• Journal of the korean academy of Pediatric Dentistry
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• v.29 no.4
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• pp.625-631
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• 2002

The effect of combinations of 8 antimicrobial agents on the growth of Streptococcus mutans and Streptococcus sobrinus was investigated with the minimum inhibitory concentration and fractional inhibitory concentration(FIC) and ${\Sigma}FIC$ index. According to the ${\Sigma}FIC$ values by. The American Society for Microbiology and Berenbaum, Approximately 34% and 82% of the combinations were synergistic respectively. Partial synergy described by Isenberg was also observed in the half of the combinations. There was a tendency for additive antimicrobial effect against cariogenic bacteria though the test results showed difference according to the applied values. It may be beneficial to use combined antimicrobial agents that have various activities against an ecosystem and metabolism of bacteria than using individual agents.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.46 no.5
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• pp.14-28
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• 2009

The PageRank algorithm is an important component for ranking Web pages in Google and other search engines. While many improvements for the original PageRank algorithm have been proposed, it is unclear which variations (and their combinations) provide the "best" ranked results. In this paper, we evaluate the ranking quality of the well-known variations of the original PageRank algorithm and their combinations. In order to do this, we first classify the variations into link-based approaches, which exploit the link structure of the Web, and knowledge-based approaches, which exploit the semantics of the Web. We then propose algorithms that combine the ranking algorithms in these two approaches and implement both the variations and their combinations. For our evaluation, we perform extensive experiments using a real data set of one million Web pages. Through the experiments, we find the algorithms that provide the best ranked results from either the variations or their combinations.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.29 no.2
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• pp.82-97
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• 2016

Objective : The aim of this study was to search and analyze the herbal combinations in formulas used to treat atopic dermatitis in Korean medicine. Methods : Articles on the atopy were searched for from among those registered on the OASIS up to December, 2015. After the articles were reviewed, information on both internal and external formulas for atopy was constructed. Then, the herbal combination in the formulas was analyzed by using frequency distribution, network analysis, and data mining. Results : The combination of 'Saposhnikovia Radix - Schizonepetae Spica' and 'Scutellariae Radix - Phellodendri Cortex ' was mostly used in both internal and external formulas to treat atopy in articles. By using the network analysis and data mining, twelve combinations including ' (Saposhnikovia Radix, Ponciri Fructus Pericarpium) - (Platycodi Radix, Schizonepetae Spica) ' were discovered. Five effective combinations were also searched for external formulas.Conclusions : This study could help researchers to analyze the formulas in various ways. Moreover, the herbal combination in atopy formulas could be used to search for atopy formulas in other databases or make a new prescription.

• Korean Journal of Clinical Pharmacy
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• v.23 no.3
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• pp.239-247
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• 2013

Background: Fixed drug combinations are formulations containing two or more active ingredients in a single dosage form. Such combination therapies are commonly applied to improve efficacy, reduce adverse events and replace co-administration, etc. National and international guidelines for hypertension treatment recommend addition of other classes of antihypertensive drugs rather than incremental dose of mono-therapy, when blood pressure is not adequately controlled. Thus, many dual combinations of antihypertensive drugs have been approved and pharmaceutical companies are recently interested in developing antihypertensive triple combinations. Clinical trial designs for the fixed combinations are various depending on the target patients, dosage and clinical endpoints. Thereby, further discussions for the clinical trials of antihypertensive triple therapies are required regarding the indication claimed. Conclusion: This article provides a review for the assessment of the label and medical reports of the clinical trials on antihypertensive triple therapies in advanced foreign countries.

• Korean Journal of Oriental Medicine
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• v.17 no.3
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• pp.61-68
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• 2011

Through analyzing the frequencies of medicinal herb combinations in the prescriptions of "Wenbingtiaobian(溫病條辨)", we could understand the characteristics of prescription composition and author's medical thoughts. So we conducted this study that analyze combination of 258 medicinal herbs in 206 prescriptions, and found meaningful combinations of 700. Among these, the most meaningful combinations are the two of 8 herbs. One consists of Glycyrrhiza uralensis Fischer, Platycodon grandiflorum, Lonicera japonica Thunberg, Sojae Semen Praeparatum, Mentha piperascens (Malinv.) Holmes, Forsythia suspensa, Phyllostachys nigra var henonis, Schizonepeta tenuifolia var. japonic, the other consists of Glycyrrhiza uralensis Fischer, Platycodon grandiflorum, Lonicera japonica Thunberg, Mentha piperascens (Malinv.) Holmes, Forsythia suspensa, Arctium lappa, Phyllostachys nigra var henonis, Schizonepeta tenuifolia var. japonica. The former is Yeonkyo-san without Arctium lapp, the letter is Yeonkyo-san without Sojae Semen Praeparatum. It means these combinations are kind of modified Yeonkyo-san which is effective in outthrustting through the exterior with pungent-cool and clearing heat and detoxify. In conclusion, prescriptions of "Wenbingtiaobian(溫病條辨)" involve herbs mostly used to outthrust through the exterior with pungent-cool and clear heat and detoxify. Through this study, we know the author' s one of medical view points on outthrustting through the exterior with pungent-cool and clearing heat and detoxify.

• Wind and Structures
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• v.29 no.5
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• pp.323-337
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• 2019

Wind tunnel testing technique has been established as a powerful experimental method for predicting wind-induced loads on high-rise buildings. Accurate assessment of the design wind load combinations for tall buildings on the basis of wind tunnel tests is an extremely important and complicated issue. The traditional design practice for determining wind load combinations relies partly on subjective judgments and lacks a systematic and reliable method of evaluating critical load cases. This paper presents a novel optimization-based framework for determining wind tunnel derived load cases for the structural design of wind sensitive tall buildings. The peak factor is used to predict the expected maximum resultant responses from the correlated three-dimensional wind loads measured at each wind angle. An optimized convex hull is further developed to serve as the design envelope in which the peak values of the resultant responses at any azimuth angle are enclosed to represent the critical wind load cases. Furthermore, the appropriate number of load cases used for design purposes can be predicted based on a set of Pareto solutions. One 30-story building example is used to illustrate the effectiveness and practical application of the proposed optimization-based technique for the evaluation of peak resultant wind-induced load cases.

• Journal of Acupuncture & Meridian Studies
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• v.11 no.6
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• pp.367-374
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• 2018

This study describes the reliability of pragmatic combinations of acupuncture points for lateral epicondylalgia (LE) as prescribed by physiotherapists who were experts in acupuncture. Raters (n = 14; 33-59 years) independently prescribed acupuncture points for 30 simulated human patients with LE who were surveyed via a printed questionnaire. The frequency and cooccurrence of acupuncture points prescribed for patients with lateral epicondylitis were assessed. Absolute agreement and Light's kappa (${\kappa}_{Light}$) with 95% confidence interval (CI) were used to quantify the interrater agreement. Raters prescribed 103 unique acupuncture points in different combinations with a median (min-max) of 5 (0-11) acupuncture points. The most prescribed acupuncture point was LI-11 (297 of 420; 71%), and the most common cooccurring acupuncture points were LI-11 and LI-4 (160 of 420; 38%). The absolute agreement for prescribing the acupuncture points ranged from 70% (point GB-20) to 0% (points LI-10, SP-6, LI-11, GB-34, LI-12, and LI-4). Point LR-3 showed the highest interrater reliability for prescribing the acupuncture points [${\kappa}_{Light}=0.112$, 95% CI = (0.055-0.194)], whereas point LI-4 showed the lowest reliability [${\kappa}_{Light}=-0.003$, 95% CI = (-0.024 to 0.024)]. These findings suggest that pragmatic prescriptions of acupuncture points for LE are unreliable among physiotherapists who are experts in acupuncture. Explicit, high-level evidence-based rules for prescribing and teaching combinations of acupuncture points for LE are warranted.

• Nuclear Engineering and Technology
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• v.54 no.6
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• pp.2276-2296
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• 2022

This study validates the applicability of the CUPID code for simulating subcooled wall boiling under high-pressure conditions against number of DEBORA tests. In addition, a new numerical technique in which the interfacial momentum non-drag forces are calculated at the cell faces rather than the center is presented. This method reduced the numerical instability often triggered by calculating these terms at the cell center. Simulation results showed good agreement against the experimental data except for the bubble sizes in the bulk. Thus, a new model to calculate the Sauter mean diameter is proposed. Next, the effect of the relationship between the bubble departure diameter (D_dep) and the nucleation site density (N) on the performance of the Wall Heat Flux Partitioning (WHFP) model is investigated. Three correlations for D_dep and two for N are grouped into six combinations. Results by the different combinations show that despite the significant difference in the calculated D_dep, most combinations reasonably predict vapor distribution and liquid temperature. Analysis of the axial propagations of wall boiling parameters shows that the N term stabilizes the inconsistences in D_dep values by following a behavior reflective of D_dep to keep the total energy balance. Moreover, ratio of the heat flux components vary widely along the flow depending on the combinations. These results suggest that separate validation of D_dep correlations may be insufficient since its performance relies on the accompanying N correlations.

• Nuclear Engineering and Technology
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• v.54 no.1
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• pp.110-116
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• 2022

Human failure event (HFE) dependency analysis is a part of human reliability analysis (HRA). For efficient HFE dependency analysis, a maximum number of minimal cut sets (MCSs) that have HFE combinations are generated from the fault trees for the probabilistic safety assessment (PSA) of nuclear power plants (NPPs). After collecting potential HFE combinations, dependency levels of subsequent HFEs on the preceding HFEs in each MCS are analyzed and assigned as conditional probabilities. Then, HFE recovery is performed to reflect these conditional probabilities in MCSs by modifying MCSs. Inappropriate HFE dependency analysis and HFE recovery might lead to an inaccurate core damage frequency (CDF). Using the above process, HFE recovery is performed on MCSs that are generated with a non-zero truncation limit, where many MCSs that have HFE combinations are truncated. As a result, the resultant CDF might be underestimated. In this paper, a new method is suggested to incorporate HFE recovery into the MCS generation stage. Compared to the current approach with a separate HFE recovery after MCS generation, this new method can (1) reduce the total time and burden for MCS generation and HFE recovery, (2) prevent the truncation of MCSs that have dependent HFEs, and (3) avoid CDF underestimation. This new method is a simple but very effective means of performing MCS generation and HFE recovery simultaneously and improving CDF accuracy. The effectiveness and strength of the new method are clearly demonstrated and discussed with fault trees and HFE combinations that have joint probabilities.

• International Journal of Industrial Entomology and Biomaterials
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• v.47 no.1
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• pp.34-43
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• 2023

The eighteen (18) F₁ hybrid combinations were tested to identify potential combinations adaptable to type 1 climatic conditions in the Philippines. The six (6) bivoltine purelines (DMMMSU 108, DMMMSU 109, DMMMSU 110, DMMMSU 111, DMMMSU 113, and DMMMSU 119); and three (3) multivoltine purelines (DMMMSU 1000, DMMMSU 1007, and DMMMSU 1014), were crossed (multivoltine x bivoltine) in a mating plan. These were arranged in a Completely Randomized Design (CRD), replicated three times, and analyzed using Analysis of Variance (ANOVA). A test of significance was done using ANOVA across years and Tukey's Honest Significant Difference Test (HSD). The multiple trait evaluation index (EI) method was also used in the identification of potential F₁ hybrids. Three major phases were done: (1) parental rearing of multivoltine and bivoltine pure lines for breed multiplication; (2) hybridization process; and (3) evaluation of F₁ hybrids. Rearing evaluations were conducted for three consecutive years. Based from the three evaluations, 10 potential crosses were identified: DMMMSU MV-12, DMMMSU MV-11, DMMMSU MV-13, DMMMSU MV-16, DMMMSU MV-07, DMMMSU MV-14, DMMMSU MV-05, DMMMSU MV-09, DMMMSU MV-03, and DMMSU MV-10. The topmost combinations with the best economic and commercial characters and are consistently adaptable during two (2) cropping seasons were DMMMSU MV-07, DMMMSU MV-12, DMMMSU MV-05, DMMMSU MV-09 and DMMMSU MV-11. These newly-identified F₁ hybrids are considered potential breeds that could improve cocoon production.