• The Journal of Korean Academy of Sensory Integration
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• v.22 no.1
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• pp.25-42
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• 2024

Objective : The aim of this study was to investigate the effects of a sensory integration intervention on the sensory processing and posture control of children with developmental delays and a simultaneous family-centered coaching intervention on their parents' parenting efficacy. Methods : This study adopted a multiple probe design across four children aged five to six with developmental delays and their parents. A sensory integration intervention and a family-centered coaching intervention were employed twice a week in a total of 16 sessions over 8 weeks. Sensory profiles were evaluated, and the Korean version of the Parenting Sense of Competence was used before and after the interventions, and changes in post-intervention posture control were measured using Biorescue equipment. Results : During the intervention period, weight support in the sitting, Sitting with eyes closed, and standing positions evaluated using Biorescue was higher than two standard deviations from the baseline. After the interventions, all children showed enhanced sensory processing. Conclusion : Sensory integration and family centered coaching interventions have positive effects on the sensory processing and posture control of children with developmental delays and on their parents' parenting efficacy.

• Korean Journal of Child Studies
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• v.34 no.5
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• pp.1-16
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• 2013

This study examined the effects of paternal smoking on the developmental levels of children younger than 3 years of age. For this purpose, the paper made use of data from the Panel Study on Korean Children which has been released in 3 waves - 2008, 2009, and 2010. The main findings are as follows. First, the smoking characteristics of parents (e.g., the amount of smoking in the morning, the time starting the first cigarette of the day) rather than the duration of smoking or whether the father smoked or not revealed significant relationships with developmental levels. Second, children whose fathers preferred smoking in the morning exhibited lower activity levels or more areas with developmental delays than did their counterparts. Third, children whose fathers smoked more than 11 cigarettes a day were more likely to show problematic developmental levels, especially among those whose fathers responded so only for 1 year out of 3 years. Based on these findings, this study suggests that future research may be conducted, relating to the mechanisms through which morning smoking affects children and possible interventions for such morning smokers.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.7
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• pp.4198-4211
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• 2014

The purpose of this study was to integrate the general education activities in the preschool developmental delay regarding the effect on the social skills of infant and young children. The participants of this research were young children with a developmental delay, who were enrolled in a school for the physically challenged in Gim-Hae City, South Kyongsangnamdo in Korea. An experimental qualitative module was selected to observe the social consequences after taking the extensive educational programs on young children with a developmental delay. The data was based on the observations of a researcher regarding the child's behavior and videotaped material was analyzed qualitatively in terms of the occasions and their social behaviors while extensive education was performed. The qualitative analysis explains the lower arena of the learning social skill including the quantitative changes in the communicational skill, and self-control skills.

• Therapeutic Science for Rehabilitation
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• v.13 no.1
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• pp.75-86
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• 2024

Objective : The purpose of this study was to examine the effects of an occupational therapy program on the school readiness, focusing on adaptation skills and daily life skills, in children with developmental delays. Methods : The study involved a boy with developmental delay, aged 5 years and 8 months. The program was conducted twice a week, with a total of 8 sessions spread over 4 weeks. The Canadian Occupational Performance Measure (COPM) was employed, targeting class preparation and use of the toilet. Pre-post tests and follow-up evaluations were carried out to compare changes. Data analysis involved video recordings of the subject's performance. Results : The COPM results indicated improvements in both the performance and satisfaction levels for class preparation and toilet use. Processing skills showed seven improvements in class preparation and eight improvements in toilet use during post-testing. Activity performance observations further confirmed improvements in both class preparation and toilet use during post-test and follow-up evaluations. Conclusion : Occupational therapy improves school readiness (adaptation skill, daily living activity skill) for children with developmental delays, and has a positive effect on overall school readiness.

• Therapeutic Science for Rehabilitation
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• v.11 no.3
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• pp.81-92
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• 2022

Objectives : This study aimed to investigate the effect of beat-keeping games in smartphone applications on improving executive functions in children with developmental delays. Methods : Three children diagnosed with developmental delay were included in this study. The ABA design used a single-subject experimental research design. The independent variable was the beat-keeping game. The game was held three times a week for a total of seven times for 20 minutes, including breaks. The dependent variable, "Visual-motor speed," was measured every session to assess if the beat-keeping game was effective in improving the participant's executive function. Further, before and after the intervention, "Children's Color Trails Test (CCTT)", "Block design," and "Finding hidden picture" were measured. Results : All three participants showed improvement in the performance of the beat-keeping game and the executive functions of "Visual-motor speed" and visual attention. Conclusions : Based on the results of this study, various effective applications for learning and intervention can be developed and applied to children with developmental delays who have difficulty in motivating themselves and lack attention.

• Clinical and Experimental Pediatrics
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• v.59 no.sup1
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• pp.25-28
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• 2016

Phelan-McDermid syndrome is a rare genetic disorder caused by the terminal or interstitial deletion of the chromosome 22q13.3. Patients with this syndrome usually have global developmental delay, hypotonia, and speech delays. Several putative genes such as the SHANK3, RAB, RABL2B, and IB2 are responsible for the neurological features. This study describes the clinical features and outcomes of Korean patients with Phelan-McDermid syndrome. Two patients showing global developmental delay, hypotonia, and speech delay were diagnosed with Phelan-McDermid syndrome via chromosome analysis, fluorescent in situ hybridization, and multiplex ligation-dependent probe amplification analysis. Brain magnetic resonance imaging of Patients 1 and 2 showed delayed myelination and severe communicating hydrocephalus, respectively. Electroencephalography in patient 2 showed high amplitude spike discharges from the left frontotemporoparietal area, but neither patient developed seizures. Kidney ultrasonography of both the patients revealed multicystic kidney disease and pelviectasis, respectively. Patient 2 experienced recurrent respiratory infections, and chest computed tomography findings demonstrated laryngotracheomalacia and bronchial narrowing. He subsequently died because of heart failure after a ventriculoperitoneal shunt operation at 5 months of age. Patient 1, who is currently 20 months old, has been undergoing rehabilitation therapy. However, global developmental delay was noted, as determines using the Korean Infant and Child Development test, the Denver developmental test, and the Bayley developmental test. This report describes the clinical features, outcomes, and molecular genetic characteristics of two Korean patients with Phelan-McDermid syndrome.

• The Journal of the Convergence on Culture Technology
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• v.10 no.6
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• pp.35-46
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• 2024

This study aimed to examine the effects of an art rehabilitation program developed based on the fine motor skills component of the Korean Bayley Scales of Infant and Toddler Development(K-Bayley-III) on the fine motor development of children with developmental delays. Early intervention programs for children with developmental delays are crucial, as they can significantly enhance motor skills during formative stages. The study focused on a 36-month-old boy with delayed fine motor development, and the program was implemented twice a week for a total of 40 sessions. The program included the following areas: Eye Movement Control, Early Stage Hand Movements, Reaching in Space, Object Grasping and Manipulation, Bilateral Coordination, Pre-writing Skills and Pencil Grasp, Finger and Hand Movement Control, Tool Use and Motor Planning. Pre- and post-program assessments were conducted to evaluate the effectiveness of the program, and the changes in the child were qualitatively analyzed. The results confirmed that the child's scores in the fine motor domain improved and his hand and finger manipulation skills improved. This study suggests the use of an art rehabilitation program to promote fine motor development in children, and serves as a foundation for their further developmental progress.

• Journal of Genetic Medicine
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• v.11 no.2
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• pp.79-82
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• 2014

Mowat-Wilson syndrome is an extremely rare genetic disease that is characterized by intellectual disability, facial dysmorphism, Hirschsprung's disease, and other congenital anomalies. This disorder is caused by heterozygous mutations or deletions in the zinc finger E-box-binding homeobox-2 gene (ZEB2). Thus far, approximately 200 cases of Mowat-Wilson syndrome have been reported worldwide. In Korea, only one case with a 2q22 deletion, which also affects ZEB2, has been previously reported. Here, we describe a patient with Mowat-Wilson syndrome who presented with developmental delays, typical facial dysmorphism, and Hirschsprung's disease. Molecular analysis of ZEB2 identified a novel heterozygous mutation at c.190dup ($p.S64Kfs^*6$). To our knowledge, this is the second report of a Korean patient with Mowat-Wilson syndrome that has been confirmed genetically.

• Clinical and Experimental Pediatrics
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• v.59 no.1
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• pp.16-23
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• 2016

Purpose: The 1p36 deletion syndrome is a microdeletion syndrome characterized by developmental delays/intellectual disability, craniofacial dysmorphism, and other congenital anomalies. To date, many cases of this syndrome have been reported worldwide. However, cases with this syndrome have not been reported in Korean populations anywhere. This study was performed to report the clinical and molecular characteristics of five Korean patients with the 1p36 deletion syndrome. Methods: The clinical characteristics of the 5 patients were reviewed. Karyotyping and multiplex ligation-dependent probe amplification (MLPA) analyses were performed for genetic diagnoses. Results: All 5 patients had typical dysmorphic features including frontal bossing, flat right parietal bone, low-set ears, straight eyebrows, down-slanting palpebral fissure, hypotelorism, flat nasal roots, midface hypoplasia, pointed chins, small lips, and variable degrees of developmental delay. Each patient had multiple and variable anomalies such as a congenital heart defect including ventricular septal defect, atrial septal defect, and patent duct arteriosus, ventriculomegaly, cryptorchism, or hearing loss. Karyotyping revealed the 1p36 deletion in only 1 patient, although it was confirmed in all 5 patients by MLPA analyses. Conclusion: All the patients had the typical features of 1p36 deletion. These hallmarks can be used to identify other patients with this condition in their early years in order to provide more appropriate care.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.33 no.1
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• pp.16-23
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• 2022

Objectives: Early detection of developmental issues in infants and necessary intervention are important. To identify the comorbid conditions, a comprehensive evaluation is required. The study's objectives were to 1) generate scale items by identifying and eliciting concepts relevant to young children (12-71 months) with developmental delays, 2) develop a comprehensive screening tool for developmental delay and comorbid conditions, and 3) assess the tool's validity and cut-off. Methods: Multidisciplinary experts devised the "Infant Comprehensive Evaluation for Neurodevelopmental Delay (ICEND)," an assessment method that comes in two versions depending on the age of the child: 12-36 months and 37-71 months, through monthly seminars and focused group interviews. The ICEND is composed of three parts: risk factors, resilience factors, and clinical scales. In parts 1 and 2, there were 41 caretakers responded to the questionnaires. Part 3 involved clinicians evaluating ten subscales using 98 and 114 questionnaires for younger and older versions, respectively. The Child Behavior Checklist, Strengths and Difficulties Questionnaire, Infant-Toddler Social Emotional Assessment, and Korean Developmental Screening Test for Infants and Children were employed to analyze concurrent validity with the ICEND. The analyses were performed on both typical and high-risk infants to identify concurrent validity, reliability, and cut-off scores. Results: A total of 296 people participated in the study, with 57 of them being high-risk (19.2%). The Cronbach's alpha was positive (0.533-0.928). In the majority of domains, the ICEND demonstrated a fair discriminatory ability, with a sensitivity of 0.5-0.7 and specificity 0.7-0.9. Conclusion: The ICEND is reliable and valid, indicating its potential as an auxiliary tool for assessing neurodevelopmental delay and comorbid conditions in children aged 12-36 months and 37-71 months.