• Journal of Microbiology and Biotechnology
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• 제22권5호
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• pp.708-720
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• 2012

In this study, we assessed the effects of ginsenoside Re (GRe) administration on repeated immobilization stress-induced behavioral alterations using the forced swimming test (FST), the elevated plus maze (EPM), and the active avoidance conditioning test (AAT). Additionally, we examined the effect of GRe on the central adrenergic system by observing changes in neuronal tyrosine hydroxylase (TH) immunoreactivity and brain-derived neurotrophic factor (BDNF) mRNA expression in the rat brain. Male rats received 10, 20, or 50 mg/kg GRe (i.p.) 30 min before daily exposures to repeated immobilization stress (2 h/day) for 10 days. Activation of the hypothalamic-pituitary-adrenal (HPA) axis in response to repeated immobilization was confirmed by measuring serum levels of corticosterone (CORT) and the expression of corticotrophin-releasing factor (CRF) in the hypothalamus. Repeated immobilization stress increased immobility in the FST and reduced open-arm exploration in the EPM test. It also increased the probability of escape failures in the AAT test, indicating a reduced avoidance response. Daily administration of GRe during the repeated immobilization stress period significantly inhibited the stress-induced behavioral deficits in these behavioral tests. Administration of GRe also significantly blocked the increase in TH expression in the locus coeruleus (LC) and the decrease in BDNF mRNA expression in the hippocampus. Taken together, these findings indicate that administration of GRe prior to immobilization stress significantly improved helpless behaviors and cognitive impairment, possibly through modulating the central noradrenergic system in rats. These findings suggest that GRe may be a useful agent for treating complex symptoms of depression, anxiety, and cognitive impairment.

• 인지과학
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• 제35권2호
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• pp.113-127
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• 2024

주의와 정서는 밀접하게 상호작용한다, 이중 불안정서은 주의 메커니즘을 수정하여 위협 관련 정보를 더 효과적으로 처리한다고 알려져 있다. 이런 현상은 주로 정서스트룹 과제의 연구결과로 나타났는데, 이 과제에서 불안한 참가자는 중성적 단어보다 부정적 단어의 색이름을 말하는데 더 늦은 반응을 보인다는 것이며, 이를 불안 관련 주의편향이라고 한다. 그러나 이런 주의편향 현상이 정보처리의 어떤 단계에서 발생하는지는 아직 많은 논란이 있어왔다. 본 연구에서는 정서스트룹과제를 변형하여 단어와 색을 분리하고 두 자극의 제시 시간을 조작하여(SOA 0ms, 120ms, & 240ms) 정서스트룹관련 주의편향이 정보처리의 초기 단계에서 일어나는지를 조사하였다. 실험결과 불안을 가진 참가자의 경우 0ms의 SOA에서만 부정단어에 의해 간섭 효과가 나타난 반면, 불안하지 않은 참가자의 경우 간섭 효과는 나타나지 않았다. 이러한 결과는 불안이 주의 메커니즘을 조절하여 정서정보처리의 초기단계에서 부정 정보를 더 빠르게 처리하도록 조절한다는 주의의 초기개입 가설을 지지하는 것으로 나타났다.

• 한국생활과학회지
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• 제22권4호
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• pp.539-558
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• 2013

The purpose of this study is to examine relationships among university students' self-differentiation, self-esteem and mental health. The subjects were 400 students of four universities in Busan and Gyungnam area. A questionnaire survey was done. The results of this study are as follows : First, the levels of university students' self-differentiation and self-esteem were high. Second, university students' self-differentiation and self-esteem were correlated positively. Third, the levels of university students' depression and anxiety were relatively low. It showed that the subjects' mental health of this study were not bad. Fourth, depression had no significant difference by gender. However, female students had higher anxiety than male students had. Fifth, university students' self-differentiation and self-esteem had negative correlation with depression and anxiety, and self-esteem played a role of mediating variable between self-differentiation and mental health. Sixth, family projection, family regression and self integration of self-differentiation had indirect influence upon the students' mental health through self-esteem, while cognitive-emotional function had direct influence upon mental health and had indirect influence upon mental health through self-esteem as well. In this study, university students' self-differentiation and self-esteem were found to be important variables having influence upon mental health, and self-differentiation had indirect influence upon mental health through self-esteem. Counselling intervention strategies should be established considering self-differentiation and self-esteem of the students who complained about their maladjusted emotion and human relation problems at schools. Also, programs enhancing self-differentiation and self-esteem of university students should be developed and the execution of these programs will be needed to help the university students who experienced mental health problems such as depression, anxiety and so on.

• 한국콘텐츠학회논문지
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• 제14권11호
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• pp.1008-1018
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• 2014

본 연구의 목적은 한국 중학생의 남 여학생과 영어 학업성취도에 따라 구분된 상 하위의 두 집단 간 학업적 자기효능감과 시험불안에 차이가 있는가를 알아보는 것이다. 연구 대상은 중학생 98명으로 이들 중 남학생은 36명, 여학생은 62명이다. 본 연구에서는 학업적 자기효능감과 시험불안 수준 측정을 위해 설문지를 이용하였다. 그리고 성별과 성적으로 분류된 두 집단 간 학업적 자기효능감과 시험불안의 차이를 알아보기 위해 t검증을 실시하였다. 연구 결과는 성별로 나누어진 두 집단 간 학업적 자기효능감과 시험불안의 차이는 통계적으로 매우 유의적인 차이가 발견되었다. 그러나 영어 학업성취도로 분류된 상 하위의 두 집단 간 학업적 자기효능감과 시험불안의 차이는 통계적으로 유의미한 차이가 없었다. 향후 연구는 본 연구에서 나타난 연구 도구와 연구 대상의 제한점을 고려하여 보다 폭넓게 이루어져야 하겠다. 또한 두 집단 간의 다른 정의적 변수의 차이에 관해서도 이루어져야 된다고 본다.

• 한국학교수학회논문집
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• 제17권4호
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• pp.589-611
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• 2014

정도의 차이는 있겠지만 사람이면 누구나 불안을 경험하기 때문에 수학불안증에 대한 연구는 수학교육이 발달하면서부터 주요 주제가 되어왔다. 최근엔 기기의 발달로 그간 연구하기 힘들었던 뇌 과학 연구의 새 영역이 가능해진 바 본 연구에서는 시대적 변화에 따른 수학불안증을 재조명하고, 이를 측정할 수 있는 방법과 수학불안증 감소 방안에 대한 선행연구의 결과를 종합적으로 분석하여 앞으로의 연구방향에 시사점을 얻고자 하였다. 연구결과로써 몇 안 되는 뇌 과학적 접근을 시도한 연구에서는 단순연산과제만을 사용하였는데 심지어 대학생을 대상으로 한 연구에서도 이와 유사한 문제를 사용하였다. 검사지를 활용한 연구에서는 인지적, 정의적 영역을 모두 조사할 수 있는 다차원적 검사척도가 개발되었다. 수학불안증 감소를 위한 처치로는 인지적 행동적 방법에 체계적 둔감법, 이완훈련, 그리고 이들을 복합적으로 사용한 임상상담기법 등이 사용되었으며 교수 학습 방법으로 STAD 교수법, 쓰기기법 등 개발되었으나 좀 더 세분화되고 신뢰도 있는 방안들이 앞으로 더 많이 연구되어져야함을 알 수 있었다.

• 생물정신의학
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• 제24권4호
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• pp.212-218
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• 2017

Objectives We aimed to examine whether mindfulness skills are mediating the improvements of depressive symptoms in patients with mood disorders who practiced Mindfulness-Based Cognitive Therapy (MBCT). Methods A total of 19 patients with mood disorder were included in this study. The participants were divided into two subgroups: a normal to mild depression group and a moderate depression group. The participants completed questionnaires to assess depressive symptoms, anxiety, quality of life, suicidal idea, and mindfulness skills which were measured by the Five Facets of Mindfulness Questionnaire (FFMQ) before and after MBCT course. Results The moderate depression group showed improvements through MBCT in depressive symptoms and suicidal idea, but not in anxiety and quality of life. The normal to mild depression group showed no significant change through MBCT. The improvement of depressive symptoms in the moderate depression group was predictable by improvements of the five facets of mindfulness, especially by 'observe' and 'non-react' components. Conclusions This study showed that currently depressive patients with moderate severity but not with normal to mild severity benefit from MBCT in reducing depressive symptoms and suicidal idea. The improvement of depressive symptoms was mediated by improved mindfulness skills through MBCT.

• 대한간호학회지
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• 제13권2호
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• pp.1-21
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• 1983

The purposes of this study were to(a) develop theoretical modifications of the extended gate control theory of pain using Fishbein's model and（b) test the efficacy of these modifications. Attitude, social subjective norm, personal subjective norm, habit and state anxiety were operationalized to represent internal stimuli for the cognitive-evaluative and motivational-affective dimensions of the theory. Pain expression was operationalized as sensory and affective responses to pain, and pain endurance. Sixty-two female nurses from 20 to 50 years of age participated. A semantic differential scale measured attitude and motivations to comply; a Likerty-type scale measured personal and social norms and habit. Spielberger's STAI measured state anxiety, Pain was produced using a modified submaximum effort tourniquet technique. Pair expression was measured using ratio scales of sensory intensity and unpleasantness developed by Gracely and his associates. Pain endurance was measured by subtracting time of pain threshold from pain tolerance. The first hypothesis examining whether pain endurance would be more significantly related to the affective response than to the sensory response was net rejected. Four remaining hypotheses, testing the ability of the five variables to predict the sensory and affective responses were not rejected. However, the habit of pain expression and the attitude toward pain expression contributed to the prediction of both sensory and affective responses to pain. The interaction between the cognitive-evaluative and the sensory-discriminative dimensions and the interaction between the cognitive-evaluative and motivational-affective dimensions were partially supported by the data from these two variables. The interaction between the motivational-affective and the sensory-discriminative dimensions was also supported by the relationship of sensory to affective responses. The variables which did not significantly predict pain expression appeared to have potential for prediction. Revision and testing of the tools for better reliability, validity, and clinical usuability are needed. The study contributed to theory building. The identification of variables which pre-dict pain behavior must occur before effective nursing interventions can be developed.

• 대한불안의학회지
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• 제4권2호
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• pp.148-156
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• 2008

Objective : Although cognitive-behavior therapy (CBT) is effective in patients with panic disorder, its the-rapeutic mechanism of action in the brain remains unclear. This study was performed to investigate regional blood flow changes associated with successful completion of CBT in drug-naive patients with panic disorder. Method : The regional blood flow in 4 patients with panic disorder was compared to that in 11 healthy controls before and after a 12-week group CBT using $^{99m}Tc$-ECD SPECT imaging. Psychopathology was assessed using Panic Disorder Severity Scale. Data were analyzed using software for statistical parametric mapping (SPM2). Results : Before CBT, significantly decreased blood flow was found in the parietal and occipital area in panic patients than normal volunteers. In all the patients who showed remission after CBT, increased blood flow was detected in the right cingulate gyrus, left lingual gyrus, and left superior parietal lobule, whereas decreased blood flow was seen in the left inferior temporal gyrus. Conclusion : These results suggested that CBT is effective for panic disorder and change the activity of cingulate gyrus and left temporal gyrus, a part of the brain areas associated with fear in panic disorder.

• 정신신체의학
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• 제20권2호
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• pp.105-111
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• 2012

연구목적 : 본 연구는 경도인지장애(Mild cognitive impairment, 이하 MCI)와 알쯔하이머형 치매(Dementia of Alzheimer's type, 이하 AD)의 신경정신증상 빈도와 점수를 조사하고 비교 분석한 뒤, 인지기능과 Korean Neuropsychiatric Inventory(K-NPI) 결과와의 상관관계를 알아보고자 하였다. 방 법 : MCI 또는 AD를 진단받은 163명의 환자들을 세 군으로 분류하였다. K-NPI를 이용하여 MCI 환자 55명, 경도의 AD 환자 56명, 중등도 이상의 AD 환자 52명을 대상으로 신경정신증상을 조사하였고, 세 군간의 K-NPI의 부척도별 빈도와 composite score를 비교하였다. 결 과 : MCI군에서 가장 흔한 증상은 우울/불쾌감, 수면/야간행동, 불안, 과민/불안정 순이었다. 경도 AD군에서의 증상은 초조/공격, 우울/불쾌감, 불안, 무감동/무관심, 수면/야간행동 순으로 빈번하게 나타났다. 중등도 이상 AD 군에서는 무감동/무관심, 우울/불쾌감, 초조/공격, 망상 순이었다. 이 중 망상, 환각, 초조/공격, 무감동/무관심, 이상행동증상, 식욕/식습관의 변화의 빈도는 세 군 간에 통계적으로 유의한 차이를 나타내었다. 총 NPI 점수는 MMSE-KC 점수와는 음의 상관관계를, GDS와는 양의 상관관계를 보였고, 모두 통계적으로 유의하였다. 결 론 : 신경정신증상은 MCI, AD에서 흔히 보이는데, 본 연구에서는 MCI와 경도의 AD에서 이들 증상들이 유사한 양상을 나타내었다. 정신증은 중등도 이상 AD에서 가장 흔하게 나타났고, 이로 인해 더욱 빠른 인지기능의 저하를 초래할 수 있다. 따라서 MCI와 AD의 각 진행 단계에 따른 적절한 치료가 필요하다.

• 대한간호학회지
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• 제46권3호
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• pp.420-430
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• 2016

Purpose: The purpose of this study was to test a hypothetical model of chemotherapy-related cognitive impairment (CRCI) and depression in people with gastrointestinal cancer. Methods: A purposive sample of 198 patients undergoing chemotherapy was recruited from November 2014 to July 2015. The instruments were Everyday Cognition (ECog), Hospital Anxiety Depression Scale (HADS), Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F), and M. D. Anderson Symptom Inventory-Gastrointestinal Cancer Module. Data were analyzed using descriptive statistics, correlation, and path analysis. Results: CRCI was directly affected by cancer symptoms (${\beta}=.19$, p=.004) and fatigue (${\beta}=.56$, p<.001)($R^2=47.2%$). Depression was directly affected by fatigue (${\beta}=.48$, p<.001) and CRCI (${\beta}=.27$, p<.001). However, The impact of cancer symptoms on depression was confirmed through the mediating effect of CRCI. Conclusion: Results indicate that in patients with gastrointestinal cancer undergoing chemotherapy along with the direct physiologic effects (fatigue, symptoms) of cancer treatment may have altered cognitive function leading to depression.