• Annual Conference of KIPS
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• 2004.11a
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• pp.51-54
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• 2004

시멘틱 웹은 기존의 웹과는 달리 정보의 의미가 정의되고, 이들 간의 의미적 연결을 지원한다는 특징이 있어서, 최근 차세대 웹으로 부각되고 있다. 이러한 의미적 연결을 위해서 시맨틱 웹의 기반인 온톨로지가 필요하다. 온톨로지는 리소스에 대한 메타데이터를 정의하여 의미적 연결이 가능하게 하므로 효율적인 정보 검색이 가능하다. 이 논문에서는 정보 검색의 효율을 증가시키기 위해서 시맨틱 웹의 핵심인 온톨로지 기반의 정보 검색 시스템을 제안한다. 쇼핑 사이트에서 효율적인 마케팅을 위해 사용자의 구매 패턴을 조사하여 고객에게 알맞은 정보 추천을 하기 위한 것을 목적으로 한다. 온톨로지의 구축은 XTM을 기반으로 토픽맵을 이용하였다. 그리고 온톨로지를 기반으로, 사용자의 구매패턴을 찾아서 정확한 정보 전달을 위해서 데이터 마이닝 기법을 이용하였다. 빈발패턴 트리 기법을 기반으로 하는 멀티 레벨 멀티 디멘션 빈발 패턴 마이닝 알고리즘을 이용하여 사용자 패턴을 분석하여 정보 검색에 효율을 기하였다.

• Annual Conference of KIPS
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• 2001.10a
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• pp.105-108
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• 2001

cDNA(complementary DNA)를 복제(cloneing)하여 염기 서열화 한 EST(Expressed Sequence Tag) 데이터는 여러 생물체들의 염기서열 정보들과 비교를 통해 유사점을 찾거나 기능적 부위 검색을 통해 유전자 기능을 추정한 수 있어 기능 유전체 연구에 많이 사용되고 있다. EST 데이터를 식물은 특정종(Species)별로, 동물의 경우 종의 조직별로 클러스터링 함으로써 아직 알려지지 않은 종의 유전자를 밝혀낼 수 있음은 물론 유전자의 발현에 따른 단백질의 기능도 알아낼 수 있다. 따라서 이 논문에서는 NCBI에서 flatfile 형태로 제공하는 EST 데이터를 분석하여 관계형 데이터베이스로 모델링하고 구축하였다. 또한 EST 데이터의 효율적인 사용을 위하여 데이터를 특정 종의 조직별로 클러스터링하여 제공하는 시스템을 설계하고 구현하였다.

• Proceedings of the KSRS Conference
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• 2003.11a
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• pp.564-566
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• 2003

There are no immutable phenomena in reality. A lot of applications are dealing with data characterized by spatial and temporal and/or uncertain features. Currently, there has no any data model accommodating enough those three elements of spatial objects to directly use in application systems. For such reasons, we introduce a fuzzy spatio -temporal data model (FSTDM) and a method of integrating temporal and fuzzy spatial operators in a unified manner to create fuzzy spatio -temporal (FST) operators. With these operators, complex query expression will become concise. Our research is feasible to apply to the management systems and query processor of natural resource data, weather information, graphic information, and so on.

• Safe Food
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• v.6 no.3
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• pp.31-41
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• 2011

• KOREAN JOURNAL OF CROP SCIENCE
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• v.44 no.4
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• pp.364-367
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• 1999

Swordbean was recently introduced to Korea, and cultural technique for stable production, e.g. optimum seeding date and planting space, has not been established. This experiment was conducted to elucidate the changes of growth characteristics, yield components, and yield as affected by different seeding dates and planting spaces. Days to flowering was shortened by 4∼28 days as seeding was delayed. Stem diameter, number of pods per plant, number of seeds per plant, 100-seed weight, and seed yield tended to increase with delaying seeding up to 5 April and then to decrease with further delaying seeding. These results indicate that optimum seeding date of swordbean in unheated polyvinyl house would be early April. Although, the swordbean exhibited large increases in plant height, number of branches per plant, and stem diameter at the wider spacings, planting space could be decreased to the 60 cm plant-spacing and 30 cm row-spacing with no deleterious effect on yield.

• Horticulture, Environment, and Biotechnology : HEB
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• v.59 no.6
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• pp.899-907
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• 2018

The methanol extracts of flowers obtained from 67 plant species were screened for their inhibitory activity on aldose reductase (AR). Alnus japonica, Aster spathulifolius, Chionanthus retusus, Morus bombycis, Crysanthemum boreale, Persicaria tinctoria, Platycarya strobilacea, and Serratula coronata var. insularis exhibited potent aldose reductase inhibitory (ARI) activity. HPLC-UV analysis of quercetin, an AR inhibitory flavonoid, was performed on extracts showing strong ARI activity. Quercetin was detected in C. retusus, C. boreale, P. tinctoria, and S. coronata var. insularis at concentrations of 1.33, 1.56, 0.82, and $3.37mg\;g^{-1}$ extract, respectively, indicating that quercetin contributed to the ARI activity of these extracts. In the samples in which quercetin was absent, other compounds may be responsible for their potent ARI activity. These results serve as a basis for further studies regarding the bioactive components responsible for the inhibitory effects of various flower extracts on AR activity.

• Journal of Ginseng Research
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• v.42 no.3
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• pp.361-369
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• 2018

Ginsenosides, dammarane-type triterpene saponins obtained from ginseng, have been used as a natural medicine for many years in the Orient due to their various pharmacological activities. However, the therapeutic potential of ginsenosides has been largely limited by the low bioavailability of the natural products caused mainly by low aqueous solubility, poor biomembrane permeability, instability in the gastrointestinal tract, and extensive metabolism in the body. To enhance the bioavailability of ginsenosides, diverse micro-/nano-sized delivery systems such as emulsions, polymeric particles, and vesicular systems have been investigated. The delivery systems improved the bioavailability of ginsenosides by enhancing solubility, permeability, and stability of the natural products. This mini-review aims to provide comprehensive information on the micro-/nano-sized delivery systems for increasing the bioavailability of ginsenosides, which may be helpful for designing better delivery systems to maximize the versatile therapeutic potential of ginsenosides.

• The Korean Journal of Physiology and Pharmacology
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• v.15 no.5
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• pp.313-317
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• 2011

The effects of extremely low frequency electromagnetic fields (EMF) on intracellular $Ca^{2+}$ mobilization and cellular function in RBL 2H3 cells were investigated. Exposure to EMF (60 Hz, 0.1 or 1 mT) for 4 or 16 h did not produce any cytotoxic effects in RBL 2H3 cells. Melittin, ionomycin and thapsigargin each dose-dependently increased the intracellular $Ca^{2+}$ concentration. The increase of intracellular $Ca^{2+}$ induced by these three agents was not affected by exposure to EMF (60 Hz, 1 mT) for 4 or 16 h in RBL 2H3 cells. To investigate the effect of EMF on exocytosis, we measured beta-hexosaminidase release in RBL 2H3 cells. Basal release of beta-hexosaminidase was $12.3{\pm}2.3%$ in RBL 2H3 cells. Exposure to EMF (60 Hz, 0.1 or 1 mT) for 4 or 16 h did not affect the basal or $1{\mu}m$ melittin-induced beta-hexosaminidase release in RBL 2H3 cells. This study suggests that exposure to EMF (60 Hz, 0.1 or 1 mT), which is the limit of occupational exposure, has no influence on intracellular $Ca^{2+}$ mobilization and cellular function in RBL 2H3 cells.

• Biomolecules & Therapeutics
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• v.8 no.1
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• pp.22-26
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• 2000

In order to study the cytotoxic properties of sesquitepenes, dehydrocostus lactone (DL) and costunolide from Saussurea lappa, cytotoxicity was measured by SRB method using various human cancer cell lines. Dehydrocostus lactone(DL) and costunolide exhibited significant cytotoxicity against A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT 15 cells. The U937 human leukemia cells treated with DL showed several apoptotic evidences like chromosome condensation and formation of apoptotic bodies. From the results of FACS analysis, early apoptosis was observed by phosphatidylserine externalization detected by annexin V-FITC. Furethermore, these studies determined hypodiploid contents and effects on the cell phase distribution of DL-treated U937 cells. After exposure of U937 cells to $30\mu\textrm{M}$ DL effectively led to G2/M modified cell cycle distribution within 24hr. These observations suggest that DL can be used efficiently for the cancer treatment.

• Journal of Oriental Neuropsychiatry
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• v.1 no.1
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• pp.71-80
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• 1990

For giving a person to understand that the relation between being used medicine and psychiatric medicine in the Nae ui won(內醫院). The psychiatric medicine were studied in the Nae ui won's diary. The results are as follows ; 1. It is supposed that the symtoms of Geong Chung, Hyun hun (眩暈) and Bulmyn(不眠) mainly appeared in 1908. 2. It is supposed that the symptoms of Guibeong(氣病) and ulchung(蔚症)mainly appeared in 1920. 3. It is supposed that the symptoms of Guibeong(氣病) and Talyeong(脫營) mainly appeared in 1924. 4. There were Cheongshim(淸心), Anshin(安神) and chingan(鎭肝) which added to a regular medical prescription. Finally with the help of these conclusions of which we have refered, we found that the cause of disease were changed according to the social situation of being free or repressed, and it also coinside with what Nae ui won's record said and practical result.