• International journal of advanced smart convergence
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• 제13권2호
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• pp.222-228
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• 2024

The purpose of this study was to investigate the effect of 8 weeks of forestry exercise on the quality of life and physical self-concept of breast cancer survivors. The subjects of this study were eight breast cancer survivors 6 months after mastectomy. The forest combined exercise program consisted of aerobic exercise through forest walking and resistance exercise using elastic bands. The forest combined exercise was conducted twice for 8 weeks. Forest trekking consisted of a 2km walking speed and resistance exercise consisted of three levels of sets and intensity. The format was divided into gradual increases. The exercise time was 40 to 60 minutes for forest trekking, 20 to 30 minutes for descent, and 40 to 60 minutes for resistance exercise, for a total of 120 to 130 minutes per day. Breast cancer survivors' quality of life was measured using a questionnaire, and changes in quality of life were measured using a t-test (α=.05). Physical self-concept was assessed through in-depth interviews. There was no statistically significant difference in quality of life before and after 8 weeks of combined forestry exercise, but there was a slight tendency to increase in the area of physical well-being. Physical self-concept showed positive changes in motivation, physical strength improvement, health promotion, physical competence, and self-confidence through the forest composite exercise. Therefore, the forest composite exercise is believed to have a positive effect on the physical self-concept of breast cancer survivors.

• Journal of Microbiology and Biotechnology
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• 제13권3호
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• pp.338-343
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• 2003

Various factors, such as the adsorption pH, adjuvant dose, and adjuvant age, which affect the adsorption degree and immunogenicity of an antigen, were investigated. In addition, the effect of pH, antigen content, and adjuvant content on immunogenicity was also studied through animal experiments. Within the ranges studied, a low pH for adsorption, freshly preformed gel, and low pH formulation for the combined DTwP-HepB vaccine were preferrable for the adsorption of the antigens. In addition, a higher DT content was found to have a positive effect on the HBsAg immunogenicity in the combined vaccine. Accordingly, considering the factors affecting the adsorption rate and immunogenicity of the antigens, a novel DTwP-HepB vaccine (40 Lf/ml of diphtheria toxoid, 15 Lf/ml of tetanus toxoid, 20 OU/ml of detoxified whole cell pertussis, $24\;\mu\textrm{g}$ of HBsAg, $24\;\mu\textrm{g}\;Al/ml\;of \;Al(OH)_3\;gel,\;776\;\mu\textrm{g}\; Al/ml\;of\;AIPO_4\;gel$, and pH 7.1) was developed, whose immunogenicity was comparable to the case of administrating, separately and simultaneously, a combined DTwP vaccine (40 Lf/ml of diphtheria toxoid, 15 Lf/ml of tetanus toxoid, 20 OU/ml of detoxified whole cell pertussis, $300\;\mu\textrm{g}\;Al/ml\;of\; AIPO_4\;gel$, and pH 7.1) and mono HepB vaccine [$Hepavax^{\circledR},\;24\;\mu\textrm{g}/ml$ of HBsAg and $500\;\mu\textrm{g}\;Al/ml\;of\;Al(OH)_3\;gel$], which satisfies the potency criteria of the K-FDA for a combined DTwP vaccine and mono HepB vaccine.

• 디지털융복합연구
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• 제13권4호
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• pp.387-393
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• 2015

본 연구는 12주간 비만 여성을 대상으로 규칙적인 복합운동과 policosanol 섭취 병행이 염증표지인자 LDH와 CPK, Leptin에 미치는 변화를 분석함으로써 복합운동과 policosanol 섭취 병행이 생체 방어반응과 지방세포 조절 호르몬 변화에 미치는 영향을 규명하는데 있다. 통제집단 12명, policosanol 섭취집단 12명, 복합운동집단 12명, 복합 처치 집단 12명으로 무선 배정하였고 주 2회는 근저항성 운동, 주2회는 걷기형태의 유산소운동을 실시하였다. 12주 후 LDH는 운동시기에서 유의한 차이를 보였고(p<.01), 운동시기와 그룹간의 상호작용 효과에서도 유의한 차이 (p<.05)를 나타냈다. 또한 leptin의 변화에서는 운동시기에 유의한 차이(p<.001)를 나타내었다. 이상의 결과를 종합하면 복합 운동이나, policosanol 섭취는 염증표지인자와 렙틴에 긍정적인 영향을 미치며, 복합운동과 policosanol 섭취의 병행은 그 효과를 더욱 증대시키는 것으로 사료된다.

• 한국식품영양과학회지
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• 제46권10호
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• pp.1265-1269
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• 2017

본 연구에서는 신선 농산물의 미생물학적 안전성을 제고하기 위해 항균 효과가 있는 clove bud essential oil(CBEO)과 mild heat(MH) 처리를 병합 처리하여 Escherichia coli O157:H7이 접종된 red oak leaf의 미생물 수 변화를 측정하였다. 0.2% CBEO와 $50^{\circ}C$ MH 병합 처리구는 단순 물세척 처리구보다 1.45 log CFU/g 더 낮은 미생물 수를 나타내어 모든 병합 조건 중 가장 높은 미생물 제어 효과를 보였다. 또한, 본 병합 처리구는 비 세척 처리구와 비교하여 9일간의 저장 기간 동안 1.67~2.25 log CFU/g 더 낮은 미생물 수를 나타내어 미생물 제어 효과가 지속됨을 확인하였다. 따라서 이러한 결과들로부터 CBEO와 MH의 병합 세척 처리는 저장 중 red oak leaf와 같은 신선 농산물의 미생물학적 안전성을 확보하는 데 효과적으로 사용될 수 있다고 판단된다.

• Geomechanics and Engineering
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• 제24권2호
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• pp.129-141
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• 2021

The vacuum preloading method has been used in many countries for soil improvement and land reclamation. However, the treatment time is long and the improvement effect is poor for the straight-line vacuum preloading method. To alleviate such problems, a novel combined air booster and straight-line vacuum preloading method for shallow ground treatment is proposed in this study. Two types of traditional vacuum preloading and combined air booster and straight-line vacuum preloading tests were conducted and monitored in the field. In both tests, the depth of prefabricated vertical drains (PVDs) is 4.5m, the distance between PVDs is 0.8m, and the vacuum preloading time is 60 days. The prominent difference between the two methods is when the preloading time is 45 days, the injection pressure of 250 kPa is adopted for combined air booster and straight-line vacuum preloading test to inject air into the ground. Based on the monitoring data, this paper systematically studied the mechanical parameters, hydraulic conductivity, pore water pressure, settlement and subsoil bearing capacity, as determined by the vane shear strength, to demonstrate that the air-pressurizing system can improve the consolidation. The consolidation time decreased by 15 days, the pore water pressure decreased to 60.49%, and the settlement and vane shear strengths increased by 45.31% and 6.29%, respectively, at the surface. These results demonstrate the validity of the combined air booster and straight-line vacuum preloading method. Compared with the traditional vacuum preloading, the combined air booster and straight-line vacuum preloading method has better reinforcement effect. In addition, an estimation method for evaluating the average degree of consolidation and an empirical formula for evaluating the subsoil bearing capacity are proposed to assist in engineering decision making.

• 대한정형도수물리치료학회지
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• 제29권2호
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• pp.49-57
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• 2023

Background: This study aims to investigate the effect of lower limb strengthening training combined with electro muscle stimulation on the quadriceps femoris muscle activity of soccer players. Methods: Thirty university soccer players were selected as study subjects and divided into a lower limb strengthening training group combined with EMS (Group I) and a general lower limb strengthening training group (Group II), and 15 subjects were randomly assigned. After receiving general soccer training, subjects in this study additionally mediated lower limb strengthening training combined with EMS and general lower limb strengthening training for 26 minutes, 3 times a week for 8 weeks. Quadriceps femoris muscle activity was analyzed before mediation. Vastus medialis, vastus lateralis, and rectus femoris were measured with maximum isometric contraction in the manual muscle test position in order to analyze leg muscle activity. The same items as above were re-measured and a between-group analysis was conducted after 8 weeks of mediation. Results: As a result of comparative analysis of lower extremity muscle activity between groups, the lower limb strengthening training group combined with EMS showed a statistically significant difference in lower extremity muscle activity compared to the general lower limb strengthening training group. Conclusion: As a result, it was found that lower limb strengthening training combined with EMS was more effective in improving quadriceps femoris muscle activity. Based on this study, we are going to provide basic data on the possibility of using EMS in the field of sports rehabilitation for soccer players.

• Journal of Veterinary Science
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• 제25권1호
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• pp.12.1-12.10
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• 2024

Background: Staphylococcus aureus and S. pseudintermedius are the major etiological agents of staphylococcal infections in humans, livestock, and companion animals. The misuse of antimicrobial drugs has led to the emergence of antimicrobial-resistant Staphylococcus spp., including methicillin-resistant S. aureus (MRSA) and methicillin-resistant S. pseudintermedius (MRSP). One novel therapeutic approach against MRSA and MRSP is a peptide nucleic acid (PNA) that can bind to the target nucleotide strands and block expression. Previously, two PNAs conjugated with cell-penetrating peptides (P-PNAs), antisense PNA (ASP)-cmk and ASP-deoD, targeting two essential genes in S. aureus, were constructed, and their antibacterial activities were analyzed. Objectives: This study analyzed the combined antibacterial effects of P-PNAs on S. aureus and S. pseudintermedius clinical isolates. Methods: S. aureus ATCC 29740 cells were treated simultaneously with serially diluted ASP-cmk and ASP-deoD, and the minimal inhibitory concentrations (MICs) were measured. The combined P-PNA mixture was then treated with S. aureus and S. pseudintermedius veterinary isolates at the determined MIC, and the antibacterial effect was examined. Results: The combined treatment of two P-PNAs showed higher antibacterial activity than the individual treatments. The MICs of two individual P-PNAs were 20 and 25 µM, whereas that of the combined treatment was 10 µM. The application of a combined treatment to clinical Staphylococcus spp. revealed S. aureus isolates to be resistant to P-PNAs and S. pseudintermedius isolates to be susceptible. Conclusions: These observations highlight the complexity of designing ASPs with high efficacy for potential applications in treating staphylococcal infections in humans and animals.

• Journal of Acupuncture Research
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• 제18권1호
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• pp.76-87
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• 2001

Objective : Zusanli(ST36) and Hoku(Li4) are analgesic acupuncture points frequently used for acupuncture in Oriental medicine. The present study was conducted to see the antinociceptive effects produced by electroacupuncture combined two frequencies(Low, High) and two different acupuncture points(LI4, ST36) in the rat tail flick test. Method : In this study the Rats (Sprague-Dawley, 250-300g) were partially anesthetized with thiopental sodium(40mg/kg, i.p.). The basal reaction time for the tail-flick was 3${\pm}$0.5 sec. Low frequency(3Hz, 5V, biphasic) and high frequency(100Hz, 5V, biphasic) were applied to the inserted needle for the period of insertion(twenty minutes). Experimental groups are divied as follow; a) electroacupuncture stimulation groups at Hoku with or high frequency(L-EA, H-EA), b) electroacupuncture stimulation groups at Zusanli with low or high frequency(1-EA, h-EA), c) low frequency at Hoku and Zusanli(LIEA), d) low frequency at Hoku and high frequency at Zusanli(LhEA), e) high frequency at Hoku and low frequency at Zusanli(HIEA), f) high frequency at Hoku and Zusanli(HhEA) Results : The individual stimulation at either Hoku or Zusanli with low frequency has stronger and longer analgesic effect than high frequency stimulation. In addition, the combined stimulation at Hoku and Zusanli with low frequency has superior effect to individual stimulation with low frequency. LhEA and LIEA have superior effect to other stimulation groups among the combined groups. In order to determine the involvement of opioid system on the different antinociceptive effects, Naloxone, an opioid antagonist, was used in the combined groups. LIEA is the most sensitive when naloxone was administrated among study groups. HhEA is the least sensitive in the administration of naloxone. Conclusion : From results, this study confirmed that the opioid system is involved in analgesic effect of low frequency stimulation of acupuncture point, and we also can suggest the stronger analgesic effect of combining stimulation points is due to the theory of spatial summation in the nervous system.

• 한국환경과학회지
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• 제8권2호
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• pp.145-150
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• 1999

To estimate the thermal effect of the vegetation canopy on the surface sublayer environment numerically, we used the combined model of Pielke's1) single layer model for vegetation and Deardorff's2) Force restore method(FRM) for soil layer. Application of present combined model to three surface conditions, ie., unsaturated bare soil, saturated bare soil and saturated vegetation canopy, showed followings; The diurnal temperature range of saturated vegetation canopy is only 20K, while saturated bare soil and unsaturated bare soil surface are 30K, 35K, respectively. The maximum temperature of vegetation canopy occurs at noon, about 2 hours earlier than that of the non-vegetation cases. The peak latent heat fluxes of vegetation canopy is simulated as a 600Wm-2 at 1300 LST. They have higher values during afternoon than beforenoon. Furthermore, the energy redistribution ratios to latent heat fluxes also increased in the late afternoon. Therefore, oasis effect driving from the vegetation canopy is reinforced during late afternoon compared with the non-vegetated conditions.

• Journal of Acupuncture Research
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• 제31권4호
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• pp.163-171
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• 2014

Objectives : The aim of this study was to observe the effect of needle-embedding combined with oriental medical treatment therapy on hemifacial spasm. Methods : 2 patients were treated with needle-embedding therapy with oriental medical treatment. After treatment, we evaluated the effect by Scott's scale. And we checked the satisfaction degree and side effect. Results : After treatment, the grade of spasm classified by Scott's scale was decreased and hemifacial spasm was visibly improved. Conclusions : This study showed that needle-embedding therapy with oriental medical treatment was effective to improve hemifacial spasm.