• Child Health Nursing Research
• /
• 제24권1호
• /
• pp.101-108
• /
• 2018

Purpose: This study aimed to identify the effects of the mother-medical staff partnership on mothers' condition management ability for children with chronic allergic diseases. Methods: A total of 109 Korean mothers caring for a child with a chronic allergic diseases, identified according to the allergic march, such as food allergy, atopic dermatitis, allergic rhinitis, and allergic asthma, were recruited from the pediatric department of a general hospital in Seoul through convenience sampling. Data were collected using structured self-reported questionnaires from August 1, 2017 to October 31, 2017. and analyzed by descriptive statistics and multiple regression using SPSS version 22.0. Results: The Mother-medical staff partnership had a statistically significant effect on mothers' condition management ability for children with chronic allergic diseases (p<.05). Among the general characteristics, satisfaction with nursing services had a statistically significant effect on mothers' condition management ability (p<.05). Conclusion: In conclusion, strategies to support children with chronic allergic diseases, as well as their caregivers, should consider the mother-medical staff partnership as part of a family-centered approach.

• Journal of Microbiology and Biotechnology
• /
• 제25권11호
• /
• pp.1966-1969
• /
• 2015

Canine atopic dermatitis (CAD) is a ubiquitous, chronic inflammatory skin disorder prevalent in dogs, which results in production of abnormal levels of IgE antibodies in reciprocation to an allergen challenge. In this study, administration of the probiotic strain Lactobacillus sakei probio-65 for 2 months significantly reduced the disease severity index in experimental dogs diagnosed with CAD. In addition, one month pre-medication of L. sakei probio-65 revealed significant difference in the PVAS score in experimental dogs for both probio-65 and placebo groups. However, post 2 months treatment resulted in a significant decrease in the CASESI score values in the probio-65-treated group (p < .0.06).

• Journal of Ginseng Research
• /
• 제44권1호
• /
• pp.8-13
• /
• 2020

Atopic dermatitis (AD) is a chronic and relapsing inflammatory disease that affects 1%-20% of people worldwide. Despite affecting many people, AD current treatments, such as corticosteroids and calcineurin inhibitors, have not only harmful secondary effects but are also often ineffective. Therefore, natural nontoxic compounds are on high demand for developing new effective AD treatments. Panax ginseng Meyer has been used traditionally for its promising healing and restorative properties to treat many diseases including skin disorders, reason why in this review we want to explore the research performed with AD and P. ginseng as well as determining its potential for new drug development. Previous researches have shown that P. ginseng has positive effects in AD patients such as lower eczema area and severity index, transepidermal water loss, and immunoglobulin E levels and better quality of sleep. In vivo animal models, as well, have shown positive results to P. ginseng and derived ginsenosides, such as the decrease of transepidermal water loss, immunoglobulin E levels in serum, allergy-related cytokines, and downregulation of NF-κB, MAPK, and Ikaros pathways. All of these previous data suggest that P. ginseng and its derived ginsenosides are undoubtedly a nontoxic effective option to treat AD.

• 대한약침학회지
• /
• 제23권3호
• /
• pp.173-178
• /
• 2020

Objectives: Atopic dermatitis (AD) is a prevalent and chronic, pruritic inflammatory skin condition that can influence all age groups. AD is associated with a poor health-related quality of life. This randomized clinical trial was performed to compare the effectiveness of Olivederma (combination of aloe vera and virgin olive oil) or betamethasone regarding disease severity, quality of life, serum IgE and eosinophil count. Methods: Thirty-six AD patients were randomly allocated to topical Olivederma or betamethasone, and were followed for 6 weeks. Results: Total SCORAD severity scores showed significant decrease in both groups, while it was more prominent in Olivederma group (64.5% improvement in Olivederma vs. 13.5% improvement in Betamethasone, p-value < 0.001). Quality of life (DLQI questionnaire) of AD patients was significantly improved after 6 weeks treatment with Betamethasone (22.3%, p < 0.001) and Olivederma (60.7%, p-value < 0.001). Olivederma group showed a significantly lower DLQI score in comparison with Betamethasone treated patients after 6 weeks of therapy (p < 0.001). Improvements in eosinophil count and serum IgE was observed. Conclusion: In summary, this study shows that Olivederma is superior to topical Betamethasone after 6 weeks of therapy with regard to disease severity, quality of life and eosinophil count.

• 동의생리병리학회지
• /
• 제21권6호
• /
• pp.1646-1654
• /
• 2007

The aim of this study was to investigate the effects of several herbal prescriptions in patients with allergy or atopic disease, such as atopic dermatitis, asthma and allergy rhinitis and others, on the blood immunological parameters and to verify the safety of long-term use of herbal medicine. Eighty one patients with allergy or atopy disease who taken herbal medicine at least for 2 months were compared with patients who taken same medicine with no allergy & atopy disease (n=14) and normal healthy subjects (n=22). According to the comparison of immunological parameters change, the data showed that herbal medicine decreased IgE (P=0.003), Eosinophil ratio (P<0.001) and count (P<0.001) of White Blood Cell (WBC) and did not affect to the liver cell enzymes in blood. This results indicated that herbal medicine decreased immune hypersensitivity and improved chronic inflammation related to blood immunological parameters of allergy or atopy diseases. In addition, herbal medicine seemed to be safe to the liver function for long-term use.

• Biomolecules & Therapeutics
• /
• 제30권6호
• /
• pp.501-509
• /
• 2022

Atopic dermatitis (AD) is a chronic inflammatory skin disorder. Suppression of MAPKs and NF-κB is implicated as a vital mechanism of action of several traditional Chinese medicines for AD therapy. Although overexpression of MAPK mRNA in the skin tissue has been shown in the AD model, the roles of each MAPK in AD pathogenesis have rarely been studied. This study examined the effect of NJK14047, an inhibitor of p38 MAPKs, on AD-like skin lesions induced in BALB/c mice by sensitization and challenges with 1-chloro-2,4-dinitrobenzene (CDNB) on dorsal skin and ears, respectively. After induction of AD, NJK14047 (2.5 mg/kg) or dexamethasone (10 mg/kg) was administrated for 3 weeks via intraperitoneal injection. Following its administration, NJK14047 suppressed CDNB-induced AD-like symptoms such as skin hypertrophy and suppressed mast cell infiltration into the skin lesions. It also reduced CDNB-induced increase in T_H2 cytokine (IL-13) and T_H1 cytokines (interferon-γ and IL-12A) levels but did not decrease serum IgE level. Furthermore, NJK14047 blocked CDNB-induced lymph node enlargement. These results suggest that NJK14047, a p38 MAPK inhibitor, might be an optimal therapeutic option with unique modes of action for AD treatment.

• Journal of Microbiology and Biotechnology
• /
• 제34권4호
• /
• pp.940-948
• /
• 2024

Codium fragile has been traditionally used in oriental medicine to treat enterobiasis, dropsy, and dysuria, and it has been shown to possess many biological properties. Atopic dermatitis (AD) is one of the types of skin inflammation and barrier disruption, which leads to chronic inflammatory skin diseases. In the current investigation, the protective effects of C. fragile extract (CFE) on anti-inflammation and skin barrier improvement were investigated. In LPS-stimulated RAW 264.7 cells, nitric oxide generation and the expression levels of interleukin (IL)-1β, IL-4, IL-6, iNOS, COX-2, and tumor necrosis factor-alpha (TNF)-α were reduced by CFE. CFE also inhibited the phosphorylation of NF-κB-p65, ERK, p-38, and JNK. Additionally, CFE showed inhibitory activity on TSLP and IL-4 expression in HaCaT cells stimulated with TNF-α/interferon- gamma (IFN-γ). Enhanced expression of factors related to skin barrier function, FLG, IVL, and LOR, was confirmed. These findings implied that CFE may be used as a therapeutic agent against AD due to its skin barrier-strengthening and anti-inflammatory activities, which are derived from natural marine products.

• 한방안이비인후피부과학회지
• /
• 제14권1호
• /
• pp.94-104
• /
• 2001

A Reports were done on 3 cases of proriasis, 1 case of chronic urticaria which were admition and treated by fasting therapy in Dept. surgery, opthalmology & otolaryngology, college of Oriental Medicine, Kyungsan University, Pohang, Korea, from March 1999 to October 2000. The results were as follows: 1. In the case chronic urticaria, symptom and sign(jtching, wheal, erythema), except of pigment, were showed conciderable improvement. 2. In the case proriasis, it is different of person, bellow 5cm sized erythematous popules were disappeared during fasting therapy, above 5cm sized erythematous papules and plaque were improved by using medication after fasting therapy. Silver-white colored scales was improved about $50-60\%$, itching was disappeared during fasting therapy. 3. After fasting therapy there was a recurrence, but about $40-50\%$ decreased symptoms were showed. 4. Besides upper diagnosis and treatment based on overall of symptoms and signs considered by documentary investigation, medications by Sasang prescription also can be expected good treatment effect.

• Biomolecules & Therapeutics
• /
• 제29권1호
• /
• pp.31-40
• /
• 2021

All living beings on earth have an important mechanism of 24-h periodicity, which controls their physiology, metabolism, and behavior. In humans, 24-h periodicity is regulated by the superchiasmatic nucleus (SCN) through external and environmental cues. Peripheral organs demonstrate circadian rhythms and circadian clock functions, and these are also observed in cultured cell lines. Every cell contains a CLOCK: BMAL1 loop for the generation of circadian rhythms. In this review, we focused on cell autonomous circadian rhythms in immune cells, the inflammatory diseases caused by disruption of circadian rhythms in hormones, and the role of clock genes in inflammatory diseases.

• 한국식품과학회지
• /
• 제53권2호
• /
• pp.139-148
• /
• 2021

아토피피부염은 성인 및 어린이에서 모두 발생할 수 있지만, 특히 어린이에게서 많이 발병하는 질환으로 만성, 재발성, 염증성 피부질환이며, 심한 가려움증을 동반해 일상생활을 힘들게 한다. 현재까지 아토피피부염에 대한 치료법은 스테로이드성 연고를 도포하는 것뿐이지만, 많은 환자들은 스테로이드 장기 사용에 의한 부작용을 겁내고, 이는 스테로이드 포비아로까지 번지고 있어 아토피피부염의 완화를 위한 천연 대체재가 절실한 상황이다. 과거 뼈 건강과 칼슘 대사만을 담당하는 것으로 알려져 왔던 비타민 D가 면역조절에서 있어서 중요한 역할을 담당한다는 사실이 밝혀지며, 대표적인 알레르기성 질환의 하나인 아토피피부염과 비타민 D 사이의 상관관계를 분석한 연구가 다수 보고되었다. 아토피피부염의 발병 또는 중증도는 다양한 원인이 복합적으로 작용한다고 알려져 있다. 많은 연구들이 이러한 변수들을 통제하지 않고 단면조사연구로 진행되었기에 발표된 연구들 간에 상충성이 존재하지만 과반수 이상의 연구결과들이 유의적인 상관관계를 보고하고 있고, 인구집단을 특정하였을 때, 상관관계를 보였다는 연구 결과를 토대로 하면 혈중 비타민 D 농도와 아토피 피부염의 발생 또는 중증도 사이에는 약한 상관관계가 있을 가능성이 있는 것으로 생각된다. 그러나 명확한 상관관계를 파악하기 위해서는 다양한 변수를 통제한 연구가 진행되어야 할 것으로 생각된다. 최근에는 혈중 비타민 D 농도와 아토피피부염 간의 관계를 파악하기 위해 단면조사연구보다는 아토피피부염 환아에게 직접 비타민 D를 투여 후 질환의 개선효과를 확인하는 무작위대조군 연구가 많이 시도되고 있다. 본 논문에서 검토한 논문 중 70%는 경구로 1000-5000 IU의 비타민 D를 21일-3개월 투여 시 아토피피부염의 중증도가 유의적으로 개선되었음을 보고하였다. 연구들 간의 상충성은 연령, 계절, 위도, 자외선 선량 및 자외선 조사 시간 등 다양한 변수들이 작용하였기 때문이라 생각된다. 다소 상반되는 연구결과들이 있지만, 비타민 D가 아토피피부염을 유의적으로 개선하였다는 결과들은 아토피피부염을 비롯한 알레르기성 질환의 완화에 있어서 비타민 D의 활용 가능성을 제시하고 있다. 비타민 D를 아토피피부염 개선을 위한 치료제로서 적용하기 위해서는 좀 더 체계적으로 설계된 실험이 진행되어야 할 것으로 생각되며, 면역조절기능을 위한 적절한 섭취용량이 도출되어야 할 것으로 사료된다.