• Proceedings of the Korean Society of Plant Pathology Conference
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• 2003.10a
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• pp.84.1-84
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• 2003

Magnaporthe grisea, the casual agent of rice blast, forms an appressorium to penetrate its host. Much has been learned about environmental cues and signal transduction pathways, especially those involving CAMP and MAP kinases, on appressorium formation during the last decade. More recently, pharmacological data suggest that calcium/calmodulin-dependent signaling system is involved in its appressorium formation. To determine the role of phosphoinositide-specific phospholipase C (PI-PLC) on appressorium formation, a gene (WPLCl) encoding PI-PLC was cloned and characterized from M. grisea strain 70-15. Sequence analysis showed that MPLCl has alt five conserved domains present in other phospholipase C genes from several filamentous fungi and mammals. Null mutants (mplcl) generated by targeted gene disruption exhibited pleiotropic effects on conidial morphology, appressorium formation, fertility and pathogenicity. mplcl mutants developed nonfunctional appressoria and are also defective in infectious growth in host tissues. Defects in appressorium formation and pathogenicity in mplcl mutants were complemented by a mouse PLCdelta-1 cDNA under the control of the MPLCl promoter. These results suggest that cellular signaling mediated by MPLCl plays crucial and diverse roles in development and pathogenicity of M. grisea, and functional conservation between fungal and mammalian Pl-PLCs.

• Biomedical Science Letters
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• v.20 no.1
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• pp.25-31
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• 2014

Atopic dermatitis (AD) is an inflammatory, relapsing, chronic skin disease and lesions in AD are frequently colonized with Staphylococcus aureus (S. aureus). Activation of T cells and IgE production by staphylococcal enterotoxins B (SEB) plays a crucial role in the pathogenesis of AD. Enterococcus faecalis (E. faecalis) is a nonpathogenic bacterium and produces the probiotic products that have been shown to have inhibitory effects on inflammatory responses. In present study, we carried out to assess the anti-inflammatory role of lyzed E. faecalis against the damaging effects of SEB on AD related immune responses. Furthermore, we attempted to determine whether the co-cultured lyzed E. faecalis can influence the colonization of S. aureus. As a result, we identified the effect of E. faecalis lysate as a potent therapeutic agent for atopic dermatitis (AD). E. faecalis lysate reduces the productions of total IgE and cytokines of AD-related immune cells in response to SEB stimulation. The proliferation of S. aureus was also inhibited by E. faecalis lysate. In conclusions, E. faecalis lysate may improve the skin-defense system disturbed by atopic condition, and may prevent subsequent secondary infection of S. aureus and development of AD.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.12 no.6
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• pp.478-487
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• 2002

This paper presents a hybrid method to compute the solutions of an optimization Problem. The present hybrid algorithm is the synthesis of an artificial life algorithm and the random tabu search method. The artificial life algorithm has the most important feature called emergence. The emergence is the result of dynamic interaction among the individuals consisting of the system and is not found in an individual. The conventional artificial life algorithm for optimization is a stochastic searching algorithm using the feature of artificial life. Emergent colonies appear at the optimum locations in an artificial ecology. And the locations are the optimum solutions. We combined the feature of random-tabu search method with the conventional algorithm. The feature of random-tabu search method is to divide any given region into sub-regions. The enhanced artificial life algorithm (EALA) not only converge faster than the conventional artificial life algorithm, but also gives a more accurate solution. In addition, this algorithm can find all global optimum solutions. The enhanced artificial life algorithm is applied to the optimum design of high-speed, short journal bearings and its usefulness is verified through an optimization problem.

• Journal of The Korea Institute of Healthcare Architecture
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• v.11 no.3
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• pp.61-73
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• 2005

Recently, Korea is becoming a world-leading country in various industrial fields with it's advanced information technology. In the 20th century, Korea went through a chaotic period from Japanese colonization via the Korean war to IMF because of lack of globalization. Now, we have a mission and the abilities to lead world-wide trends in entire fields of society. This study, comparing the modern healthcare planning trends in Korea, China, Japan and the United States, proposes the Northeast Asia Healthcare Network Plan which Korea leads. United States is the starter of healthcare network, but it's location is too far from Asia and IT is also inferior to the Korean. Japan seems to have no concerns with this healthcare network. And the current China is a rapid growing period and is too much for building its domestic healthcare infra-structure. they still have no concerns with re-structuring of healthcare system and facilities. Because of these reasons, I think Korea should have to lead Northeast Asia Healthcare network.

• Environmental Engineering Research
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• v.19 no.3
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• pp.275-281
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• 2014

Aim of this study was to investigate biofilms attached in pipeline of water reuse from the MBR system treating sewage without chlorination in correlation to the outflow water quality. Two general pipe materials: polyvinyl chloride (PVC) and polyethylene (PE) were employed in the experiment. The peak growths were found at week 4 in both pipes. The maximum biofilms in PE pipe was $33mgVSS/cm^2$ with the growth rate of $4.75mgVSS/cm^2-d$ which was significant higher than that of PVC pipe. Biofilms examined by PCR-DGGE technique revealed five bacterial species in PE biofilms namely Sinorhizobium medicae WSM419, Sinorhizobium fredii NGR234, Geobacter sp. M18, Parachlamydia acanthamoebae UV-7, and Mycobacterium chubuense NBB4. The VSS concentrations in outflow had directly correlated to the biofilm attachment and detachment. High COD concentrations of outflow appeared during biofilm detaching phase. In summary, water quality of reuse water corresponded to the biofilms attachment and detachment in the pipeline.

• The Southeast Asian review
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• v.21 no.2
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• pp.1-41
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• 2011

Southeast Asia developed maritime trade from the early period due to the suitable physical and cultural conditions. The land consists of peninsular and archipelago, and located at the junction of the two monsoons in South China Sea and India Ocean. The people inherit cultural openness to receive outer influences positively. When Portuguese came to Southeast Asia in 16th century, the region had already enjoyed certain level of commercial development and sociocultural dynamics through the long time experience of interactions with outer world. The Portuguese contact to Southeast Asia was more of participation and assimilation than of conquest and rule experienced in South America. It was due to the higher level of spiritual and material civilization existed in Southeast Asia. Portuguese brought several new elements into Southeast Asia such as colonization and new weapons, Cartaz system and commercial monopoly, and Catholic mission and Casado policy. These new elements, however, did not impact much on the existing Maritime trade that played an important role to change the sociocultural structure of Southeast Asia. Even though Portuguese contact itself did not make significant differences in Southeast Asia, it was meaningful in a sense that it opened a path and left a model case for the more powerful Europeans who came soon after her.

• Journal of Microbiology and Biotechnology
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• v.33 no.10
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• pp.1309-1316
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• 2023

To exert their beneficial effects, it is essential for the commensal bacteria of probiotic supplements to be sufficiently protected as they pass through the low pH environment of the stomach, and effectively colonize the intestinal epithelium downstream. Here, we investigated the effect of a multilayer coating containing red ginseng dietary fiber, on the acid tolerance, and the adhesion and proliferation capacities of three Lactobacillus strains (Limosilactobacillus reuteri KGC1901, Lacticaseibacillus casei KGC1201, Limosilactobacillus fermentum KGC1601) isolated from Panax ginseng, using HT-29 cells, mucin-coated plates, and human pluripotent stem cell-derived intestinal epithelial cells as in vitro models of human gut physiology. We observed that the multilayer-coated strains displayed improved survival rates after passage through gastric juice, as well as high adhesion and proliferation capacities within the various gut epithelial systems tested, compared to their uncoated counterparts. Our findings demonstrated that the multilayer coat effectively protected commensal microbiota and led to improved adhesion and colonization of intestinal epithelial cells, and consequently to higher probiotic efficacy.

• The Journal of Fisheries Business Administration
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• v.14 no.2
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• pp.110-138
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• 1983

After Liberation of Korea, Korean fisheries economy fell into an exhausted conditions because of the damage of Japanese colonization policy and the Korean War, and fisheries organizations of those days established for the improvement of fishermen's welfare could not carry out their primary purposes and functions. Under such circumstances, Fisheries Cooperatives starting on April 1st in 1961 played a great role in settling the socio-economic confusion of those days. Fisheries financing was also more systematic and substantial after establishment of Fisheries Cooperatives. In fact fisheries industry was faced with much more riskiness than any other industry on account of its speciality and such a riskiness induced general financial institutions to be reluctant to lend money to the fishermen. In order to overcome such a capital rationing, it was necessary to establish the reciprocal financing system based on the principle of mutual protection of economic weakers. Credit business in Fisheries Cooperatives beginning in 1963 was mainly dependent on governmental fund as fund sources. But the size of fund was too small to satisfy fishermen's fund demand, therefore Fisheries Cooperatives carried out the movement of raising its own fund. As a result of the movement the ratio of its own fund to total funds amounted to 47.7% in 1980, but external funds still take a greater part of all funds. To settle the weakness of the ratio of its own fund and chronic deficiency of fund, a conclusion can be drawn as follows : 1. The enlargement of Fisheries Cooperatives' raising ability of funds. .The expansion of urban branch to absorb idle funds in urban area. .The diversification of financing service to compete with genetral financial institutions. 2. The enlargement of governmental fund and preferential treatment of fishermen's savings. 3. Vitalization of mutual finance and fixation of Fisheries Cooperatives' two-phase organization. 4. The re-enforcement of supervisory financing and post management system.

• Health Policy and Management
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• v.23 no.2
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• pp.196-206
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• 2013

On September 24th of 1945, the existing Health Department under the Bureau of Economy and Trade was abolished complying with the Article 1 of the Ordinance of US military occupation "Establishment of Health Bureau". After the establishment of the Health Bureau, one of its first priorities was to select South Korean medical doctors and send them away to the US for training "in order to educate the talents necessary for the Health Bureau to address the public hygiene and health issues of Korea". Under the sponsorship of Rockefeller Foundation, the US Military Government sent 10 Korean medical doctors to three universities. After they came back to Korea from the training in the US, they played significant roles in building and managing the Korean health and medical system under the US Military Government as well as during the post-war of Korea and in the 1960s-1970s. Furthermore, they made a great contribution to expanding and transplanting the 'American-style' health and medical system in heath administration, health research and medical education in Korea. On the one hand, this means the limitation and elimination of an independent, progressive idea in the health and medical field as the influence of the US within the country after the liberation expanded. The lives of 10 doctor represent an important symbol of how the Korean health and medical field has been established under the domestic and overseas political conditions, 'colonization-liberation-military occupation of the Powers', and one part of the concrete history.

• Journal of the Korean association of regional geographers
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• v.3 no.1
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• pp.135-154
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• 1997

The purpose of this study is to clarify the reason of the change of production-and-marketing system and of the regional division. The data for this study were collected by administering interviews with people engaging in hemp fabric industry: namely, craftsmen and managers in the production and marketing of "hemp fabric" handcraft. The summary of this study is as follows: First, the hemp fabric industry is a main subsidiary business of agriculture in Andong. The process of making hemp fabric heavily depends on manual labor. The process is divided into five stages: namely, cultivating hemp, pre-reeling, reeling, weaving, and colouring. Second, Andong "hemp fabric" handicrafts industry had been continuously growth until the late 1960s. During the period of Japan colonization, it was under boom condition: while the other traditional fabric industries were declined. In the 1970s, the decrease of the demand of hemp fabric was the result of mass production of substitute goods on factory system: while, in the 1980s, the growth of per capital income play an important role in bringing about the increased demand of hemp fabric. Third, in the 1980s. production-and-marketing system was changed as the result of the effort to improve the quality and the process, the advanced age of craftsmen, and the weak function of existing marketing systems. The social division of labor within the district is well developed between cultivating hemp, reeling and weaving. The social division of labor is also found in the partly process of handcratfs, and between the production and marketing. The social division of labor between production and marketing is not strongly developed to establish a reliable enterprise that develops a new product and opens a new market. Fourth, the spatial boundary of the production of hemp fabric handcrafts becomes limited into a special region based on the regional specialization of hemp cultivating and the differentiation of utilization of labor.