• Analytical Science and Technology
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• v.20 no.4
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• pp.347-354
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• 2007

A simple and rapid high-performance liquid chromatography assay for the determination of residual novobiocin levels in bovine, porcine, chicken, flatfish and japanese eel muscle has been developed and validated. The separation condition for HPLC/UV was optimized with phenyl hexyl ($4.6{\times}150mm$, $5{\mu}m$) column with 10 mM monobasic sodium phosphate buffer (pH 2.5)/acetonitrile (50/50, v/v) as the mobile phase at a flow rate of 1.0 mL/min and detection wavelength was set at 254 nm. Residues were extracted from tissue by blending with methanol and lipid materials were removed with n-hexane. Then, the methanol extract was evaporated to dryness under a nitrogen stream, reconstituted in the mobile phase. Aliquot of the organic extract was decanted and filtered through $0.45{\mu}m$ syringe filter. The $20{\mu}L$ of the resulting solution was injected into the HPLC system. The calibration ranges were $0.5{\sim}5{\mu}g/g$ and calibration curves were linear with coefficients of correlation better than 0.95. The limits of quantification were $0.5{\mu}g/g$ for all muscles. The recoveries of bovine, porcine, chicken, flatfish and japaneseel muscles were 99.8%, 102.4%, 91.0%, 104.0% and 93.0%, respectively. The procedures were validated according to the CODEX guideline, determining specificity, linearity, accuracy, precision, quantitation limit and recovery.

• THE HEALTH and ORGANIC FARMING
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• no.209
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• pp.1-12
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• 2004

제26회 한국유기농업대회 성황리 개최/우리모두 유기농업으로 무장한 한마리의 송사리가 되자!/국제 CODEX에 준한 한국 유기농업의 실천사례/제초제가 필요없는 쌀겨농법/유기농업의 기초/무 엇을 먹을까? 어떻게 먹 을까?/유기농업대회 화보/제6회 친환경농산물 품평회/친환경유기농산물 소비·유통의 활성화 방안/21C 지속가능한 사회를 향한 국가와 기업의 새 경영 패러다임/순환농업의 지역별 유형/국제 기준에 의한 유기농산물 생산기술/오이 검은별 무늬병 방제/딸기 흰가루병의 발생생태/가축분뇨 퇴비 품질기준 및 퇴비화 악취 저감기법/친환경농업에서의 규소의 적용성

• THE HEALTH and ORGANIC FARMING
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• no.176
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• pp.1-24
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• 2002

FAO/WHO Codex 유기식품규격에맞추어나가자./청와대오찬/일본의유기농업과 제1회Bio Fach Japan(일본유기산업전람회)견학기(하)/벼논 오리로 실천하는 유기농업 (1)/작물의필수원소와 미생물의역할/게르마늄 효능이란?/친환경농업은 생산자의의무/유기농업에의한과수(배) 재배(20)/질병치료의지름길은생활습관의개선/벼재배, 파종에서수확까지/천적을 이용한 생물적 방제방법/유기농업에 있어서 미생물의 중요성과 사용법/본회 토막소식

• Journal of the korean veterinary medical association
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• v.42 no.7
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• pp.599-605
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• 2006

‘국가항생제내성안전관리사업’을 총괄하고 있는 식약청은 수산용 항생제 사용이 인체에 미치는 영향을 평가하고 인체 위해를 최소화하기 위한 국제 전략을 수립하고자, 관련 국제기구인 FAO/WHO/OIE/Codex와 공동으로 2006년 6월13일부터 6월16일까지 제3차 국제전문가 회의(Joint FAO/WHO/OIE Expert Consultation on Antimicrobial Use in Aquaculture and Antimicrobial Resistance)를 개최하였다고 밝혔다. 이번 전문가 회의는 항생제내성에 대한 제1차 Geneva, 제2차 Oslo 회의에 이어 아시아에서는 처음으로 Seoul (식약청)에서 개최되었다.

• YAKHAK HOEJI
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• v.57 no.3
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• pp.226-233
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• 2013

Although the dissolution test can serve as an effective tool for quality control and predictor of in vivo performance, there are a number of drugs with no established dissolution specification in Korean Pharmaceutical Codex (KPC). So, with each reference and test drugs, the dissolution test method and an analytical procedure by HPLC were developed and validated to establish dissolution specification for acebrophylline capsules and bromhexine hydrochloride tablets. The dissolution condition was determined based on the "Guidelines on Specifications of Dissolution tests for Oral dosage forms" of Ministry of Food and Drug Safety (MFDS). The analytical method of HPLC was validated in specificity, linearity, precision and accuracy. Final dissolution test was performed with commercially available samples of 3 lots to establish specification. In addition, no difference was observed by the inter-laboratory evaluation. Dissolution specifications and conditions will be used for revising the monograph of acebrophylline capsules and bromhexine hydrochloride tablets in next supplement of KPC.

• Journal of Animal Environmental Science
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• v.8 no.1
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• pp.25-34
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• 2002

In view of increasing environmental pollution, the organic farming in animal production is becoming increasingly urgent. The problems of veterinary medicine have not diminished through the most dangerous epidemic diseases. Organic farming attempts to function in harmony with the environment. The first criterion of the organic farm is that the animal must be self-sustaining. Their food must be produced to a large extent on the farm. The position of ruminants in biological systems is determined by the fact that this group of farm animals is provided with a digestive system which optimizes the utilization of the products of gut microfloral fermentation. The cattle do not require large amounts of concentrate feeling nor gross ugly farm building for intensive rearing. The economic profitability of a cow depends. on the first instance, on the level of milk production and the number of lactations. The length of life is an important factor since the tilde to maturing is relatively high in a cow. The result is that dairy cows in organic farming have greater length of live, and produce more milk in their life time than the shorter lived high input cow. This paper. therefore, discussed the problems of modern cattle farming and development trends of organic farming in Germany and Korea.

• Journal of the Korean Dietetic Association
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• v.4 no.2
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• pp.160-167
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• 1998

Current status of nutrient fortification in processed food in Korea were presented by analyzing the information shown on food labels. The obtained information was assessed by the regulations on food fortification in both Korea and other countries including Codex. The most current regulations were gathered from internet. The results are summarized as follows. 1. Major nutrients fortified were calcium, Vit C, Vit B complex, iron and fiber. The forfified foods were not limitted to certain food group with more frequent fortification in snackfoods, cereal, ramyun, retort pouch foods, milk, and youguart. The descriptive terms of nutrition label for the fortification were various including high, supplemented, added, source, fortified, and abundance though the difference among these terms were not distinct. 2. Current regulation on nutrition label requires to give the content of the fortified nutrient and % RDA. However not all of food items carry above information. Also some ingredients such as chitosan, DHA, taurine, $\omega$-3 fatty acid, chondrichin, bifidus were supplemented mainly to the snack foods which FDA(USA) does not allow to be fortified. 3. The nutrient most frequently fortified was calcium and general practice of fortification appears to follow the regulation in Korea. Presently the regulation itself is not well described, this nutient fortification can cause toxic effect. Since calcium was supplemented to wide range of food group consumers who are not conscious of the safe upper limit may intake the fortified food up to the level of 2g/day. 4. For the effective fortification in Korea, the regulation on fortification should be reformed in accordance with the international guideline Codex and the regulations in other countries especially in America and Japan.

• Journal of Dairy Science and Biotechnology
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• v.23 no.2
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• pp.155-160
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• 2005

Many countries divide infant formula into special nutrient food and they are in control of thorn very carefully. CODEX prescribes that the components which can be added to infant formula must be exist in the breast milk and the additives must be scientifically proved to be safe. Therefore infant formula manufacturers make efforts to develop infant formula to be similar to human milk based on research of human and bovine milk components. Domestic infant formulas are rich with functional components in comparison with foreign formulas ; such as immunity, anti-allergy, growth factor, developments of brain and digestion organs etc. At this point, progress of bioscience technology and introduction of various new technologies lead micro components in human and bovine milk to be separated and purified. Therefore many functional components are commercialized and infant formula companies use these. Various functional components are added to infant formula ; DHA and arachidonic acid as brain growth components, nucleotide and lactoferrin as immunity increment and oligosaccharides fur digestion. And new infant formula is being developed by using bone growth factor and dehydration components f3r atopy and allergy decrement.

• Food Science of Animal Resources
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• v.35 no.1
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• pp.121-129
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• 2015

${\beta}$-agonists are anabolic compounds that promote fat loss and muscle gain, and their administration to livestock may provide economic benefits by increasing growth rate and feed efficiency. For these reasons, ${\beta}$-agonists are also commonly added to livestock feed as growth promoters. This can introduce a significant risk of secondary human poisoning through intake of contaminated meat. A new method for the simultaneous determination of three ${\beta}$-agonists (clenbuterol, ractopamine, and zilpaterol) was developed in this study and applied to various meat samples. The limits of quantification, derived through a validation test following Codex guidelines, were $0.2{\mu}g/kg$ for clenbuterol and zilpaterol, and $0.4{\mu}g/kg$ for ractopamine. The average recoveries for clenbuterol, ractopamine, and zilpaterol ranged from 109.1% to 118.3%, 95.3% to 109.0%, and 94.1% to 120.0%, respectively. The recovery and coefficient of variation (CV) values fell within the acceptable range according to the Codex guidelines. This method reduced the analysis time without decreasing detection efficiency by modifying the pretreatment steps. This method could be utilized to manage the safety of imported meat products from countries where zilpaterol use is still permitted, thereby improving public health and preventing ${\beta}$-agonist poisoning due to secondary contamination.

• Korean journal of food and cookery science
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• v.32 no.6
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• pp.686-695
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• 2016

Purpose: This study aimed to investigate the quality characteristics of traditional and commercial soybean pastes (Doenjang) for development of traditional soybean pastes. Methods: Proximate compositions, amino acid nitrogen contents, pH, acidity, salt contents, chromaticity, viable bacteria and inorganic substance contents of nineteen traditional and three commercial Doenjang were investigated. Results: Analysis of proximate compositions indicated a significant difference between samples. In moisture content, D10 did not meet the standard of food codex. The contents of moisture, fat, protein and ash were slightly higher in traditional than commercial Doenjang. However, the carbohydrate content was 2-fold higher in commercial than traditional, and thus, the calories were also higher. The amino nitrogen content was lower in commercial than traditional Doenjang. pH, acidity and salt contents of Doenjang were pH 4.67-6.15, 1.53-3.29%, and 9.01-18.78%, respectively. pH and acidity showed no significant differences between traditional and commercial Doenjang, however, salt contents were significantly higher in traditional than commercial Doenjang. In case of chromaticity, the averages of L, a, b values were higher in traditional Doenjang. In microbiological analysis, total bacteria counts were higher in traditional than commercial Doenjang. The number of Bacillus cereus in D12 and D19 exceeded the standard of food codex. Staphylococcus aureust was undetected in all samples. The number of fungi varied widely between samples, with no detection in five traditional and all commercial Doenjang. Results of inorganic substance analysis indicated that contents of inorganic substances in Doenjang were in order of Na, K, Mg and Ca. Overall, Na content was higher in traditional Doenjang. Contents of inorganic substances showed wide variations in traditional Doenjang. Conclusion: For the development of traditional Doenjang, quality standardization and ensuring safety are considered necessary.