• 제목/요약/키워드: CoPtP

검색결과 98건 처리시간 0.022초

Fusobacterium nucleatum infection induces CSF3 expression through p38 MAPK and JNK signaling pathways in oral squamous cell carcinoma cells

  • Ahyoung Jo;Jung-Min Oh
    • International Journal of Oral Biology
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    • 제49권1호
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    • pp.1-9
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    • 2024

  • Oral bacterial infections substantially affect the development of various periodontal diseases and oral cancers. However, the molecular mechanisms underlying the association between Fusobacterium nucleatum (F. nucleatum ), a major periodontitis (PT)-associated pathogen, and these diseases require extensive research. Previously, our RNA-sequencing analysis identified a few hundred differentially expressed genes in patients with PT and peri-implantitis (PI) than in healthy controls. Thus, in the present study using oral squamous cell carcinoma (OSCC) cells, we aimed to evaluate the effect of F. nucleatum infection on genes that are differentially regulated in patients with PT and PI. Human oral squamous cell carcinoma cell lines OSC-2O, HSC-4, and HN22 were used. These cells were infected with F. nucleatum at a multiplicity of infection of 100 for 3 hours at 37℃ in 5% CO2. Gene expression was then measured using reverse-transcription polymerase chain reaction. Among 18 genes tested, the expression of CSF3, an inflammation-related cytokine, was increased by F. nucleatum infection. Additionally, F. nucleatum infection increased the phosphorylation of AKT, p38 MAPK, and JNK in OSC-20 cells. Treatment with p38 MAPK (SB202190) and JNK (SP600125) inhibitors reduced the enhanced CSF3 expression induced by F. nucleatum infection. Overall, this study demonstrated that F. nucleatum promotes CSF3 expression in OSCC cells through p38 MAPK and JNK signaling pathways, suggesting that p38 MAPK and JNK inhibitors may help treat F. nucleatum-related periodontal diseases by suppressing CSF3 expression.

  • https://doi.org/10.11620/IJOB.2024.49.1.1 인용 PDF

Co/Si/Ti P형 4H-SiC 오옴성 접합에서 낮은 접촉 저항에 관한 연구 (Low Resistivity Ohmic Co/Si/Ti Contacts to P-type 4H-SiC)

  • 양성준;이주헌;노일호;김창교;조남인;정경화;김은동;김남균
    • 대한전기학회:학술대회논문집
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    • 대한전기학회 2001년도 추계학술대회 논문집 전기물성,응용부문
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    • pp.112-114
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    • 2001

  • In this letter, we report on the investigation of Si/Ti, Pt/Si/Ti, Co/Si/Ti Ohmic contacts to p-type 4H-SiC. The contacts were formed by a 2-step vacuum annealing at $550^{\circ}C$ for 5 min, $850^{\circ}C$ for 2 min respectively. The contact resistances were measured using the transmission line model method, which resulted in specific $10^{-4}{\Omega}cm^2$, and the physical properties of the contactcontact resistivities in the $9.2{\times}10^{-4}$, $7.1{\times}10^{-4}$ and $4.5{\times}s$ were examined using microscopy, AES(auger electron spectroscopy). AES analysis has shown that, at this anneal temperature, there was a intermixing of the Ti and Si, migration of into SiC. Overlayer of Pt, Co had the effect of decreasing the specific contact resistivity and improving the surface morphology of the annealed contact.

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몇가지 $d^8$ 전이금속-디포스핀 착물 ($MCl_2PP$)의 합성과 촉매적 응용 (M = $Ni^{2+}$, $Pd^{2+}$, $Pt^{2+}$, $Au^{3+}$ ; PP = diphosphines) (Synthesis Catalytic Application of Several$d^8Transition Metal Diphosphine Complexes, (MCl_2PP) (M = Ni^{2+}, Pd^{2+}, Pt^{2+}, Au^{3+} ; PP = diphosphines)$)

  • 박유철;김경채;조영제
    • 대한화학회지
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    • 제36권5호
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    • pp.685-691
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    • 1992

  • 디포스핀을 포함한 몇가지 $d^8$ 전이금속착물$(MCl_2PP)$은 출발물질 $K_nMCl_m$을 사용하여 합성하였다. 중심금속(M)은 Ni(II), Pd(II), Pt(II), Au(III)이며, 디포스핀(PP)은 bis(diphenylphosphino)methane(dppm), bis(diphenylphosphino)ethane(dppe), bis(diphenylphosphino)propane (dppp) 및 bis(diphenylphosphino)ethylene(dppety)이었다. 착물의 조성이나 특성은 원소분석과 $^1H-NMR$, $^{31}P-NMR$ 및 UV-Visible 스펙트럼을 이용하여 확인하였다. 이들 착물의 촉매적 활성은 3(2H)-furanone 및 cyclic carbonate 생성반응에 대하여 각각 조사하였다. 2-methyl-3-butyn-2-ol로부터 생성물 3(2H)-furanone을 얻은 반응 (1)에서 Ni(II)-, Pd(II)-diphosphine 착물은 좋은 촉매적 효과를 나타내었다. 그러나 이들 diphosphine 착물들은 cyclic carbonate 생성반응 (2)에 대해 촉매제로서의 활성을 거의 나타내지 않았다.

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마샬공화국 고코발트망간각 화학조성의 원소 상관관계 (Elemental Correlations of Chemical Compositions in Co-rich Mn-crusts of the Republic of Marshall Islands)

  • 황의덕;장세원;김두영
    • 한국광물학회지
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    • 제12권2호
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    • pp.77-90
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    • 1999

  • Characteristics and variations of chemical compositions in Co-rich crusts occurred in the EEZ of the Republic of Marshall Islands were reviewed. Correlation coefficient analysis, hierarchical cluster analysis, and Q-mode factor analysis for 62 samples were done in this study. All data were selected and gathered from the open file report of the cooperative cruise done by United States Geological Survey with Scripps Institute of Oceanography, University of Hawaii or Korea Ocean Research Development Institute. The average of crust thickness. Co content, and Ni content of 62 samples from the 21 seamounts were 30mm, 0.58 wt% and 0.40%, respectively. The mineral phases and associated elements assigned by correlation coefficients, cluster analysis and Q-mode factor analysis are following four. 1) CFA: P, Ca, CO2, Y, Sr: 2) Mn-oxide mineral: As, Mn, Co, Na: 3) Al-silicate mineral: Pd,Si, Al, Cu, Fe: 4) PGE-bearing mineral: Rh, Pt, Ir.

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