• 제목/요약/키워드: Clinical anatomy

검색결과 634건 처리시간 0.031초

임상용 3T MRI를 이용한 마우스 뇌의 영상 (Imaging Studies in Mouse Brain Using Clinical 3T MRI Scanner)

  • 임수미;박은미
    • 한국의학물리학회지:의학물리
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    • 제21권4호
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    • pp.348-353
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    • 2010
  • 임상적용 전 단계에서 마우스와 같은 작은 설치류를 이용한 신경학적 실험의 필요성이 높아지면서 임상용 3T MRI를 이용한 마우스 뇌 영상의 요구가 높아지고 있다. 본 연구에서는 임상용 3T MRI를 이용한 마우스 뇌 영상의 가능성과 기술적인 적용과 최적화에 대해 알아보고자 하였다. 20~25g 체중 마우스 3마리에서 임상용 3T MRI를 이용하여 T1 강조영상(T1WI), T2 강조영상(T2WI), FLAIR (Fluid Attenuated Inversion Recovery) 영상, 가돌리늄 조영 T1 강조영상(Gd-T1WI), 확산 강조영상(DWI)을 시행하였다. 대상이 되었던 마우스 1마리는 뇌 경색을 유발시키지 않았으며 2마리는 우측 중대뇌동맥을 결찰하여 일측 뇌경색을 유발하고 1시간, 24시간, 72시간에 각각의 MRI 영상을 시행하였으며 각 영상에서 마우스 뇌의 striatum, 뇌실, 대뇌 피질의 해부학적 구별, 뇌 경색 부위의 진단 가능성 등을 분석하였다. T2WI에서 마우스 뇌의 striatum, 뇌실, 대뇌 피질의 해부학적 구별이 모두 가능하였고 T1WI, FLAIR, DWI 영상에서는 위의 해부학적 경계부위의 해상도는 감소하였다. 뇌경색 부위는 경색 후 1시간, 24시간, 72시간 영상 모두에서 발견되었고 T2WI, FLAIR에서는 24시간, 72시간에서만 구분되었다. 임상용 3T MRI를 이용한 마우스 뇌 영상에서 해부학적 부위의 구별이 가능하였고 특히 DWI를 이용하여 급성기 뇌 경색의 진단이 가능하였다. 앞으로 기술적인 적용과 최적화를 위한 노력이 계속 진행된다면 임상 실험에 큰 도움을 줄 수 있을 것이라 생각된다.

기능적인 움직임 치료를 위한 경근(經筋)의 임상활용에 대한 연구(I) (The Study of Myofascial Meridian Clinical Application for Functional Exercise and Manual Therapy)

  • 임형호;송윤경
    • 대한추나의학회지
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    • 제3권1호
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    • pp.65-83
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    • 2002
  • We are made a comparison between 12 meridian tendino-musculature and myofascial/locomotor anatomy in which the bodywide connections among the muscles within the fascial net. We consider that these unique 'whole systems' view is of vital importance to understanding the role of fascial in normal movement and postural distortion and to application of manual and movement therapy.

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The Prospects of Vitamin C in Cancer Therapy

  • Lee, Wang-Jae
    • IMMUNE NETWORK
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    • 제9권5호
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    • pp.147-152
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    • 2009
  • Ascorbate (vitamin C) is a cofactor for a number of metabolic enzymes and is an indisputable essential vitamin C for humans. However, the potential of ascorbate as an anticancer agent has been a topic of controversy. A number of previous reports have addressed both positive aspects and limitations of ascorbate in cancer therapy. In this review, we briefly summarize the potential antitumor effects of ascorbate and its prospects for clinical use.

Cervical Radiculopathy due to Cervical Degenerative Diseases : Anatomy, Diagnosis and Treatment

  • Kim, Kyoung-Tae;Kim, Young-Baeg
    • Journal of Korean Neurosurgical Society
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    • 제48권6호
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    • pp.473-479
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    • 2010
  • A cervical radiculopathy is the most common symptom of cervical degenerative disease and its natural course is generally favorable. With a precise diagnosis using appropriate tools, the majority of patients will respond well to conservative treatment. Cervical radiculopathy with persistent radicular pain after conservative treatment and progressive or profound motor weakness may require surgery. Options for surgical management are extensive. Each technique has strengths and weaknesses, so the choice will depend on the patient's clinical profile and the surgeon's judgment.

Lumbar foraminal neuropathy: an update on non-surgical management

  • Choi, Young Kook
    • The Korean Journal of Pain
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    • 제32권3호
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    • pp.147-159
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    • 2019
  • Lumbar foraminal pathology causing entrapment of neurovascular contents and radicular symptoms are commonly associated with foraminal stenosis. Foraminal neuropathy can also be derived from inflammation of the neighboring lateral recess or extraforaminal spaces. Conservative and interventional therapies have been used for the treatment of foraminal inflammation, fibrotic adhesion, and pain. This update reviews the anatomy, pathophysiology, clinical presentation, diagnosis, and current treatment options of foraminal neuropathy.

Management of Pediatric Intracranial Arteriovenous Malformations

  • Alfred Pokmeng See;Edward R. Smith
    • Journal of Korean Neurosurgical Society
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    • 제67권3호
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    • pp.289-298
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    • 2024
  • Pediatric intracranial arteriovenous malformations (AVMs) are challenging lesions managed by pediatric neurosurgeons. The high risk of hemorrhage and neurologic injury is compounded by the unique anatomy of each malformation that requires individualizing treatment options. This article reviews the current status of pediatric AVM epidemiology, pathophysiology and clinical care, with a specific focus on the rationale and methodology of surgical resection.

의사면허 필기시험 제도의 성과와 과제 (Major Reforms and Issues of the Medical Licensing Examination Systems in Korea)

  • 백상호
    • 의학교육논단
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    • 제15권3호
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    • pp.125-135
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    • 2013
  • Since the establishment of the national medical licensing examination board in 1992, the medical licensing examination system has changed enormously and this has had a number of impacts on examination services. All those reforms were aimed at improving the relevance and reliability of the test. Several attempts of the testing system have appeared in the new examination service, and which have also brought about the changes in the medical school curriculum such as introducing integrated courses instead of traditional subjects, using test scores as a reference to the post-graduation selection test. Some examples of changes in the examination system are as follows: 1) choosing three integrated test subjects and outlines of their reference content instead of 15 academic subjects, 2) adjusting the ratio of multiple choice question items to focus more on the problem solving level, 3) introduction of 'one-best answer' single set and 'extended matching type items, 4) item construction based on real clinical cases and real clinical materials. Recently, a clinical skill test system has been introduced to measure examinees' basic clinical skills competencies. Despite continuing efforts, the examination system still has many issues remaining to be solved. These problems include the differential weighting of test items, appropriate threshold for passing, and practicality of pre-testing to stabilize the passing rate and avoid the hazards of newness and undesirably difficult test items.

PET/CT 결합영상진단 검사에 관한 연구 (A Study on the PET/CT Fusion Imaging)

  • 김종규
    • 대한임상검사과학회지
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    • 제36권2호
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    • pp.193-198
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    • 2004
  • PET/CT combines the functional information from a positron emission tomography (PET) exam with the anatomical information from a computed tomography (CT) exam into one single exam. A CT scan uses a combination of x-rays and computers to give the radiologist a non-invasive way to see inside your body. One advantage of CT is its ability to rapidly acquire two-dimensional pictures of your anatomy. Using a computer these 2-D images can be presented in 3-D for in-depth clinical evaluation. A PET scan detects changes in the cellular function - how your cells are utilizing nutrients like sugar and oxygen. Since these functional changes take place before physical changes occur, PET can provide information that enables your physician to make an early diagnosis. The PET exam pinpoints metabolic activity in cells and the CT exam provides an anatomical reference. When these two scans are fused together, your physician can view metabolic changes in the proper anatomical context of your body. PET/CT offers significant advantages including more accurate localization of functional abnormalities, and the distinction of pathological from normal physiological uptake, and improvements in monitoring treatment. A PET/CT scan allows physicians to measure the body's abnormal molecular cell activity to detect cancer (such as breast cancer, lung cancer, colorectal cancer, lymphoma, melanoma and other skin cancers), brain disorders (such as Alzheimer's disease, Parkinson's disease, and epilepsy), and heart disease (such as coronary artery disease).

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치기공과 교육과정의 개선방안 (An improvement plan of Curriculum in Departments of Dental Technology)

  • 배봉진;이화식;박병호
    • 대한치과기공학회지
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    • 제31권4호
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    • pp.55-66
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    • 2009
  • This research collected the curriculum for Dental Technology from a total of 20 schools --3-year colleges and 4-year colleges-- all in Korea. And we analyzed the average credits of subjects from students. As a result of this analysis, we get the conclusion below: 1. In the arithmetic mean of the major basis subjects which graduates and undergraduates answered about each subjects; Seminar, Dental morphology I II, Dental morphology practice I II, and Dental devices & instruments don't have many credits. And averages of the major application subjects credits which are Implants(especially low), Occlusal anatomy practice I II, Dental ceramics practice I II, and Dental ceramics practice are low, mostly have a converged tendency in high points. 2. In an analysis of the correlation which is based on the major basis subjects: Dental esthetic, oral anatomy I II, Dental materal practice III, Dental casting pracedure, Oral hygiene, Health & medical law, Management administration, and Medical terminology have a meaningful difference. (${\rho}$ < 0.05) 3. In an analysis of the correlation which is based on the major application subjects; Crown and bridge prosthodontics practice IV, Complete denture prosthodontics I II III, Complete denture prosthodontics practice I II III, Dental ceramics I II, Dental ceramics practice I II, Dental ceramics practice IIII, Occlusal anatomy I II, Occlusal anatomy practice I, Operative dentistry laboratory technology I, Operative dentistry laboratory technology practice II, Dental attachment laboratory technology practice, Implants, and Dental laboratory clinical practice have meaningful difference. (${\rho}$ < 0.05) 4. In an analysis of the correlation which is based on the ratio of a theory to an actual training; 40:60(38.57%) is the highest, followed by 30:70(30.04%), 50:50(23.32%), 60:40(5.83%), and 70:30(2.24%). These have meaningful difference. (${\rho}$ < 0.05) 5. In an analysis of the correlation which is based on the distinction of sex: Partial denture prosthodontics practice I II III, Complete denture prosthodontics I II III, Complete denture prosthodontics practice I II III, Occlusal anatomy practice I II, Implants, Medical terminology have meaningful difference. (${\rho}$ < 0.05) For the purpose of training entrepreneurs of middle standing who is required by a future society, Department of Dental Technology's Curriculum need to be managed with planning a curriculum which reflects opinions of graduates, undergraduates and a society, and also are considered not focusing on a supplier but focusing on a user.

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폴리도파민으로 코팅된 다공성 PCL/PLGA 복합 폴리머 지지체를 이용한 흉선상피세포의 3차원 세포배양 (Three-Dimensional Culture of Thymic Epithelial Cells Using Porous PCL/PLGAComposite Polymeric Scaffolds Coated with Polydopamine)

  • 최승미;이도영;임예선;황선영;송원훈;정영훈;윤식
    • 생명과학회지
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    • 제33권8호
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    • pp.612-622
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    • 2023
  • 생체 면역조직에서는 면역세포의 성장, 분화에 있어서 매우 중요한 역할을 수행하는 면역조직 기질세포가 존재하며, 이들은 서로 연결된 3차원적인 그물구조를 형성하면서 그 사이의 공간에 위치한 면역세포와의 상호작용을 통해 다양한 면역반응을 수행한다. 따라서 생체환경을 모사한 면역세포의 배양이 이루어지기 위해서는 면역세포들이 상호작용할 수 있는 3차원적 면역조직 기질세포 뼈대의 구축이 매우 중요한 의의를 지닌다. 특히 면역반응에서 핵심적인 기능을 수행하는 T세포의 생존, 성장 및 분화에 있어서 필수적인 역할을 하는 흉선상피세포에 대한 3차원적 배양은 T세포의 연구에 필수적으로 요구되지만, 아직 이에 관한 연구가 거의 이루어지지 않은 실정이다. 본 연구에서 흉선상피세포는 폴리도파민으로 코팅된 PCL 및 PCL/PLGA 지지체에서 비코팅군에 비해 부착 및 성장이 촉진되었다. 또한 폴리도파민으로 코팅된 지지체에서 흉선상피세포를 배양하였을 때 2차원 배양군에 비해 흉선세포형성촉진인자의 유전자 발현이 더 증가하였다. 따라서 본 연구는 면역조직 기질세포의 3차원 배양 기술의 개발에 크게 기여할 수 있을 것으로 사료된다.