• 대한세포병리학회지
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• 제12권1호
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• pp.45-48
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• 2001

Acinic cell carcinoma(ACC) is the third common malignancy in major salivary gland. Fine needle aspiration cytology is a useful tool for the diagnosis of salivary gland lesions. However, some low grade malignancies, such as ACC and mucoepidermoid carcinoma show relatively high false negative rate, mainly due to deceptively benign cytomorphologic appearance. We experienced a papillary-cystic variant of ACC, having different cytopathologic features compared with those of classic ACC. Our case showed monolayered sheets and papillary clusters without any acinic structures or naked nuclei of the tumor cells. Foamy proteinaceous material was seen in the background. The tumor cells had a large amount of granular cytoplasm and eccentric nuclei. Many vacuolated or clear cells were also noted.

• 대한세포병리학회지
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• 제15권2호
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• pp.116-119
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• 2004

Primary clear cell adenocarcinoma of uterine cervix is rare and cytomorphology in the vaginal smear have not been previously described in Korean literatures. The cytologic characteristics of clear cell adenocarcinoma of the uterine cervix include : malignant cells with abundant, finely vacuolated cytoplasm ; hobnail appearance, and distinctive basement membrane-like hyaline materials within cellular aggregates. A 36-year-old woman presented with vaginal bleeding. Cytologic examination of vaginal smear and histopathologic examination of a radical hysterectomy specimen allowed the diagnosis of hemorrhagic tumor in the uterine cervix as a clear cell adenocarcinoma. Cytologic findings were very characteristic. The tumor cells had abundant, pale, finely vacuolated cytoplasm with indistinct cytoplasmic membrane. The nuclei were round to oval with finely dispersed chromatin. Extracellular basement membrane-like hyaline substance, which stained a light green color in Papanicolaou's preparation, was frequently observed within the cancer cell clusters.

• 대한미생물학회지
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• 제22권1호
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• pp.55-59
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• 1987

Salmonella typhi infection, which was the most frequent enteric infection in Korea, has been decreasing, while the infection of other serogroups of Salmonella has been increasing since the later part of 1970s. In 1986, the number of serogroup B isolated by us increased to 46, which corresponds 21.1% of all enteropathogenic bacteria isolated from stool specimens. Salmonella isolates resistant to antimicrobial agents were extremly rare in Korea, in the 1970s. However, 7 of 13 serogroup B isolates showed resistance to ampicillin or to chloramphenicol in 1984. Among the serogroup B isolates in 1986, 71.7% and 69.6% were resistant to ampicillin and to chloramphenicol respectively. The minimum inhibitory concentrations of ampicillin and chloramphenicol against these isolates were >$128\;{\mu}g/ml$ and $128\;{\mu}g/ml$ respectively.

• Asian Pacific Journal of Cancer Prevention
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• 제17권6호
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• pp.2861-2866
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• 2016

It is thought that population characteristics of breast cancer may be due to a variation in the frequency of different alleles of genes such as CYP1B1. We aimed to determine the association of CYP1B1 polymorphisms in 200 breast cancer cases and 40 controls by PCR-RFLP. Frequencies were assessed with clinical and risk factors in Egyptian patients. The genotype LV and the Leu allele frequencies for patients and controls were 42.9% and 50%, and 52.9% and 53.3%, respectively), with no significant differences observed (P values = 0.8 and 0.6, respectively). There was also no significant association between genotypes and any risk factors for cases (P>0.05) except laterality and metastasis of the tumor (P values=0.006 and 0.06, respectively). The CYP1B1 polymorphism Val432Leu was not associated with breast cancer in Egypt, but may provide clues for future studies into early detection of the disease.

• 대한세포병리학회지
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• 제18권2호
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• pp.161-164
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• 2007

Metastasis to the thyroid gland is very rare in clinical practice. We recently encountered a 65-year-old woman who presented with a large thyroid nodule that mimicked the cytologic features of a papillary thyroid carcinoma on fine needle aspiration biopsy (FNAB). Although initially diagnosed as a papillary thyroid carcinoma, a thorough clinical work-up revealed multiple lesions in the bones, liver, and nasal cavity, which were confirmed as metastases of a malignant melanoma. Despite a thorough physical examination, however, the primary skin lesion could not be identified. Although FNAB shows a high degree of accuracy in diagnosing primary thyroid tumors, it is less accurate in diagnosing metastases to the thyroid gland. A thorough clinical history with appropriate immunohistochemical staining assays is necessary for the accurate diagnosis of metastatic malignant melanoma.

• Molecules and Cells
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• 제43권2호
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• pp.145-152
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• 2020

RUNX1 plays an important role in the regulation of normal hematopoiesis. RUNX1 mutations are frequently found and have been intensively studied in hematological malignancies. Germline mutations in RUNX1 cause familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML). Somatic mutations of RUNX1 are observed in various types of hematological malignancies, such as AML, acute lymphoblastic leukemia (ALL), myelodysplastic syndromes (MDS), myeloproliferative neoplasm (MPN), chronic myelomonocytic leukemia (CMML), and congenital bone marrow failure (CBMF). Here, we systematically review the clinical and molecular characteristics of RUNX1 mutations, the mechanisms of pathogenesis caused by RUNX1 mutations, and potential therapeutic strategies to target RUNX1-mutated cases of hematological malignancies.

• Archives of Plastic Surgery
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• 제50권1호
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• pp.101-105
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• 2023

Benign cartilaginous tumors, known as chondrogenic tumors, show cartilage components in the microscopic diagnosis. We present two clinical cases with cartilaginous tumors of the toes showing distinctive clinical manifestations. Two juvenile patients visited our outpatient clinic due to tumors with toenail deformities. A 10-year-old girl presented with a palpable mass with a nail deformity on the left third toe. The initial pathology report was soft tissue chondroma until complete resection. Another 15-year-old male patient visited the dermatology department with a toenail deformity and underwent a punch biopsy. The pathology report was fibrosis with myxoid degeneration. Excisional biopsies were performed for both patients. In the operative field, we observed exophytic tumors connected to the distal phalangeal bones. The final pathology reports were subungual osteochondroma on both patients. The specimen exhibited mature bone trabeculae with a focal cartilaginous cap. Benign cartilaginous tumors have a slow, progressive course and do not show significant symptoms. However, tumors in subungual areas are accompanied by toenail deformities and they can cause pain. Their clinical characteristics lead to a delayed diagnosis. Surgeons can be confused between soft tissue and chondrogenic tumors. When they conduct physical examinations, these categories should be considered in the differential diagnosis.

• 동의생리병리학회지
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• 제18권6호
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• pp.1543-1547
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• 2004

In this study, symptoms, pathologies, compositions and clinical applications of 52 prescriptions for woman-related disease treatment descripted in Bang Yahk Hap Peun were investigated. The results were same as following; Classification of prescriptions for woman-related disease treatments was 23 prescriptions in high-chepter, prescriptions in 16 medium-chepter, and prescriptions in 13 low-chepter prescriptions and the frequency of clinical applications for high-chepter, medium-chepter and low-chepter prescriptions was 44%, 31% and 25%, respectively. Clinical applications of woman-related disease prescriptions were identified aocording to pre-pregnancy and post-birth, uterus, breast disease, before pregnancy. Infertile, emmeniopathy, uterus Blooding made practical application to high frequency in the treatments. Oriental Medical Pathology applied with prescriptions were Biheo(脾虛), Ganbinoyool(肝脾怒鬱), Infirmity(虛弱), 熱入血室, Jungpung(中風), Gihyulguheo(氣血俱虛), hyulheo(血虛), Aeohyul(瘀血) etc. Prescriptions applied with the most frequency in woman-related disease were Samuoltang(四物湯), Sagunjatang(四君子湯), Gungkuitang(芎歸湯), Boanbaekchuolsan(保安白朮散), Dangguibohyeltang(當歸補血湯), Sanhyointang(酸棗仁湯), Dohongsamuoltang(桃紅四物湯), Jipeisan(芷貝散), Silsosan(失笑散).

• Journal of Yeungnam Medical Science
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• 제4권1호
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• pp.97-103
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• 1987

1987년 1월에서 동년 7월까지 본 임상병리과에 M. pneumoniae의 감염을 의심하여 한냉응집소와 항Mycoplasma 항체가 소아환자 191명중 추적조사를 시행한 환자 48명을 대상으로 다음과 같은 결과를 얻었다. 1. 한냉응집소 만으로 M. pneumoniae를 진단하는 데에는 유용성이 떨어진다. 2. M. pneumoniae의 감염을 진단하는 데에는 한냉응집소치 보다 항Mycoplasma 항체가 더 감수성이 있는 것으로 나타났다. 3. 초기에 한냉응집소가 정상으로 나타나더라도, 추적조사에서 양성으로 나타날 수 있으므로, 임상적으로 M. pneumoniae의 감염이 의심되면 추적조사가 필요하다. 4. 소아 폐렴에서 M. pneumoniae에 의한 감염이 많으므로(37.5%), 소아 폐렴환자에선 반드시 한냉응집소와 항Mycoplasma 항체 측정을 동시에 할 필요가 있다.

• 대한세포병리학회지
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• 제10권2호
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• pp.163-167
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• 1999

Primary small cell carcinoma of the salivary gland is a rare neoplasm that accounts for approximately 1.8% of all primary major salivary gland malignancies. Because of its rarify, it is difficult to diagnose small cell carcinoma of the parotid gland by fine needle aspiration cytology(FNAC). We experienced a case of primary small cell carcinoma of the parotid gland in a 72-year-old woman who presented with two palpable masses of the left infraauricular and ocular legions of two to three month's duration, respectively. Aspirate smears from the left infraauricular area were highly cellular on necrotic and lymphocytic background and showed individually dispersed cells or three-dimensional clusters of small cells. The tumor cells were round to oval with a very high nucleocytoplasmic ratio. Nuclei were about two times the size of lymphocytes and had uniformly dispersed but hyperchromatic to pyknotic chromatin. Nucleoli were occasionally visible but were generally inconspicuous. Numerous mitotic figures were detected. The clusters of these small tumor cells exhibited angular nuclear molding, irregular nuclear outlines, and occasionally rosette like arrangement. The tumor was confirmed by histology and immunohistochemistry.