• 한국융합학회논문지
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• 제9권3호
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• pp.153-163
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• 2018

본 연구의 목적은 국내에서 이루어진 자폐스펙트럼장애아동을 대상으로 한 로봇 활용 융합연구동향을 살펴보는 것이다. 이를 위하여 최근에 장애 아동의 교육적, 치료적 중재에 연구되고 있는 로봇연구 동향을 살펴보고자 하였다. 연구방법으로, 자폐를 키워드로 2009년 이후에 발표된 논문을 검색하여 총 17편의 연구 논문을 최종 선정하였고, 활용로봇, 독립변인, 종속변인 유형, 연구방법을 바탕으로 하여 주제별 범주로 묶어 내용 분석하였다. 연구결과, 그 중 자폐아동을 위한 로봇개발은 발전이 빠른 분야 중 하나이며, 자폐스펙트럼장애아동의 중재에 유용한 것으로 나타났다. 연구를 통해 향후 로봇활용의 일반화를 촉진할 수 있는 적용 절차 및 단계 등에 대한 세분화된 접근이 필요함을 알 수 있었다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제31권1호
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• pp.41-45
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• 2020

Objective: The objective of this study was to assess serum, hair, and urinary magnesium (Mg) levels in children with attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and both ASD and ADHD to reveal potential interactive effects. Methods: A total of 148 boys aged 4-9 years old were enrolled in this study, including 44 children with ADHD, 40 pediatric patients with ASD, 32 patients with both ADHD and ASD, as well as 32 healthy neurotypical children. Hair, serum, and urinary Mg levels were assessed using inductively-coupled plasma mass spectrometry (ICP-MS). Laboratory quality control was performed using certified reference materials of human hair, plasma, and urine. Results: No significant group difference in serum Mg levels was observed. Mg content in hair was found to be reduced in children with ADHD and ADHD+ASD compared to that in healthy controls by 11% and 15%, respectively. Urinary Mg levels in children with ADHD+ASD exceeded the control, ADHD, and ASD values by 51, 76, and 65%, respectively. Factorial analysis revealed significant contribution of ADHD to hair and urinary Mg levels. Multiple regression analysis demonstrated that hair and urinary Mg levels were considered as significant predictors of neurodevelopmental disorder complexity. Conclusion: We propose that impaired Mg status may provide a link between ADHD and ASD.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제29권2호
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• pp.80-85
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• 2018

Objectives: We aimed to assess the test-retest reliability, internal consistency, and validity of the Korean version of the Quantitative Checklist for Autism in Toddlers (Q-CHAT). Methods: The Korean version of the Q-CHAT and the Korean version of the Child Behavior Checklist (CBCL) 1.5-5 were completed by parents of 24 toddlers and preschoolers with autism spectrum disorder (ASD) and 80 unselected toddlers and preschoolers. Parents of the ASD group also completed the Social Communication Questionnaire (SCQ), and Childhood Autism Rating Scale (CARS) scores were obtained from medical records. Results: The ASD group scored higher on the Q-CHAT than the unselected group. The Cronbach's alpha coefficient of the Q-CHAT was 0.658, and test-retest reliability was calculated to be 0.836. The estimated area under the curve was 0.793. The total scores of the Q-CHAT in the ASD group demonstrated significant positive correlations with findings regarding pervasive development problems in the CBCL, SCQ, and CARS. A total score of 33.5 may be a useful cutoff point to use when identifying toddlers at risk of ASD. Conclusion: The Korean version of the Q-CHAT has good reliability and validity and can be used as a screening tool in order to identify toddlers and preschool children at risk of ASD.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제21권3호
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• pp.153-160
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• 2010

Objectives: The purpose of this study was to evaluate the prenatal, perinatal, and infancy history of children with autism spectrum disorder (ASD) as compared to unaffected siblings (SIB) and typically developing children (TC). Methods: Subjects with ASD, their SIB, and TC were recruited. All subjects were assessed using both the Korean version of Autism Diagnostic Interview-Revised (K-ADI-R) and the Korean version of Autism Diagnostic Observation Schedule (K-ADOS) and were subsequently identified as affected or unaffected. Prenatal, perinatal, and infancy history was obtained from the primary caregivers and each facet was compared in those with ASD, the SIB, and the TC groups using SPSS ver. 17.0 (p<.05). Results: 70 individuals with ASD (63 males, 87.94${\pm}$37.8months), 53 SIB (27 males, 85.4087.94${\pm}$48.06 months), and 32 TC (19 males, 104.1987.94${\pm}$23.409 months) were analyzed. The ASD group showed significantly higher rates of insufficient vaccination as they aged age ($x^2$=15.54, p=.000). Among the scheduled vaccinations, the DPT vaccination ($x^2$=10.08, p=.006) was insufficient in ASD groups. The ASD group also showed higher rates of sleep disturbances from infancy. Differences in maternal/paternal age at conception, gestational age, and growth parameters at birth were not significantly difference among the three groups. Conclusion: These results do not support the previous controversies regarding the relationship between prenatal/perinatal complications and ASD. However, these results indicate that perinatal and prenatal factors may contribute to the development of ASD.

• 대한통합의학회지
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• 제9권2호
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• pp.131-140
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• 2021

Purpose : The purpose of this study was to systematically review the studies on the effects of social story intervention on the individuals with autism spectrum disorders(ASD) to provide the basis for evidence-based practice. Methods : In order to find out the studies on the effect of social story intervention on individuals with ASD, studies published from 2011 to December 2020 were searched on Google Academic Search. The keywords used were "autism spectrum disorder AND social story". A total of 16,900 studies were searched, and from these, 12 studies were selected based on the application of the selection and exclusion criteria. The included studies comprised of 10 single subject design studies and 2 randomized controlled trials design studies. The included studies were analyzed in accordance to population, intervention, outcome measures and results. Results : As a result of analysing the subjects of the included studies, we found out that pre-school children and adolescents were the most common groups of individuals diagnozsed with ASD. In addition to ASD, the diagnosis of the subjects included intellectual disability, Asperger, and Prader-willi. We found out that there were more interventions that were mixed with other interventions, than just the pure social story interventions. In particular, video modeling was found to be the most frequent intervention. This was followed by photo-based social stories. For outcome measure, autism social skills profile was found to be the most often used standardized assessment. For a non-standardized assessment, social desired behavior was found to be the most frequently evaluated behavior, followed by personal problem behavior. Of all the dependent variables, the dependent variable reported as "effective" was the most, followed by "some effective". Conclusion : This study is organized to help the individuals with ASD, families, researchers, and therapists understand the effects of social story intervention on the individuals with ASD in an easy fashion. Further, therapists can use this study as the basic data for evidence-based practice.

• 디자인학연구
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• 제20권3호
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• pp.215-224
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• 2007

본 연구에서는 발달장애 아동을 위한 VR-Tangible Interaction 치료 시스템을 디자인하고 개발하였다. 본 치료시스템의 목적은 감각통합치료, 사회성 훈련, 협응능력 측정의 세 분야에 있어 발달장애 아동이 VR과 Tangible Interaction을 즐겁게 체험하는 과정에서 아동의 능력을 진단하고 자연스럽게 치료효과를 얻을 수 있도록 하는 것이다. 디자이너와 의사, 심리학자, 공학자가 학제적인 연구를 통하여 총 14종의 인터랙션 시나리오를 작성하고 콘텐츠를 디자인했다. 표정을 보고 사람의 마음 짐작하기, 상대방이 바라보고 있는 대상이 어느 것인지 맞추기, 지시봉으로 가상의 풍선 터뜨리기 등의 인터랙션이 디자인되었다. 프로토타입 시스템을 제작하고 임상테스트를 실시한 결과 발달장애 아동들이 VR-Tangible Interaction이라는 새로운 환경에 자연스럽게 적응하는 것을 확인할 수 있었으며 긍정적인 치료효과들을 예견하게 하는 정성적, 정량적인 결과들을 얻을 수 있었다.

• 정신신체의학
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• 제24권2호
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• pp.157-164
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• 2016

Objectives : The objective of this study was to investigate the characteristics of language profiles according to whether or not Korean children with autism spectrum disorder(ASD) also have ADHD, and to examine the relationship with executive function. Methods : Participants in the study were boys with ADHD aged 6 to 11 years who visited the clinic from January 2012 to December 2013. In this study, 25 boys with ASD were included, and completed scales included the Korean version of Autism Diagnostic Interview-Revised(K-ADI-R), Korean version of Autism Diagnostic Observation Schedule(K-ADOS), Korean ADHD Rating Scale(K-ARS), and Korean-Conners' Parent Rating Scale(K-CPRS). They also completed neuropsychological tests and assessed language profiles. Patients were categorized into two groups(with ADHD and without ADHD). T-test and Multivariate analysis of covariance (MANCOVA) was used for analysis. Results : Statistically, no difference was found in receptive and expressive language ability between the ASD groups with and without ADHD. However, a lower score in Test of Problem solving(TOPS) was observed for ASD with ADHD than for ASD without ADHD, with problem solving and finding cues showing significant differences. Conclusions : These findings suggest that language profiles in the ASD group without ADHD could be similar to those in the ASD group with ADHD, but comorbid ADHD could lead to more difficulty in linguistic ability for problem solving and could be related with executive function of the frontal lobe.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제26권4호
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• pp.273-278
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• 2015

Objectives : We retrospectively investigated the efficacy and tolerability of risperidone monotherapy in subjects with autism spectrum disorder (ASD). In addition, we did mixed effect model analysis of the effects of risperidone in patients with ASDs naturalistically treated in a routine clinical setting to determine whether the clinical effects were maintained and the side effects were tolerable. Methods : This retrospective study assessed children and adolescents with ASD, who were on risperidone monotherapy from July 2010 to July 2011 at the Child and Adolescent ASD Clinic at Seoul National Hospital. Outcome measures included the Clinical Global Impression-Severity of Illness (CGI-S) and the CGI-Improvement (CGI-I) scales along with other clinical indices: dosage, target symptoms, and side effects. Results : The mean dose of risperidone in 47 children and adolescents with ASD (40 males, 7 females; age range 5-19 years) who were on risperidone monotherapy was $1.6{\pm}0.8mg/day$, and the mean duration of the treatment period was $20.2{\pm}17.3months$. Aggressive behavior, stereotypic behavior, irritability, and self-injurious behavior were the most frequent target symptoms of risperidone. The most common side effects were weight gain followed by somnolence and extrapyramidal symptoms. In a mixed effects model analysis of CGI-I scores, the mean CGI-I score at the 1 month follow-up was significantly different from the mean CGI-I score of the 3-month follow-up (p=.046), and the CGI-I scores were equally maintained over 3 to 48 months [F(6, 28.9)=4.393, p=.003]. Of the 47 patients, 33 patients (70.2%) were identified as the response group, showing an end point CGI-I rating of 3 or under and having continued risperidone treatment for at least 6 months. The baseline CGI-S score showed significant association with clinical response to risperidone (p=.005), the mean baseline CGI-S was higher in the response group compared to the non-response group. Conclusion : In this study, clinical improvement of risperidone stabilized around 3 months and was equally maintained up to 48 months with tolerable side effects, supporting maintenance of risperidone treatment in children and adolescents with ASDs.

• 아동학회지
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• 제23권4호
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• pp.185-197
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• 2002

The Korean Wechsler Preschool and Primary Scale of Intelligence (K-WPPSI) was administered to 27 autistic children, 3 to 7 years of age. The average IQ was 51.96. There were negative correlations of verbal and performance IQs with chronological age. These children generally performed very poorly on each subtest. Paradoxically, the verbal subtest scores of these autistic children were higher than their performance scores; thus, the typical verbal inferionity of autistic children was not evident in this study. These results suggest that autistic children's K-WPPSI performance needs to be interpreted with care; additional raw score analysis was recommended. Administrative revision of the K-WPPSI will be necessary to measure detailed intellectual differences among autistic children.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제5권1호
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• pp.41-53
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• 1994

1944년 Hans Asperger는 아동기에 사회적인 고립과 특이한 행동 양식을 보이는 400명의 증례를 보고하고 자폐적 병질(autistic psychopathy)이라 명명하였는데 이 아동들은 1943년 Kanner에 의하여 기술된 자폐 아동들과 여러 가지면에서 유사하였으나 임상적인 관찰에서 몇몇 현저한 차이를 나타냈다. 가장 주목할 만한 것은 정상 언어 발달과 지능 수준의 차이를 들 수 있다. 이후에 이들은 Asperger's syndrome([CD-10) 혹은 Asperger's disorder(DSM-IV)로 명명되었는데 이들은 자폐증과 연속선상에 있는 높은 기능 수행을 보이는 경한 형태의 발달장애로 보는 시각, 아동기 인격 장애의 특수한 형태로 보는 시각, 혹은 성인 정신분열증의 초기 아동기 행태로 보는 시각등이 있는데, 모두 그들 나름대로 연구 방법의 타당성과 결과 해석의 문제점을 안고 있다. ICD-10(1992)과 DSM-IV(1994)에서 전반적 발달 장애의 영역내에 새로이 독립된 진단 체계로써 확고히 자리한 지금에 와서도 이들 질환과 완전히 분리된 개념으로 간주하기에는 미흡한 실정이다. 저자는 이 질환의 현재 개념에 이르기까지의 역사적 고찰과 더불어 독립된 질환이냐의 논의점과 최근 연구 경향에 대해 문헌 고찰을 하였으며 이 증후군이 큰 맥락에서 사회적 본능(social instinct)에 결함이 있는 장애라는 견지에서 연계 질환들과의 관계를 도식적으로 요약해 보았다.