• Natural Product Sciences
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• 제23권4호
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• pp.299-305
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• 2017

P-methoxycinnamic acid and 3,4,5-trimethoxycinnamic acid are the compounds found in Polygalae Radix, the root of Polygala tenuifolia Willdenow, and have been reported to have hepatoprotective and anti-neurodegenerative effects. On the other hand, there are no reports of their effects on gastric lesions. This study examined the inhibitory effects of cinnamic acids, including p-methoxycinnamic acid, 3,4,5-trimethoxycinnamic acid, and 8 compounds (cinnamic acid, 2-(trifluoromethyl) cinnamic acid, 3-(trifluoromethyl) cinnamic acid, trans-4-(trifluoromethyl) cinnamic acid, 4-(dimethylamino) cinnamic acid, 3,4-(methylenedioxy) cinnamic acid and 3,4-dihydroxycinnamic acid), which were selected based on their presence in medicinal herbs and molecular weight, against gastric lesions. Animal models were used to confirm the protective effects on acute gastritis caused by the administration of HCl/EtOH. Gastric acid inhibition was examined by an acid-neutralizing test and the proton pump ($H^+/K^+$-ATPase) inhibiting activity. In addition, antioxidant tests were performed and the gastric emptying rate was determined. The results showed that cinnamic acid, p-methoxycinnamic acid, and 3,4,5-trimethoxycinnamic acid had an inhibitory effect on gastric lesions.

• Journal of Ginseng Research
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• 제33권2호
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• pp.111-114
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• 2009

백삼 및 백삼에 함유된 페놀성 성분 6종의 산화적 손상에 대한 신경세포보호효과와 LPS로 유도된 대식세포에서의 NO 생성억제효과를 검정한 결과 백삼 추출물은 두가지 모두에서 농도의존적인 효과를 나타내었다. 백삼에 함유된 페놀성 성분 중에는 cinnamic acid 및 maltol이 우수한 신경세포보호활성을 나타내었고 NO 생성억제효과는 ascorbic acid 및 cinnamic acid가 높았다. 또한 페놀성성분의 백삼내 함량을 정량한 결과 ascorbic acid, cinnamic acid, esculetin가 다른 성분들에 비하여 비교적 많이 함유되어 있었으며 이를 종합하여 볼 때 백삼의 신경보호효과 및 항염증효과에는 높은 함량 및 우수한 활성을 보이는 성분인 cinnamic aicd가 크게 기여하는 것으로 판단된다.

• 대한화학회지
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• 제6권1호
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• pp.94-98
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• 1962

The polycondensates of isophthalic acid-cinnamic acid-glycerine system were synthesized. The molecular weights of these products were determined by two methods, viscosity method and osmotic pressure methods. In the synthesis of resin, the reaction temperature was kept at 232$^{\circ}C$ and the mole ratio of the reactants was chosen as follows: Glycerine ;1.0 Isophthalic acid ;1.0 Cinnamic acid ;2.8 Excessive cinnamic acid prevented gelation of reaction mixtures. As the solution became very dilute, reduced osmotic pressure P/C (at the concentration of solution below 0.24g/100 ml of acetone) and reduced viscosity ${\eta}_{sp}/C$ (at the concentration of solution below 0.32 g/100 ml of acetone) increased rapidly. The correspondence between molecular weights determined by the two methods made Huggin's equation applicable to the prepared polymer. The values of K and a are $2.77{\times}10^{-5}$ and 1.063, respectively.

• The Korean Journal of Physiology and Pharmacology
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• 제22권3호
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• pp.257-267
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• 2018

The present study aimed to evaluate the cinnamic acid effect on memory impairment, oxidative stress, and cholinergic dysfunction in streptozotocin (STZ)-induced diabetic model in mice. In this experimental study, 48 male Naval Medical Research Institute (NMRI) mice (30-35 g) were chosen and were randomly divided into six groups: control, cinnamic acid (20 mg/kg day, i.p.), diabetic, and cinnamic acid-treated diabetic (10, 20 and 40 mg/kg day, i.p.). Memory was impaired by administering an intraperitoneal STZ injection of 50 mg/kg. Cinnamic acid was injected for 40 days starting from the 21st day after confirming STZ-induced dementia to observe its therapeutic effect. Memory function was assessed using cross-arm maze, morris water maze and passive avoidance test. After the administration, biochemical parameters of oxidative stress and cholinergic function were estimated in the brain. Present data indicated that inducing STZ caused significant memory impairment, whereas administration of cinnamic acid caused significant and dose-dependent memory improvement. Assessment of brain homogenates indicated cholinergic dysfunction, increase in lipid peroxidation and reactive oxygen species (ROS) levels, and decrease in glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) activities in the diabetic group compared to the control animals, whereas cinnamic acid administration ameliorated these indices in the diabetic mice. The present study demonstrated that cinnamic acid improves memory by reducing the oxidative stress and cholinergic dysfunction in the brain of diabetic mice.

• 미생물학회지
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• 제24권2호
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• pp.168-174
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• 1986

보리쌀중의 phenol 화합물 을 분리.확인하고 그 phen이 화합물의 추출액과 각 phenol 화합물이 Saccharomyces cerevlszae의 생육에 미치는 영향을 조사하였다. GLC로 분석한 결과, 보리쌀 중에는 cinnamic, protoca techuic, ferullic, sinapic. vanillic, syringic, gallic acid의 7 종이 분리.학인되었으며 그 중에서 sinapic, ferulic, cinnamic, prot toca techuic acid가 많이 존재 하는 편이였고 vanillic, syringic, gallic acid가 적게 존재하는 편이었다. Phenol 화합물의 추출액은 total phenol함량으로 100 ppm이상에서 Saccharomyces cerevisiae의 생육을 24시간 까지는 억제했으나 48시간 이후에는 억제하지 않았다. 분리.확인된 각 phen이 화합물 중에서 cinnamic, ferulic, vanillic acid는 효모의 생육을 전반적으로 억제했으며 그 중에서 cinnamic acid의 억제효과가 가장 컸다. Syringic acid는 생육초기에만 억제했으며 sinapic acid와 protocatechuic acid는 저농도에서 다소 촉진하는 것으로 나타났고 gallic acid는 생육에 별 영향이 없는 것으로 나타났다.

• 약학회지
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• 제12권3_4호
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• pp.89-90
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• 1968

현삼의 성분 p-methoxycinnamic acid의 전합성 기전을 검토하는 예비시험에서 trans-cinnamic acid의 출현을 동정하였다.

• 한국식품영양과학회지
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• 제35권6호
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• pp.713-720
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• 2006

식물자원으로부터 생리활성 물질의 이용측면에서 국내에서 자생하고 있는 광나무 잎을 대상으로 하여 다양한 생리활성을 가지는 것으로 보고된 페놀성 화합물의 분포를 확인하였다. 총 페놀성 함량은 $0.89{\sim}1.53%$, 축합형 탄닌은 $0.10{\sim}0.13%$였으며, flavonoid는 aglycone인 apigenin, luteolin과 칼럼크로마토그라피를 행하여 분획으로 분리한 후 가수분해하여 이들의 배당체를 확인하였다. 페놀산의 분획 중 유리형 페놀산 화합물에는 tyrosol, t-cinnamic acid, p-Hydroxybenzoic acid, vanillic acid, shikimic acid, protocatecuic acid등이 존재하였다. 에스테르형 페놀산 화합물에는 tyrosol, t-cinnamic acid, ferulic acid, esculetin, caffeic acid, p-coumaric acid, hydroxytyrosol 등이 함유되었다. 결합형 페놀성 화합물에는 tyrosol, t-cinnamic, p-coumaric acid와 미확인 페놀성 물질들이 존재하였다. 따라서 광나무 잎은 xanthine oxidase 활성저해, LDL 산화, 혈소판 응집저해, 항균활성 등 다양한 생리활성을 나타내는 것으로 보고되고 있는 tyrosol, hydroxytyrosol, protocatecuic acid 등 풍부한 페놀성 화합물을 함유하고 있으므로 유용한 식물자원이 될 수 있음을 확인하였다.

• 한국식품과학회지
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• 제29권4호
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• pp.823-826
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• 1997

소나무(Pinus densiflora Siebold et Zuccarini) 잎의 EtOAc 추출물이 세균, 효모, 곰팡이에 대하여 항미생물활성을 나타냈다. 활성물질은 solvent fractionation, silica gel adsorption column chromatography, Sephadex LH-20 column chromatography 등에 의해 정제되고 HPLC에 의해 분리되었다. 분리된 물질은 MS, $^{1}H-NMR,\;^{13}C-NMR$ 등의 기기분석에 의해 trans-cinnamic acid로 동정되었으며 이 물질은 솔잎 생체중량 g당 $9.27\;{\mu}g$정도 함유되어 있었다.

• 약학회지
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• 제13권2_3호
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• pp.67-70
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• 1969

Gall duct cannulated rats were given daphnetin, umbelliferone, 4-hydroxy-coumarin, dicoumarol, 4,7-dihydroxycoumarin, 4,7-dimethyl-5-hydroxy-coumarin, coumarin-3-carboxylic acid, cinnamic acid, ferulic acid, caffeic acid by duodenal catheter at room temperature and output of bile flow was detected. All of the subjected compounds in this experiment indicated a significant effect on the biliary elimination except cinnamic acid alone. It is suggested that a relationship exists between chemical pattern and biological activity for coumarin derivatives and their precursors, and that the choleretic activity of these compounds requires hydroxylated cinnamic acid structure as the most fundamental chemical pattern.

• 생약학회지
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• 제11권2호
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• pp.75-80
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• 1980

The decoctions and extracts were prepared on the traditionally prescribed four kinds (Kejigamcho-tang, Kejibanha-tang, Keji-tang, Kejiinsam-tang) of preparations containing Cinnamoni Raulus. The contents of cinnamic acid and cinnamic aldehyde in these preparations were determined by high performance liquid chromatography using reverse phase partition column, and 12% MeOH as eluting solvent. The sample was determined using the two wave length, 254nm and 280nm. This method was sucessfully applied to the analysis of cinnamic acid and cinnamic aldehyde of various preparations containing Cinnamons.