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Radiosurgical Techniques and Clinical Outcomes of Gamma Knife Radiosurgery for Brainstem Arteriovenous Malformations

  • Choi, Hyuk Jai;Choi, Seok Keun;Lim, Young Jin
    • Journal of Korean Neurosurgical Society
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    • v.52 no.6
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    • pp.534-540
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    • 2012
  • Objective : Brainstem arteriovenous malformation (AVM) is rare and radiosurgical management is complicated by the sensitivity of the adjacent neurological structures. Complete obliteration of the nidus is not always possible. We describe over 20 years of radiosurgical procedures for brainstem AVMs, focusing on clinical outcomes and radiosurgical techniques. Methods : Between 1992 and 2011, the authors performed gamma knife radiosurgery (GKRS) in 464 cerebral AVMs. Twenty-nine of the 464 patients (6.3%) reviewed had brainstem AVMs. This series included sixteen males and thirteen females with a mean age of 30.7 years (range : 5-71 years). The symptoms that led to diagnoses were as follows : an altered mentality (5 patients, 17.3%), motor weakness (10 patients, 34.5%), cranial nerve symptoms (3 patients, 10.3%), headache (6 patients, 20.7%), dizziness (3 patients, 10.3%), and seizures (2 patients, 6.9%). Two patients had undergone a previous nidus resection, and three patients had undergone a previous embolization. Twenty-four patients underwent only GKRS. With respect to the nidus type and blood flow, the ratio of compact type to diffuse type and high flow to low flow were 17 : 12 and 16 : 13, respectively. In this series, 24 patients (82.8%) had a prior hemorrhage. The mean target volume was 1.7 $cm^3$ (range 0.1-11.3 $cm^3$). The mean maximal and marginal radiation doses were 38.5 Gy (range 28.6-43.6 Gy) and 23.4 Gy (range 18-27 Gy), and the mean isodose profile was 61.3% (range 50-70%). Results : Twenty-four patients had brainstem AVMs and were followed for more than 3 years. Obliteration of the AVMs was eventually documented in 17 patients (70.8%) over a mean follow-up period of 77.5 months (range 36-216 months). With respect to nidus type and blood flow, the obliteration rate of compact types (75%) was higher than that of diffuse types (66.7%), and the obliteration rate of low flow AVMs (76.9%) was higher than that of high flow AVMs (63.6%) (p<0.05). Two patients (6.9%) with three hemorrhagic events suffered a hemorrhage during the follow-up period. The annual bleeding rate of AVM after GKRS was 1.95% per year. No adverse radiation effects or delayed cystic formations were found. Conclusion : GKRS has an important clinical role in treatment of brainstem AVMs, which carry excessive surgical risks. Angiographic features and radiosurgical techniques using a lower maximal dose with higher isodose profiles are important for lesion obliteration and the avoidance of complications.

MANDIBULAR ADVANCEMENT WITH DISTRACTION OSTEOGENESIS FOR ADULT CLASS II MALOCCLUSION PATIENT WITH CONDYLAR RESORPTION (악관절 흡수양상을 보이는 성인 하악 후퇴증 환자에서 양측 하악골 골신장술을 이용한 하악 전진술)

  • Paeng, Jun-Young;Lee, Sang-Woo;Lee, Jin-Yong;Myoung, Hoon;Hwang, Soon-Jung;Seo, Byoung-Moo;Choi, Jin-Young;Lee, Jong-Ho;Choung, Pill-Hoon;Kim, Myung-Jin
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.29 no.3
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    • pp.217-226
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    • 2007
  • Purpose: Distraction osteogenesis is considered to take favorable effect on the TMJ and be beneficial to prevent the relapse after the mandibular advancement of Class II malocclusion patient. This is the report with literature review on the mandibular advancement in the patients showing preoperative condylar resorption and who need larger amount of advancement. Patients and method: Distraction osteogenesis using intraoral device was performed for three mandibular hypoplasia patients (one male and two females). All patients were adult over 18 years old. The patients showed condylar bony resorption preoperatively. The distraction was performed intraorally with modified SSRO. After 7 days of latency period, activation was performed at the rate of 1.0 mm/day with twice turn. The devices were removed after 4-8 month consolidation period. Results: Total advancement of mandible was average 13 mm. One patient showed openbite immediately after removal of distraction device. It took long time to guide the openbite with elastics. The comparison between cephalometries immediately after device removal and postoperative six month revealed average 3.4 mm relapse. This means that mandibular advancement with distraction osteogenesis needs overcorrection and elastic rehabilitation even after enough consolidation periods. Conclusion: Larger amount of mandibular advancement could be achieved with distraction osteogenesis in severe mandibular hypoplasia with condylar resorption. However, some relapse was found during the follow-up period and the over correction is considered to be needed. The effect of distraction osteogenesis seems to be investigated with long-term follow-up.

The Analysis of the P-VEP on the Normal Monocular Vision and Amblyopia in Binocular (앙안에서 정상 단안시와 약시안의 P-VEP 분석)

  • Kim, Douk-Hoon;Kim, Gyu-Su;Sung, A-Young;Park, Won-Hak
    • Journal of Korean Ophthalmic Optics Society
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    • v.10 no.1
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    • pp.41-46
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    • 2005
  • The aim of the study was performed the wave analysis of P-VEP on the normal monocular vision and amblyopia in binocular. The P-VEP of three channels were recorded by the Nicolet system. Five adults (three males, two females, mean=22 years, range=19 to 24) subjects were recorded The subjects were researched the history including the systemic health, medication, genetics, allergy and ocular disease. Visual acuity and stereopsis were recorded for each subject monocularly and binocularly. Also subjects viewed the P-VEP stimulus both monocularly and binocularly through the corrected visual acuity during the VEP were recorded. The results of study suggest that the visual acuity of binocularly is better than with monocularly and the stereopsis was about over 140 sec. On the other hand, the analysis of P-VEP suggest that the amplitude of wave is larger when the monocular eye receives the P-VEP stimulus compared with the binocular eye. However the amplitude of wave in amblyopia had more smaller than the normal monocular The latency period of P-VEP was similar to results between the normal eye and binocular vision. But the amblyopia was a long period compared with the normal monocular and binocular vision. In conclusion, this study indicated that the visual acuity of binocularly have a better than the normal monocular vision, But in the P-VEP test, the amplitude of wave on normal monocularly vision appears to be better through the binocularly. But the amblyopia appeared the low amplitude wave of P-VEP and decreased the visual acuity.

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Comparison on Accommodative Response Changes in the Normal Group and Convergence Insufficiency (정상군과 폭주부족군에서 조절반응 변화량의 비교)

  • Kwak, Ho-Weon;Lee, Se-Hee;Kwak, Hyung-Bin
    • Journal of Korean Ophthalmic Optics Society
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    • v.19 no.1
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    • pp.79-85
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    • 2014
  • Purpose: This study investigated accommodative changes by measuring accommodative response, appearing on the normal and convergence insufficiency Group, by using both eyes open-view auto-refractometer (Nvision-K5001, shin-nippon, Japan). Methods: It carried out objective and subjective refractions, targeting 74 college students (54 males and 20 females) aged between 19 and 29 ($21.59{\pm}2.53$), spherical equivalent OD $-2.28{\pm}2.03$ D, OS $-2.18{\pm}2.01$ D, by measuring accommodative responses at full correction and under correction with plus lens +0.25, +0.50, +0.75 arbitrarily added. Results: In the group of normal and convergence insufficiency, the shorter fixation distances were, the greater accommodative lags showed. The group of convergence insufficiency showed the lesser changes of accommodative response than those of normal. But we found that the convergence insufficiency group had a little larger accommodative amplitude in the total fixation distances. The full correction of convergence insufficiency group and the under correction (+0.50 D) of normal were alike in the accommodative responses. We have also investigated that the correlation between accommodative responses and fixation distances was decreased steeply at the excessive low vision correction. Conclusions: Under correction (+0.50 D) in a near distance is expected to avoid unnecessary accommodative responses, make eyes relaxed and comfortable.

A study of elementary school pupils using traditional herbal medicines (초등학생에서 한약 이용 실태에 관한 연구)

  • Ahn, Young Joon
    • Clinical and Experimental Pediatrics
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    • v.50 no.4
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    • pp.381-385
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    • 2007
  • Purpose : Traditional herbal medicines may be overused in Korea. Expenditures and inaccuracies of hospital prescription are increasing gradually. So we investigated the frequency and nature of herbal medicine use among elementary school pupils. Methods : We interviewed students of three elementary schools located in Gwangju with survey papers. We analyzed 905 returned surveys. Results : They consisted of 421 males and 484 females. Five hundred ninety (65.2 percent) of pupils who have taken herbal medicines since birth. First grade made up 74.1 percent, 2nd grade 63.0 percent, 3rd grade 64.8 percent, 4th grade 63.3 percent, 5th grade 65.5 percent, and sixth grade 61.9 percent, respectively. The mean frequency of herbal medicine use was 3.2 times. 6th grade was 3.3 times, 5th grade 3.9 times, 4th grade 3.7 times, 3rd grade 2.7 times, 2nd grade 2.7 times, and 1st grade 2.6 times, respectively. The mean cost of herbal medicine use was from 50,00-100,000 won. The mean age of pupils who took their 1st herbal medicine was 55 months, 6th grade 67 months, 5th grade 58 months, 4th grade 54 months, 3rd grade 55 months, 2nd grade 51 months, and 1st grade 47 months. The most common reason of herbal medicine use was "looking weak, without disease." The rate of elementary pupils who had good effects was 63.7 percent; the rate of side effects was 4.5 percent. Conclusions : The rate of elementary pupils who took herbal medicines was high and gradually higher in lower grades. So, clinicians have to cope directly with this situation and to educate parents about herbal medicines.

A study on the use of dental hygiene devices in Korean adolescents (청소년의 구강관리보조용품 사용에 관한 연구)

  • Park, Sin-Young;Ryu, So-Yeon
    • Journal of Korean society of Dental Hygiene
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    • v.17 no.2
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    • pp.181-191
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    • 2017
  • Objectives: The objective of the study was to investigate the use of dental hygiene devices in Korean adolescents. Methods: The study subjects were 70,362 adolescents in 800 schools who completed the 2015 Korean Youth Risk Behavior Web-based survey. Dependent variables included usage of dental floss, interdental brushes and mouthwash solutions. Independent variables included demographic characteristics of the subjects, health state and behaviors, and oral health behaviors and experience of oral diseases. Results: The related factors of usage of dental hygiene devices included gender, where females showed higher usage (OR=1.10) compared to males, father and mother's level of education where usage was higher in above university graduates (OR=1.20, OR=1.14) compared to less than high school graduation, economic status where usage was higherin high and middle (OR=1.93, OR=1.26) compared to low, vigorous physical activity where usage was higher in those who responded yes (OR=1.35) compared to no, subjective weight recognition where usage was higher in normal (OR=1.07) compared to under weight, sleep time where usage was higher in enough (OR=1.12) compared to not enough, number of toothbrushing (day) where usage was higher in 2 times or over 3 times (OR=1.35, OR=1.75) compared to below 1, oral health education experience (OR=1.10), sealant experience (OR=1.17) and scaling experience (OR=1.45) where usage was higher in those who responded yes compared to no, school where usage was lower in high school (OR=0.64) compared to middle school, residential type where usage was lower in rural area (OR=0.74) compared to metropolitan area, living form where usage was lower in other (OR=0.77), compared to with family, smoking (OR=0.93), and alcohol drinking (OR=0.90) where usage was lower in those who engage in the activities compared to those who didn't, BMI where usage was lower in normal (OR=0.87) and over weight (OR=0.98) compared to under weight. Conclusions: To expand the use of dental hygiene devices in the adolescents, it is necessary to improve the continuing education program for need and motivation of dental hygiene device usage.

Effects of Thoracolumbosacral Orthosis on Cobb angle at The Idiopathic Scoliosis (흉요천추 보조기착용이 특발성 척추 측만증 환자의 Cobb 각도 개성에 미치는 효과)

  • Song Jun-Chan;Lee Hyun-kee;Chang In-Su;Park Rae-Joon
    • The Journal of Korean Physical Therapy
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    • v.14 no.4
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    • pp.274-307
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    • 2002
  • The TLSO was customized for this study in OO ortho-prosthesis institute from Jan. 1th., 2000 to Dec. 31th., 2000 and in order to measure effects of TLSO. 20 females in a growth period applicable to medical care took part in this study, they were on accidental spine scoliosis (From $15^{\circ}to35^{\circ}$). They were consisted of Group I(10 chest-bend) and Group II (10 dual-bend). The results were follows: 1. It showed the average difference in height by 1.37cm, 3.14cm in comparison between before and after TLSO, before and after one year and they were also statistically available(p < .05). 2. It showed the average difference in Cobb angle of a chest and waist by ($-10.95^{\circ},-8.50^{\circ}$), between before and right after TLSO. The results means that the Cobb angle of the chest and weist at right after TLSO was largely decreased, and it was also statistically available(p < .05). 3. It showed the difference in Cobb angle of the chest waist by $-9.50^{\circ},-7.35^{\circ} $ between before and one year after TLSO. It means that the Cobb angle of the chest and waist at the one year after TLSO was largely decreased, and it was also statistically available(p < .05). 4. It showed the difference in Cobb angle of the chest and waist by $2.34^{\circ},2.15^{\circ} $ between the right after and the one year after. TLSO, but the change of Cobb angle of the chest was regularly constant by a little increased, and it was also statistically available(p < .05). 5. In the measurement of the change of Cobb angle of the chest and waist according to the taking time on TLSO, it showed the slightest change in 10 people on TLSO for 23 hours by $13.30^{\circ},11.20^{\circ}$ , the change in 6 people on TLSO for 16 hours by $14.75^{\circ},12.67^{\circ}$, the change in 4 people on TLSO for 8 hours by $16.83^{\circ},14.00^{\circ} $ in this order. It means that the longer time on TLSO was to be the smaller the Cobb angle of the chest and waist, but it was not statistically available.

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ANS responses in Negative Emotions Induced by Audio-visual Film Clips (시청각 동영상에 의해 유발된 부정적 감성에 따른 자율신경계 반응)

  • Lee, Young-Chang;Jang, Eun-Hye;Chung, Soon-Cheol;Sohn, Jin-Hun
    • Science of Emotion and Sensibility
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    • v.10 no.3
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    • pp.471-480
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    • 2007
  • Negative emotions play an important function as to human's existence. In this research, we employed the audio-visual film clips to induce negative emotions and examined the classified responses in the autonomic nervous system(ANS) due to each negative emotion.30 adults(22.6 years $old{\pm}1.24$, 15 males and 15 females) took part in this experiment. Through the preliminary experiment, 2 minutes film's stimuli were selected as the emotion-induced stimuli. During the period when participants were viewing and listening to the selected movie, EDA and ECG were examined as soon as one stimulus was displayed, participants were tested by completing the psychological appraisals of their experienced emotion due to each emotional stimulus. With regard to the result of analyzing the psychological responses, each negative emotion appropriately and effectively induced its target emotion. While concerning the result of analyzing ANS responses, each negative emotion induced its respective activation in ANS. What is more, compared with other types of negative emotional stimuli, the scaring stimulus induced higher activation of the sympathetic nervour system(SNS) as to the indexes in EDh and ECG. This research made segmentation of ANS responses to each negative emotion, which has its significance.

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A Clinical Effect on Quality of Life to Allergic Rhinitis Patients treated by Quingbixiaoyanwan-Derivatives (청비소염환(淸鼻消炎丸)이 알레르기성 비염환자의 삶의 질에 미치는 임상적 효과)

  • Rhee, Hyung-Koo;Han, Dong-Ha
    • The Journal of Internal Korean Medicine
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    • v.23 no.1
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    • pp.73-81
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    • 2002
  • Objective : in order to be convinced of improvement in quality of life in allergic rhinitis patients, I observed clinically remedical effect of Quingbixiaoyanwan-Derivatives(淸鼻消炎丸) on allergic rhinitis with a questionnaire. Methods : We treated forty five allergic patients at the Nam Chun Oriental Medical Hospital from October, 2001 to January, 2002. They were treated with Quingbixiaoyanwan-Derivatives(淸鼻消炎丸), nasal cleansing solution and dietary treatment, and the health-related quality of life with a questionnaire. Results : 1. The gender proportion was twenty five males(55.6%) and twenty females(44.4%); seven teenagers (15.6%); ten patients in their 20s(22.2%); twenty patients in their 30S(44.4%); six patients in their 40s(13.3%); two patients in over 50s (4.4%) 2. The duration of the disease: 0 case within six months; three cases for six months to one year (6.6%); fourteen cases for one year to five years(31.1%); twenty six cases for over five years(62.2%) 3. Major symptoms; forty three cases for watery rhinorrhea (95.5%); thirty one caess for nasal itching(68.8%); 91.1 cases for sneezing(41.0%);thirty nine cases for nasal obstruction (86.6%); sixteen cases for difficulty in smelling(35.5%);seventeen postnasal drip(37.7%);three bloody rhinorrhea (6.6%);fourteen cases for headaches(31.1%); nine cases for eyelid itching (60.0%). 4. Seasonal Distribution: perennial allergic rhinitis occurred as follows: 55.6% in winter; 13.3% in fall; 11.1 % in spring;2.2% in summer. 5. Other combined allergic symptoms; sixteen cases for allergic conjunctives (37.8%); eight cases for sinus(17.8%);four cases for atopic dermatitis (8.9%); three cases for bronchial asthma(6.7%); sixteen cases for none(35.6%) 6. After a specific prescription of Quingbixiaoyanwan-Derivatives(淸鼻消炎丸), nasal cleansing solution and dietary therapy, the quality of life in allergic rhinitis patients was improved to 20.27%, which was significantly.(P<0.001) 7. The specific treatment did not affect GOT/GPT and BUN/Creatinine. 8. The specific treatment did not influence the level of total IgE serum significantly. Conclusions : Based on the above results, I have concluded that the specific treatment of Quingbixiaoyanwan-Derivatives(淸鼻消炎丸), nasal cleansing solution and dietary therapy can improve the quality of life in allergic rhinitis patients.

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Educational Effects of Self-directed Learning Method Using 3D Printing Products on Radiological Science Students (3D 프린팅 구조물을 이용한 자기주도 학습방법이 방사선학과 학생들에 미치는 교육 효과)

  • Seoung, Youl-Hun
    • Journal of the Korean Society of Radiology
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    • v.14 no.1
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    • pp.45-51
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    • 2020
  • The purpose of this study was to analyze the educational effect of self-directed learning method using 3D printed anatomy on radiological science students. The subjects were 32 students (20 males and 12 females) in the second year of radiological science at university. They were divided two groups as a non-active student group and an active student group. A learning method was self-directed learning using 3D printed anatomical structures, and the effects of quantitative learning improvement were evaluated before and after the learning. The qualitative evaluation of the students was analyzed on the Likert's 5-point scale for the interest, satisfaction, and learning effects (memorization convenience of anatomy name, radiography Interpret ability, understanding on bones structure, and X-ray projection technique). As a result, the enhancement of learning improved 65.4% on average, and all students got scored high on all variables. Especially non-active student groups showed higher correlation coefficients in all variables except interest and radiography interpret than active student groups. These results might suggest that self-directed learning using 3D printed anatomical structures could have a positive educational effect on radiological science students.