• Journal of Life Science
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• v.24 no.10
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• pp.1144-1150
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• 2014

The eIF4E protein is the key regulator of translation initiation. The interaction of eIF4E with eIF4G triggers the translation of mRNA, and several proteins interrupt this association to modulate translation. Human 4E-T is one of the eIF4E-binding partners that represses the translation of bound mRNAs, and it is involved in the transport of eIF4E to processing bodies (P-bodies). Although Clast4, the mouse homolog of human 4E-T, might play critical roles in the regulation of translation, its properties are not well known. In this report, we deciphered the properties of Clast4 by determining its phosphorylation state, binding to eIF4E, and effects of overexpression on cell proliferation. Clast4 was phosphorylated by protein kinase A (PKA) in vivo on several residues of its amino terminus. Nevertheless, the PKA phosphorylation of Clast4 appeared to have no effect on either its eIF4E-binding ability or localization. Clast4 interacted with eIF4E1 and CPEB. The conserved eIF4E-binding sequence in Clast4, $YXXXXL_{\phi}$, was important for binding eIF4E1A but not eIF4E1B. Similar to that of another well-known eIF4E regulator, the eIF4E binding protein (4E-BP), the overexpression of Clast4 decreased cell proliferation. These results suggest that Clast4 acts as a global translation regulator in cells.

• Ocean and Polar Research
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• v.23 no.2
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• pp.97-107
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• 2001

The Sejong Formation of Late Paleocene to Eocene is a lower volcaniclastic sequence unconformably overlain by upper volcanic sequence, and distributed along the southern and southeastern cliffs of the Barton Peninsula. The Sejong Formation is divided into five sedimentary facies; disorganized matrix-supported conglomerate (Facies A), disorganized clast-supported conglomerate (Facies B), stratified clast-supported conglomerate (Facies C), thin-bedded sandstone (Facies D), and lapilli tuff (Facies E), based on sedimentary textures, primary sedimentary structures and bed geometries. Individual sedimentary facies is characterized by distinct sedimentary process such as gravel-bearing mudflows or muddy debris flows (Facies A), cohesionless debris flows (Facies B),unconfined or poorly confined hyperconcentrated flood flows and sheet floods (Facies C), subordinate streamflows (Facies D), and pyroclastic flows (Facies E). Deposition of the Sejong Formation was closely related to volcanic activity which occurred around the sedimentary basin. Four different phases of sediment filling were identified from constituting sedimentary facies. Thick conglomerate and sandstone were deposited during inter-eruptive phases (stages 1, 3 and 4), whereas lapilli tuff was formed by pyroclastic flows during active volcanism (stage 2). These records indicate that active volcanism occurred around the Barton Peninsula during Late Paleocene to Eocene.

• Journal of the Korean earth science society
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• v.31 no.1
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• pp.18-35
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• 2010

Facies analysis of the Late Triassic Hajo Formation, the lowest stratigraphic unit in the Chungnam Basin, shows that the lower part is composed mainly of breccias or conglomerates; the middle part, conglomerates; and the upper part, conglomerates and sandstones. The formation consists of 13 facies, which include horizontally stratified clastsupported conglomerate, clast-supported massive breccia, matrix-supported massive breccia or conglomerate, matrixsupported graded conglomerate, massive pebbly sandstone, horizontally laminated sandstone, massive sandstone, graded sandstone, inversely graded sandstone, planar cross-bedded sandstone, trough cross-bedded sandstone, low angle crossbedded sandstone, and massive mudstone. These are grouped into 4 facies associations (FA). FA I consisted of clastsupported and matrix-supported massive breccias presumably deposited in the talus or upper fan delta environment. FA II consists of matrix-supported massive conglomerate and horizontally stratified clast-supported conglomerate of cobble size and it seems to have been deposited in the upper fan delta environment. FAIII consisted of matrix-supported massive conglomerate of pebble size, horizontally laminated sandstone and massive sandstone may have been deposited in the middle fan delta environment. FAIV consists of massive pebbly sandstone, horizontally laminated sandstone and massive sandstone and presumably was deposited in the lower fan delta environment. In general the Hajo Formation is interpreted to have been deposited at the talus/upper fan delta environment in early stage; it might have been deposited in the alternating environments of upper and middle fan delta in middle stage; and it seems to have been deposited in alternating environments of middle and lower fan delta in late stage.

• Journal of Periodontal and Implant Science
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• v.29 no.4
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• pp.995-1005
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• 1999

Alveolar bone destruction is a character-istic of periodontal disease. Treponema denticola are found in significantly increased numbers in the sites affected with periodontal disease. In order to clarify the role of T. denticola in destruction of alveo-lar bone in periodontal disease, this study was undertaken to determine the effect of sonicated extract of T. denticola on osteo-clast differentiation in co-culture system of mouse bone marrow cells and calvaria cells. The ability of osteoclast formation was estimated by counting the number of tar-tartrate resistant acid phosphatase(TRAP) positive cells. Sonicated extract of this bacteria stimulated osteoclast formation in a dose dependent manner(p<0.05). Indomathacin, an inhibitor of prostaglandin synthesis, decreased osteoclast formation induced by sonicated extract of this bacte-bacteria(p<0.05). Extract-induced osteoclast formation was decreased, when sonicated extract of bacteria was heated(p<0.05). These findings suggest that T. denticola induces osteoclast differentiation, and protein component of this bacteria and $PGE_2$ may play an important role in this process.

• The Journal of the Petrological Society of Korea
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• v.4 no.2
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• pp.144-152
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• 1995

The Jangsan Quartzite of the Joseon Supergroup and the foliated granite (so-called granitlc gneiss of presumed Precambrian age) of the Yeongnam massif are in direct contact at Cheondong-ri area, 6 km @SE of Danyang. sllthough it has been thought traditionally that the Jangsan Quartzite overlies unconformably the f&ted granite, it is difficult to interpret the contact as an unconformity smce the basal conglomerate in- the lower part of the Jangsan Quartzite does not have any clast of the foliated granite, Rather, recent structural studies of this area indlcate that the contact is a ductile shear zone. However, the sense and age of the shear movement are still problematic. Our mesoscopic and microscopic studies of &tre Cheondong-11 semi-brittle shear zone involving foliated cataclasite and phyllonite, which is a pa& of the Ogdong fault, indlcate a top-to-the northeast shearing, i.e., dextral strike slip. We also performed Pb-Pb dating for the age-unknown foliated granite, since the age of deformed granite ccarr emtrain the maximum age of deformation. The whole rock and feldspar Pb isotape data for the foliated granite and a micaceous xenolith define an isoc chron age of $2.16{\pm}0.15$ Ga ($2{\sigma}$;MSWD=4.4) which is interpreted as the emplacement age of the granite. This early Proterozoic age agrees with those of Precambrian igneous activity In the Yeongnam massif reported previously. The obtaiPrfid gge confirms the traditional idea about the age of the foliated granite and indicates that other methd(s) should be employed to constrain the age of the shear movement.

• Journal of The Geomorphological Association of Korea
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• v.23 no.1
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• pp.17-33
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• 2016

Samples from newly exposed outcrop of sedimentary layers forming Jeongdongjin coastal terrace in Gangreung area are collected and analyzed to find the sedimentary environment. The site are located at the gentle hillslope of the terrace surface area. The height of the outcrop is about 8m and the altitude of it's highest part is 68~73m MSL. The lowest part of this out crop is the partly consolidated sand layer with gravel veneer within it. It is found that this part is not in-situ weathered sand stone through the OSL method. This sand layer is overlain by the gravel layer with sand matrix. The shapes of the gravels from this part are mainly 'platy', 'elongated', and 'bladed' by the index of Sneed and Folk(1958). In addition, mean roundness is not so high. It is sceptical to regard this part as marine sediments which are continuously exposed to erosional processes. The boundary between the lowest sand layer and gravel layer showing the abrupt change in forming material without any mixture or transitional zone, so gravels are seemed to deposited after some degree of consolidation of the lowest sand layer. In addition, the hight of the boundary between layers are changed by the place, so the surface of the partly consolidated sand layer is not flat and has irregularity on topography when it buried by gravels. Main part of this out crop is the poorly sorted coarse gravel(22.4mm) with sand matrix($1.36{\phi}$) layer with at least 2m thick covering the relatively fine gravels discussed above. Over 20% of particles have 'very platy', 'very elongated' and 'very bladed' shape and only less than 5% of particles have 'compact' shape, So this particles are also very hard to be regard as marine gravels which are abraded by marine processes. It can be concluded that this gravel layer formed by fluvial processes rather than coastal processes base on the form of the clast and sedimentary structure. The gravel layer is covered by fine($3{\sim}4{\phi}$) material layers of psudo-gleization which showing inter-bedding of red and white layers. Chemical composition of matrix and other fine materials should be analyzed in further studies. It is attempted to fine the burial ages of the sediment using OSL method, but failed by the saturation. So it can be assumed that these sediments have be buried over 120ka.

• Journal of the Korean earth science society
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• v.40 no.1
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• pp.24-36
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• 2019

In the mid-eastern Yellow Sea, glacio-eustatic sea-level fluctuations and a regional tectonic subsidence have combined to represent an aggradational stacking pattern of sedimentary units during late Pleistocene-Holocene. The accumulated sediments are divisible into two-type units of Type-A and Type-B in high-resolution air-gun seismic profiles and the deep-drilled core of YSDP-105. Type-A unit largely comprises clast-rich coarse-grained sediments of non-marine to paralic origin, whereas Type-B unit consists mostly of tidal fine-grained sediments. Based on a bottom model of the sedimentary units, this study suggested a geoacoustic model of long-coring bottom layers at the YSDP-105 drilling site of the mid-eastern Yellow Sea. The geoacoustic model of 64-m depth below the seafloor with four-layer geoacoustic units was reconstructed in continental shelf strata at 45 m in water depth. For actual modeling, the geoacoustic property values of the models were compensated to in situ depth values below the seafloor using the Hamilton modeling method. We suggest that the geoacoustic model will be used for geoacoustic and underwater acoustic experiments of mid- and low-frequency reflecting on the deep bottom layers in the mid-eastern Yellow Sea.

• The Journal of the Petrological Society of Korea
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• v.11 no.3_4
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• pp.259-270
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• 2002

A small granodiorite-quartz monzonitic stock containing sericitic and propylitic alteration assemblages hosts a Cu-W breccia-pipe deposit in the southeastern Cyeongsang basin. The mineralized breccia-pipe contains angular to subangular brecciated fragments of granitic rocks showing clast-supported textures. An assemblage of quartz, tourmalines, sulfide minerals (mainly chalcopyrite, arsenopyrite and pyrrhotite) and calcite was precipitated as a hydrothermal cement between the brecciated fragments. A tourmaline aureole surrounds the breccia pipe. Extensive tourmalinization of the granitic rocks near and within the pipe and no tourmalinization in the sedimentary and volcanic rocks. The tourmalines are marked by Fe-rich, black charcoal-like schorl (80 mol% schorl relative) nearer the schorl-dravite solid solution. The chemical changes in the hydrothermal fluid are reflected by variations in compositional Boning from cores to rims. They generally contain cores with low values of Fe/(Fe+Mg) and high values of Na/(Na+ca) relative to rims. This is because of an increase Fe and Ca contents toward rims. The main trend of these variations is a combination of the exchange vectors Ca(Fe, Mg) $(NaAl)_{- }$ $_1$ and $Fe^{3}^{+}$ $Al_{[-10]}$ $_1$ It is thought that boiling causes the loss of $H_2$ into the vapor phase resulting in the oxidation of Fe in the aqueous phase. pH of the melt would be one of important controlling factors for the tourmaline stability. The tourmalines could be precipitated when the system evolved to the acidic hydrothermal regime as most hydrothermal brines and acidic gases exsolved from the magma. The Ilgwang tourmaline crystallization is products of hypogene orthomagmatic hydrothermal processes that were strongly pipe-controlled.