• Journal of Periodontal and Implant Science
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• v.49 no.3
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• pp.138-147
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• 2019

Purpose: Several studies have shown that the oral cavity is a secondary location for Helicobacter pylori colonization and that H. pylori is associated with the severity of periodontitis. This study investigated whether H. pylori had an effect on the periodontium. We established an invasion model of a standard strain of H. pylori in human periodontal ligament fibroblasts (hPDLFs), and evaluated the effects of H. pylori on cell proliferation and cell cycle progression. Methods: Different concentrations of H. pylori were used to infect hPDLFs, with 6 hours of co-culture. The multiplicity of infection in the low- and high-concentration groups was 10:1 and 100:1, respectively. The Cell Counting Kit-8 method and Ki-67 immunofluorescence were used to detect cell proliferation. Flow cytometry, quantitative real-time polymerase chain reaction, and western blots were used to detect cell cycle progression. In the high-concentration group, the invasion of H. pylori was observed by transmission electron microscopy. Results: It was found that H. pylori invaded the fibroblasts, with cytoplasmic localization. Analyses of cell proliferation and flow cytometry showed that H. pylori inhibited the proliferation of periodontal fibroblasts by causing G2 phase arrest. The inhibition of proliferation and G2 phase arrest were more obvious in the high-concentration group. In the low-concentration group, the G2 phase regulatory factors cyclin dependent kinase 1 (CDK1) and cell division cycle 25C (Cdc25C) were upregulated, while cyclin B1 was inhibited. However, in the high-concentration group, cyclin B1 was upregulated and CDK1 was inhibited. Furthermore, the deactivated states of tyrosine phosphorylation of CDK1 (CDK1-Y15) and serine phosphorylation of Cdc25C (Cdc25C-S216) were upregulated after H. pylori infection. Conclusions: In our model, H. pylori inhibited the proliferation of hPDLFs and exerted an invasive effect, causing G2 phase arrest via the Cdc25C/CDK1/cyclin B1 signaling cascade. Its inhibitory effect on proliferation was stronger in the high-concentration group.

• Journal of Korean Neurosurgical Society
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• v.62 no.5
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• pp.536-544
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• 2019

Objective : The objective of this study was to evaluatelong-term radiologic prognosis and characteristics of in-stent stenosis (ISS) after stent assisted coiling (SAC) for cerebral aneurysm and analyze its risk factors. Methods : Radiological records of 362 cases of SAC during 10 years were retrospectively reviewed. Patients were included in this study if they had follow-up angiogram using catheter selected angiography at least twice. All subjected were followed up from 12 months to over 30 months. Of 120 patients, 123 aneurysms were enrolled. Patient data including age, sex, aneurysm size, neck size, procedural complication, kinds of stent, ISS associated symptom, ruptured state, location of ISS, degree of ISS, radiologic prognosis of ISS, follow-up period of time, and medical comorbidities such as hypertension, diabetes mellitus (DM), dyslipidemia, and smoking were collected.Statistical comparisons of group clinical characteristics were conducted for the total population. Results : Among 123 casesof aneurysm, 22 cases (17.9%) of ISS were revealed on follow-up angiography. Multiple stenting was performed in three cases and intra-procedural rupture occurred in two cases. Most cases were asymptomatic and symptomatic stenosis was identified in only one case. Sixteen cases were ruptured aneurysm. Mild stenosis was observed in 11 cases. Moderate stenosis was found in eight cases and severe stenosis was identified in three cases. Mean timing of identification of ISS was 8.90 months. The most common type was proximal type. Most cases were improved or not changed on follow-up angiography. Only one case was aggravated from mild stenosis to occlusion of parent artery. Mean follow-up period was 44.3 months. We compared risk factors and characteristic between ISS group and non-ISS group using univariate analysis. Multiple stenting was performed for three cases (13.6%) of the ISS group and four cases (4.0%) of the non-ISS group, showing no statistical difference between the two groups (p=0.108). Additionally, the proportion of patients who had more than two risk factors among four medical risk factors (hypertension, DM, dyslipidemia, and smoking) was higher in the ISS group than that in the non-ISS group, the difference between the two was not statistically significant either (31.8% vs. 12.9%, p=0.05). Conclusion : Clinical course and long-term prognosis of ISS might be benign. Most cases of ISS could be improved or not aggravated. Control of medical co-morbidity might be important. To the best of our knowledge, our study had more cases with longer follow-up period of time than other reports.

• The Journal of Engineering Geology
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• v.29 no.2
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• pp.137-151
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• 2019

Geophysical exploration techniques are effective for monitoring changes in the ground condition around the excavation project to prevent subsidence risks during excavation work, therefore, improving analysis techniques is required for applying and supplementing various geophysical exploration technologies. In this study, a field-scale on-site test was conducted to detect possible ground subsidence hazards and areas of relaxation zone that may occur during excavation work and due to underground water level changes. In order to carry out the field test, a real-scale excavation test bed was constructed and the geophysical exploration methods, such as electrical resistivity survey and multi-channel analysis of surface wave (MASW) survey for urban sites condition, have researched for optimal geophysical exploration parameter, design and correlation analysis between the results by reviewing the validity of each individual geophysical exploration and modeling. The results of this study showed the impact of each geophysical exploration on the relaxation zone and, in particular, the location of the underground water surface and the effects of excavation were identified using electrical resistivity survey. Further research on modeling will be required, taking into account the effects of excavation and groundwater.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.30 no.6
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• pp.286-297
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• 2018

In the present study, wave measurements at KOGA-W01 were analyzed and then the numerical wind waves simulations have been conducted to investigate the characteristics of wind waves in the Yellow sea. According to the present analysis, even though the location of the wave stations are close to the coastal region, the deep water waves are prevailed due to the short fetch length. Chun and Ahn's (2017a, b) numerical model has been extended to the Yellow Sea in this study. The effects of tide and tidal currents should be included in the model to accommodate the distinctive effect of large tidal range and tidal current in the Yellow Sea. The wave hindcasting results were compared with the wave measurements collected KOGA-W01 and Kyeockpo. The comparison shows the reasonable agreements between wave hindcastings and measured data, however the model significantly underestimate the wave period of swell waves from the south due to the narrow computational domain. Despite the poorly prediction in the significant wave period of swell waves which usually have small wave heights, the estimation of the extreme wave height and corresponding wave period shows good agreement with the measurement data.

• Korean Chemical Engineering Research
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• v.59 no.4
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• pp.521-531
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• 2021

Vacuum Pressure Impregnation (VPI) is a process that enhances physical properties by coating some types of epoxy resins on windings of stator used in large rotators such as generators and motors. During vacuum and pressurization of the VPI process, resin gas is generated by vaporization of epoxy resin. When the tank is opened for curing after finishing impregnation, resin gas is leaked out of the tank. If the leaked resin gas spreads throughout the workplace, there are safety and environmental problems such as fire, explosion and respiratory problems. So, exhaust system for resin gas is required during the process. In this study, a case study of exhaust efficiency by location of vent was conducted using Computational Fluid Dynamics (CFD) in order to design a system for exhausting resin gas generated by the VPI process. The optimal exhaust system of this study allowed more than 90% of resin gas to be exhausted within 1,800 seconds and reduced the fraction of resin gas below the Low Explosive Limit (LEL).

• Journal of Korea Water Resources Association
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• v.54 no.5
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• pp.301-309
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• 2021

In this study, we tried to improve the performance of the existing U-net-based deep learning rainfall prediction model, which can weaken the meaning of time series order. For this, ConvLSTM2D U-Net structure model considering temporal consistency of data was applied, and we evaluated accuracy of the ConvLSTM2D U-Net model using a RainNet model and an extrapolation-based advection model. In addition, we tried to improve the uncertainty in the model training process by performing learning not only with a single model but also with 10 ensemble models. The trained neural network rainfall prediction model was optimized to generate 10-minute advance prediction data using four consecutive data of the past 30 minutes from the present. The results of deep learning rainfall prediction models are difficult to identify schematically distinct differences, but with ConvLSTM2D U-Net, the magnitude of the prediction error is the smallest and the location of rainfall is relatively accurate. In particular, the ensemble ConvLSTM2D U-Net showed high CSI, low MAE, and a narrow error range, and predicted rainfall more accurately and stable prediction performance than other models. However, the prediction performance for a specific point was very low compared to the prediction performance for the entire area, and the deep learning rainfall prediction model also had limitations. Through this study, it was confirmed that the ConvLSTM2D U-Net neural network structure to account for the change of time could increase the prediction accuracy, but there is still a limitation of the convolution deep neural network model due to spatial smoothing in the strong rainfall region or detailed rainfall prediction.

• Journal of Navigation and Port Research
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• v.44 no.6
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• pp.550-556
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• 2020

Over the past years, the role of ports in the global network of supply chains has becoming increasingly important, not merely as a physical location for loading and unloading goods, but also as an essential center of economic activity where additional value is added to cargo. Due to the overall growing importance of ports, each country has chosen to adopt hub growth as a primary economic strategy. Northeast Asia in particular, due to its high population density, experiences intense competition between its ports. Busan's port, as a result, has used the establishment of Distripark in order to attract high and stable trade volume, and compete more effectively with other ports in the region. This study estimates the unit cost of the logistic process for the all principal cargos handled at Busan New Port, with the findings revealing that unit cost increases gradually starting with chemical products, LME bulk goods, automobile parts, LME containers, general cargoes, and LME inland transportation goods coming in last. Future research will look more closely at all all categories of cargo handled in the Distrpark of Busan New Port, thereby enabling us to better understand the value created by the port, and how to best implement effective trade volume-attraction strategy.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.34 no.3
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• pp.167-174
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• 2021

Recent investigation into the integrity of nuclear containment buildings has highlighted the importance of developing an elaborate diagnostic method to evaluate the distribution and size of cavities inside concrete walls. As part of developing such a method, this paper presents a finite element approach to modeling elastic waves propagating in the containment building walls of a nuclear power plant. We introduce a perfectly matched layer (PML) wave-absorbing boundary to limit the large-scale nuclear containment wall to the region of interest. The formulation results in a semi-discrete form with symmetric damping and stiffness matrices. The transient elastic wave equations for a mixed unsplit-field PML were solved for displacement and stresses in the time domain. Numerical results show that the sensitivity of displacement, velocity, acceleration, and stresses is large depending on the size and location of the cavity. The dynamic response of the wall slightly differs depending on the existence of the containment liner plate. The results of this study can be applied to a full-waveform inversion approach for characterizing cavities inside a containment wall.

• Journal of Advanced Navigation Technology
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• v.22 no.2
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• pp.76-83
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• 2018

In order to prevent overusing the fishing gear and to reduce discarded fishing gear, there is a need for a technique that can efficiently transmit the information including the type and location of the fishing gear and the user's real name to the fishing boat and the control center using IoT-based communication. In order to do this, it is necessary to be able to confirm the position information of a plurality of buoys that can be identified by the base stations on the land. In this paper, in order to service the maritime IoT communication system, we calculate the link budget between the land base station and the targets on the sea to derive the service coverage. To design a marine IoT radio network for building a fishing gear monitoring system, we calculate link budget for wireless service optimization at sea for NB-IoT using 1.8 GHz frequency band and LoRa service using 900 MHz frequency band. In addition, the link budget between the land base station and buoy, the link budget between the land base station and fishing boat are calculated and the results are analyzed.

• Korean Journal of Agricultural and Forest Meteorology
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• v.23 no.2
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• pp.100-107
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• 2021

An agrivoltaic system (AVS) is a system of innovation that comprises productions of photovoltaic power and agricultural crops on the same area. However, the decline in crop yield will be fatally occurred because the pigments of crop absorbs less light energy under AVS. In addtion, the photosynthetic capacity of crop grown under the partial shading of AVS is not well reported. In this study, the electron transport rate (ETR) and non-photochemical fluorescence quenching (NPQ) of soybean and rice under the AVS in Boseong and Naju was investigated using chlorophyll fluorescence measurement. The ETR value of soybean and rice under AVS were not significantly differed by location. It represents that the photophosphorylation rate of the crops is not critically different. It means that the decreases in total photosynthesis under AVS were mostly affected by the amount of light absorbed by leaves. Under AVS the photosynthesis of crops will be lower than field crops grown in open fields. This is because the crops under AVS observed higher NPQ, which means that the available energy cannot distribute to photophosphorylation reaction.