessary for application of non-esterified bio-diesel fuel blended with diesel oil 95% on the latest diesel engine. In this study, test using fractional factorial design was accomplished at 25% and 50% partial load in order to evaluate influence of controllable 6 factors on responses such as specific fuel consumption, nitrogen oxides and coefficiency of variation of indicated mean effective pressure as basic experiment for performance optimization of this fuel. It is cleared that the injection timing and common rail pressure of 6 factors are mainly effective and its effect level is different according to load.

• Journal of Korean Tunnelling and Underground Space Association
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• v.20 no.5
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• pp.869-886
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• 2018

Rockbolt is one of the most common supports used to reinforce discontinuous rock during underground excavation. Extra drain pipes are installed to improve excavation workability and the anchorage of rockbolts in water bearing ground. The drain pipe is effective in improving the workability by providing drainage path, but it is difficult to expect the reinforcement effect, increasing disturbance of the discontinuous rock mass and the construction cost. To solve this problem, dual purpose rockbolt (DPR) has been developed for the reinforcement of rock and the drainage of ground water. DPR was able to improve the mechanical and hydraulic stability of the rocks quickly and economically. Two kinds of DPRs using FRP (Fiber Reinforced Plastic) and steel were investigated for the mechanical and hydraulic performance. Also, the workability and stability of DPR were analyzed.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.3
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• pp.1037-1040
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• 2015

Hepatitis C is a blood-borne infectious disease of liver, caused by a small enveloped, positive-single stranded RNA virus, called the hepatitis C virus (HCV). HCV belongs to the Flaviviridae family and has 6 genotypes and more than 100 subtypes. It is estimated that 185 million people are infected with HCV worldwide and 5% of these are in Pakistan. The study was designed to evaluate different genotypes of HCV circulating in District Mardan and to know about the behavior of these genotypes to different anti-viral regimes. In this study 3,800 patients were exposed to interferon alfa-2a plus Ribavirin treatment for 6-months and subjected to real-time PCR to check the viral response. Among these 3,677 (97%) patients showed no detectable HCV RNA while 123 (3%) patients (non-responders) remained positive for HCV RNA. Genotypes of their analyzed showed that most of them belonged to the 3a genotype. Non-responders (123) and relapsed (5) patients were subjected to PEG-interferon and Ribavirin therapy for next 6 months, which resulted into elimination of HCV RNA from 110 patients. The genotypes of the persisting resistant samples to anti-viral treatment were 3b, 2a, 1a and 1b. Furthermore, viral RNA from 6 patients remained un-typed while 4 patients showed mixed infections. HCV was found more resistant to antiviral therapy in females as compared to mals. The age group 36-45 in both females and males was found most affected by infection. In general 3a is the most prevalent genotype circulating in district Mardan and the best anti-viral therapy is PEG-interferon plus Ribavirin but it is common practice that due to the high cost patients receive interferon alfa-2a plus Ribavirin with consequent resistance in 3% patients given this treatment regime.

• The Journal of the Korea Contents Association
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• v.11 no.2
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• pp.331-340
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• 2011

The purpose of this research is to target the health examination examinees to compare and analyze the common elements that influence prevention and preventive medical services and to analyze the share of the physical examination categories desired following the analysis by element. Likewise, this research was attempted to provide base data so that it is possible to reduce cost required for the prevention and treatment of each examination. This research targeted health examination examinees and conducted survey from April 1to May 31, 2010. The key findings after conducting analysis on 707 examinees are as follows. In case of men, those who are older and who live their spouses tended to be subjected to health examination, cancer examination and preventive injections. Those who had subscribed to the medical policy from the private sector, those with healthy state, those with higher educational level, tended to get health examination, cancer examination and preventive injections less. In case of women, those who are older, tended to get health examination and cancer examination more while those who had subscribed to the medical policy from the private sector and those with higher educational level tended to get health examination, cancer examination and preventive injections less. Those who are healthy and who live their spouse tended to get more cancerexamination and preventive injections.

• Journal of KIISE:Software and Applications
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• v.36 no.7
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• pp.590-606
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• 2009

We present a static analyzer that detects memory leaks in C programs. It achieves relatively high accuracy at a relatively low cost on SPEC2000 benchmarks and several open-source software packages, demonstrating its practicality and competitive edge against other reported analyzers: for a set of benchmarks totaling 1,777 KLOCs, it found 332 bugs with 47 additional false positives (a 12.4% false-positive ratio), and the average analysis speed was 720 LOC/sec. We separately analyze each procedure's memory behavior into a summary that is used in analyzing its call sites. Each procedural summary is parameterized by the procedure's call context so that it can be instantiated at different call sites. What information to capture in each procedural summary has been carefully tuned so that the summary should not lose any common memory-leak-related behaviors in real-world C program. Because each procedure is summarized by conventional fixpoint iteration over the abstract semantics ('a la abstract interpretation), the analyzer naturally handles arbitrary call cycles from direct or indirect recursive calls.

• The Journal of Society for e-Business Studies
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• v.9 no.2
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• pp.145-161
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• 2004

CBD(Component Based Development) can make use of component of block unit that is implementation beforehand and shorten software development cost and time. Also, component can reduce complexity for the large application development because it can hide detail part of internal and offer interface. Common requirement of family in the enterprise framework environment can express workflow, but it is very difficult that express special workflow in single component on various family member's requirement. Therefore, necessity about workflow variability management between component for family member and implementation method had been required constantly This treatise presents implementation techniques for component workflow variability in enterprise framework under .NET base. Presented component workflow variability implementation techniques supposes that commonness business workflow that family can use in enterprise workflow was created already in component, and improve workflow's extensity between component by workflow composition between special component and techniques for practice to various family member.

• The Journal of Society for e-Business Studies
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• v.18 no.2
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• pp.81-93
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• 2013

Remote user authentication is a method, in which remote server verifies the legitimacy of a user over an common communication channel. Currently, smart card based remote user authentication schemes have been widely adopted due to their low computational cost and convenient portability for the mutual authentication. 2009 years, Wang et al.'s proposed a dynamic ID-based remote user authentication schemes using smart cards. They presented that their scheme preserves anonymity of user, has the feature of storing password chosen by the server, and protected from several attacks. However, in this paper, I point out that Wang et al.'s scheme has practical vulnerability. I found that their scheme does not provide anonymity of a user during authentication. In addition, the user does not have the right to choose a password. And his scheme is vulnerable to limited replay attacks. In particular, the parameter y to be delivered to the user is ambiguous. To overcome these security faults, I propose an enhanced authentication scheme, which covers all the identified weakness of Wang et al.'s scheme and an efficient user authentication scheme that preserve perfect anonymity to both the outsider and remote server.