• 정신신체의학
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• 제26권2호
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• pp.145-151
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• 2018

연구목적 만성정신질환자들의 회복 및 사회적 복귀를 돕기 위해 주거시설 서비스가 제공되고 있지만, 집단적인 보호방식 및 획일화된 훈련 등으로 인해 문제가 되고 있다. 이에 주거훈련시설에 대한 연구 참여자들의 기대 및 욕구를 알아보기 위해 조사 연구가 이루어졌다. 방 법 안산 지역 내 정신보건 기관을 이용하는 만성정신질환자 139명을 대상으로, 설문을 통해 인구사회적 특성, 자립의지, 원하는 주거 시설 형태 및 주거 서비스에 대해 조사하였다. 결 과 과반수이상이 자립에 대한 욕구를 보였으며, 이를 위해 일자리 지원을 가장 필요로 했다. 주거 시설 이용에 대해서는 긍정적인 태도를 보였으며, 일상생활 및 사회기술 훈련이 필요하다고 하였다. 시설형태는 주간재활방식을 선호했고, 주중에는 공동생활을 하다가 주말에는 집으로 귀가하는 운영방식을 원했다. 결 론 주거훈련시설 참여와 관련하여 실제 이용자들의 욕구가 실질적인 치료 및 재활프로그램에 반영될 수 있도록, 주거훈련시설 및 재활서비스의 개선이 필요하겠다.

• Molecular & Cellular Toxicology
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• 제3권2호
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• pp.127-131
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• 2007

Chronic treatment with olanzapine (OLZ), an atypical antipsychotic drug, is associated with the adverse effects of weight gain, hyperglycemia and/or hypertriglyceridemia. Green tea or epigallocatechin gallate (EGCG), one of the most abundant green tea polyphenols, significantly reduces or prevents an increase in glucose levels, lipid markers and/or body weight. We hypothesized that combined treatment with OLZ and green tea extract (GTE) or EGCG may prevent body weight gain and increase of the lipid markers. ICR male mice weighing an average of 30.51 g (n=32) at the beginning of the experiment were used. OLZ, OLZ+GTE and OLZ+EGCG were administered for 27 d in the drinking water, and then the levels of fasting glucose, nitric oxide (NO), and a typical lipid marker triglyceride (TG) were determined in plasma. The body weight and food intake were also compared. The chronic treatment of OLZ increased the average body weight compared with that of controls. In the presence of GTE or EGCG, the OLZ-induced increase in body weight was significantly prevented. Furthermore, in the OLZ group, the plasma levels of glucose, NO and TG were significantly increased, whereas GTE or EGCG prevented these increases. These results implicate that OLZ may induce systematic inflammatory reaction, and suggest that GTE or EGCG can protect against OLZinduced weight gain, hyperglycemia and hypertriglyceridemia.

• 보건의료생명과학 논문지
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• 제8권2호
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• pp.135-142
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• 2020

본 연구는 강원도 영북지역에 주소를 둔 환자의 입원/외래 진료의 이용빈도를 분석하여 영북지역의 의료수요 및 의료이용 현황 파악을 하고자 국민건강보험공단 공공데이터포털(www.data.go.kr) 2003년 부터 2017년까지 건강보험 및 의료급여(입원/외래) 진료비 청구자료를 분석하였다. 다빈도 순위는 '진료건 및 %'에 따라 최빈도의 상병순으로 1-60순위까지의 순위를 선정하였다. 또한, 영북권 유일의 속초의료원 환자의 이용 추이를 병행 분석하였다. 분석결과 강원도 영북지역은 과거 급성기 질환에서 점차 만성인 비감염성 질환의 형태로 상병에 따른 외래 진료 이용과 입원환자의 이용이 증가하고 있다. 특히 조현병과 산과진료의 기능을 확충하고 지역사회의 건강관리에 필요한 구체적인 보건사업을 수행할 필요가 있으며 이를 통해 강원도 영북지역 주민의 삶의 질적 향상을 높여야 한다.

• 대한간호학회지
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• 제24권1호
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• pp.5-17
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• 1994

The purpose of this research was to determine whether or not a consistent program of aerobic exercise as a nursing intervention would have beneficial effect on schizophrenic patients. Nonequivalent control group pre-post test research was designed. Subjects for this study were selected from thirty-eight chronically schizophrenic patients who were hospitalized at S psychiatric hospital in Taejeon city. Of them seventeen were experimental group, twenty-one were control group. The data were collected during the period from November 1 to December 30, 1992. The instruments used in this study were Scale for Assessment of Negative Symptom developed by Andreason, Behavioral Observational Checklist (SASS) developed by Jorgensen, Harvard Step Up Test. The data were analyzed by descriptive statistics, t-test and paired t-test, using the SPSS program. The results of this study are summerized as follows : 1. The scores of SANS were a significantly difference from pre to posttesting, when the experimental group was contrasted to the control group (t=4.73, p=.00). 2. The scores of SASS were a significantly difference from pre to posttesting, when the experimental group was contrasted to the control group (t=3.42, p=.00). 3. The scores of physical fitness were a significantly difference from pre to posttesting, when experimental group was contrasted to the control group (t=-5.87, p=.00).

• 임상간호연구
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• 제15권2호
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• pp.127-138
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• 2009

Purpose: The purpose of this study was to explore self-reported perceived stigma, self-efficacy, and quality of life among psychiatric outpatients Methods: In the present study, researchers analyzed the survey responses of 195 patients recruited in the S hospital psychiatry outpatient clinic. The measurement tools used in this study were the "Devaluation & Discrimination" scale to determine perceptions of stigmatization, general and social efficacy scales to measure self-efficacy, and the "General Well-Being Index" to measure quality of life in psychiatric outpatient. Statistical analysis included means with standard deviation, t-test, ANOVA and Pearson correlation coefficients to identify relationships between the variables. Results: There was a significant difference in self-perceived stigma and quality of life in psychiatric outpatients (r=-.233, p=.001) and a negative correlation between self-efficacy and quality of life (r=-.424, p=.000). Correlation analysis results support the hypothesis that higher self-perceived stigma scores were related to reduced quality of life among patients with schizophrenia (r=-.231, p=.021), while there was a positive correlation between self-perceived stigma scores and self-efficacy scores among patients with bipolar disorder (r=.362, p=.013). Conclusion: The findings suggest that nursing imtervention strategies should include education programs to reduce stigmatization and enhance self-efficacy and quality of life among patients with chronic psychiatric illnesses.

• Journal of Yeungnam Medical Science
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• 제10권2호
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• pp.338-344
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• 1993

1990년 1월부터 1993년 2월까지 영남대학교 의과대학 부속병원 정신과 및 국립부곡정신병원 정신과에 외래 및 입원한 만성 정신분열증환자 78명, 급성 정신분열증환자 62명인 140명(60.6%)과 정상 집단 91명(39.4)로 총 231명을 대상으로 하였다. 이들을 대상으로 하여 Eysenck 성격차원 검사중에서 외-내향성 차원의 척도를 중심으로 하여 측정한 특질적 피질각성수준에 대한 다음과 같은 결과를 얻었다. 정상 집단과 만성 및 급성 정신분열증 집단에서 EPQ검사 중 외-내향성 척도를 사용하여 특질적 피질각성수준을 비교한 결과, 특질적 피질각성수준은 만성 정신분열증 집단이 정상 집단보다 더 높은 것으로 나타났으며, 또한 만성 정신분열증 집단이 급성 정신분열증 집단보다 더 높은 것으로 나타났다. 이러한 결과는 정신분열증 집단의 각성수준이 정상 집단보다 높다는 것을 나타내고 있었다. 특질적 피질각성수준이 정상 집단과 급성 정신 분열증 집단에서는 차이를 보이지 않았다. 그러나 급성보다 만성 정신분열증 집단에서 더 높게 나타난 결과는 정신분열증 증상이 나타난 시간에 따라 특질적 피질각성수준이 달라짐을 시사해 주는 것으로 볼 수 있었다. 이러한 연구결과는 병의 경과가 오래될수록 특질적 피질각성수준이 더 높아지는 것으로 사료된다. 급성 정신분열증보다 만성 정신분열증은 특질적 피질각성수준이 더 높을 것으로 나타났다. 이는 정상인보다 정신분열증 환자의 각성수준이 더 높으며, 증상이 만성화되어 감에 따라서 특질적 피질각성 수준이 더 높아지는 것으로 해석되었다.

• 생물정신의학
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• 제4권1호
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• pp.84-94
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• 1997

본 연구는 27명의 만성 정신분열증 환자들을 대상으로 비정형적 항정신병 약물인 clozapine을 8주간 투여하여 임상증상 치료반응(PANSS와 CGI 척도 이용)과 혈장 대사물(혈장 HVA 농도, 5-HIAA 농도 및 HVA/5-HIAA 농도비 측정) 변화와의 상관관계를 알아보고, 아울러 clozapine 치료 반응군과 치료 비반응군간의 약물투여전 기준 혈장 대사물과 clozapine투여 8주후 대사물의 변화율을 비교하여 혈장 대사물 농도가 clozapine 치료의 예측인자로서 가능성이 있는 가를 알아 보기 위하여 시행되었다. 전체 연구대상군에서 clozapine 투여기간에 따른 혈장 HVA 농도, 5-HIAA 농도는 각각 유의한 감소가 있었으나, 혈장 HVA/5-HIAA 농도비는 유의한 변화가 없었다. 전체 연구대상군에서 clozapine 투여 8주 후 혈장 HVA 농도변화율, 혈장 5-HIAA 농도변화율, 혈장 HVA/5-HIAA 농도비 변화율 각각과 8주후 정신병리(PANSS 양성척도점수, 음성척도점수, 일반정신병리척도 점수, 전체점수) 변화율과의 상관분석결과 혈장 HVA 변화율은 PANSS 양성척도점수 변화율, 일반정신병리척도 점수 변화율, 그리고 전체점수의 변화율과 각각 유의한 정 상관성이 있었으며, 반면 혈장 5-HIAA 농도 변화율은 PANSS 음성척도점수 변화율과 유의한 정 상관성이 있었다. 전체 연구대상군에서 clozapine 투여 8주 후 혈장 HVA 농도변화율은 PANSS 양성척도 항목중 특히 망상 및 환각행동 항목점수의 변화율과 각각 유의한 정 상관성이 있었으며, PANSS 음성척도 항목중에서는 대화흐름 및 자발성 결여 항목점수의 변화율과 유의한 정 상관성이 있었다. 혈장 5-HIAA 농도 변화율은 PANSS 음성척도 항목 중 둔마된 정동, 빈약한 신뢰감 항목 점수의 변화율과 각각 유의한 정 상관성이 있었다. Clozapine 투여 8주 후 PANSS 전체점수가 20% 이상 감소되고 CGI 심도점수가 경도 이하인 경우를 치료반응의 기준으로 정의했을 때, 전체 27명의 대상환자 중 48%(13명)가 치료반응군이었다. Clozapine 치료 반응군(N=13명)과 치료 비반응군(N=14명)의 비교에서 약물투여 전 기준 혈장 HVA 농도와 기준 혈장 HVA/5-HIAA 농도비는 치료 반응군이 유의하게 높았으며, 기준 혈장 5-HIAA 농도는 양 군 간의 유의한 차이가 없었다. Clozapine 치료반응군의 경우 약물투여 8주 후 혈장 HVA 농도가 40.3% 감소하고, 치료 비반응군은 혈장 HVA 농도가 3.1% 증가하여 양군 간의 유의한 차이를 보였다. Clozapine 투여 8주 후 혈장 5-HIAA 농도변화율과 혈장 HVA/5-HIAA 농도비 변화율은 치료반응군과 비반응군 간에 각각 유의한 차이가 없었다. 이상의 연구결과는 만성 정신분열증 환자에서 clozapine의 항정신병효과 중 양성증상은 도파민 길항효과와 관련이 있고, 음성증상은 세로토닌 길항효과와 관련이 있음을 시사하였다. 또한 만성 정신분열증 환자에서 약물투여 전 혈장 HVA 농도와 약물투여 후 혈장 HVA 농도변화가 각각 clozapine의 치료반응 예측인자로서 이용 가능성이 있음을 시사하였다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제34권1호
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• pp.37-44
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• 2023

Objectives: Tic disorders are highly heritable; however, growing evidence suggests that environmental factors play a significant role in their pathogenesis. Studies on these factors have been inconsistent, with conflicting results. Therefore, this study aimed to examine the associations of pre- and perinatal exposure to Tourette syndrome (TS) or chronic tic disorders (CTD) in Korean school-aged children. Methods: This case-control study used data from a large prospective cohort study. The primary outcome was TS/CTD diagnosis according to the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) criteria and Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version-Korean Version. Demographic, pre-, and perinatal information was obtained from the maternal questionnaires. Data between the TS/CTD and control groups were compared using the chi-squared or Student's t-test, as appropriate. Two-step logistic regression analyses were used to test the association between TS/CTD and pre- and perinatal risk factors. Results: We included of 223 children (78 with TS/CTD and 145 controls). Significant differences in the demographic data between the two groups were observed. The male sex ratio, mean parental age, parental final education level, and family history of tics were included as confounders. In the final adjusted multivariable model, TS/CTD was significantly associated with antiemetic exposure during pregnancy (odds ratio [OR]=16.61, 95% confidence interval [CI] 1.49-185.22, p=0.02) and medically assisted reproduction (OR=7.89, 95% CI 2.28-27.28, p=0.01). Conclusion: Antiemetic exposure and medically assisted reproduction are significantly associated with the risk of TS/CTD. These results should be replicated in future prospective and gene-by-environment studies.

• Neonatal Medicine
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• 제25권1호
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• pp.7-15
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• 2018

We need to understand the outcomes into adulthood for survivors born either extremely low birthweight (ELBW; <1,000 g) or extremely preterm (EP; <28 weeks' gestational age), particularly their blood pressure and cardiovascular metabolic status,respiratory function, growth, psychological and mental health performance, and functional outcomes. Blood pressure is higher in late adolescence and early adulthood in ELBW/EP survivors compared with controls. In some studies, expreterm survivors have higher insulin and blood lipid concentrations than controls, which may also increase their risk for later cardiovascular disease. ELBW/EP survivors have more expiratory airflow obstruction than do controls. Those who had bronchopulmonary dysplasia (BPD) in the newborn period have even worse lung function than those who did not have BPD. As a group, they are unlikely to achieve their full lung growth potential, which means that more of them are likely to develop chronic obstructive airway disease in later life. Although they are smaller than term born controls, their weight gradually rises and ultimately reaches a mean z-score close to zero in late adolescence, and they ultimately attain a height z-score close to their mid-parental height z-score. On average, ex-preterm survivors have intelligence quotient (IQ) scores and performance on tests of academic achievement approximately 2/3 SD lower than do controls, and they also perform less well on tests of attention and executive function. They have similar high rates of anxiety and depression symptoms in late adolescence as do controls. They are, however, over-represented in population registries for rarer disorders such as schizophrenia and Autism Spectrum Disorder. In cohort studies, ex-preterm survivors mostly report good quality of life and participation in daily activities, and they report good levels of self-esteem. In population studies, they require higher levels of economic assistance, such as disability pensions, they do not achieve education levels as high as controls, fewer are married, and their rates of reproduction are lower, at least in early adulthood. Survivors born ELBW/EP will present more and more to health carers in adulthood, as they survive in larger numbers.

• 한국의료질향상학회지
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• 제2권2호
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• pp.112-129
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• 1996

Background : A small number of high cost patients usually spend a larger proportion of scarce health resources. Aged, long-term care and readmitted patients usually belong to these high cost patient group. Among others, long length of stay and readmission can be reduced by checking its cause, and these are the areas needed most of quality improvement activity. Characteristics of high cost medical users between health insurance program and medical assistance program were reviewed. Methods : The inpatient claims of health insurance and medical assistance program were analyzed. Patients were divided by 6 groups; long-term, mid-term, short-term, readmitted, cancer and aged. We defined high cost patients as those who had spent one and half million won and over per 6 months. Characteristics of high cost patients for each group were reviewed. Results : medical assistance patients used much more resources than the insured members in the average hospital cost per case but less in daily hospital cost. The former had a longer length of stay and had much heavier diseases. Major diseases of both group were cancer, diseases of circulatory system and chronic degenerative diseases. Gallstone and schizophrenia were more in the insured program. However, pulmonary tuberculosis, asthma were more common among the medical assistance patients. Early readmission before 2 weeks were 28-30% of the total readmission. Readmission rate in the malignat neoplasm and renal failure were 80% and more. Q.A program should be installed to prevent unnecessary readmissions. Conclusion : Almost 30% of early readmissions and admissions due to complications and long length of stay should be reviewed carefully to keep cost down and to enhance the quality of hospital care.