The Korean Journal of Cytopathology (대한세포병리학회지)

The Korean Society for Cytopathology (대한세포병리학회)
권호 표지

Cytology of the Uterine Cervico-vaginal Smear of Clear Cell Adenocarcinoma in Uterine Cervix - Report of a Case -

자궁경부 투명세포 샘암종의 자궁경부질 세포학적 소견 - 1예 보고 -

  • Maeng, Lee-So (Department of Clinical Pathology, The Catholic University of Korea, College of Medicine) ;
  • Kim, Kyouug-Mee (Department of Clinical Pathology, The Catholic University of Korea, College of Medicine) ;
  • Kang, Chang-Suk (Department of Clinical Pathology, The Catholic University of Korea, College of Medicine) ;
  • Lee, An-Hi (Department of Clinical Pathology, The Catholic University of Korea, College of Medicine)
  • 맹이소 (가톨릭대학교 의과대학 임상병리학교실) ;
  • 김경미 (가톨릭대학교 의과대학 임상병리학교실) ;
  • 강창석 (가톨릭대학교 의과대학 임상병리학교실) ;
  • 이안희 (가톨릭대학교 의과대학 임상병리학교실)
  • Published : 2004.11.30
Download PDF
⟨ Previous Next ⟩

Abstract

Primary clear cell adenocarcinoma of uterine cervix is rare and cytomorphology in the vaginal smear have not been previously described in Korean literatures. The cytologic characteristics of clear cell adenocarcinoma of the uterine cervix include : malignant cells with abundant, finely vacuolated cytoplasm ; hobnail appearance, and distinctive basement membrane-like hyaline materials within cellular aggregates. A 36-year-old woman presented with vaginal bleeding. Cytologic examination of vaginal smear and histopathologic examination of a radical hysterectomy specimen allowed the diagnosis of hemorrhagic tumor in the uterine cervix as a clear cell adenocarcinoma. Cytologic findings were very characteristic. The tumor cells had abundant, pale, finely vacuolated cytoplasm with indistinct cytoplasmic membrane. The nuclei were round to oval with finely dispersed chromatin. Extracellular basement membrane-like hyaline substance, which stained a light green color in Papanicolaou's preparation, was frequently observed within the cancer cell clusters.

Keywords

References

  1. Kurman RJ. Blaustein's Pathology of the Female Genital Tract. Fifth edition, New York, Springer-Verlag Inc, 2002;356-7
  2. Mikami Y, Hata S, Melamed J, et al. Basement membrane material in ovarian clear cell carcinoma; correlation with growth pattern and nuclear grade. Int J Gynecol Pathol 1999;18:52-7 https://doi.org/10.1097/00004347-199901000-00007
  3. Zirkin HJ. Cytology of clear cell carcinoma of the ovary in ascitic fluid(lett). Acta Cytol 1984;28:777-8
  4. Watanabe Y, Haruhiko U, Kouichi N, et al. Advanced primary clear cell carcinoma of the vagina not associated with Diethylstilbestrol. Acta Cytol 2002;46:557-81
  5. Ito H, Hirasawa T, Yasuda M, Osamura RY, Tsutsumi Y. Excessive formation of basement membrane substance in clear cell carcinoma of the ovary: Diagnostic value of the 'Raspberry body' in ascites cytology. Diagn Cytopathol 1997;16:500-4 https://doi.org/10.1002/(SICI)1097-0339(199706)16:6<500::AID-DC6>3.0.CO;2-D
  6. Nishida M, Kuramoto H, Tatsumi H, Hamano M, Hata H. Cytologic findings of ascities in patients with ovarian clear cell carcinoma: Diagnostic significance and genesis of mirror ball pattern. Nippon Rinsho Sabio Gakkai Zasshi 1979;18:280-94(in Japanese with English abstract)
  7. Atahan S, Cemil E, Fikri I, Nural E. Cytology of clear cell carcinoma of the female genital tract in fine needle aspirates and ascites. 2000;44:1005-9
  8. Weir M, Pitman MB. The vascular architecture of renal cell carcinoma in fine needle aspiration biopsies. Cancer(Cancer Cytopathol) 1997:81:45-50
  9. Grafton WD, Kamm RC, Cowley LH. Cytologic char-acteristics of adenoid cystic carcinoma of the cervix uteri. Acta Cytol 1976; 20:162-6